Sex education is a complex and often controversial issue, and in Chile, this is no exception. The country's progress towards a curriculum that extends beyond public health-related sex topics has experienced ups and downs, resulting in the current lack of a comprehensive program. Comprehensive sexual education (CSE) programs typically include topics known to have a positive effect on individuals' overall sexual health, such as body self-esteem. The effectiveness of these programs can be measured through individuals' sexual satisfaction. Given the limited national evidence on this subject, the objective of this study was to analyze the relationship between body self-esteem and sexual satisfaction in Chilean adults, considering various socio-demographic variables. The sample consisted of 203 cisgender individuals who completed body self-esteem and sexual satisfaction scales. The results indicated a positive relationship between body self-esteem and sexual satisfaction. Using multiple regression, it was found that body self-esteem explained 17% of sexual satisfaction variability. These findings underscore the importance of sex education and its impact on individuals' sexual well-being.