Functional failures and faults are regular occurrences in buildings and construction industries. The rate of building collapse in Nigeria has increased dramatically over the last decade and shows no signs of abating which has led to massive losses causing loss of physical properties, destruction of movable properties, injury, and loss of life. Beyond this, building collapse always has far-reaching economic, financial, psychological, and sociological implications. This study reported the causes of functional failures of buildings in Akure South Local Government Area, Nigeria. As a result, this study aimed to investigate the causes of functional failures in buildings and their impact on the quality and functionality of a building to build a theoretical framework that can help address the functional failures in buildings. The study utilized a questionnaire-based survey in the Akure South Local Government area. Data was collected from residents occupying the buildings. Information obtained includes the type of building and the current physical condition of the houses they live in, and 90 responses were collected and analyzed. The analysis identified six factors of functional failures in buildings investigated; damp 30%, cracks 50%, poor plumbing 45%, poor electrical wiring 35%, roofing defects 25% and Inadequate maintenance 70% and four causes of building failures; poor construction materials 32.7%, human errors 20.7%, natural disasters 12.4%, and a combination of the three factors 34.2%. Based on the findings, the results showed that the combination of the three factors was the most significant cause of building functional failures in the Akure South LGA, while natural disasters were the least significant cause. To mitigate the functional failures in buildings, it is important to enforce stringent regulations and standards by involving Governmental bodies (architectural Engineers and structural Engineers) to check building drawings and structural analysis report properly and correctly before design approvals, conduct regular inspections and internal audits, to help detect and rectify errors and maintaining standards throughout the construction process in order to enhance the quality, safety, and resilience of buildings, ensuring their functionality and longevity.