Guajava Research Articles

An economic, and environmentally benign Psidium guajava L. leaves catalyst for biodiesel production at room temperature: Process optimization, and life cycle cost analysis

Biodiesel has emerged as a popular alternative to conventional fossil fuel in transportation sector and thus producing low-cost biodiesel is a topic of interest for a large community of researchers. This study reports the preparation of an efficient and robust heterogeneous catalyst from dried Psidium guajava L. (Guava) leaves and its application towards generation of biodiesel from soybean oil at room temperature. The biomass material was calcinated at variable temperature and the efficiency of each of the catalyst prepared was studied. The catalyst generated as well as the product biodiesel was thoroughly characterized using sophisticated analytical techniques. The catalyst was found to have mesoporous structure with active basic sites which contributed towards accelerating the transesterification process. Detailed characterization unveiled the occurrence of Ca as oxide and carbonate, in addition to a certain quantity of K in oxide and carbonate form, which contribute to the catalyst’s activity. Maximum biodiesel yield of 95.8 % was observed for reaction performed under optimum experimental conditions i.e., 1:17 oil-to-methanol ratio, 6 wt% loading of GL-850 (catalyst prepared by calcination at 850°C), and 15 % n-Hexane loading for 3 h at room temperature. GL-850 demonstrated exceptional recyclability for up to the fifth cycle exhibiting a mere 3.7 % decline in yield. The calculated expense for 1 kg catalyst was found to be $0.478, whereas the production cost of 1 kg biodiesel was found to be merely $1.120, indicating a strong economic feasibility of the process.

Effect of Leaf and Seed Powder Based Edible Coating with Beeswax and Clove Essential Oil on the Shelf Life of Guava (Psidium guajava) cv. Allahabad Safeda

The guava is thought to be India's most significant commercial fruit crop. Due to their high respiration rate, vulnerability to different pathogens, and mechanical damage that can quickly deteriorate the quality and concised its shelf life. Nonetheless, the purpose of the experiment was to investigate how guava's edible coatings affected its postharvest quality and shelf life. Guava fruits were treated by seven treatments of different concentrations of beeswax, guava leaf powder, neem leaf powder, tamarind seed powder, and clove oil with different combinations were used as edible coating were studied in a Factorial Completely Randomized Design (CRD) with three replications. All seven treatments were used to examine the impact of edible coating materials on the physical and chemical properties. Under ambient conditions, the variations in physiological and chemical parameters were seen. The findings of present study showed maximum fruit weight (120.29 g), highest vitamin C (163.19 mg/100g), maximum acidity (0.49%) and antioxidant activity (35.43%) obtained from T4 [Neem leaves powder (2%) + Beeswax (1%)+ clove oil (1%)] compared with untreated fruits. The result suggested that the applications of [Neem leaves powder (2%) + Beeswax (1%) + clove oil (1%)] as an edible coating material in guava fruit is more effective than other treatments to improve the shelf life of Guava.

Guaijaverin And Epigallocatechin Gallate Exerts Antiinflammatory And Antiallergenic Effects Through Interleukin-12 Production.

Our aim in the current study was to determine the in vitro and invivo synergistic antiinflammatory and antiallergic effect associated with the IL-12 production of guaijaverin and epigallocatechin gallate (EGCG) complex (GEC) and ILS-F-2301 (2:8 extract of Psidium guajava and Camellia sinensis). Compared to EGCG alone, GEC showed synergistic inhibition of nitric oxide (NO), inducible NO synthase, and cyclooxygenase-2 by 3.8, 5.1, and 4.1%, respectively. The downregulation of interleukin-12 (IL-12) by 2,4-dinitrophenyl-human serum albumin conjugate/DNP-immunoglobulin E or ovalbumin (OVA) was synergistically increased by GEC by about 7.5% or 5.4% compared to EGCG alone. The level of downregulation of IL-12 in plasma increased by 100 mg/kg with ILS-F-2301 (28.7%) when compared to the OVA/Alu-treated group. Also, GEC synergistically increased by GEC by about 7.5% or 5.4% compared to EGCG alone. The level of down and cyclooxygenase C synergistically inhibited p-Akt, PI3K, mTOR, p-STAT6, and GATA3 by 4.9%, 4.1%, 19.2%, 23.8%, and 35.3%, respectively, while increasing the expressions of p-STAT1 and T-bet (showing 53.3% and 9.4% activation) when compared to EGCG alone. In an allergenic rhinitis mouse model, 100 mg/kg of ILS-F-2301 was shown to inhibit p-Akt, PI3K, mTOR, p-c-Jun N-terminal kinase (p-JNK), p-extracellular signal-regulated kinase (p-ERK), and p-p38 by 23.3%, 43.8%, 17.2%, 32.2%, 29.1%, and 41.8% when compared to the OVA/Alu-sensitized group. Taken together, our findings suggest that ILS-F-2301 may have potential as a functional food for alleviating antiallergic rhinitis.

