Proper Use Of Antibiotics Research Articles

JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias.

JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias.

Comparing the Effects of Mobile-Based Education and Booklet-Based Education on Iranian Mothers’ Perception on Antibiotics: A Quasi-Experimental Study

PurposeThe aim of this study was to investigate the effect of mobile-based education in comparison with booklet-based education on mothers' perception on antibiotics. Design and methodsThis quasi-experimental study was performed on 160 mothers of children aged 1 to 6 years (80 in the experimental group and 80 in the control group) who referred to the urban community health centers in Iran. Both groups were taught about the proper use of antibiotics. The experimental group was taught using a mobile application and the control group was taught using a booklet. The Parental Perception on Antibiotics (PAPA) scale was used to collect data at the beginning and two to four weeks after the educational intervention. The data were analyzed using SPSS version 19. ResultsThe results showed that 91.9% of mothers used the knowledge of nurses or other health care providers and 86.3% used their previous experience as the source of information about antibiotics. Also, mothers' perceptions about antibiotics in the subscales of knowledge and beliefs, behaviors, adherence and awareness about antibiotics resistance in the experimental group improved significantly compared to the control group (p < 0.05). ConclusionsMobile-based education was more effective in improving mothers' perception on antibiotics than booklet-based education. Practice implicationsHealth care providers can use mobile-based educational method for different groups of society to promote health in various fields.

Perfil de resistencia a la tetraciclina de Cutibacterium acnes en pacientes con acné vulgar en un centro dermatológico de Colombia

IntroductionAcne is a chronic inflammatory disease, in which different events intervene in its pathogenesis, one of which is Cutibacterium acnes (C. acnes). Resistance of this bacteria to different antimicrobials used in treatment has been described in different regions of the world. The purpose of the study is to estimate the resistance of C. acnes to cyclins in patients with moderate and severe acne over 18 years of age. Materials and MethodsAn analytical cross-sectional study was carried out. Samples were taken from inflammatory lesions with a comedone extractor. The content of the samples was incubated in an anaerobic atmosphere to grow C. acnes. Finally, the susceptibility of C. acnes to tetracycline, minocycline and doxycycline was determined. ResultsSamples were taken from 147 patients, of which 129 showed growth of C. acnes, finding that 5.43% of the strains were resistant to tetracycline, 5.43% to doxycycline, 0.78% to minocycline and cross resistance between doxycycline and tetracycline in all the cases. An association was found between resistance and being 25 years of age or older. No association was found with the prior use of antibiotics, a history of misuse of oral or topical antibiotics, and other demographic and clinical characteristics evaluated. ConclusionsThe resistance found of C. acnes to cyclines was lower than that reported in other studies. Although no relationship was found with the previous use of antibiotics, it is a factor described in previous studies, which is why the proper use of antibiotics is imperative to avoid the appearance of resistance.

An Investigation of the Male Genitourinary Abscess Originated from Urinary Tract in a Tertiary Hospital, Shanghai, China, from 2004 to 2019.

