Global industries are investing in technology to accelerate digital transformation. Construction is also most likely to be digitalised based on current technology trends. However, technology adoption is not the only ingredient to successfully transform the construction industry towards the fourth industrial revolution (4IR). This transformation requires additional changes for the employees. It is expected to significantly impact the talent landscape, ranging from job categories to skill sets. While this transformation holds excellent benefits, it also poses many challenges. This paper discusses the challenges that individuals, construction companies and governments face from a talent perspective. The data is obtained from literature review results and content analysis through focus group discussion. A focus group discussion was conducted among experts with high knowledge in both the construction industry and 4IR. Information obtained from the discussion was used to identify and categorise the determining challenges. The study revealed nine (9) major talent challenges that the construction industry is currently facing, such as inadequate high skilled talent, lack of education and training to widen talent readiness, talent job security, lack of awareness or clarity of 4IR, dependency on outside talent, employer’s readiness, negative attitude of future talent towards changes, the potential of emigration of highly trained or qualified talent, and strong resistance towards new changes and technologies. 4IR can be implemented effectively in the Malaysian construction industry if key challenges that hold the talent are overcome. In conclusion, an active role from quadruple helix collaboration positively assist the transformation.