In many water scarce areas, saline water has been included as an important substitutable resource in agricultural irrigation. It would be of practical use to investigate the effect of stage-specific saline irrigation on yield, fruit quality, and other growth responses of greenhouse tomato, to establish a proper irrigation management strategy for tomato production in these regions. Here, saline irrigations (3.33, 8.33, and 16.67 dS m−1 NaCl solution) were applied during four growth stages of greenhouse tomato (L. esculentum Mill. cv. Zhongza No. 9) grown in the North China Plain, respectively. These include flowering and fruit-bearing stage (stage 1), first cluster fruit expanding stage (stage 2), second cluster fruit expanding stage (stage 3), and harvesting stage (stage 4). Compared with the following three stages, yield loss was most remarkable in stage 1 under all three salinity levels. Under irrigation practices using 3.33 dS m−1 saline water in all four stages, 8.33 dS m−1 saline water in latter three stages, and 16.67 dS m−1 saline water in stage 4, yield reduction was not significant while fruit quality was improved. In conclusion, it is feasible to use stage-specific saline irrigation for tomato production in water scarce areas like North China Plain.