Psychophysical Studies Research Articles

Neural processing and perception of Schroeder-phase harmonic tone complexes in the gerbil: Relating single-unit neurophysiology to behavior.

Schroeder-phase harmonic tone complexes have been used in physiological and psychophysical studies in several species to gain insight into cochlear function. Each pitch period of the Schroeder stimulus contains a linear frequency sweep; the duty cycle, sweep velocity, and direction are controlled by parameters of the phase spectrum. Here, responses to a range of Schroeder-phase harmonic tone complexes were studied both behaviorally and in neural recordings from the auditory nerve and inferior colliculus of Mongolian gerbils. Gerbils were able to discriminate Schroeder-phase harmonic tone complexes based on sweep direction, duty cycle, and/or velocity for fundamental frequencies up to 200 Hz. Temporal representation in neural responses based on the van Rossum spike-distance metric, with time constants of either 1ms or related to the stimulus' period, was compared with average discharge rates. Neural responses and behavioral performance were both expressed in terms of sensitivity, d', to allow direct comparisons. Our results suggest that in the auditory nerve, stimulus fine structure is represented by spike timing, whereas envelope is represented by rate. In the inferior colliculus, both temporal fine structure and envelope appear to be represented best by rate. However, correlations between neural d' values and behavioral sensitivity for sweep direction were strongest for both temporal metrics, for both auditory nerve and inferior colliculus. Furthermore, the high sensitivity observed in the inferior colliculus neural rate-based discrimination suggests that these neurons integrate across multiple inputs arising from the auditory periphery.

Image features influence reaction time

We aim to ask and answer an essential question " how quickly do we react after observing a displayed visual target?" To this end, we present psychophysical studies that characterize the remarkable disconnect between human saccadic behaviors and spatial visual acuity. Building on the results of our studies, we develop a perceptual model to predict temporal gaze behavior, particularly saccadic latency, as a function of the statistics of a displayed image. Specifically, we implement a neurologically-inspired probabilistic model that mimics the accumulation of confidence that leads to a perceptual decision. We validate our model with a series of objective measurements and user studies using an eye-tracked VR display. The results demonstrate that our model prediction is in statistical alignment with real-world human behavior. Further, we establish that many sub-threshold image modifications commonly introduced in graphics pipelines may significantly alter human reaction timing, even if the differences are visually undetectable. Finally, we show that our model can serve as a metric to predict and alter reaction latency of users in interactive computer graphics applications, thus may improve gaze-contingent rendering, design of virtual experiences, and player performance in e-sports. We illustrate this with two examples: estimating competition fairness in a video game with two different team colors, and tuning display viewing distance to minimize player reaction time.

Facilitation and inhibition effects of anodal and cathodal tDCS over areas MT+ on the flash-lag effect.

The perceived position of a moving object in vision entails an accumulation of neural signals over space and time. Due to neural signal transmission delays, the visual system cannot acquire immediate information about the moving object's position. Although physiological and psychophysical studies on the flash-lag effect (FLE), a moving object is perceived ahead of a flash even when they are aligned at the same location, have shown that the visual system develops the mechanisms of predicting the object's location to compensate for the neural delays, the neural mechanisms of motion-induced location prediction are not still understood well. Here, we investigated the role of neural activity changes in areas MT+ (specialized for motion processing) and the potential contralateral processing preference of MT+ in modulating the FLE. Using transcranial direct current stimulations (tDCS) over the left and right MT+ between pre- and posttests of the FLE in different motion directions, we measured the effects of tDCS on the FLE. The results found that anodal and cathodal tDCS enhanced and reduced the FLE with the moving object heading to but not deviating from the side of the brain stimulated, respectively, compared with sham tDCS. These findings suggest a causal role of area MT+ in motion-induced location prediction, which may involve the integration of position information.NEW & NOTEWORTHY Perceived positions of moving objects are related to neural activities in areas MT+. We demonstrate that tDCS over areas MT+ can modulate the FLE, and further anodal and cathodal tDCS facilitated and inhibited the FLE with a moving object heading to but not deviating from the side of the brain stimulated, respectively. These findings suggest a causal role of area MT+ in motion-induced location prediction and contribute to understanding the neural mechanism of the FLE.