Phytochemical Screening And Antimcrobial Efficacy of Leaf Extract Of Guava (Psidium guajava) On Selected Bacteria

Guava leaf extract has analgesic, anti-inflammatory, antimicrobial, hepato protective and antioxidant activities. The high resistance of bacteria to modern day drugs has led researchers in the pharmaceutical industry to look towards plant-based extracts for solutions. Hence, this studywas aimed at evaluating the phytochemical and antibacterial efficacy of leaf extracts of Psidium guajava (guava) on some selected bacteria. Pure isolates of bacteria gotten from urine of patients in Charis Rhema Research and Diagnostic Laboratory were used in the study. Extracts from the leaves of Psidium guajava were tested for presence of phytochemicals. Separation of active components of the extracts was one using Chromatographic technique. The antibacterial activityof Psidium guajava leaves was determined using agar diffusion bioassay. Phenols were present at all concentrations (100, 80 and 60mg). The study discovered a significant relationship between extract concentration and the zones of inhibition at 60% N-hexane/40% methanol for Klebsiellasp., and 0.0% N-hexane/100% methanol for S. aureus. Flavonoids, tannins, saponins and phenols were the active compounds in guava that helped in the inhibition of growth on the sampled isolates. Methanol and N-hexane extracts of guava can be used as potent medicines for inhibitingthe growth of Klebsiella and Staphylococcus aureus.

Evaluation of PGRrsquo;s, girth of hard wood stem cuttings and rooting media for rapid multiplication of guava (Psidium guajava L.) cv. Allahabad Safeda

Evaluation of PGRrsquo;s, girth of hard wood stem cuttings and rooting media for rapid multiplication of guava (Psidium guajava L.) cv. Allahabad Safeda

Enhancing post-harvest shelf life of guava (Psidium guajava L.) using herbal coating enriched with Allium cepa green leaves

Enhancing post-harvest shelf life of guava (Psidium guajava L.) using herbal coating enriched with Allium cepa green leaves

Evaluating the effect of plant growth regulators on qualitative characteristics of guava (Psidium guajava L.)

Evaluating the effect of plant growth regulators on qualitative characteristics of guava (Psidium guajava L.)

Guaijaverin and Epigallocatechin Gallate Complex Modulate Th1 and Th2 Cytokine-Mediated Allergic Responses Through STAT1/T-bet and STAT6/GATA3 Pathways.

We aimed to determine the in vitro and invivo synergistic antiallergic effect of guaijaverin and epigallocatechin gallate (EGCG) complex (GEC), and the antiallergic rhinitis (AR) properties of guaijaverin-rich Psidium guajava and EGCG-rich Camellia sinensis (ILS-F-2301). GEC showed synergistic inhibition of β-hexosaminidase by 4.20% and interleukin (IL)-4, -5, and -13 by 4.08%, 0.67%, and 4.71%, respectively, while increasing interferon (IFN)-γ by 12.43%, compared with EGCG only. In addition, 50 μg/mL of ILS-F-2301 inhibited β-hexosaminidase release, and inhibited IL-4, -5, and -13 by 61.54%, 58.79%, and 59.25%, respectively, while increasing IFN-γ (showing 133.14% activation). Moreover, 50 μg/mL of ILS-F-2301 suppressed p-STAT6 and GATA3, while p-STAT1 and T-bet increased, and 0.039 μg/mL of guaijaverin or 5.275 μg/mL of EGCG modulated T helper (Th)1- and Th2-related proteins. These data suggested that guaijaverin and EGCG in ILS-F-2301 was the main active compound involved in Th1/Th2 modulation. In the AR mouse model, the administration of ILS-F-2301 inhibited ovalbumin (OVA)-specific IgE, histamine in serum; it also inhibited IL-4 and -5 by 28.23% and 47.15%, respectively, while increasing IFN-γ (showing 37.11% activation), compared with OVA/Alu-treated mice. Taken together, our findings suggest that ILS-F-2301 is a functional food for alleviating anti-AR.