BackgroundMale genitourinary abscess is one of the serious complications of urinary tract infections (UTIs). There were few researches on the clinical and pathogenic characteristics of male genitourinary abscess.Patients and MethodsA retrospective observational study was conducted between January 2004 and April 2019. Male patients with genitourinary abscess originated from urinary tract, including sites of scrotum, testis, epididymis, spermatic cord, and prostate, were enrolled. Clinical and microbial records were collected and analyzed, and antimicrobial susceptibility testings were performed according to CLSI standard. Whole-genome sequencing was applied to detect the β-lactamase genes and virulence genes, as well as to determine the multilocus-sequence typing (MLST) of the collected Klebsiella pneumoniae (K. pneumoniae) isolates.ResultsA total of 22 male patients were included. The main clinical symptoms were fever (86.4%), scrotal swelling (68.2%), local skin warmth (59.1%) and ulceration (45.5%). Urinary irritation was often presented in prostate involved abscess. Ultrasound features had a 94.7% positive rate. Surgical treatment, including abscess drainage, was helpful to the prognosis. No matter where the specimens obtained from, including blood, urine or pus, multidrug-resistant K. pneumoniae was the dominant (11 cases, 50.0%) microorganism in positive cultures. Nine of eleven K. pneumoniae isolates had been preserved and recovered. As for MLST typing, all the nine available isolates of K. pneumoniae belonged to the ST11 type and characterized with blaKPC-2 carbapenemase gene. Virulence genes rmpA2, ybtS, kfuC, wzi, aerobactin genes (iucABCD and iutA) and type 3 fimbriae genes (mrkAD) were identified in all the K. pneumoniae isolates.ConclusionIt seemed that more patients under 35 years old were vulnerable to genitourinary abscess. There was an increasing trend that multidrug-resistant K. pneumoniae isolates with multiple virulence genes were involved in male genitourinary abscess. Prompt and proper antibiotic use, combined with adequate drainage of the abscess, was important to prognosis.

Antibiotic resistance among the Lahu hill tribe people, northern Thailand: a cross-sectional study

BackgroundAntibiotic resistance is often reported and great concerned as one of public health problems especially people living with poverty in developing countries including Thailand. The hill tribe people is defined as vulnerable population for antibiotic resistance in Thailand due to poor economic and education status particularly the Lahu people who is the second greatest group of the hill tribe people in Thailand. The study aimed to estimate the prevalence, factors associated with, and typing major species of bacteria with antibiotic drugs resistance among the Lahu hill tribe people in northern Thailand.MethodsA cross-sectional study was conducted to gather the information from the participants. A validated questionnaire was used for data collection. Participants who presented an illness related to infectious diseases were eligible to participate the study and were asked to obtain specific specimen; sputum, urine or stool. Antibiotic susceptibility was tested by Kirbey Bauer’s disc diffusion test. Chi-square and logistic regression were used to detect the associations between variables at the significant level of α = 0.05.ResultsA total of 240 participants were recruited into the study. The majority had urinary tract infection (67.9%) with two major pathogenic species of the infection; Escherichia coli (12.8%), and Enterobacter cloacae (8.0%). The prevalence of antibiotic resistance was 16.0%. Escherichia coli and Klebsiella pneumoniae species were found to have multidrug resistance that was greater than that of other species, while ampicillin was found to have the greatest drug resistance. It was found that those who had poor knowledge of antibiotic use had a 2.56-fold greater chance (95% CI = 1.09–5.32) of having antibiotic resistance than did those who had good knowledge of antibiotic use, and those who had poor antibiotic use behaviors had a 1.79-fold greater chance (95% CI = 1.06–4.80) of having antibiotic resistance than did those who had good antibiotic use behaviors.ConclusionEffective public health interventions are urgently needed to reduce antibiotic drug resistance among the Lahu people by improving their knowledge and skills regarding the proper use of antibiotics and eventually minimizing antibiotic resistance. Moreover, health care professionals should strictly follow the standard guideline to prescribe antibiotics.

Antibiotic Abuse: A Cross-Sectional Study on Knowledge, Attitude, and Behavior Among the University Students in Dhaka, Bangladesh

Objective: Antibiotic abuse has contributed to the development of antimicrobial resistance (AMR) and has become a global concern. With a poorly regulated health system and a general lack of data, Bangladesh remains under high risk of AMR spread. To minimize the existing gap in the literature, this study was conducted to assess the knowledge, attitude, and behavior regarding antibiotic use and misuse among university students. Methods: A cross-sectional study design was used to survey 1400 students using a self-administered questionnaire from the University of Dhaka, Bangladesh. Descriptive and inferential analyses were performed with statistical significance defined as p < 0.05. Results: More than half of the respondents had poor knowledge and neutral attitude towards antibiotics. The students from bioscience were found to have better knowledge and attitude than arts and business. Respondents with good knowledge were more likely to show a positive attitude, p<0.05. Most of the respondents did not know that antibiotics are ineffective against most coughs and cold; and above 60% practiced self-medication. About one-third did not know that antibiotics mainly target bacteria, and surprisingly, more than four-fifth perceived that humans & animals could become resistant to antibiotics. Also, half of the participants did not fulfill their prescribed antibiotic course. Conclusion: There is a substantial amount of knowledge and attitude gap about and non-compliance to the proper use of antibiotics among the university students. The research findings, therefore, reflect the need for policy-level interventions to increase awareness and develop effective countermeasures to prevent the misuse of antibiotics.