Color Variability Constrains Detection of Geometrically Perfect Mirror Symmetry

Symmetry in nature is a result of biological self-organization, driven by evolutionary processes. Detected by the visual systems of various species, from invertebrates to primates, symmetry determines survival relevant choice behaviors and supports adaptive function by reducing stimulus uncertainty. Symmetry also provides a major structural key to bio-inspired artificial vision and shape or movement simulations. In this psychophysical study, local variations in color covering the whole spectrum of visible wavelengths are compared to local variations in luminance contrast across an axis of geometrically perfect vertical mirror symmetry. The chromatic variations are found to delay response time to shape symmetry to a significantly larger extent than achromatic variations. This effect depends on the degree of variability, i.e., stimulus complexity. In both cases, we observe linear increase in response time as a function of local color variations across the vertical axis of symmetry. These results are directly explained by the difference in computational complexity between the two major (magnocellular vs. parvocellular) visual pathways involved in filtering the contrast (luminance vs. luminance and color) of the shapes. It is concluded that color variability across an axis of symmetry proves detrimental to the rapid detection of symmetry, and, presumably, other structural shape regularities. The results have implications for vision-inspired artificial intelligence and robotics exploiting functional principles of human vision for gesture and movement detection, or geometric shape simulation for recognition systems, where symmetry is often a critical property.

Human retinal dark adaptation tracked in vivo with the electroretinogram: insights into processes underlying recovery of cone- and rod-mediated vision.

The substantial time taken for regaining visual sensitivity (dark adaptation) following bleaching exposures has been investigated for over a century. Psychophysical studies yielded the classic biphasic curve representing recovery of cone-driven and rod-driven vision. The electroretinogram (ERG) permits direct assessment of recovery at the level of the retina (photoreceptors, bipolar cells), with the first report over 70 years ago. Over the last two decades, ERG studies of dark adaptation have generated insights into underlying physiological processes. After large bleaches, rod photoreceptor circulating current, estimated from the rod-isolated bright-flash ERG a-wave, takes 30min to recover, indicating that products of bleaching, thought to be free opsin (unbound to 11-cis-retinal), continue to activate phototransduction, shutting off rod circulating current. In contrast, cone current, assessed with cone-driven bright-flash ERG a-waves, recovers within 100ms following similar exposures, suggesting that free opsin is less able to shut off cone current. The cone-driven dim-flash a-wave can be used to track recovery of cone photopigment, showing regeneration is 'rate-limited' rather than first order. Recoveries of the dim-flash ERG b-wave are consistent also with rate-limited rod photopigment regeneration (where free opsin, desensitising the visual system as an 'equivalent background', is removed by rate-limited delivery of 11-cis-retinal). These findings agree with psychophysical and retinal densitometry studies, although there are unexplained points of divergence. Post-bleach ERG recovery has been explored in age-related macular degeneration and in trials of visual cycle inhibitors for retinal diseases. ERG tracking of dark adaptation may prove useful in future clinical contexts.

