In this paper we study the regularity of the non-cutoff Vlasov-Poisson-Boltzmann system for plasma particles of two species in the whole space $\mathbb{R}^3$ with hard potential. The existence of global-in-time nearby Maxwellian solutions is known for soft potential from [15]. However the smoothing effect of these solutions has been a challenging open problem. We establish the global existence and regularizing effect to the Cauchy problem for hard potential with large time decay. Hence, the solutions are smooth with respect to $(t,x,v)$ for any positive time $t>0$. This gives the regularity to Vlasov-Poisson-Boltzmann system, which enjoys a similar smoothing effect as Boltzmann equation. The proof is based on the time-weighted energy method building also upon the pseudo-differential calculus.