Quality Of Life In Type Research Articles

From Numbers to Narratives: Understanding Quality of Life in Type 2 Diabetes

From Numbers to Narratives: Understanding Quality of Life in Type 2 Diabetes

(Keynote) Enabling Continuous Molecular Monitoring in vivo via Implantable and Wearable Aptamer-Based Sensors

The ability to continuously monitor fluctuating concentrations of specific molecules in the body can drastically improve precision medicine by allowing the real-time correlation of dynamic molecular processes with health and disease. While this ability has been pursued from multiple directions, electrochemical strategies have been successful and commercializable platforms. For example, continuous glucose monitors have dramatically improved the therapeutic management and quality of life for Type 1 diabetics. Unfortunately, the enzymatic sensing used in glucose monitors is not applicable to a large number of clinically relevant biomarkers. This limitation significantly reduces the scope of dynamic biochemical processes we can probe to study healthy human physiology and disease. In response, my laboratory is developing in vivo electrochemical aptamer-based sensors, a platform that is generalizable to the highly specific sensing of arbitrary molecular targets and supports continuous molecular monitoring in the body. In this presentation I will discuss the current state-of-the-art of these sensors, and the challenges we are addressing to enable preclinical and clinical applications.

Quality of Life for Type 2 Diabetes Mellitus Patients in Kirkuk City: A Cross-Sectional Study

Objectives: This study aims to assess the quality of life of diabetics living in Kirkuk and the factors affecting it. Methods: This cross-sectional study was carried out in primary care centers in Kirkuk, Iraq, from September 2021 to March 2022. The participants consisted of 150 participants who fulfilled the criteria for participation in the study. Clinical, and sociodemographic data and WHO Brief Quality of Life Scale format were collected from participants. Descriptive analysis, Kolmogorov-Smirnov, and Chi-square tests were used in the study's statistical analysis. Results: The majority of patients were over 59 years, psychological and social indicators scores were found as 52.7±13.8, the mean independence dimension scores were 41.7±11.8, the physical indicator scores were 38.1±12.1, the environmental indicator scores were 14.8±3.8, and finally the spiritual dimension was found as 8.7±6.2. Age, marital status, and quality of life were statistically significant (p=0.001), between income levels and quality of life were significant as p=0.03, and educational levels and quality of life were statistically significant (p=0.001). In addition, there was a statistical correlation between occupation, residence, family type, and smoking with quality of life. Conclusion: To improve the patient's quality of life, it is important to increase family awareness and provide appropriate family support in collaboration with the family in the care and treatment of the patient.

Health-Related Quality of Life in Type 2 Diabetes Mellitus Patients at Moi County Referral Hospital in Taita-Taveta County, Kenya

Non-transmittable diseases are becoming a burden in Sub-Saharan Africa due to changing lifestyle habits like smoking, inactivity, and poor diet. Although diabetes was once thought to the affluents-only disease, it is now more commonly seen in low- and middle-income nations like Kenya. The cross-sectional study's goal was to determine socio-demographic and health-related characteristics affiliated to QOL (quality of life) as well as how this condition affected patients with T2DM (type 2 diabetes mellitus) at Moi County Referral Hospital (MCRH) in Taita-Taveta County. were. The study adopted ADDQOL (audit of diabetes dependent quality of life) tool with 19 items version 2006, no alterations were done, and license number HPR4458 was issued to utilize the tool in this study. The 165 patients were picked using a systematic random sampling method. 127(77percent) of the study's participants had a mean quality of life score concerning diabetes of -1.88, roughly corresponding to "quality of life would be much better in the absence of diabetes" at a score of –2. An average weighted impact score of -4.48, indicated an unfavourable impact on the patients' QOL by diabetes mellitus. Foot ulcers/sores (p=0.005; a OR=7.348) and numbness/pain in hands, legs, or feet (p=0.001; a OR=0.155) were associated to low quality of life. The socio-demographic characteristics were not related to the quality of life. The domain-specific element of "sex life" was considered the most essential and negatively impacted at a weighted impact score of -5.14. Overall, quality of life of T2DM patients in MCRH was low. It is important to focus on the often-overlooked health-related characteristics coupled with the disability adjusted life years of diabetic patients and how they both influence their quality of life

Health-related quality of life and its determinants among South Indian type 2 diabetes patients with and without non-alcoholic fatty liver disease

