Life Quality Index Research Articles

Aerobic training effect on mental health and biological indicators in Post-COVID-19 patients

Introduction. One of the aspects of health most affected in patients infected by COVID-19 was mental health. Leading organizations worldwide have recommended physical activity as one of the main actions. Objective. To analyze the effect of a short-term aerobic training program on biological and mental health and quality of life indicators in post-Covid-19 patients. Methods. Symptomatology of depression, anxiety, stress, quality of life, vital signs, physical fitness and body composition were measured in 10 post COVID-19 patients. An aerobic physical exercise program was applied at 40-60% intensity, five days a week, 50 minutes per session for four weeks. Results. A 30% decrease in depression symptomatology, 58% in stress and 44% in anxiety was found during the intervention period (p<0.001). Regarding the perception of quality of life, the psychological area was the one that presented a positive effect during the intervention (p=0.035). An increase in leg strength (p=0.018) and a decrease in body fat (p=0.005) were found during the intervention. Conclusion. A short-term physical exercise program shows benefits in mental health indicators in post-COVID-19 patients. Key Words: Physical activity; Mental health; Quality of life, COVID-19; Fitness.

Effect of financial deprivation on the quality of life of patients with traumatic brain injury

BACKGROUND: Traumatic brain injury (TBI) is a global public health problem and one of the leading causes of mortality and disability. The prevalence and increase in the number of cases of TBI, high percentage of complications, disability, uncertain medical and social prognosis determine the relevance of studying this medical and social problem, the most significant in which are the consequences of craniocerebral trauma, often acquiring a chronic course, affecting the quality of life of the patient and his family.
 AIM: To study the influence of financial deprivation on the quality of life of patients with post-TBI.
 MATERIALS AND METHODS: The study of quality of life in patients with a post-TBI event was conducted using the WHOQOL-100 questionnaire. The study randomly sampled 414 respondents of working age (93.6% men). 54% of the respondents had suffered TBI within 1 to 5 years. The control group included clinically healthy subjects. The Dembo–Rubinstein test was used to diagnose the adequacy of respondents’ self-assessment with TBI. In the study of the impact of financial deprivation on the quality of life of the respondents, 4 degrees of deprivation correlated with the level of income per patient’s family member were considered.
 RESULTS: The study of the impact of financial deprivation on the quality of life of patients with TBI identified 4 deprivation groups of respondents. The study obtained evidence of the effect of deprivation on the quality of life of respondents with TBI. The indicators of quality of life of patients included in the study significantly increase when moving from the group with degree 4 of deprivation to the group with degree 1 of deprivation. The greatest decrease in quality of life indicators was observed in respondents with degrees 2–4 of deprivation.
 CONCLUSION: A multicomponent assessment of the results of TBI takes into account quality of life, a somatic and socially determined criterion of a patient’s social functioning that has prognostic value. The definition and typology of predictors of quality of life will allow the development of prognostic models of quality of life after TBI of different severity.

Right-sided colonic diverticulitis. Short and long-term surgical outcomes and 2-year quality of life.

We aimed to investigate the short and the long-term outcomes and 2-year Quality of Life (QoL) of patients with right-sided colonic diverticulitis (RCD) surgically managed. We conducted an ambidirectional cohort study of patients with RCD undergoing surgery between 2012/2022. A colonoscopy was performed at 1-year post surgery. The enrolled patients completed the EuroQoL (EQ-5D-3L) during a regular follow-up visit at 12 and 24months after surgery. Three hundred nineteen patients with RCD were selected: 223 (70%) patients were treated by non-operative management (NOM) while 33 underwent surgery. Acute diverticulitis occurred in 30 patients: 9 (27.2%) were classified by CT as uncomplicated and 21 (63.6%) as complicated diverticulitis. Additionally, chronic diverticulitis occurred in 3 cases (9.2%). Specifically, 27 patients were classified by CT as 1a (81.8%) and 6 patients as 3 (18.2%). Right hemicolectomy was performed in 30 patients (90.8%), and ileo-caecectomy in 3 (9.2%). Nine (27.27%) experienced postoperative complications: 7 (77.7%) were classified according to the Clavien-Dindo as grade I-II, and 2 (22.2%) as grade III. No disease recurrence or colorectal cancer (CRC) was detected on colonoscopy. Thirty (90.8%) patients completed the 24-month follow-up. A statistically significant difference between preoperative and 24-month QoL index values (median 0.72; IQR=0.57-0.8 vs. median 0.9; IQR=0.82-1; p=0.0003) was observed. The study results demonstrate satisfactory surgical outcomes and a better QoL after surgery. No disease recurrence or CRC was observed at colonoscopy 1year after surgery.

