Objective: To implement humanized quality care in critical respiratory failure nursing, observe the effect, and analyze the satisfaction. Methods: 80 patients with severe respiratory failure were divided into 40 cases per group (admitted from February 2022 to December 2023) by double-blind method, the control group performed routine care, and the observation group was given humanized quality care. Results: After the nursing care, two respiratory function indexes of the observation group were lower than those of the control group, and two pulmonary function indexes were higher than those of the control group (P < 0.05); regarding the complication situation, the incidence rate of the observation group was lower (P < 0.05); regarding the nursing care satisfaction situation, the observation group had a higher level of total satisfaction (P < 0.05). Conclusion: The application of a humanized quality nursing intervention model in the care of critical respiratory failure can actively improve patients’ respiratory status and lung function, reduce complications, and satisfy patients.