BIJAK MENGGUNAKAN ANTIBIOTIK DI DESA TUNGKARAN PANGERAN KABUPATEN TANAH BUMBU

The current problem that occurs is the increased use of antibiotics freely and mistakenly causing antibiotics to become resistant to bacteria as well as inappropriate storage which causes the antibiotic to be damaged so that their effectiveness is lost. A Survey that started in the village of Tungkaran Pangeran, Tanah Bumbu district identified that there is a lack of public knowledge about the use of antibiotics. It also found mistakes in storing drugs, especially antibiotics. The output target of community service activities is to increase community knowledge about antibiotics from the understanding, classification, storage, and resistance of antibiotics. Besides, the public also understands the regulation of getting the right antibiotic in Indonesian. As a result of community service activities in Tungkaran Pangeran Village, Tanah Bumbu District, there has been a significant increase in community knowledge on the proper and correct use and storage of antibiotics

EFFECT OF AN EDUCATIONAL INTERVENTION ON MOTHERS' KNOWLEDGE, ATTITUDE AND PRACTICE ABOUT PROPER ANTIBIOTIC USE IN A SELECTED FAMILY HEALTH CENTER

Background: Improper antibiotic use is a significant community health issue that contributes to antibiotic resistance. Insufficient mothers’ knowledge about the cautious antibiotics use in treating common childhood diseases can end in its misuse. Improving mothers’ awareness about correct antibiotic use is the main aspect. The study is aimed to assess the effect of an educational intervention on mothers' knowledge, practice and attitude about proper antibiotic use. Method: A quasi-experimental design – one group pre-post-test among 130 mothers was carried out in selected family health centers. Baseline knowledge, practice and attitude (pre-intervention) regarding judicious antibiotic use was assessed using structured interview questionnaire developed by researcher which comprised of socio-demographic data of mother and child, source of knowledge, the mothers’ knowledge, subjective practice and their attitude about appropriate antibiotic use. Educational intervention on proper antibiotic use of children was administered after baseline assessment. The effect of this intervention was evaluated using same questionnaire post the intervention and after 3 months. Findings: About 41.5% of the mothers age were from 20 to not more than 35 years. Mothers had poor knowledge about the concept of judicious use of antibiotics, indication of proper antibiotic use, side effect and causes of antibiotic resistance in the pre-test that improved after implementation of the educational session. Health education sessions significantly improved antibiotic-related practice and attitude of the mothers. Conclusion: The health education session about appropriate antibiotic use revealed a major effect in improving the participants’ level of awareness, practice and changing attitude about proper use of antibiotic of their children.

Health vigilance concerning female urinary tract infections: Epidemiological profile and antibiotic resistance

The objectives of our work were to establish the epidemiological and bacteriological profile of female urinary tract infection at the Mohammed VI University Hospital of Oujda (Morocco), and then to study the drug resistance of the bacterial strains isolated. This is a retrospective study over 36 months including urine samples from patients hospitalized or consulting at the CHU Mohamed VI of Oujda (Morocco). Urines were processed according to the recommendations of the Medical Microbiology Reference (REMIC) and the EUCAST (European Committee on Antimicrobial Susceptibility Testing). We collected 12556 requests for CBEU from different departments. At the top of the list was the emergency department with a rate of 37% (n= 4666) followed by outpatient clinics (33.1%; n=4226). 5% (n=630) of the CBEU were positive. Escherichia coli (E. coli ) dominated the epidemiological profile with a rate of 72.50% (n=482). E. coli was resistant to penicillins in 69.50% (n=299) of cases, protected penicillins in 34.80% (n=149), third generation cephalosporins (C3G) in 9% (n=38), fluoroquinolones in 17.5% (n=73), Trimethoprim-Sulfamethoxazole in 46% (n=196) of cases and gentamicin in 12% (n=51) of cases. None of the strains were resistant to carbapenems. Awareness-raising on the proper use of antibiotics, issuing national recommendations for the treatment of urinary tract infections in order to standardize therapeutic regimens. Effective control of these infections requires a global prevention strategy that implies close collaboration between epidemiologists, clinicians, bacteriologists, hygienists and the health care team.