Life quality of the population of the Republic Bashkortostan: A comparative analysis of housing conditions and infrastructure

Subject. The article considers issues of providing for basic human needs. Objectives. The purpose is to assess the main objective indicators of life quality of the population of the Republic of Bashkortostan. Methods. The study employs methods of statistical analysis. Results. The paper established that the Republic of Bashkortostan occupies a relatively low position among the leading regions in terms of the quality of life of the population. However, in the Republic of Bashkortostan, measures are being taken to support and develop certain sectors of the economy, contributing to gradual growth of the population’s welfare. Conclusions. The findings can be applied in designing and implementing regional housing development programs.

Machine-learning model predicting quality of life using multifaceted lifestyles in middle-aged South Korean adults: a cross-sectional study

BackgroundIn the context of population aging, advances in healthcare technology, and growing interest in healthy aging and higher quality of life (QOL), have gained central focus in public health, particularly among middle-aged adults.MethodsThis study presented an optimal prediction model for QOL among middle-aged South Korean adults (N = 4,048; aged 30–55 years) using a machine-learning technique. Community-based South Korean population data were sampled through multistage stratified cluster sampling. Twenty-one variables related to individual factors and various lifestyle patterns were surveyed. QOL was assessed using the Short Form Health Survey (SF-12) and categorized into total QOL, physical component score (PCS), and mental component score (MCS). Seven machine-learning algorithms were used to predict QOL: decision tree, Gaussian Naïve Bayes, k-nearest neighbor, logistic regression, extreme gradient boosting, random forest, and support vector machine. Data imbalance was resolved with the synthetic minority oversampling technique (SMOTE). Random forest was used to compare feature importance and visualize the importance of each variable.ResultsFor predicting QOL deterioration, the random forest method showed the highest performance. The random forest algorithm using SMOTE showed the highest area under the receiver operating characteristic (AUC) for total QOL (0.822), PCS (0.770), and MCS (0.786). Applying the data, SMOTE enhanced model performance by up to 0.111 AUC. Although feature importance differed across the three QOL indices, stress and sleep quality were identified as the most potent predictors of QOL. Random forest generated the most accurate prediction of QOL among middle-aged adults; the model showed that stress and sleep quality management were essential for improving QOL.ConclusionThe results highlighted the need to develop a health management program for middle-aged adults that enables multidisciplinary management of QOL.

Social Determinants of Health Among Persons Living with HIV Impact Important Health Outcomes in Michigan.

Addressing social determinants of health (SDOH) is a national priority for improving quality of life and addressing obstacles to accessing care for people living with HIV (PLWH). Utilizing the Oregon Social Determinants of HIV Health Index and CDC's Medical Monitoring Project, we examined the association between social determinants of health and various HIV clinical outcomes and quality of life indicators, including stigma and mental health, for people living with HIV in Michigan. We calculated estimates of SDOHs, clinical outcomes, stigma, and mental health using weighted percentages and prevalence ratios with predicted marginal means, adjusting for age, race/ethnicity, and gender/sexual orientation. Compared with PLWH reporting 0-1 SDOH challenges, those reporting ≥ 4 SDOH challenges were more likely to miss ≥ 1 HIV care appointment (aPR: 2.57, 95% CI 1.70-3.88), have symptoms of depression (aPR: 4.03, 95% CI 2.68-6.05) and anxiety (aPR: 3.55, 95% CI 2.25-5.61), and less likely to have 100% antiretroviral therapy (ART) adherence (aPR: 0.62, 95% CI 0.50-0.78) and sustained viral suppression (aPR: 0.77, 95% CI 0.65-0.90). Stigma scores were highest for those reporting ≥ 4 SDOH challenges. Our findings indicate significant associations between SDOH and adverse HIV health and quality of life outcomes which can inform and direct federal, state, and local strategies aimed at improving these outcomes. Linking PLWH to social support services and providing mental health screening and care services could benefit their mental and emotional well-being, leading to better healthcare outcomes.

