To identify psychopathological features of chronic endogenous depression that develops in youth and determine most significant diagnostic and prognostic criteria. Sixty-two male inpatients were examined who had suffered from a chronic depressive state over 2 - years in their youth (16-25 years old) and were treated at FSBSI MHRC clinic in 2008-2010. The exclusion criteria were the presence of psychotic episodes, severe deficiency symptoms, as well as clinically significant somatic, neurological and mental disorders that complicated the study. Clinical-psychopathological, psychometric (HDRS, SANS and SOPS) and statistical methods were used. Youth chronic endogenous depression is characterized by the dominance of symptoms of negative affectivity in their structure. In addition, there are disorders that differ from those of an affective spectrum. Based on the analysis of psychopathological characteristics of youth chronic endogenous depressions, two typological varieties are identified: unitary depressions (type I) and supplementary depressions (type II). Among type II depressions, 2 subtypes are distinguished: with neurosis-like and with psychopathic- like disorders. The presence of psychopathic disorders in the structure of depression is a prognostically unfavorable sign.