Psidium guajav-mediated zinc oxide nanoparticles as a multifunctional, microbicidal, antioxidant and antiproliferative agent against destructive pathogens.

Bio-inspired zinc oxide nanoparticles are gaining immense interest due to their safety, low cost, biocompatibility, and broad biological properties. In recent years, much research has been focused on plant-based nanoparticles, mainly for their eco-friendly, facile, and non-toxic character. Hence, the current study emphasized a bottom-up synthesis of zinc oxide nanoparticles (ZnO NPs) from Psidium guajava aqueous leaf extract and evaluation of its biological properties. The structural characteristic features of biosynthesized ZnO NPs were confirmed using various analytical methods, such as UV-Vis spectroscopy, X-ray diffraction (XRD), energy-dispersive X-ray analysis (EDX), Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), Scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HR-TEM). The synthesized ZnO NPs exhibited ahydrodynamic shape with an average particle size of 11.6-80.2nm. A significant antimicrobial efficiency with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 40 and 27µg/ml for Enterococcus faecalis, followed by 30 and 40µg/ml for Staphylococcus aureus, 20 and 30µg/ml for Staphylococcus mutans, 30µg/ml for Candida albicans was observed by ZnO NPs. Additionally, they showed significant breakdown of biofilms of Streptococcus mutans and Candida albicans indicating their future value in drug-resistance research. Furthermore, an excellent dose-dependent activity of antioxidant property was noticed with an IC50 of 9.89µg/ml. The antiproliferative potential of the ZnO NPs was indicated by the viability of MDA MB 231 cells, which showed adrastic decrease in response to increased concentrations of biosynthesized ZnO NPs. Thus, the present results open up vistas to explore their pharmaceutical potential for the development of targeted anticancer drugs in the future.

Hydroalcoholic extract of Psidium guajava plant and bone marrow cells: examination and analysis of effects

Hydroalcoholic extract of Psidium guajava plant and bone marrow cells: examination and analysis of effects

From Waste to Wonder: Leveraging Rust Dyeing and Eco-Printing for Modern Sustainable Textiles

In rust dyeing, rusted objects are repurposed to transfer unique patterns and earthy tones onto fabric, transforming what might be considered waste into beautiful, sustainable works of art. This study investigates the combined effects of rust dyeing and eco-printing on different fabric types—cotton, modal, viscose, and polyester. Rust dyeing was performed using rusted iron nails to impart earthy tones of brown and orange to the fabrics. Following the dyeing process, eco-printing was carried out using Psidium guajava (guava) leaves that were pre-mordanted with a ferrous sulphate solution. The colourfastness, pattern quality, and overall appearance of the rust-dyed fabrics post eco-printing was assessed. Results revealed that rust dyeing produced distinct shades on each fabric type, with cotton and modal showing the most pronounced colour retention and eco-print detail. Viscose exhibited moderate colour absorption, while polyester showed limited dye adhesion and eco-print definition. The study concludes that while rust dyeing and subsequent eco-printing can effectively enhance the aesthetic qualities of natural and regenerated cellulosic fabrics, polyester's synthetic nature poses challenges in achieving vibrant and durable impressions. The findings provide insights into optimizing eco-printing techniques for diverse fabric types and contribute to the broader understanding of sustainable textile processes. By embracing the unpredictability of nature, artists and designers can create one-of-a-kind designs that reflect the textures, shapes, and hues found in the environment. These eco-friendly approaches not only reduce reliance on synthetic dyes but also transform everyday materials, often considered waste, into beautiful works of art.

Effect of fertilization and flower bud dormancy breaker on yield and fruit quality of crystal guava (Psidium guajava L.)