A STUDY OF 50 CASES OF DIABETIC FOOT AT TERTIARY CARE HOSPITAL

BACKGROUND AND OBJECTIVES :- The present study was attempted to nd out the role of conventional and newer modalities for the treatment and rehabilitation and prevention of complication of diabetic foot patients. MATERIALAND METHOD:-. 50 patients of diabetic foot admitted in civil Hospital,ahmedabad were studied within two years from 2018 to 2020 and careful assessment of history, clinical ndings, investigation, management and follow-up of these patients done. RESULT:-According to my study, Diabetic foot is common in males &amp; 51-60 years of age group,in smokers, in lower socio-economic class, with average duration of 8 to 10 years of diabetes melitus, most common type of lesion was abscess,most common site was forefoot, mostly was of neuropathic in nature &amp; mostly managed by debridement. Mean hospital stay was 1 week to 1 month. CONCLUSION:- Patient education and awareness regarding good sugar control of diabetes, use of proper antibiotics, adequate debridement and proper dressing ;with eusol, betadine hydrogen peroxide along with newer dressing methods like vacuum dressing found to be effective. Amputation done only for gangrene and proper rehabilitation method carried out for these patients.

Evaluation of antibiotic prescribing pattern in pediatrics in a tertiary care hospital.

ABSTRACTBackground:The irrational use of antibiotics is a global issue and it can lead to morbidity, mortality, and increased health care costs. Hence, proper use of antibiotics is imperative and should be included in the pharmaceutical care plan.Objective:The objective of this study was to evaluate the prescribing pattern of antibiotics for children using WHO core prescribing indicators.Materials and Methods:A prospective, observational study was carried for 6 months in the pediatric department at a tertiary care hospital, Pune. The WHO prescribing indicators were used to evaluate the prescriptions, and the ideal WHO range was considered as a determining factor for rational prescription.Results:A total of 302 patients were included in the study, with a mean patient age of 4.92 ± 4 years. The average number of drugs per encounter was 6.12 (WHO standard is less than 2). The percentage of antibiotics prescribed was 26.3% with an average of 1.63 antibiotics per prescription. Of the 493 antibiotics, 85.59% were injectable which is higher than the WHO standard of 13.4–24.1%. A near-optimal value of 99.59% antibiotics was prescribed from the hospital formulary which is similar to WHO standards, and the antibiotics prescribed with generic names were 25.76%. The most common class of antibiotics prescribed were cephalosporins and penicillins.Conclusion:Polypharmacy, high injectable use, and non-adherence to generic prescription were common in our tertiary care center. Continuous audits, training, and new treatment protocols are recommended.

Current status of initial antibiotic therapy and analysis of infections in patients with solitary abdominal trauma: a multicenter trial in Korea.