Background and aimsNon-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease in type-2 diabetics. The quality of life among those patients was not explored well. Hence, the present study aimed to correlate the determinants with the quality of life (QoL) among the study subjects.MethodsA hospital-based case–control study was conducted at Bhargavi Gastro and Surgical Hospital, Warangal, Telangana, with 358 subjects, from 1 November 2019 to 31 October 2021 (24 months). A 358 of cohort type-2 diabetes mellitus (T2DM) subjects were recruited with 1:1 of NAFLD and without NAFLD. QoL was determined with the SF-36 questionnaire, which comprises eight domains. Statistical analysis included t test, chi-square, and Spearman correlation performed with SPSSV.25 software.ResultsOut of 358 subjects, 200 (55.8%) were males and 158 (44.1%) were females. Glycemic parameters (FBS and HbA1c), lipid profile, liver transaminases (SGPT and SGOT), and serum uric acid levels were significantly high in NAFLD subjects (p < 0.05). The SF-36 score, four domains (physical, energy, mental health, and pain) are significantly reduced in NAFLD subjects p < 0.05). A significant correlation between blood urea and impaired physical, emotional mental, and general health was observed in NAFLD subjects. In the NAFLD subjects, elevated FBS levels lead to impairment of physical and emotional status. Social functioning, general health, and pain were impaired with BMI and TG levels in NAFLD subjects. The mean, SD of SF-36 scores showed no significant difference in contrast to HbA1c among both groups (p > 0.05).ConclusionThe decreased QoL was observed in subjects of T2DM with NAFLD. The QoL is significantly influenced by elevated FBS, SGPT, SGOT, and TG levels. Hence, clinicians need to be vigilant and implement strategies to improve the quality of life in type 2 diabetics with NAFLD.

The Benefits of Telehealth on Quality of Life of People Living with Type 2 Diabetes Mellitus: A Literature Review

Introduction: Advancement technology and information benefit societies by way telehealth access, including those with diabetes mellitus. Telehealth implementation in diabetes mellitus management is a great solution of increasing access to healthcare and reducing geographical inequalities. Nevertheless, the effectiveness of service among people living with diabetes remains inconsistant. This review aims to summarize and evaluate the evidence on the effectiveness of telehealth on quality of life in type 2 diabetes mellitus&#x0D; Method: This review considers the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guideline. The results reported in descriptive narrative approach. The following databases; Scopus, Science Direct, PubMed, and Web of Science were comprehensively searched to find article from January, 1st 2018 to December 31st 2023. Inclusion was made to English and full-text article. &#x0D; Results: Two articles were included in the final review. A total of 482 type 2 DM patients were used telehealth. Findings on the impacts of the usability of telehealth on the QoL of Type 2 DM is telehealth relevant alternative to the care of DFU patients, with stable health, well-being and quality of life conditions and smartphone application-based interventions in the management of type 2 DM show that the quality of life in the following four dominants; psychological, social, environmental, and physical health revealed significant improvements&#x0D; Conclusions: Telehealth has good potential to be developed in the service of diabetes mellitus patients. The following internet-based delivered mode; web, and smartphones improve the quality of life and the well-being of patients with type 2 diabetes mellitus. However, lack of studies measuring the effectivity of telehealth among people with diabetes mellitus. Future development of internet-based interventions should further take into consideration the consolidated set of diabetes mellitus principles.&#x0D; Keyword: Type 2 Diabetes Mellitus, Quality of Life, Telehealth, Nursing Practice, Nursing Care

Impact of Dapagliflozin as add-on therapy on glycemic status and quality of life in type 2 diabetic patients

Evaluate the efficacy of dapagliflozin on glycaemic and non-glycaemic indices and assess quality of life in type 2 diabetes patients (T2DM) with inadequate glycaemic control on three oral antidiabetic agents (OADs). Patients with uncontrolled type 2 diabetes [Haemoglobin A1c 7.0%-12.0%] on sulfonylurea, metformin and gliptin were selected to receive dapagliflozin 5mg/day for 16 weeks (n=40). Fasting and postprandial plasma glucose, glycated haemoglobin A1c, body weight, and waist circumference were measured. Assessment of patients’ quality of life was performed using Quality of Life Scale for Iraqi Diabetic patients (QOLSID) at baseline and after administration of dapagliflozin. Dapagliflozin showed high significant reduction in fasting and postprandial plasma glucose, glycated haemoglobin A1c (HbA1c), body mass index (BMI) and index of central obesity (ICO) (p&lt;0.001). High significant changes in the QOLSID score after treatment (p&lt;0.001). High BMI is negative predictor for patients’ quality of life. Dapagliflozin improved both glycaemic and non-glycaemic parameters in T2DM patients who already on three OADs. This is promising results in short period makes the treatment a suitable alternative to insulin specially in patients not prefer to use injected medication. Dapagliflozin showed an improvement in the patients’ physical and psychological condition and consequently overall QOL.