Guava (Psidium guajava L.) crystal variety or often called crystal guava is a type of fruit that has recently become increasingly popular in the community and is highly favored by consumers. The advantages of this guava compared to other guavas are fast fruiting (8 months after planting has started production), small habitus so that the population per hectare is high, the fruit is large with thick pulp, tastes good, fresh, and crunchy, very few seeds only 4-6 per fruit, even many are seedless (seddless), and the appearance of the fruit is attractive. With its various advantages, the crystal guava population in Bali has grown very rapidly since the last 5 years, but farmers complain that although certified superior seeds are used, the production, quality and continuity of the fruit produced are not as expected. The continuity of fruit harvest is not sustainable because many naturally induced flower buds do not develop into flowers due to dormancy. The aim of this study was to increase the production and quality of crystal guava fruit through fertilization and the application of flower bud dormancy breakers. The research was conducted in Semanik Village, Petang District, Badung from January to July 2024. The experiment was arranged in a 2-factor factorial with 9 replications, using a group randomized design. The first factor was fertilization consisting of 3 levels; fertilization as the farmer's way/control (P1), fertilization with N, P, K, and Ca (P2), and fertilization with N, P, K, Ca and microfertilizers Zn, and Cu (P3), while the second factor was the application of flower bud dormancy breaker type consisting of 3 levels; without dormancy breaker/control (Dt), Ethreel dormancy breaker (De), and KNO3 dormancy breaker (Dk). The results showed that fertilization level P2, namely the provision of urea, TSP, KCl and calcium fertilizer in the form of gypsum (CaSO4.2H2O) at a dose of 250 g, 300 g, 300 g, and 1,250 g/plant respectively and fertilization level P3, namely the provision of urea, TSP, KCl and gypsum at a dose of 250 g, 300 g, 300 g, and 1,250 g/plant coupled with the provision of micro-fertilizers ZnSO4 and CuSO4 tend to increase the growth, production and quality of crystal guava fruit. Similarly, the application of Ethreel and KNO3 flower bud dormancy breakers tended to increase the number of new buds per plant, number of fruits per plant, weight of fruits per plant and percentage of grade A fruits.

Quantitative Phytochemical Investigation, Antibacterial Potency, and Drug-ability Assessment of Three Indian Medicinal Plants Leaf Extracts Using Bioinformatics Tools

Natural regimens have long-held ethnomedicinal values, serving as primary sources for mainstream medicine. Therefore, scientists are paying more attention to studying the biological activity of existing plant species in organized ways to select potent bioactive metabolites to use for specific therapeutic purposes. This study used the same approach to find potent antibacterial phytoconstituents in three well-known Indian medicinal plants: Psidium guajava L., Syzygium cumini L. and Punica granatum L. In the earlier study, methanolic leaf extracts of the above plant extracts were more effective than n-hexane extracts against biofilm and drug-resistant pathogenic bacteria. Accordingly, we selected methanolic crude extracts for gas chromatography-mass spectrometry (GC-MS) to identify the phytoconstituents presented. In addition, we added a few reported candidates from the above plant extracts for molecular docking studies against four bacterial targets. For molecular docking studies, we retrieved all phytoconstituents or ligands from the PubChem database and bacterial target proteins from the protein data bank using PyRx 0.8-AutoDock 4.2 software. Furthermore, we used various bioinformatics and chemoinformatics tools to examine the investigated phytoconstituents physicochemical properties, toxicity, and drug-ability profiles. Out of the 30 GC-MS report-derived candidates from three plants, P5 from P. guajava, P18 from S. cumini, and P21 from P. granatum had the potent binding ability with bacterial targets. In the same way, out of the 30 reported candidates, P39, P43, and P56 from three plants, along with amikacin, showed strong binding against the same bacterial target. Both sets of candidates showed favorable physicochemical and toxicity profiles; however, all GC-MS-derived and few reported candidates exhibited negative drug-likeness. The study reveals that these crude extracts have antibacterial properties because they contain both GC-MS and existing phytoconstituents. The study starts with a crude extraction and then uses bioinformatics to choose two possible antibacterial candidates, ursolic acid and punicacortein A. This platform could be useful for finding an antibacterial agent that works specifically on a specific target. To sum up, the study encourages the isolation of more bioactive candidates from different Indian medicinal plants and uses bioinformatics tools to speed up the selection of strong leads that can speed up the process of making antibacterial drugs within limited resources.