Home-based lifestyle intervention for breast cancer survivors: A surprising improvement in the quality of life during the first year of COVID-19 pandemic.

The COVID-19 pandemic induced an extraordinary impact on public mental health to a degree not completely understood, especially in vulnerable populations such as breast cancer (BC) survivors. In this study, we described the short- (after 3-month) and long- (after 12-month) term effects of a multidisciplinary home-based lifestyle intervention in Italian women BC survivors during the first year of COVID-19 pandemic. In total, 30 Italian BC survivors with risk factors for recurrence took part in the ongoing MoviS trial (protocol: NCT04818359). Between January 2020 and January 2021, a 3-month lifestyle intervention based on psychological counseling, nutrition, and exercise was carried out. Participants were asked to fill out psychological questionnaires for the assessment of quality of life (QoL) indicators (European Organization for Research and Treatment of Cancer QoL, EORTC-QLQ-C30) and psychological health measures such as fatigue (Brief Fatigue Inventory, BFI), distress (Distress Thermometer, DT and Psychological Distress Inventory, PDI), cancer-related fatigue (Verbal Rating Scale, VRS), and mood states (Profile of Mood States Questionnaire, POMS). IBM SPSS Statistical Software version 27.0 and R Project for Statistical Computing version 4.2.1 were used to process data. All participants were assessed at four time points: T0 (baseline), T1 (3-month), and follow-up at T2 and T3 (6- and 12-month, respectively) to measure primary (quality of life indicators) and secondary (psychological health) outcomes. Friedman non parametric test and Wilcoxon signed rank test (with Bonferroni correction) were conducted to investigate the statistically significant differences in psychometric scores and between assessment times. Compared to baseline (T0), at T1 most of the QoL indicators (i.e., symptoms of fatigue and general health) were improved (p < 0.017) with the exception of a worsening in participants' social functioning ability. Also, perception of severity of fatigue, distress, cancer-related fatigue, depression, and anger enhanced. Compared to baseline (T0), at T3 we mainly observed a stable condition with T0-T1 pairwise comparison, however other secondary outcomes (i.e., fatigue mood state, confusion, and anxiety) significantly improved. Our preliminary findings support the proposal of this lifestyle intervention for BC survivors. Despite the home-confinement due to the COVID-19 pandemic, the intervention surprisingly improved QoL indicators and psychological health of the participants.

Pain intensity, physical activity, quality of life, and disability in patients with mechanical low back pain: a cross-sectional study

BackgroundPoorly managed mechanical low back pain (MLBP) and its sequelae, such as severe pain, physical inactivity, and disability, negatively impact patients’ quality of life (QoL). The study aimed to determine the pain intensity (PI), physical activity (PA), QoL, and disability, the association between selected sociodemographic variables and PI, PA, QoL, and disability, and the relationship between PI, PA, QoL, and disability among Nigerians with chronic MLBP.MethodsThis cross-sectional study employed a consecutive sampling technique. Outcome measures included the Numeric Pain Scale, International Physical Activity Questionnaire-Short Form, WHO Quality-of-Life Brief, and Oswestry Disability Index for PI, PA, QoL, and disability, respectively. Descriptive statistics were used to summarize participants’ sociodemographic variables. Chi-square, Spearman’s correlation, and structural equation modeling (SEM) were used for inferential analyses.ResultsTwo hundred and fifty chronic MLBP patients comprising 154 females and 96 males, completed the study. The mean PA, PI, QoL, and disability levels were 1118.03MET ± 615.30, 5.97 ± 2.69, 73.45% ± 14.21, and 21.7% ± 18.94, respectively. There was a significant correlation between PA and QoL (rho = 0.36, p = 0.001), PA and disability (rho = −0.42, p = 0.010), QoL and disability (rho = −0.21, p = 0.008), QoL and PI (rho = −6.72, p = 0.025), PI and disability (rho = 0.90, p = 0.022). Aside from age and PA (χ2 = 8.52, p = 0.045), there was no significant association between the sociodemographic variables and PI, PA, QoL, or disability. SEM showed a strong positive association between PI and disability (β = 0.80, p < 0.001).ConclusionIndividuals with chronic MLBP had a low PA, moderate QoL, and significant disability. Incorporating PA, QoL, and disability assessments may enhance the evaluation and management of MLBP.