Quality of life of type 2 diabetes outpatients and the associated factors: A cross-sectional study at Ha Dong General Hospital in 2020

Objectives: This study aimed to describe the quality of life (QOL) of type 2 diabetes outpatients receiving treatment and the associated factors at Ha Dong General Hospital in 2020. Methods: A cross-sectional descriptive study was conducted on 327 type 2 diabetes outpatients treated at Ha Dong General Hospital in 2020 by using the Asian Diabetic Quality of Life (Asian DQOL) questionnaire into Vietnamese. Results: The mean score of overall QOL of type 2 diabetes outpatients is 68.5 ± 9.9 points. 83.2% of outpatients have good overall QOL; there were no outpatients with poor QOL. Married patients have a higher quality of life than other groups; the lowest is in the divorced or widowed group. The family economy at the non-poor level has higher quality than the poor and near-poor groups. Female patients had a higher QOL than male patients. Patients with a disease detection time of 5–10 years had the highest QOL. The group of patients with an overweight BMI had higher quality than other patients The group of patients who did not receive insulin had a higher QOL than the patients who received insulin. Patients without comorbidities had a higher QOL than the group with comorbidities. (p&lt;0,05) Conclusions: Research results show that the majority of people with type 2 diabetes at Ha Dong General Hospital have a good QOL. Marital status, family economic status, gender, time of disease diagnosis, BMI, treatment methods, and comorbidities are factors related to patients' QOL. Key words: Quality of life, diabetes, hospital, Ha Dong

(Invited) Electrochemical Aptamer-Based Sensors for Real-Time Molecular Monitoring in the Body

The ability to continuously monitor fluctuating concentrations of specific molecules in the body can drastically improve precision medicine by allowing the real-time correlation of dynamic molecular processes with health and disease. While this ability has been pursued from multiple directions, electrochemical strategies have been successful and commercializable platforms. For example, continuous glucose monitors have dramatically improved the therapeutic management and quality of life for Type 1 diabetics. Unfortunately, the enzymatic sensing used in glucose monitors is not applicable to a large number of clinically relevant biomarkers. This limitation significantly reduces the scope of dynamic biochemical processes we can probe to study healthy human physiology and disease. In response, my laboratory is developing in vivo electrochemical aptamer-based sensors, a platform that is generalizable to the highly specific sensing of arbitrary molecular targets and supports continuous molecular monitoring in the body. In this presentation I will discuss the current state-of-the-art of these sensors, and the challenges we are addressing to enable preclinical and clinical applications. Figure 1

Metabolic control and quality of life in type 1 diabetes: Do adherence, family support, and school support matter?

This study analyzed the relationship between clinical and demographic variables, family support, school support, and adherence on adolescents' metabolic control and quality of life (QoL) based on Adaptation to Chronic Disease in Childhood's model. The sample included 100 adolescents and 100 parents. Adolescents were assessed on adherence, family support, school support, and QoL. Parents were assessed on family functioning and parental coping. A path analysis was performed to assess the adequacy of the theoretical model to the sample. Daily glycemic monitoring was associated with better metabolic control and diabetes hospitalizations with worse metabolic control. The final model showed adherence, family support, school support, and family functioning having an indirect effect on the relationship between adolescence stage, number of daily glycemic monitorings, number of hospitalizations, and metabolic control/QoL. Adherence had an indirect effect on the relationship between glycemic monitoring and family and school support, suggesting that adolescents need both types of support to perform diabetes self-care tasks. QoL showed a direct effect on metabolic control revealing the importance of QoL in the design of interventions to promote metabolic control in adolescents.