A multifunctional aspect of surface modification of cotton fabric with green synthesized titanium dioxide/iron nanocomposite using Psidium guajava leave extract

This study explores the use of green TiO2/Fe nanocomposite for surface modification of cotton fabric, aiming to minimize its limitations such as wrinkle, shrinkage, lower photocatalytic activity, microbial degradation, and poor durability. To prepare the nanocomposite, the iron (Fe) and titanium dioxide (TiO2) nanoparticles were first green synthesized using an extract of guava leaf (Psidium guajava) and mixed by using citric acid as a cross-linking agent. The modified cotton fabric was characterized by FTIR, TGA, DTG, SEM, and EDS. The FTIR spectra of the modified fabrics showed additional peaks at 483 cm−1 for Ti-O- and 1059 cm−1 for Fe-O-, indicating the incorporation of TiO2/Fe- nanoparticles which was also confirmed by SEM images. Fe nanoparticles enhanced TiO2 NPs’ photocatalytic activity, enhancing self-cleaning, UV resistance, stain resistance, anti-water absorption, and antibacterial activity in modified cotton fabric. Additionally, the wettability, thermal stability, mechanical and chemical stability of modified cotton fabric were also improved. As a result, the method of surface modification has great potential to improve the sustainability and usability of cotton fabric, supporting its wide range of uses in clothing, medical, and personal hygiene goods.

Green Synthesis of Zinc and Iron Nanoparticles Using Psidium guajava Leaf Extract Stimulates Cowpea Growth, Yield, and Tolerance to Saline Water Irrigation

Plants use a variety of physiological, biochemical, and molecular mechanisms to mitigate salt stress impacts. Many techniques, including the application of nanoparticles (NPs), are being used to increase plant stress tolerance. To assess the growth and productivity of Vigna unguiculata L. (cowpea) plants exposed to salt stress, cowpea has been cultivated using different saline water levels and subjected to green synthesized zinc NPs (ZnNPs) and iron NPs (FeNPs) applied via foliar spraying. The cowpea plants that grew under the lowest saline water level showed the best leaf traits, leaf water content per area (LWCA), pods, and seed yields, but when salinity levels increased, the plants’ growth and productivity slightly declined. ZnNP and FeNP treatments slow down the degradation of photosynthetic pigments and greatly mitigate the negative effects of salt stress. In both stressed and unstressed plants, ZnNP treatments produced the highest osmoprotectant concentrations (proline, protein, and total carbohydrates). As a result of salt stress, cowpea seeds showed a marked decrease in dry matter and protein content, but ZnNP and FeNP treatments increased it. Conclusively, the results obtained indicated that ZnNPs and FeNPs foliar application to cowpea plants stimulated leaf pigment and polyphenol production, which in turn increased seed dry matter, seed yield, protein content, and the plants’ ability to withstand saline stress.

Psidium guajava Seed Oil Reduces the Severity of Colitis Induced by Dextran Sulfate Sodium by Modulating the Intestinal Microbiota and Restoring the Intestinal Barrier.

The oil derived from Psidium guajava seeds (TKSO) exhibits an abundance of diverse unsaturated fatty acids, notably oleic, linoleic, and α-linolenic acids, conferring substantial health advantages in addressing metabolic irregularities and human diseases. This research endeavor focused on elucidating the impacts of TKSO on colonic inflammatory responses and intestinal microbiota alterations in a murine model of colitis induced by dextran sulfate sodium (DSS), demonstrated that substantial supplementation with TKSO reduces the severity of colitis induced by DSS. Furthermore, TKSO effectively attenuated the abundance and expression of proinflammatory mediators while augmenting the expression of tight junction proteins in DSS-challenged mice. Beyond this, TKSO intervention modulated the intestinal microbial composition in DSS-induced colitis mice, specifically by enhancing the relative presence of Lactobacillus, Norank_f_Muribaculaceae, and Lachnospiraceae_NK4A136_group, while concurrently diminishing the abundance of Turicibacter. Additionally, an analysis of short-chain fatty acids (SCFAs) revealed noteworthy elevations in acetic, propionic, isobutyric, and butyric acids, and total SCFAs levels in TKSO-treated mice. In summary, these findings underscore the potential of TKSO to reduce the severity of colitis induced by DSS in mice through intricate modulation of the intestinal microbiota, metabolite profiles, and intestinal barrier repair, thereby presenting a promising avenue for the development of therapeutic strategies against intestinal inflammatory conditions.

Synthesis and Biological Evaluation of Novel Psidium Meroterpenoid Derivatives against Cisplatin-Induced Acute Kidney Injury.