Ab. No. 182 A Case Series on Post Hysterectomy Quality of Life Check in Females of Select Rural Southern Haryana Villages

Introduction: Clinicians we will create the requisite awareness among the females and our clinical gentry on the importance of lading guidelines before such surgeries especially in cases with long-term recovery phase such as hysterectomy. The major reason of doing the study is the absolute lack of awareness in women of rural Haryana in the selected villages that led to the belief that women suffered the post hysterectomy bodily changes far more than before it. Methods: Selection criteria was purposive with our team visiting the villages of Bandhwari, Berka and Hajipur along with NSS team of K.R. Mangalam University, Sohna Road, Gurugram. Par-q and SF36 scale were used to qualitatively assess females’ quality of life index and their readiness to physical activity. Result: The result specifies that the PARQ and the SF36 are likely to positively correlate with age and region of women with hysterectomy. Conclusion: Females who had hysterectomy (type not specified) have had a moderate to severe impact on their physical health. Implications: This leads us to believe that the women who had undergone hysterectomy had in general been poorly informed of future implications. This led us to a revelation that females were poorly educated on the post-surgical changes in their body.

Comparison of Different Hemodialysis Frequencies per Week on Adequacy Parameters Including Electrolytes in Patients on Chronic Hemodialysis

Introduction: Due to the limitations in finding the right donor, the majority of patients with renal failure (chronic kidney disease stage 5) are treated with hemodialysis. In literature, we have extensive evidence of different hemodialysis prescriptions based on different frequencies per week and duration of each session. We tried to assess the impact of different hemodialysis frequencies on the adequacy of dialysis based on nutritional parameters, electrolyte imbalances and quality of life (QoL) parameters. Material and Methods: It was a single center, prospective, observational study conducted over three consecutive months on patients on hemodialysis and their biochemical, and QoL parameters were recorded. We could enroll 29 patients for this study. The objective was to assess the effect of different hemodialysis frequencies per week on hemodialysis adequacy parameters and QoL indices. Results: The baseline characteristics were uniform with respect to age (p=0.761) and commonly associated co-morbidities like obesity (BMI p=0.971), hypertension (p=0.927), diabetes mellitus (p=0.822). The serum albumin was observed to be similar in patients receiving either thrice weekly or twice weekly hemodialysis (p=0.736). The URR and kt/v were marginally higher in patients receiving thrice weekly dialysis but with no statistical significance (p=0.938 for URR &amp; p=0.615 for kt/v). Discussion and Conclusions: The biochemical indices of nutrition along with electrolyte imbalance and quality of life parameters observed with different frequencies of hemodialysis per week were identical over three consecutive months.

Association between participation restriction due to hearing loss and self-perception of health, social support, and quality of life in elderly people: a cross-sectional study.

To verify the association between participation restriction due to hearing loss and self-perception of health, social support, and quality of life in elderly people. This is a cross-sectional, observational, and descriptive study with a quantitative data approach. A database with information collected in a medium-sized Brazilian municipality was used. The study was conducted with 235 elderly people registered in five Family Health Strategy Units. Sociodemographic and health information and the results of the following questionnaires were used: Hearing Handicap Inventory for the Elderly - Screening Version (HHIE-S), Medical Outcomes Study (MOS) Social Support Survey, Subjective Health Assessment, and Short-Form 6-Dimension (SF-6D) Health and Quality of Life Index. Groups with and without participation restriction were compared according to sociodemographic, health, social support, and quality of life variables. A multivariate binary logistic regression method was employed to evaluate the associations between the independent variables and participation restriction. The group with participation restriction is composed of older individuals with lower quality of life and poorer self-perception of health. Poorer self-perception of health was the only predictor of participation restriction related to hearing loss. Participation restriction is associated with poorer self-perception of health. The study highlights the importance of assessing individuals' self-perception regarding biopsychosocial issues, in addition to considering the environmental context to understand the social and emotional impacts caused by hearing loss.