Oral -Somatosensory Alterations in Head & Neck Cancer Patients and Food Intake

ObjectivesPrevalence of malnutrition in cancer ranges between 25–70% with increased risk in sites related to food ingestion, namely head and neck cancer (HNC). This is attributable to oral manifestations observed during treatments such as sensory alterations (SA). SA have been well documented and are associated with altered food perception and reduced food intake. In addition to taste and smell, food perception is also influenced by somatosensation comprising of tactile/texture, thermal, and trigeminal perception. The current review aims to investigate SA, specifically oral somatosensory alteration, among HNC patients and its potential consequences on food intake. MethodsA literature search was conducted using PubMed, Scopus, and Web of Science. Related works were also identified by snowballing. Keywords searched were, but not limited to: head and neck cancer; malnutrition; taste; smell; oral somatosensation; texture; oral tactile; trigeminal; thermal; chemotherapy; radiotherapy. ResultsMalnutrition in HNC patients ranged between 9–100% depending on tumor site, treatment, and time point (before, during, or after treatment). Between 56–100% of HNC patients experienced taste and/or smell alterations. Patients with these alterations showed altered food behavior including food aversion, modified food preference, reduced appetite, and lower food enjoyment. SA were also linked to lower food intake and higher weight loss. Regarding somatosensation, psychophysical studies (n = 7) showed reduced oral tactile function among HNC patients but its correlation with texture perception remains elusive. These studies (n = 2) also indicated reduced thermal sensitivity, whereas psychophysical studies investigating trigeminal perception have not been identified. Qualitative studies reported alterations such as altered sensitivity to spices, certain food textures, and temperature. ConclusionsSA are directly linked to food perception which contributes to changes in food behavior. However, evidence is still limited on oral somatosensory alteration and overall, results are inconclusive on the relationship between altered food behavior and intake. Such insights should support optimization of personalized meal for patients. Funding SourcesDanone Nutricia Research, French Industrial Training through Research Agreements, French League against Cancer.

Control of an ultrasonic haptic interface for button simulation

This work presents the control of a piezoelectric interface that combines two vibration modes of a plate to render the haptic feeling of a button click. By principle, the two vibration modes create an elliptical motion of particles of a beam that can induce a lateral force to the fingerpulp. In this device, the synchronization of the modes’ vibrations is essential, and can be obtained with a closed loop control. In the paper, we present the control in the (d,q) frame, because it can ensure the dynamic performances to achieve a compelling haptic feedback, yet being robust besides the external disturbances produced by the user’s finger. The proposed method could achieve a 2 ms response time, and the haptic feedback was perceived by 100% of users in a psychophysical study.

Tactile Sensibility Thresholds in Implant Prosthesis, Complete Dentures and Natural Dentition: Review about Their Value in Literature

Background and Objectives: The periodontium has important proprioceptive receptors that prevent teeth from using excessive occlusal forces during chewing. There are other receptors from adjacent tissues that replace periodontal ones when teeth are extracted and rehabilitated with prosthesis, although they seem to be less effective. Psychophysical studies investigate tactile sensibility thresholds, which are useful to measure this masticatory efficiency in different prosthetic rehabilitations. There are two types of sensibility depending on the receptors that are activated during these studies: active and passive tactile sensibility. The purpose of this study is to obtain active and passive tactile sensibility threshold figures in natural dentition and prosthetic rehabilitations so we can compare them and understand how this sensibility works in different situations. Materials and Methods: We performed a systematic review of the available literature, following PRISMA guidelines and including articles from 2004 to 2021 in the MEDLINE database. Only 10 articles were included in this investigation as they provided concrete threshold figures. Results: The mean values of active tactile sensibility thresholds in complete dentures, implant prosthesis and natural dentition are 64 µ, 23.3 µ and 16.1 µ, respectively. The mean values of passive tactile sensibility thresholds in implant prosthesis and natural dentition are 6.7 N and 0.8 N, respectively. Conclusions: Implant prosthesis have lower thresholds, that are very close to those present in natural dentition, than complete dentures due to an increased tactile sensibility. Active tactile sensibility thresholds present fewer differences between values than passive tactile ones; as these are only influenced by receptors from periodontal or periimplant tissues.

Perceptual filling-in dispels the veridicality problem of conscious perception research

Conscious perceptual experiences are expected to correlate with content-specific brain activity. A veridicality problem arises when attempting to disentangle unconscious and conscious brain processes if conscious perceptual contents accurately match the physical nature of the stimulus. We argue that perceptual filling-in, a phenomenon whereby visual information inaccurately spreads across visual space, is a promising approach to circumvent the veridicality problem. Filling-in generates non-veridical although unambiguous percepts dissociated from stimulus input. In particular, the radial uniformity illusion induces a filling-in experience between a central disk and the surrounding periphery. We discuss how this illusion facilitates both the detection of neurophysiological responses and subjective phenomenological monitoring. We report behavioral effects from a large-sample (n = 200) psychophysics study and examine key stimulus parameters that drive the conscious filling-in experience. We propose that these data underpin future hypothesis-driven studies of filling-in to further delineate the neural mechanisms of conscious perception.

