Properties Of Shell Research Articles

Does High Voltage Electrical Discharge Treatment Induce Changes in Tannin and Fiber Properties of Cocoa Shell?

Cocoa shell is a by-product of the chocolate industry that is rich in dietary fiber and bioactive components. In this research, the influence of high voltage electric discharge (HVED) treatment on chemical and physical characteristics of the cocoa shell, i.e., the effects of applied time and frequencies on grinding ability, water binding capacity (WBC), dietary fibers and tannin content was investigated. HVED had a significant influence on the chemical and physical properties of cocoa shell, all of which could be linked to changes in fiber properties. Along with the fiber content, grinding ability and water binding capacity were increased. These properties have already been linked to fiber content and soluble/insoluble fiber ratio. However, this research implies that change in fiber properties could be linked to tannin formation via complexation of other polyphenolic components. Additional research is needed to verify this effect and to establish mechanisms of tannin formation induced by HVED and its influence on fiber quantification.

Influence of biomass components, temperature and pressure on the pyrolysis behavior and biochar properties of pine nut shells

The aim of this work was to compare the yields, proximate composition, structure and surface morphology of biochar derived from lignin, cellulose, hemicellulose and pine nut shell (PNS) at 400–700 ℃. PNS biochars obtained at different pyrolysis pressures in the range of 0.1–2.0 MPa were also studied. The results indicate that the interactions of lignin, cellulose and hemicellulose have smaller effects on the ash content, yield and higher heating value (HHV) of the biochar than they do on the fixed carbon and volatile matter contents. Increasing the pyrolysis temperature improves the HHV of the biochar, and increasing the pyrolysis pressure enhances the biochar yield, surface functional groups and combustion characteristics. The kinetic data for Pb2+ adsorption are best fitted by a pseudo-second-order model, indicating a chemisorption-controlled process. The PNSB550 and PNSB1.0 data are optimally fit by the Freundlich and Langmuir models, respectively. The maximum Pb2+ adsorption capacity is 237.3 mg/g.

New Prospects for Particle Characterization Using Analytical Centrifugation with Sector‐Shaped Centerpieces

AbstractAnalytical centrifugation (AC) has recently shown great potential for the accurate determination of particle size distributions. The well‐established LUMiSizer(R) is customized by a new design allowing for higher rotor speeds, improved thermal insulation, and measurement cell assembly. The latter enables sedimentation analysis of nanoparticles (NPs) in sector‐shaped centerpieces. The measurement window of AC experiments is assessed by the Peclet (Pe) number. It is shown that at low Pe numbers (0.7 < Pe < 30), sedimentation, and diffusion can be accurately and simultaneously analyzed from the sedimentation boundaries within one experiment. Moreover, sedimentation properties can be reliably determined up to Pe numbers of 4000. The thermal characteristic throughout the sedimentation analysis is validated by measuring polystyrene particles at elevated temperatures. Moreover, the performance of the setup is demonstrated by determining the sedimentation properties of SiO2 NPs at intermediate Pe numbers in excellent agreement with results from analytical ultracentrifugation experiments. Finally, for the first time, an accurate analysis of the core–shell properties of Au NPs via AC is presented. By combining the analysis of sedimentation and diffusional properties at low Pe numbers, the shell thickness of the stabilizer cetyltrimethylammonium bromide alongside the core diameter distribution of the Au NPs is determined.

Surpassing electrocatalytic limit of earth-abundant Fe4+ embedded in N-doped graphene for (photo)electrocatalytic water oxidation

Abstract Developing highly active, cost-effective, and environmental friendly oxygen evolution reaction (OER) electrocatalysts facilitates various (photo)electrochemical processes. In this work, Fe3N nanoparticles encapsulated into N-doped graphene nanoshells (Fe3N@NG) as OER electrocatalysts in alkaline media were reported. Both the experimental and theoretical comparison between Fe3N@NG and Fe3N/NG, specifically including in situ Mossbauer analyses, demonstrated that the NG nanoshells improved interfacial electron transfer process from Fe3N to NG to form high-valence Fe4+ ions (Fe4+@NG), thus modifying electronic properties of the outer NG shells and subsequently electron transfer from oxygen intermediate to NG nanoshells for OER catalytic process. Meanwhile, the NG nanoshells also protected Fe-based cores from forming OER inactive and insulated Fe2O3, leading to high OER stability. As a result, the as-formed Fe4+@NG shows one of the highest electrocatalytic efficiency among reported Fe-based OER electrocatalysts, which can as well highly improve the photoelectrochemical water oxidation when used as the co-catalysts for the Fe2O3 nanoarray photoanode.