Состояние здоровья и качество жизни детей с хронической диареей

The purpose — to comprehensively assess the health status of children and adolescents with chronic diarrhea and the impact of chronic diarrhea on quality of life indicators. Material and methods. 466 children were examined. The main group consisted of 240 children with chronic diarrhea aged from 1 month to 18 years (average age 7.3 ± 5.3 years). The comparison group consisted of 226 children of health groups 1-2 without chronic diarrhea (average age 6.9 ± 4.6 years). The exclusion criteria were newborn period, children with chronic pathology during decompensation period, severe somatic pathology. Clinical and anamnestic research methods were used: parents’ questionnaires, anthropometric measurements, system analysis of the child’s medical documentation, general clinical research methods. The quality of life was assessed in children over 2 years of age using the PedsQL4.0™ general questionnaire. Results. Children with chronic diarrhea are 3 times more likely to have allergic pathology, significantly more likely to develop deficient conditions — rickets and latent iron deficiency. When analyzing the degree of resistance in the study groups, it was revealed that children with chronic diarrhea are significantly more likely to have lower body resistance indicators. When assessing the state of the colon microflora, it was found that an excessive growth of opportunistic flora is much more common among the children of the main group. It was also found that children with chronic diarrhea at an early age are most susceptible to a decrease in body mass index. Children of the main group have low indicators of quality of life in terms of physical functioning and experience difficulties in the social sphere in the form of low communication with peers and a decrease in school performance. Conclusion. Children suffering from chronic diarrhea under dispensary supervision need additional correction of trace elements, nutritional support and prevention of acute respiratory diseases. It is important to assess the physical development of children suffering from chronic diarrhea more often for timely diagnosis of abnormalities.

Associação entre restrição à participação decorrente de perda auditiva e autopercepção de saúde, suporte social e qualidade de vida da pessoa idosa: estudo transversal

ABSTRACT Purpose To verify the association between participation restriction due to hearing loss and self-perception of health, social support, and quality of life in elderly people. Methods This is a cross-sectional, observational, and descriptive study with a quantitative data approach. A database with information collected in a medium-sized Brazilian municipality was used. The study was conducted with 235 elderly people registered in five Family Health Strategy Units. Sociodemographic and health information and the results of the following questionnaires were used: Hearing Handicap Inventory for the Elderly – Screening Version (HHIE-S), Medical Outcomes Study (MOS) Social Support Survey, Subjective Health Assessment, and Short-Form 6-Dimension (SF-6D) Health and Quality of Life Index. Groups with and without participation restriction were compared according to sociodemographic, health, social support, and quality of life variables. A multivariate binary logistic regression method was employed to evaluate the associations between the independent variables and participation restriction. Results The group with participation restriction is composed of older individuals with lower quality of life and poorer self-perception of health. Poorer self-perception of health was the only predictor of participation restriction related to hearing loss. Conclusion Participation restriction is associated with poorer self-perception of health. The study highlights the importance of assessing individuals’ self-perception regarding biopsychosocial issues, in addition to considering the environmental context to understand the social and emotional impacts caused by hearing loss.

Agent-based Model for Predictive Assessment of the Migration Flows Dynamics in Municipal areas of the Bashkortostan Republic depending on Changes in the Population Life Quality

Favorable demographic and migration situation in the region contributes to its economic prosperity, since qualified personnel are necessary for successful development of the production potential of the territory. The migration attractiveness of the territory is determined by the population life quality, which implies not only high incomes of citizens, but also the development of transport and social infrastructure, accessibility of educational and medical services, favorable climate and environmental conditions, availability of jobs. The article describes the mathematical apparatus for calculating the integral indicator of the population life quality. To support decision-making on managing migration processes, an agent-oriented model is proposed that allows predicting the intensity of migration flows in the municipal districts of the Bashkortostan Republic depending on changes in the population life quality. Algorithms for choosing a place of residence and placement of production facilities for the agents &amp;quot;Resident&amp;quot; and &amp;quot;Enterprise&amp;quot; are described in detail. The output data of the model are forecasts of changes in the satisfaction of residents of the territory with the life quality, the number of migrants in the municipal district, the level of economic development of enterprises. Based on the current Federal Program “Integrated Development of Single-Industry Towns”, scenario experiments were conducted, which made it possible to predict the indicators of migration growth of the territories of the Republic of Bashkortostan involved in the implementation of the program.