Influence of Sensory Properties in Moderating Eating Behaviors and Food Intake.

Sensory properties inform likes and dislikes, but also play an important functional role in guiding food choice and intake behavior. Odors direct food choice and stimulate sensory-specific appetites and taste helps to anticipate calorie and nutrient content of food. Food textures moderate eating rate and the energy consumed to satiation and post-ingestive metabolism. We summarize how sensory cues moderate intake, and highlight opportunities to apply sensory approaches to improve dietary behavior. Salt, sweet and savory taste influence liking, but also influence energy intake to fullness, with higher taste intensity and duration linked to lower intake. Psycho-physical studies show it is relatively easy to rank taste intensities at different concentrations but more challenging to discriminate fat contents, and fat discrimination declines further when combined with high-taste intensity. Fat has low impact on sensory intensity, but makes significant contributions to energy content. Combinations of high taste and fat-content can promote passive energy over-consumption, and adding fat also increases energy intake rate (kcals/min), reducing opportunities to orally meter consumption. Consumers adapt their oral processing behaviors to a foods texture, which can influence the rate and extent of energy intake. Understanding how texture influences eating behaviors and bolus formation, affords new opportunities to impact eating rate, energy intake and metabolic response to food. Food formulation has traditionally focused on composition and sensory appeal. Future research needs to consider the role of sensory properties in moderating consumer interaction with their food environment, and how they influence calorie selection, and shape our eating behaviors and intake.

Neural Control of Stopping and Stabilizing the Arm.

Stopping is a crucial yet under-studied action for planning and producing meaningful and efficient movements. In this review, we discuss classical human psychophysics studies as well as those using engineered systems that aim to develop models of motor control of the upper limb. We present evidence for a hybrid model of motor control, which has an evolutionary advantage due to division of labor between cerebral hemispheres. Stopping is a fundamental aspect of movement that deserves more attention in research than it currently receives. Such research may provide a basis for understanding arm stabilization deficits that can occur following central nervous system (CNS) damage.

Weakened Bayesian Calibration for Tactile Temporal Order Judgment in Individuals with Higher Autistic Traits

Previous psychophysical studies reported a positive aftereffect in tactile temporal order judgments, which can be explained by the Bayesian estimation model (‘Bayesian calibration’). We investigated the relationship between Bayesian calibration and autistic traits in participants with typical development (TD) and autism spectrum disorder (ASD). Bayesian calibration was weakened in TD participants with high autistic traits, consistent with the ‘hypo-priors’ hypothesis for autistic perceptions. The results from the ASD group were generally observed as a continuation of those from the TD groups. Meanwhile, two ASD participants showed irregularly large positive or negative aftereffects. We discussed the mechanisms behind the general results among TD and ASD participants and two particular results among ASD participants based on the Bayesian estimation model.

Electrophysiological and psychophysical studies in assessment of visual functions in patients with hereditary optic neuropathy