Relationship between self-efficacy with self-management and quality of life among Type 2 Diabetes Mellitus: A systematic review

Objective: Self-efficacy is one aspect predicted to influence the self-management of type 2 Diabetes Mellitus (DM) patients. Low self-efficacy will impact DM patients’ motivation to carry out self-care, causing uncontrolled blood glucose levels and decreasing the quality of life. This study aimed to determine the relationship between self-efficacy, self-management, and quality of life in type 2 DM patients using a systematic review.

The Effectiveness of Progressive Muscle Relaxation and Neuromuscular Taping on Ankle Brachial Index Values and Quality of Life in People With Type 2 Diabetes Mellitus

Introduction: Diabetes is a chronic disease characterized by abnormal blood sugar levels due to pancreatic disorders. Quality of life and ankle brachial index values are an area of concern for nurses related to non-pharmacological treatments to prevent complications. Progressive Muscle Relaxation (PMR) can improve relaxation and cellular immunity, as well as Neuromuscular Taping (NMT) is a non-pharmacological intervention to prevent lower extremity peripheral blood circulation decline, so both have a potential positive impact on the patient's quality of life. The aim of this study is to analyze the effectiveness of PMR and NMT on ankle brachial index (ABI) and quality of life in Type 2 Diabetes Mellitus (T2DM). Methods: The study was a quasy-experiment with a pre post test control group design. Consecutive sampling was implemented and resulted a sample of 32 T2DM patients with certain criteria, such as patients who were treated in the internal medicine ward, age 40-70 years, suffering from T2DM for more than5 years, not suffering from diabetic ulcers, and still can do some exercise. Data were analyzed using the Wilcoxon Signed Ranks Test with correlation test with alpha 0.05. Results: There was a significant effect of the PMR-NMT combination intervention on ABI (p= 0.034) and quality of life (p= 0.007) in the intervention group. Conversely, the control group showed no difference in ABI (p= 0.142) and quality of life (p= 0.739) before and after the study. Conclusion: PMR and NMT can improve ABI values and Quality of Life in patients with T2DM. This PMR-NMT combination can be an alternative non-pharmacological therapy in patients T2DM to help improve ankle brachial index and quality of life.

Ambrose, et al. Reply to: Disconnect for Tezepelumab on Exacerbations, Symptoms and Quality of Life in Type 2 Low Asthma.

"Ambrose, et al. Reply to: Disconnect for Tezepelumab on Exacerbations, Symptoms and Quality of Life in Type 2 Low Asthma." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.

Reply to Lipworth and Chan.

"Brusselle and Riemann Reply to: Disconnect for Tezepelumab on Exacerbations, Symptoms and Quality of Life in Type 2 Low Asthma." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.

Role of Pharmacist in Prevention and Management of Diabetics

In the last three decades role of pharmacist has changed dramatically. Presently, the pharmacists are becoming more patient oriented than product oriented. Patient counseling by pharmacist deals with providing information to the patients regarding the diseases, medications and lifestyle modifications. In diabetes, self management and patient adherence to the prescribed medication and lifestyle modifications is very essential and pharmacist can play an important role in counseling. A study was carried out to assess the influence of pharmacist provided patient counseling on patients' perception about quality of life in type 2 diabetes. 70 type-2 diabetes mellitus patients (48 males and 22 female) were enrolled and randomized into test and control groups. Mean capillary blood glucose levels were decreased in test group where as non-significant increase of capillary blood glucose levels was observed in the control group patients. Pharmacist provided patient counseling might be considered as an important element in implementing the disease management program.

Efektivitas SECARIC Diary dalam Meningkatkan Self-Care dan Kualitas Hidup Penderita Diabetes Mellitus Tipe 2

Diabetes mellitus is a degenerative disease that cannot be cured and has a risk of complications if not adequately controlled. Self-care is an important aspect of managing diabetes mellitus independently to improve the quality of life and well-being of the diabetic. One of the strategies to enhance the self-care management skills of the diabetic is to provide education through the booklet SECARIC Diary. This type of research is a quasi-experimental quantitative study with a pre-test-post-test design with the control group. Sampling was conducted using purposive sampling technique at several Posyandu in Desa Karang Asem Barat with a total sample of 22 respondents for the control group and 22 respondents for the intervention group. Data analysis used paired t-tests on self-care and quality-of-life variables with a p-value of 0.000 at a significance level of α = 0.05. Furthermore, data analysis was performed using an independent t-test with a p-value of 0.000 and a t-count of 4.756 on the self-care management variable and a p-value of 0.042 and a t-count of 2.098 on the quality of life variable. The results showed that the SECARIC Diary booklet media intervention could improve self-care management abilities and quality of life for type 2 diabetes mellitus patients in Desa Karang Asem Barat.