Elderly Individuals' Satisfaction With Own Physical Activity Predicts Their Need for Care 3 Years Later.

This study investigated how elderly individuals' exercise satisfaction in snowy areas relates to their health indicators and future care needs. Survey data were collected from individuals aged ≥65 years who lived in snowy-cold regions. Participants completed measures of exercise satisfaction, frailty, quality of life (QOL), and cardiovascular health study during the winter and spring of 2019, with a follow-up measure in 2022 to assess care needs. Findings revealed an association between exercise satisfaction, QOL, and frailty indicators, irrespective of the season. Notably, winter exercise satisfaction showed a stronger correlation with future care needs compared to spring exercise satisfaction. Those expressing low winter exercise satisfaction were significantly more likely to require increased care 3 years later than those reporting no inactivity. Although physical activity was not measured directly, the findings underscore that perceptions of exercise satisfaction during snowy seasons can predict future care needs in older adults. The influence of seasonal variations and subjective exercise satisfaction on long-term care requirements is vital for tailored interventions and improved healthcare strategies for older adults in cold regions.

Indicators for evaluating the quality of life of men injured by the consequences of combat actions

The article presents the results of a comparative analysis of the responses of war victims to questions of the non-specific "ShortForm-36 Health Status Survey" (SF-36) questionnaire to determine the quality of physical and mental life at the time of filling out the questionnaire. The SF-36 questionnaire is one of the most common methods of measuring health-related quality of life and shows general well-being and the degree of satisfaction with aspects of a person's life that are affected by health. The vast majority of examined men injured as a result of hostilities were aged 30–49. It was found that against the background of a decrease in all indicators on the scales of the physical components of health, the most pronounced changes were recorded in the indicators of general health and role functioning caused by physical condition. In the psychological domain, the most pronounced changes were recorded in such components as mental health, vital activity and social functioning. A number of correlations were established between quality of life indicators in victims of hostilities. The closest probable positive correlation in men injured as a result of hostilities was established between physical functioning and role functioning caused by emotional state (r=+0.64; p&lt;0.05). A positive correlation was also found between general health and physical functioning (r=+0.43; p&lt;0.05), between general health and role functioning caused by emotional state (r=+0.34; p&lt;0.05), a probable positive relationship between mental health and life activity (r=+0.34; p&lt;0.05) and pain intensity (r=+0.42; p&lt;0.05). The correlation between role functioning caused by emotional state and role functioning caused by physical state was negative and amounted to -0.37 (p&lt;0.05). Keywords: SF-36, physical health, mental health.

Оцінка ефективності програми психокорекції для пацієнток із впершеніагностованою онкологічною патологією

The article presents the author's vision of the problem of providing psychological assistance to cancer patients in the process of consultative interaction and complex psychocorrective influence. There are outlined relationships between coping strategies and psychological well-being of cancer patients. There was compared the impact of standard psychological interviews to complex psychocorrective measures developed on the basis of data obtained during the first stage of the study. There were found changes in the psycho-emotional state, the level of adaptation to the disease and the quality of life of the patients, based on quantitative and qualitative psychodiagnostic methods. There has been established the specific elements of the psychocorrection program, which are the most effective for improving the psychological state and adaptation of patients, have been identified, as the interaction of these elements with the individual characteristics of each research participant. There were demonstrated significant improvements in quality of life indicators and a decrease in the feeling of helplessness among the participants of the research group. As a result of the obtained results, it was established that psychological correction is an important component in a comprehensive approach to the treatment and rehabilitation of patients with oncological diseases. There was emphasized the need for further implementation and development of psychocorrective programs to improve the quality of life of cancer patients and ensure their effective psychoemotional support. There has been proven the importance of integrating psychological support into the general plan of treatment and rehabilitation of cancer patients. Conclusions Based on the results of the data analysis, important conclusions can be drawn regarding the positive impact of psychological correction on the quality of life and reducing the feeling of helplessness among the study participants. It was found that the participants of the research group, who underwent complex psychocorrective interventions, demonstrated a significant improvement in "Quality of life" indicators and a decrease in the feeling of "Helplessness" compared to the control group. This indicates the importance of psychological support in the complex treatment and rehabilitation of cancer patients. It is worth noting that the conduct of such studies has certain methodological limitations, in particular, in relation to the selection of participants and the assessment of the long-term effects of psychocorrective interventions. Therefore, in order to deepen the understanding of the studied phenomena, further studies with a larger number of participants and longer observation of their condition are needed.