To study the capabilities of electrophysiological and psychophysical examination methods for assessment of the functional state of ganglion cells, retina and optic nerve in patients with hereditary optic neuropathy (HON). The study included 60 patients (118 eyes) with a genetically confirmed diagnosis of HON. All study patients underwent visual field test (VFT), spectral optical coherence tomography (OCT), flash and pattern visual evoked potentials (VEP) (Flash-VEP, FVEP; Pattern-VEP, PVEP), photopic electroretinography with photonegative response (PhNR) registration and the color vision test. In 24 patients (46 eyes), these parameters were assessed before the start of treatment and one year later. The treatment involved the mitochondria-targeted antioxidant SkQ1 - plastoquinonyl-decyl-triphenylphosphonium bromide (PDTP) in the form of eye drops. The main PVEP components for 1.0° and 0.3° were registered in 20% and in 14% of patient eyes with HON and high visual functions, respectively. After one year of PDTP use, a significant decrease in P100 peak latency was found only in the group with disease duration of ≤1.5 years as of the time of treatment start (p<0.05). Significant differences were observed in the PhNR amplitude (p<0.004) between patients of the main and the control groups, as well as in the PhNR amplitude between patients with visual acuity of ≤0.1 and ≥0.13 (p<0.01). Patients with high visual functions were found to have a correlation between the PhNR amplitude, GCC thickness and the global loss index (GLV). Along with VFT, OCT and color vision tests, electrophysiological studies are one of the main methods of examining patients with HON. After one year of PDTP use, there was a significant decrease in the FVEP P2 peak latency in the group with a disease duration of ≤1.5 years as of the time of treatment start. The PhNR amplitude in patients with high visual functions was found to correlate with structural changes in the ganglion cell layer and the retinal nerve fiber layer.

The potency of architectural probabilism in shaping cognitive environments: A psychophysical approach

The article deals with a controversial issue, namely the effect of architecture and the built environment on human behaviour. Two debatable approaches dominated the architectural field in the past decades: determinism and possibilism. Both have proved inadequate in explaining human-environment relationships. Probabilism emerged as a tradeoff, providing an interface that accentuated the role of architecture in influencing human behaviour. The article presents a theoretical framework to explore the concept of probabilism, and the extent to which architectural intervention can affect the perceptual and cognitive behaviour of individuals. A psychophysical study is conducted on a selected environment (University of Baghdad campus) based on two approaches: the cognitive representation and mental mapping of individuals (the graphic recall), and the perceptual selectivity of environmental elements (the verbal recall). The findings assert the significant impact of the physical aspects (semblance and positioning attributes) of environmental stimuli, thereby accentuating the probabilistic approach to human behaviour.

Effects of Roughness and Texture on Surface Material Perception in Virtual Environments: The Psychophysics Approach

Effects of Roughness and Texture on Surface Material Perception in Virtual Environments: The Psychophysics Approach

Characterizing Detection Thresholds for Six Orthogonal Modes of Vibrotactile Display Via Stylus With Precision Grasp.

In this paper, we characterize the detection thresholds in six orthogonal modes of vibrotactile haptic display via stylus, including three orthogonal force directions and three orthogonal torque directions at the haptic interaction point. A psychophysical study is performed to determine detection thresholds over the frequency range 20-250 Hz, for six distinct styluses. Analysis of variance is used to test the hypothesis that force signals, as well as torque signals, applied in different directions have different detection thresholds. We find that people are less sensitive to force signals parallel to the stylus than to those orthogonal to the stylus at low frequencies, and far more sensitive to torque signals about the stylus than to those orthogonal to the stylus. Optimization techniques are used to determine four independent two-parameter models to describe the frequency-dependent thresholds for each of the orthogonal force and torque modes for a stylus that is approximately radially symmetric; six independent models are required if the stylus is not well approximated as radially symmetric. Finally, we provide a means to estimate the model parameters given stylus parameters, for a range of styluses, and to estimate the coupling between orthogonal modes.

A Low-Parameter Rendering Algorithm for Fine Textures.

This paper introduces a novel rendering algorithm for virtual textures, specifically those with characteristic length scales below 1 mm. By leveraging the relatively lossy mode of human tactile perception at this length scale, a virtual texture with wide-band spectral characteristics can be reduced to a spatial sequence of single-frequency texels, where each frequency is pulled stochastically from a distribution. A psychophysical study was conducted to demonstrate that, below a limiting physical texel length, virtual textures defined by identical frequency distributions are perceptually indiscriminable. Additionally, an exploratory study mapped the distribution parameters of the texel-based rendering to spectral characteristics of perceptually similar multi-frequency virtual textures.

Seeing and sensing temporal variations in natural daylight.