Omnidirectional passive acoustic identification tags for underwater navigation.

A class of passive acoustic identification (AID) tags with curved symmetry for underwater navigation is presented. These AID tags are composed of radially stratified shells designed to backscatter a unique specular reflection pattern independent of the incidence orientation in a monostatic configuration, thus acting as acoustic bar-codes. The AID tag's response can be uniquely engineered by selecting the thicknesses and material properties of the individual constitutive shells. Furthermore, in the high-frequency regime, the specular component of the AID tag's response can be simply predicted numerically assuming horizontally stratified layers. This approach is demonstrated using scaled experiments with an AID tag constructed from 3D printed hemispherical shells.

Hydroxyapatite nanoparticles derived from mussel shells for in vitro cytotoxicity test and cell viability

Hydroxyapatite (HA) nanoparticles derived from mussel shells were prepared using the wet precipitation method and were tested on human mesenchymal and epithelial cells. Shells and HA powder were characterized via X-ray diffraction analysis (XRD) and scanning electron microscopy along with energy dispersive X-ray spectroscopy (SEM/EDX), high resolution transmission electron microscopy (HR-TEM) and Fourier transform infrared spectroscopy (FTIR). The in vitro cytotoxic properties of HA and mussel shells were determined using sulphorhodamine B (SRB) assays for MCF-7 cells (HepG2) and colon (Caco-2) cells. Cell viability tests confirmed the nontoxic effects of synthesized HA and mussel shells on human mesenchymal stem cells (h-MSCs) and epithelial cells. Toxicity values were less than 50% of the cell's validity ratio based on analyses using different concentrations (from 0.01 to 1,000 μg). The results indicate that MSC and epithelial cell attachment and proliferation in the presence of both HA and shell occurred.The proliferation capability was established after 3 and 7 days. SEM images revealed that stem cells and epithelial cells attached to the scaffold indicated full and complete integration between the cells and the material. It seems that due to the ion exchange between bovine serum albumin solutions (BSA) and HA, the FTIR data confirmed an increase in the amide I and amide II bands, which indicates the compatibility of the BSA helix structure. This study sheds light on the importance of merging stem cells and nanomaterials that may lead to improvements in tissue engineering to develop novel treatments for various diseases.

A Laboratory Model for Virus Particle Nanoindentation

ABSTRACT Self-organization is ubiquitous in biology, with viruses providing an excellent illustration of bioassemblies being much more than the sum of their parts. Following nature's lead, molecular self-assembly has emerged as a new synthetic strategy in the past 3 decades or so. Self-assembly approaches promise to generate complex supramolecular architectures having molecular weights of 0.5 to 100 MDa and collective properties determined by the interplay between structural organization and composition. However, biophysical methods specific to mesoscopic self-assembly, and presentations of the challenges they aim to overcome, remain underrepresented in the educational laboratory curriculum. We present here a simple but effective model for laboratory instruction that introduces students to the world of intermolecular forces and virus assembly, and to a cutting-edge technology, atomic force microscopy nanoindentation, which is able to measure the mechanical properties of single virus shells in vitro. In addition, the model illustrates the important idea that, at nanoscale, phenomena often have an inherent interdisciplinary character.

A multiscale analysis for free vibration of fuzzy fiber-reinforced nanocomposite conical shells

Abstract In this paper, the free vibration analysis of fuzzy fiber reinforced (FFRC) nanocomposite truncated conical shell is investigated. The FFRC constructional feature is that the uniformly aligned carbon nanotubes (CNTs) are radially grown on the circumferential surfaces of unidirectional carbon fibers. Using a micromechanical model based on the simplified unit cell (SUC) method, the effective material properties of the FFRC conical shells are evaluated. The thin-walled classical shell theory and Hamilton's principle are used to extract the governing equations, and the Ritz method is used to solve the problem. The model predictions are compared with other numerical results available in the literature and the correctness of the proposed theoretical method is attested. Some novel results, including the vibration results of FFRC conical shell accompanied with different combinations of boundary conditions and different material and geometrical properties are presented. The results reveal that the FFRC conical shell vibration behavior is strongly dependent on the material properties, volume fractions of two reinforcements, geometrical characteristics and boundary conditions.