Роль корекції ендотеліальної дисфункції в комплексній профілактиці гіпертензивних ускладнень вагітності

Purpose - to study the effect of correction of endothelial dysfunction by the introduction of L-arginine in the comprehensive prevention of the development of severe hypertensive disorders in pregnant women. Materials and methods. The division into groups was carried out indiscriminately following the prescribed bath. 27 women reached the 1st group, who, in addition to basic prevention of preeclampsia (small doses of aspirin for 12 days, calcium supplement 1000 mg per dose for 16 years), took Tivortin until conception and p. It's an hour of urgency; up to the 2nd group - 54 women who did not receive basic prevention of preeclampsia. The control group (3) consisted of 16 healthy women with physiological changes in vagusity. Participants of the 1st group, during the hour of stay in the hospital, took L-arginine internally (iv) (4 g) + 2 teaspoons 2 times (4 g) per os per dose 40 minutes before admission, then 3 teaspoons spoons 2 times (6 g per dose). The average intensity of the droplets became 6. The function of the endothelium was evaluated according to the universally recognized non-invasive cuff test method, which is based on the principle of ultrasound assessment of the change in the diameter of the brachial artery in response to the restoration of blood flow in it after short-term compression of the upper limb with a cuff. Physical condition and endurance were assessed using the generally accepted 6-minute walk method. The quality of life in pregnant women who had experienced severe preeclampsia in the past was assessed in stages - according to the health-related quality of life (HRQoL) scale and the scale created by the World Health Organization (WHOQOL-BREF). Results. Arterial hypertension and preeclampsia are based on changes in endothelium-dependent vasodilatation. A positive effect on the function of the endothelium significantly improves indicators of physical well-being and quality of life. When conducting a test with a 6-minute walk in the Group 1, better indicators were found than in the Group 2 (respectively, 409±23 m vs. 381±32 m, p&lt;0.05), this indicator in the control group was 473±32 m (p&lt;0.05 according to the Groups 1 and 2). However, this indicator significantly improved in pregnant women of the Group 1 after intravenous administration of L-arginine: 441±12 m (p&lt;0.05 compared to the indicator before intravenous administration). According to the assessment of the quality of life of pregnant women of the studied groups, it should be noted that the quality of life indicators in all domains are significantly lower in women of the Group 1, which is associated with significantly worse anamnesis data of such women, significant concern about the results of the next pregnancy. When evaluating indicators of endothelium-dependent and endothelium-independent vasodilatation, it was found that in the group of women who received L-arginine preconceptionally, in the 1st trimester, the indicator before intravenous IV administration was 5.09±0.44, and after - 8.21±0.24, which indicates a significant improvement in endothelium-dependent vasodilation indicators (by 49.1%) 28-32 weeks, there are also no births of children with a body weight of less than 1500 g. Conclusions. In the group of high-risk pregnant women, the use of L-arginine in the complex prevention of preeclampsia allows to reduce the risks of early severe preeclampsia, to reduce the medication burden of two- and three-component hypotensive therapy. An increase in physical endurance, quality of life, and improvement in pregnancy outcomes are due to a positive effect on the function of the endothelium through the optimization of endothelium-dependent vasodilatation associated with the provision of the L-arginine substrate for the full synthesis of nitric oxide. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

Catheter Ablation of Paroxysmal and Persistent Atrial Fibrillation in Patients with Secondary Atrial Septal Defect. Evaluation of the Results and Impact on the Quality of Life