Natural illumination is a mixture of sunlight and skylight, modified by interactions with atmospheric particles and interreflections between physical surfaces. Unlike traditional artificial light sources, natural illumination is spectrally dynamic, changing over short and long timescales. Over the day, daylight's correlated color temperature typically ranges from cool (~12,000K) to warm (~2000K), following the well-defined daylight chromaticity locus. Analysis of existing spectral irradiance databases and new measurements reveal a characteristic tripartite pattern: for chromaticity, the periods of fastest change occur in early morning and late evening at the lowest irradiances, with an interim period of relative stability. Illuminance changes are governed systematically by changes in solar elevation and tend to be fastest at the day's extremities, but unsystematic largely weather-related factors perturb this smooth trajectory. The human visual and nonvisual responses to light evolved under these changes. Psychophysical studies demonstrate that the threshold visibility of temporal changes in global illumination chromaticity depends on the chromatic direction of change and adapting chromaticity, with the lowest sensitivity occurring for changes towards neutral. Comparisons with the measured systematic changes in natural illumination suggests that the latter are too slow to be directly detected. A speculation is that visual mechanisms dampen sensitivity to the largest natural changes in illumination chromaticity in order to maintain perceptual stability of object color. Nonvisual mechanisms appear tuned to chromaticity changes at dawn and dusk, and hence are critical for syncing the circadian clock with environmental conditions. The latter might also feed long-term memory of illumination conditions as well as subjective experiences of illumination atmosphere.

Symmetrical patterns in natural images

One of the approaches to image analysis is based on the use of visual alphabets comprising the compact patterns characteristic of the images of a particular class. Elements of these alphabets can be either obtained from a theoretical model describing the basic image structures or extracted directly from the training sets. Symmetric patterns characteristic of the images of outdoor scenes were investigated in this study. The choice of this pattern class is driven by the fact that the objects of interest usually have at least local symmetry. Furthermore, selection of only symmetric patterns allows most fragments of random textures that in most cases do not have symmetry to be dismissed. The image set used in this study comprised 829 monochromatic photographs showing natural objects and textures at different scales. Fragments with diameters of 13 pixels having 1 of 9 symmetry types were selected from this set. The obtained sets of symmetric fragments were processed using a density-based spatial clustering of applications with noise (DBSCAN) cluster analysis algorithm, which allows clusters of arbitrary shape to be analyzed. Fifteen pattern types were obtained; five of them have not previously been used as elements of visual alphabets. Most of the obtained patterns have reflection symmetry, which agrees with the results of psychophysical studies, according to which reflection symmetry is identified faster than other symmetry types. The obtained data can be used for the formation of elements of visual alphabets as well as for synthesizing the stimuli for the experiments in the field of vision physiology.

Aging effects on contrast sensitivity in visual pathways: A pilot study on flicker adaptation.

Contrast sensitivity is reduced in older adults and is often measured at an overall perceptual level. Recent human psychophysical studies have provided paradigms to measure contrast sensitivity independently in the magnocellular (MC) and parvocellular (PC) visual pathways and have reported desensitization in the MC pathway after flicker adaptation. The current study investigates the influence of aging on contrast sensitivity and on the desensitization effect in the two visual pathways. The steady- and pulsed-pedestal paradigms were used to measure contrast sensitivity under two adaptation conditions in 45 observers. In the non-flicker adaptation condition, observers adapted to a pedestal array of four 1°×1° squares presented with a steady luminance; in the flicker adaptation condition, observers adapted to a square-wave modulated luminance flicker of 7.5 Hz and 50% contrast. Results showed significant age-related contrast sensitivity reductions in the MC and PC pathways, with a significantly larger decrease of contrast sensitivity for individuals older than 50 years of age in the MC pathway but not in the PC pathway. These results are consistent with the hypothesis that sensitivity reduction observed at the overall perceptual level likely comes from both the MC and PC visual pathways, with a more dramatic reduction resulting from the MC pathway for adults >50 years of age. In addition, a similar desensitization effect from flicker adaptation was observed in the MC pathway for all ages, which suggests that aging may not affect the process of visual adaptation to rapid luminance flicker.