Synthesis of highly-branched Au@AgPd core/shell nanoflowers for in situ SERS monitoring of catalytic reactions

Alloy and small size nanostructures are favorable to catalytical performance, but not to surface-enhanced Raman spectroscopy (SERS) applications. Integrating SERS and catalytic activity into the nanocrystals with both alloy and small size structures is of great interest in fabrication of SERS platform to in situ monitor catalytical reaction. Herein, we report a facile method to synthesize Au@AgPd trimetallic nanoflowers (Au@AgPd NFs) with both SERS and catalytic activities, through simultaneous selective growth of Ag and Pd on Au core to form highly-branched alloy shell. These nanocrystals have the properties of small sizes, defects abundance, and highly-dispersed alloy shell which offer superior catalytic activity, while the merits of monodisperse, excellent stability, and highly-branched shell and core/alloy-shell structure promise the enhanced SERS activity. We further studied their growth mechanisms, and found that the ratio of Ag to Pd, sizes of Au core, and surfactant cetyltrimethylammonium bromide together determine this special structure. Using this as-synthesized nanocrystals, a monolayer bifunctional platform with both SERS and catalytical activity was fabricated through self-assembly at air/water interface, and applied to in situ SERS monitoring the reaction process of Pd-catalyzed hydrogenation of 4-nitrothiophenol to 4-aminothiophenol.

Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening

Non-invasive blood-brain barrier (BBB) opening using focused ultrasound (FUS) is being tested as a means to locally deliver drugs into the brain. Such FUS therapies require injection of preformed microbubbles, currently used as contrast agents in ultrasound imaging. Although their behavior during exposure to imaging sequences has been well described, our understanding of microbubble stability within a therapeutic field is still not complete. Here, we study the temporal stability of lipid-shelled microbubbles during therapeutic FUS exposure in two timescales: the short time scale (i.e., μs of low-frequency ultrasound exposure) and the long time scale (i.e., days post-activation). We first simulated the microbubble response to low-frequency sonication, and found a strong correlation between viscosity and fragmentation pressure. Activated microbubbles had a concentration decay constant of 0.02 d−1 but maintained a quasi-stable size distribution for up to 3 weeks (< 10% variation). Microbubbles flowing through a 4-mm vessel within a tissue-mimicking phantom (5% gelatin) were exposed to therapeutic pulses (fc: 0.5 MHz, peak-negative pressure: 300 kPa, pulse length: 1 ms, pulse repetition frequency: 1 Hz, n=10). We recorded and analyzed their acoustic emissions, focusing on emitted energy and its temporal evolution, alongside the frequency content. Measurements were repeated with concentration-matched samples (107 microbubbles/ml) on day 0, 7, 14, and 21 after activation. Temporal stability decreased while inertial cavitation response increased with storage time both in vitro and in vivo, possibly due to changes in the shell lipid content. Using the same parameters and timepoints, we performed BBB opening in a mouse model (n=3). BBB opening volume measured through T1-weighted contrast-enhanced MRI was equal to 19.1 ± 7.1 mm3, 21.8 ± 14 mm3, 29.3 ± 2.5 mm3, and 38 ± 20.1 mm3 on day 0, 7, 14, and 21, respectively, showing no significant difference over time (p-value: 0.49). Contrast enhancement was 24.9 ± 1.7 %, 23.7 ± 11.7 %, 28.9 ± 5.3 %, and 35 ± 13.4 %, respectively (p-value: 0.63). In conclusion, the in-house made microbubbles studied here maintain their capacity to produce similar therapeutic effects over a period of 3 weeks after activation, as long as the natural concentration decay is accounted for. Future work should focus on stability of commercially available microbubbles and tailoring microbubble shell properties towards therapeutic applications.