Introduction. The presence of atrial fibrillation (AF) in patients with secondary atrial septal defect (ASD) has significant impact on their quality of life (QoL) and reduces life expectancy. Current guidelines recommend catheter ablation (CA) for patients with AF in case of medical treatment failure, however, its use in patients with AF and ASD is still poorly studied.&#x0D; The aim. To study the efficacy and safety of CA and its impact on the QoL in patients with AF and secondary ASD.&#x0D; Materials and methods. In 2003-2023, 1408 patients with secondary ASD were treated at the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine. Of these, 54 patients who had AF and underwent the CA procedure were included in group 1 of our study. There were 36 (66.7%) men and 18 (33.3%) women aged 24-76 years (mean age 61.4 ± 9.8 years). Four (9.3%) patients had persistent AF and 50 (90.7%) patients had paroxysmal AF. Fifty-six patients with paroxysmal or persistent AF and with the comparable age, duration of symptoms and associated pathology but without ASD were examined as group 2. The type and results of surgical interventions were analyzed according to surgical reports. The results of the treatment and QoL were assessed using the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire during the follow-up period 1, 2 and 3 months after the procedure.&#x0D; Results. Pulmonary vein isolation was performed in all 54 (100%) patients of the group 1, as well as cavotricuspid isthmus ablation in 26 (48.2%) cases, cavotricuspid isthmus ablation and left atrial linear ablation in 2 (3.6%) cases. Type, length and complication of the procedure were comparable to those in the group 2. Fourty-four (81.5%) patients with ASD were free from AF 3 months after procedure, and their results did not differ from those obtained in the group 2 (p &gt; 0.05). Average QoL indicators according to AFEQT significantly improved in both groups of patients who underwent CA. The differences in post-treatment QoL between patients of both groups were insignificant (p &gt; 0.05).&#x0D; Conclusions. CA was found to be safe and beneficial in patients with AF and secondary ASD. The rate of procedural complications and cure rate in patients with AF and secondary ASD (81.5%) were compatible to those in patients without ASD (80.5%). AF has negative effect on the main indicators of the patient’s life. In patients with secondary AF with ASD who underwent CA, a significant improvement in AF symptoms and QoL according to the AFEQT questionnaire (total score 56.1 ± 2.7 before the procedure vs. 78.7 ± 4.0 at follow-up) was noted.

THE IMPACT OF COVID-19 ON THE QUALITY OF LIFE OF PATIENTS IN DENTAL PRACTICE: AN ANALYSIS OF HEALTH AND PSYCHOSOCIAL WELL-BEING

Quality of life (QoL) is a composite measure that reflects the overall level of satisfaction and well-being that a person experiences in their daily life. Understanding QoL is key to providing care and rehabilitation to patients, and issues identified during a QoL self-assessment may indicate the need to modify and improve treatment. It is widely recognized that COVID-19 has a diverse symptomatic spectrum. For the above reasons, COVID-19 can lead to a deterioration in health-related quality of life in both the short and long terms. The direct impact of COVID-19 on quality of life indicators, as well as the impact of coronavirus disease on dental health in general, served as a prerequisite for writing this article.&#x0D; The purpose of our study is to analyse the impact of COVID-19 on the quality of life of patients in dental practice.&#x0D; Materials and methods: all patients were interviewed for self-assessment of quality of life using the 36item Short Form-36 questionnaire.&#x0D; Results and Discussion: the obtained results among patients in group 1 and group 2 indicated a significant deterioration in both physical and psychological health components. The physical functioning (PF) score indicated average physical activity. The results of the impact of physical condition on role functioning (RP) reflected limitations in performing daily activities, both at work and at home. The pain intensity score (BP) indicated moderate body discomfort. The result for general health (GH) indicated the possibility of problems with general health and self-esteem. The vitality score (VT) indicated an average level of energy. The result obtained for the social functioning (SF) score indicated severe limitations in the social and psychological aspects of life. The value of the impact of the emotional state on role functioning (RE) indicated a significant effect of emotional difficulties on the patients' ability to perform habitual activities. The indicator of selfassessment of mental health (MH) indicated emotional and mental difficulties.&#x0D; Conclusions: This research demonstrates the ability of COVID-19 to cause long-term problems that directly affect the quality of life of patients and, accordingly, the possibility of developing dental diseases and their favourable prognosis.