Diabetes Self Management Education Assistance on The Quality of Life in Type 2 Diabetes Mellitus Patients

Patients with DM in the district. Rejang Lebong reached 382 cases, and 9 people died from this disease in 2020. Diabetes Self Management Education (DSME) is a program designed to provide understanding and skills in caring for DM sufferers daily at home. This subject of this study was to analyze the effect of DSME administration on the quality of life in type 2 DM patients in the PKM Perumnas area, Rejang Lebong district. This research is a quasi-experimental study with a pretest and posttest approach with a control group design. The sampling technique used consecutive sampling involving 30 respondents, divided into 15 respondents in the treatment group and 15 in the control group. Bivariate analysis in the form of a parametric test, namely the dependent t-test and independent t-test with ? = 0.05. Researchers use computer programs for data processing and statistical analysis. The mean quality of life for DM patients was 36.20 with a standard deviation of 10.79 and p = 0.000 &lt;0.05. This shows that after the intervention, there is an increase in the quality of life of DM patients by 36.20. There is an effect of Diabetes Self-Management Education (DSME) on the Quality of Life of Diabetes Mellitus (DM) Patients in Kab. Rejang Lebong in 2022. Education is essential for patients to change their behaviour and self-management independently to improve the quality of life of DM patients.

Determining the relationship between diet inflammatory index, mental status and quality of life in type 2 diabetes: a cross-sectional study

PurposeDiabetes is one of the health problems of increasing importance owing to the increase in its incidence and the problems it causes, and it is closely related to nutrition. This study aims to determine the relationship between the dietary inflammatory index (DII) scores of individuals with type 2 diabetes, depression, anxiety and quality of life.Design/methodology/approachIn this cross-sectional study, 158 individuals with type 2 diabetes who applied to a nutrition and diet outpatient clinic of a private hospital in Istanbul were included. Their depression status was evaluated using the Beck Depression Inventory; their anxiety status was evaluated using the Beck Anxiety Inventory; and their quality of life was evaluated using the Short Form 36 Quality of Life scale. One-way ANOVA test was used to define the difference between groups. All test results were evaluated at a significance level of 0.05.FindingsThere was no significant relationship between DII scores, depression (p = 0.814) and anxiety (p = 0.817). However, a significant decrease was observed in the scores of the quality of life criterion in the groups with high depression and anxiety scores (p < 0.05). In addition, participants with high anxiety states had higher HbA1c levels (p = 0.043).Originality/valueIndividuals in this sample with no known psychiatric diagnosis or treatment history demonstrated a significant relationship between depression and anxiety scores and quality of life.

The association between Patient Assessment of Chronic Illness Care Scores and quality of life in type 2 diabetes patients.

Chronic illness care is an important factor for health promotion in diabetes since it affects health outcomes such as quality of life. The aim of this study was to investigate the relationship between the Patient Assessment of Chronic Illness Care and the quality of life in type 2 diabetes patients. The study used a cross-sectional and correlational design. The sample included 317 patients with type 2 diabetes. A socio-demographic and disease-related questionnaire form, the Patient Assessment of Chronic Illness Care (PACIC) scale and the WHOQOL-BREF Quality of Life Scale were used to collect data. According to the regression analysis, the stronger predictor affecting all domains of quality of life was the overall PACIC. This study demonstrated the importance of satisfaction level of chronic illness care in the improvement of quality of life. Therefore, the factors affecting the satisfaction level with chronic care services should be determined to improve the quality of life of patients. In addition, healthcare based on the chronic-care model should be provided in the care of the patients. PACIC had an important effect on quality of life of the patients. This study demonstrated the importance of satisfaction level on chronic illness care in the improvement of quality of life.

Commentary: The association between Patient Assessment of Chronic Illness Care Scores and quality of life in type 2 diabetes patients.

Commentary: The association between Patient Assessment of Chronic Illness Care Scores and quality of life in type 2 diabetes patients.