Pd@Al-containing mesoporous silica Yolk–Shell-structured nanospheres as high performance nanoreactors for the selective hydrogenolysis of glucose to 1,2-propylene glycol

In this work, a series of Pd@Al-MSiO2 yolk–shell-structured nanospheres (YSNSs) with different Al contents were synthesized by a facile one-pot method. The EDX elemental analysis and high-magnification TEM image of Pd@Al-MSiO2 YSNSs confirmed that its well-defined yolk-shell structure with a moving Pd core and mesoporous silica shell rich in Al species. Furthermore, Solid state NMR and Py-FTIR results confirmed that Al species grafting mainly formed 4-coordinated Al (AlO4) in the mesoporous silica framework which led to generating abundant Lewis acid sites. The influence of Al species on the physicochemical properties of Pd@Al-MSiO2 YSNSs, as well as their catalytic performance for the hydrogenolysis of glucose to 1,2-propylene glycol (1,2-PG), was investigated. The mesoporous silica shell with abundant Lewis acid sites is a significant contributor to the isomerization of glucose into fructose, while the Pd core plays a role in promoting the hydrogenation of intermediates. The unique hollow space inside the Pd@Al-MSiO2 YSNSs provides a location for the retro-aldol condensation of fructose and consequently avoids direct hydrogenation of fructose. The as-synthesized Pd@Al3-MSiO2 YSNSs shows superior catalytic activity (1,2-PG selectivity of 47.4%, glucose conversion of 95.4%) in the hydrogenolysis of glucose, and far outperforms the Pd/Al3-MSiO2 catalysts. In addition, owing to the influence of the 4-coordinated Al species on the geometry and chemical properties of the mesoporous silica shell, the nanospheres show good stability and reusability over multiple catalytic cycles without significant loss of activity.

From the Soft to the Hard: Changes in Microchemistry During Cell Wall Maturation of Walnut Shells.

The walnut shell is a hard and protective layer that provides an essential barrier between the seed and its environment. The shell is based on only one unit cell type: the polylobate sclerenchyma cell. For a better understanding of the interlocked walnut shell tissue, we investigate the structural and compositional changes during the development of the shell from the soft to the hard state. Structural changes at the macro level are explored by X-ray tomography and on the cell and cell wall level various microscopic techniques are applied. Walnut shell development takes place beneath the outer green husk, which protects and delivers components during the development of the walnut. The cells toward this outer green husk have the thickest and most lignified cell walls. With maturation secondary cell wall thickening takes place and the amount of all cell wall components (cellulose, hemicelluloses and especially lignin) is increased as revealed by FTIR microscopy. Focusing on the cell wall level, Raman imaging showed that lignin is deposited first into the pectin network between the cells and cell corners, at the very beginning of secondary cell wall formation. Furthermore, Raman imaging of fluorescence visualized numerous pits as a network of channels, connecting all the interlocked polylobate walnut shells. In the final mature stage, fluorescence increased throughout the cell wall and a fluorescent layer was detected toward the lumen in the inner part. This accumulation of aromatic components is reminiscent of heartwood formation of trees and is suggested to improve protection properties of the mature walnut shell. Understanding the walnut shell and its development will inspire biomimetic material design and packaging concepts, but is also important for waste valorization, considering that walnuts are the most widespread tree nuts in the world.

The shell matrix and microstructure of the Ram’s Horn squid: Molecular and structural characterization

Molluscs are one of the most diversified phyla among metazoans. Most of them produce an external calcified shell, resulting from the secretory activity of a specialized epithelium of the calcifying mantle. This biomineralization process is controlled by a set of extracellular macromolecules, the organic matrix. In spite of several studies, these components are mainly known for bivalves and gastropods. In the present study, we investigated the physical and biochemical properties of the internal planispiral shell of the Ram's Horn squid Spirula spirula. Scanning Electron Microscope investigations of the shell reveal a complex microstructural organization. The saccharides constitute a quantitatively important moiety of the matrix, as shown by Fourier-transform infrared and solid-state nuclear magnetic resonance spectroscopies. NMR identified β-chitin and additional polysaccharides for a total amount of 80% of the insoluble fraction. Proteomics was applied to both soluble and insoluble matrices and in silico searches were performed, first on heterologous metazoans models, and secondly on an unpublished transcriptome of Spirula spirula. In the first case, several peptides were identified, some of them matching with tyrosinase, chitinase 2, protease inhibitor, or immunoglobulin. In the second case, 39 hits were obtained, including transferrin, a serine protease inhibitor, matrilin, or different histones. The very few similarities with known molluscan shell matrix proteins suggest that Spirula spirula uses a unique set of shell matrix proteins for constructing its internal shell. The absence of similarity with closely related cephalopods demonstrates that there is no obvious phylogenetic signal in the cephalopod skeletal matrix.

