Anatomical compatibility of centrifugal pumps used as VADs can be challenging due to the intrinsic right-angle orientation of inflow and outflow ports. Consequently a novel low-profile inflow was developed. The design goals were to create a 90° bend in the flow path while minimizing swirl and preserving uniformity of the velocity profile. Several candidate elbow- and scroll designs were evaluated by computational fluid dynamics (CFD) analysis, leading to a symmetric scrolled configuration. A sequence of over ten CFD iterations resulted in two generations of prototypes that were studied by particle-trace visualization. The chosen optimal design was adapted to a third-generation magnetically-levitated centrifugal pump (HeartQuestTM VAD, MedQuest® Products). The inlet features a 12 mm dia. inlet, which expands through a rectangular diffuser, enters into a bifurcated volute, and finally exits to an annular shaped outlet (16mm ID, 20mm OD). The inner diameter of the annulus provides a smooth transition to the central spindle hub of the pump, and the outer diameter mates with the eye of the impeller housing. The cross sectional area of the scroll was optimized to provide uniform flow without separation, excessive jet formation, or secondary flow. The flow path was analyzed over a range from 2.5 Ipm to 12 Ipm, demonstrating pressure drop from appx. 1.5 mmHg to 20 mmHg, resp. The resulting design adds minimal height to the external pump profile, and enables variable angulation of inlet to outlet ports. Initial in-vivo experience has demonstrated favorable anatomic compatibility.
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