Background: Depression is the psychiatric complication that mostly associated with HIV disease. For people in HIV positive infection stage, unstable and declining physical conditions followed by the appearance of physical symptoms and intense social pressure from the environment can be a source of stress that results in depression. After entering the stage of AIDS, depression is more susceptible to experience because of worsening health conditions. Furthermore, patients also often feel that their life will be not long so that everything that happen in his or her life will be in vain which will have an impact on their quality of life.
 Objective: To determine the correlation between Beck Depression Inventory (BDI) II and World Health Organization Quality of Life (WHOQOL-BREF) scores in stage III of HIV / AIDS patients at Pusyansus RSUP Haji Adam Malik Medan.
 Methods:This study is a cross-sectional study using a correlative analytic design, which was conducted at the Pusyansus Haji Adam Malik Hospital Medan, North Sumatra from May 2019 to November 2019. The research subjects were 65 people diagnosed with HIV / AIDS stage III. The degree of depression was measured based on the Beck Depression Inventory (BDI) II and the quality of life was measured based on the World Health Organization Quality of Life (WHOQOL-BREF).
 Conclusion: There is a significant correlation between Beck Depression Inventory (BDI) II score and World Health Organization Quality of Life (WHOQOL-BREF) score in HIV / AIDS patients stage III at the RSUP Haji Adam Malik Medan Hospital.
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