Pecan (Carya illinoinensis (Wagenh.) K. Koch) Nut Shell as an Accessible Polyphenol Source for Active Packaging and Food Colorant Stabilization.

Herein, the antioxidant and food stabilizing properties of a pecan nut shell (PNS) hydroalcoholic extract (PNSE) are reported. Chemical degradation of PNSE demonstrated the presence of condensed tannins as the main phenolic components. PNSE showed remarkable antioxidant properties in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay (EC50 = 0.004 mg/mL). PNSE was initially tested as an inhibitor of mushroom tyrosinase, exhibiting a quite low IC50 value (0.055 mg/mL) against the enzyme diphenolase activity, suggesting its use in enzymatic browning inhibition. The anthocyanin stabilization properties were evaluated under accelerated aging conditions of both pure pigments and commercial fruit juices, and PNSE was found to be effective at concentrations (0.05 mg/mL) at which well-known stabilizers such as chlorogenic and ferulic acids proved to fail. PNSE also performed well in the stabilization of spray-dried anthocyanins for use as a food colorant, increasing the half-life of blackberry anthocyanins up to 20%. In order to explore the possibility of using PNSE as a functional additive for active packaging, polylactic acid (PLA) films containing PNSE were prepared by solvent casting, and no substantial alteration of the mechanical properties was found on addition of the extract up to 10% w/w. The films showed remarkable antioxidant properties (DDPH reduction >60% with a 3% w/w loading, at a dose of 1 mg/mL in the DPPH solution) and delayed the onset of browning of apple smoothies (ca. 30% inhibition with a 10% w/w loading). These results highlight the exploitation of PNS as a low-cost polyphenol source for food industry applications.

The combined effects of salinity and pH on shell biomineralization of the edible mussel Mytilus chilensis

Coastal ecosystems influenced by river discharges are subjected to important environmental changes. Understanding how marine biota cope with its environment is relevant in predicting the responses to future conditions imposed by climate change. To date, a large number of studies have addressed the role of pH on shell and biomineralization properties on multiple calcifying species; however the role of salinity in combination with other stressors has been poorly studied. In particular, the edible mussel Mytilus chilensis, an important marine resource of the Chilean coasts, inhabits estuarine areas which show high natural variability in terms of pH and salinity. Here, we studied how M. chilensis shell periostracum, shell organic matrix and crystal orientation are affected by different pH (8.1 and 7.7) and salinity conditions (30, 25 and 20 psu), isolated and in combination, at different time intervals. Our results show differences in the plasticity of the different biomineralogical properties studied during the experiment under the different pH and salinity treatments. While the periostracum thickness and the total shell organic matter were not affected by pH and salinity, the periostracum organic composition did. Higher amounts of polysaccharides were observed under low pH conditions after 20 days of experiment, while after 60 days, low salinity was responsible for the decrease of the polysaccharides and proteins in the periostracum. Low salinity also produced a major disorder in crystal organization at the outer shell surface. Finally, total shell weight was only affected by low pH conditions under lower salinity conditions (20 psu). From the results, in the majority of the shell properties observed we did not observe any combined effect of pH and salinity. Also, we detected that the magnitude of the impacts of salinity and pH are variable and time-dependent. This would be suggesting some level of acclimatization of M. chilensis to lower pH and salinity conditions.

Aqueous Contact Ion Pairs of Phosphate Groups with Na+, Ca2+ and Mg2+ – Structural Discrimination by Femtosecond Infrared Spectroscopy and Molecular Dynamics Simulations

Abstract The extent of contact and solvent shared ion pairs of phosphate groups with Na+, Ca2+ and Mg2+ ions in aqueous environment and their relevance for the stability of polyanionic DNA and RNA structures is highly debated. Employing the asymmetric phosphate stretching vibration of dimethyl phosphate (DMP), a model system of the sugar-phosphate backbone of DNA and RNA, we present linear infrared, femtosecond infrared pump-probe and absorptive 2D-IR spectra that report on contact ion pair formation via the presence of blue shifted spectral signatures. Compared to the linear infrared spectra, the nonlinear spectra reveal contact ion pairs with increased sensitivity because the spectra accentuate differences in peak frequency, transition dipole moment strength, and excited state lifetime. The experimental results are corroborated by long time scale MD simulations, benchmarked by density functional simulations on phosphate-ion-water clusters. The microscopic interpretation reveals subtle structural differences of ion pairs formed by the phosphate group and the ions Na+, Ca2+ and Mg2+. Intricate properties of the solvation shell around the phosphate group and the ion are essential to explain the experimental observations. The present work addresses a challenging to probe topic with the help of a model system and establishes new experimental data of contact ion pair formation, thereby underlining the potential of nonlinear 2D-IR spectroscopy as an analytical probe of phosphate-ion interactions in complex biological systems.

