Aim. To reveal prevalence of coronary heart disease (CHD), arterial hypertension (AH) and risk factors for atherosclerosis (RFA) in men sentenced to imprisonment and to evaluate efficacy of secondary prevention for those with CHD and AH. Material and methods. An epidemiological study conducted with 986 imprisoned men at the age 21-69 y.o., included 24-hour blood pressure monitoring (APBM) and ECG monitoring (Holter) within random selection; evaluation of efficacy of complex medical-psychological monitoring (pharmacotherapy + medical enlightenment) in 46 persons with CHD and AH. Results. A high prevalence of CHD was established (15,6%), myocardial infarction (7,6%), AH (49,8%), cardiac rhythm disorders (CRD, 35,3%), borderline psychic disorders (89,2%), smoking (96,0%), alcohol consumption (AC, 96,9%), low physical activity (89,2%), left ventricle hypertrophy (52,3%), anxiety (49,7%), depression (39,5%) and their concomitance (85,0-92,0%); very low level of an existence of AH acknowledgement (10,3%), of CHD (1,6%) and CRD (4,7%). In ABPM and Holter first time were found disorders of 24-hour profile in all persons with AH and also hypertension reactions (66,6%) in normal BP, as deviations of coronary flow — episodes of transient myocardial ischemia (66,6%) and CRD (33,3%). Thanks to the treatment-educational complex, efficacy was marked in 80,0% prisoners of the 1st group, 87,5% — of the 2nd group and 93,3% — of the 3rd. Conclusion. First time a significant prevalence revealed of CHD and AH, of CRD and RFA, significant deviations of peripheral and coronary flow in isolated persons, therapeutical efficacy of secondary prevention (80,0%-93,3%) among prisoners with CHD and AH.