Cisplatin is a widely used drug for the clinical treatment of tumors. However, nephrotoxicity limits its widespread use. A series of compounds including eight analogs (G3-G10) and 40 simplifiers (G11-G50) were synthesized based on the total synthesis of Psiguamer A and B, which were novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Among these compounds, (d)-G8 showed the strongest protective effect on cisplatin-induced acute kidney injury (AKI) in vitro and vivo, and slightly enhanced the antitumor efficacy of cisplatin. A mechanistic study showed that (d)-G8 promoted the efflux of cisplatin via upregulating the copper transporting efflux proteins ATP7A and ATP7B. It enhanced autophagy through the activation of the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. (d)-G8 showed no acute toxicity or apparent pathological damage in the healthy mice at a single dose of 1 g/kg. This study provides a promising lead against cisplatin-induced AKI.

Elements relocation and gene expression in salt-exposed guava (Psidium guajava L.)

Elements relocation and gene expression in salt-exposed guava (Psidium guajava L.)

Antimicrobial characteristics of endophytic Aspergillus terreus and acute oral toxicity analysis

BackgroundEndophytic fungi produce biologically robust metabolites suitable for diverse applications, which support the increasing exploration of these fungi. The study aimed to investigate the in vitro antimicrobial properties of the metabolites of endophytic fungus Aspergillus terreus which isolated from the leaves of Psidium guajava plants while the acute oral toxicity was assessed in vivo. ResultsA. terreus (OR125572) was successfully isolated for the first time from P. guajava. The ethyl acetate extract of A. terreus exhibited antibactericidal effects against Enterobacter aerogenes with a minimum inhibitory concentration of 18.75 mg/ml in contrast to 75.00 ± 0.0, 37.50, and 37.50 mg/ml, respectively against Staphylococcus aureus, Escherichia coli, and Bacillus sphaericus were 75.00 ± 0.0, 37.50, and 37.50 mg/ml, respectively. Analysis of the crude extract obtained from A. terreus by GC-MS revealed a total of 32 distinct compounds. The major components included 1,2-benzenedicarboxylic acid, di-iso-octyl ester; hexyl oxecan-2-one and phenol. The acute oral toxicity study found no symptoms of toxicity and no mortality until the 14th d, suggesting that the LD50 value of A. terreus extract might exceed 1 ml/kg. The group receiving 0.5 ml/kg of A. terreus extract experienced a 42.9% increase in body weight, while administration of varying dosages resulted in a significant reduction in MCV levels. There was also a significant increase in the proportion of monocytes across all treated groups. ConclusionsThe study demonstrated the potential of A. terreus as a source of antimicrobial and other bioactive compounds, with relatively low acute toxicity.How to cite: Shehabeldine AM, Abdelaziz AM, Abdel-Maksoud MA, et al. Antimicrobial characteristics of endophytic Aspergillus terreus and acute oral toxicity analysis. Electron J Biotechnol 2024;72. https://doi.org/10.1016/j.ejbt.2024.07.003.

Structural, optical, antibacterial, antifungal, and anticancer activity of sodium alginate-pluronic-F127-tin dioxide nanoparticles prepared via microwave-assisted green process

The green synthesis of inorganic metal oxide nanoparticles is essential because it reduces environmental impact and enhances biocompatibility by using eco-friendly materials and processes. This sustainable approach also minimizes hazardous chemicals, promoting safer and cleaner production methods. The sodium alginate-Pluronic F127-modified SnO2 (SAPFSO) NPs were prepared using the green method using Psidium guajava leaf extract. The SAPFSO NPs exhibit a tetragonal rutile structure from the X-ray diffraction patterns. The FESEM and EDAX spectra identified the morphology and chemical composition. The Sodium Alginate, Pluronic-F127, and SnO2 functional group vibrations can be seen in the FTIR spectra. The DLS spectra and hydrodynamic sizes of SAPFSO NPs were observed at 183 nm. The various surface defects of SAPFSO NPs were identified from the PL spectrum. The antimicrobial activity of SAPFSO NPs was tested against gram-positive and gram-negative strains such as S. aureus, K. pneumoniae, S. dysenteriae, S. pneumoniae, Bacillus megaterium, Proteus valgaris, and Candida albicans fungal strain using the well-diffusion method. To increase the concentration, SAPFSO NPs also increased the antimicrobial activity. The anticancer activity of SAPFSO NPs tested against the human breast cancer cell line (MDA-MB-237). SAPFSO NPs exhibits potential anticancer activity against triple negative breast cancer cell line. These results support that SAPFSO NPs can be applied in healthcare and industrial settings to improve human health.