Torrefaction of palm kernel shell using conventional and microwave irradiation pretreatment

This study describes the properties of torrefied palm kernel shell (PKS) by conventional and microwave irradiation (MI) pretreatment. In conventional pretreatment, the untreated PKS was torrefied using fixed bed reactor at temperature of 210, 230, 250, 270 and 290 °C for 60 min of holding time. In MI pretreatment, the untreated PKS was irradiated with microwave power of 200, 300, 450 and 600 W for 8 min of holding time. The torrefied samples were analysed for mass and energy yield, energy density, calorific value and proximate and ultimate analysis. The results showed that, the properties of torrefied samples were improved with increasing torrefaction temperature and microwave power. The mass and energy yield, moisture, volatile matter and oxygen content of torrefied PKS decreased, whereas, the calorific value, energy density and carbon content increased with increasing torrefaction temperature and microwave power. The torrefaction temperature of 270 °C and microwave power of 450 W were appropriate to upgrade the PKS properties. Therefore, the change in properties of torrefied PKS revealed the potential of applying pretreatment prior to further thermal conversion such as pyrolysis and gasification.

Shell properties play an important role in the stability of green quantum dots

A comprehensive study reveals the structural requirements for achieving bright and stable green light-emitting quantum dots that exhibit suppressed blinking or photobleaching.

Influence of the Acetabular Cup Material on the Shell Deformation and Strain Distribution in the Adjacent Bone-A Finite Element Analysis.

In total hip arthroplasty, excessive acetabular cup deformations and altered strain distribution in the adjacent bone are potential risk factors for implant loosening. Materials with reduced stiffness might alter the strain distribution less, whereas shell and liner deformations might increase. The purpose of our current computational study was to evaluate whether carbon fiber-reinforced poly-ether-ether-ketones with a Young´s modulus of 15 GPa (CFR-PEEK-15) and 23 GPa (CFR-PEEK-23) might be an alternative shell material compared to titanium in terms of shell and liner deformation, as well as strain distribution in the adjacent bone. Using a finite element analysis, the press-fit implantation of modular acetabular cups with shells made of titanium, CFR-PEEK-15 and CFR-PEEK-23 in a human hemi-pelvis model was simulated. Liners made of ceramic and polyethylene were simulated. Radial shell and liner deformations as well as strain distributions were analyzed. The shells made of CFR-PEEK-15 were deformed most (266.7 µm), followed by CFR-PEEK-23 (136.5 µm) and titanium (54.0 µm). Subsequently, the ceramic liners were radially deformed by up to 4.4 µm and the polyethylene liners up to 184.7 µm. The shell materials slightly influenced the strain distribution in the adjacent bone with CFR-PEEK, resulting in less strain in critical regions (<400 µm/m or >3000 µm/m) and more strain in bone building or sustaining regions (400 to 3000 µm/m), while the liner material only had a minor impact. The superior biomechanical properties of the acetabular shells made of CFR-PEEK could not be determined in our present study.

Improved room temperature magnetoelectric response in CoFe2O4-BaTiO3 core shell and bipolar magnetostrictive properties in CoFe2O4

A large Magnetoelectric (ME) response at room temperature in CoFe2O4 - BaTiO3 core shell composite is crucial for the biomedical application because of its biocompatibility. Good ME response of core–shell system is directly related to synthesis conditions as it determinesextent of coupling between core and shell structures. In this work, CoFe2O4 - BaTiO3 core shell structures with improved ME response were prepared through hydrothermal and citric gel synthesis. Reitveld refinement analysis and microscopic images confirmed the successful formation of CoFe2O4 - BaTiO3 core shell structure. The core shell sample is composed of tetragonal BaTiO3 and cubic spinel CoFe2O4 phases. CoFe2O4 was found to exhibit both positive and negative magnetostriction at room temperature. ME coefficient of 12.38 mV/cm Oe was observed at room temperature, which is quite high and can enhance the efficiency of targeted drug delivery.