PurposeProper use of antibiotics during emergency abdominal surgery is essential in reducing the incidence of surgical site infection. However, no studies have investigated the type of antibiotics and duration of therapy in individuals with abdominal trauma in Korea. We aimed to investigate the status of initial antibiotic therapy in patients with solitary abdominal trauma.MethodsFrom January 2015 to December 2015, we retrospectively analyzed the medical records of patients with solitary abdominal trauma from 17 institutions including regional trauma centers in South Korea. Both blunt and penetrating abdominal injuries were included. Time from arrival to initial antibiotic therapy, rate of antibiotic use upon injury mechanism, injured organ, type, and duration of antibiotic use, and postoperative infection were investigated.ResultsData of the 311 patients were collected. The use of antibiotic was initiated in 96.4% of patients with penetrating injury and 79.7% with blunt injury. Initial antibiotics therapy was provided to 78.2% of patients with solid organ injury and 97.5% with hollow viscus injury. The mean day of using antibiotics was 6 days in solid organ injuries, 6.2 days in hollow viscus. Infection within 2 weeks of admission occurred in 36 cases. Infection was related to injury severity (Abbreviated Injury Scale of >3), hollow viscus injury, operation, open abdomen, colon perforation, and RBC transfusion. There was no infection in cases with laparoscopic operation. Duration of antibiotics did not affect the infection rate.ConclusionAntibiotics are used extensively (84.2%) and for long duration (6.2 days) in patients with abdominal injury in Korea.

Bacterial Isolates from Blind Tracheal Aspirates and Their Anti-Microbial Sensitivity: An Observational Study in ICU of a Tertiary Care Hospital in Bangladesh

Background: The number of organisms developing resistance to commonly used antibiotics is increasing day by day. The exact national scenario of antimicrobial sensitivity pattern is not well known in Bangladesh owing to the absence of proper guideline for prescribing antibiotics.&#x0D; Aims: The aim of this study is to identify the group of organisms developing resistanceso that antibiotic policy can be formulated for the proper and effective use of antibiotics.&#x0D; Settings and Design: This observational study was conducted for a period of 1 year from January 2018 to December 2018 in a tertiary care hospital in Bangladesh.&#x0D; Materials and methods: This descriptive cross-sectional study was conducted in the Department of Microbiology, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh from January 2018 to December 2018, using the convenient sampling technique. Tracheal secretions from patients in the intensive care unit (ICU), tested in Department of Microbiology, National Institute of Neurosciences and Hospital, were included in the study. The culture was done on blood and MacConkey agar and the sensitivity pattern was performed on Muller Hinton agar. Data were analyzed using SPSS version 23.0.&#x0D; Results: Out of the microorganisms isolated from positive growth cultures, Acinetobacter (57.8%) was the most common isolate followed by Klebsiella (22.9%). Acinetobacter, pseudomonas and klebsiella had good sensitivity to colistin(87.80%, 82.40% and 77.80% respectively), where as they showed less sensitivity to higher generationcephalosporin, penicillin and aminoglycosides.&#x0D; Conclusion: The commonest organism which was isolated from the endotracheal aspirate cultures were Acinetobacter, followed by Pseudomonas and Klebsiella and antimicrobial susceptibility testing showed sensitivity to Colistin, Tazobactam/piperacillin, Meropenem and aztreonam. Whereas coagulase negative staphylococci was isolated only in minority cases with highest sensitivity to vancomycin and linezolid.&#x0D; Bangladesh Crit Care J September 2020; 8(2): 81-85

Monitoring antimicrobial cross‐resistance with cross‐resistance rate correlation diagrams: Changes in antibiotic susceptibility of Pseudomonas aeruginosa due to hospital relocation

Though most medical institutions calculate antimicrobial susceptibility and resistance rates of microbes isolated at their own facility as part of their efforts to promote the proper use of antibiotics, very few, if any, regularly monitor cross-resistance rates between antimicrobial agents. The authors have devised a tool in the form of a cross-resistance rate correlation diagram (CRR diagram) that allows easy identification of increases or decreases in, or changes in the pattern of, antimicrobial cross-resistance. The objective was to perform an analysis by CRR diagrams of the effect of relocation to a newly built facility on antimicrobial resistance and cross-resistance rates at a medical facility. The Sakai City Medical Center relocated in July 2015 to a newly built facility located in a different primary medical care zone 3.5km away. Based on the drug susceptibility test data compiled at the Sakai City Medical Center, resistance and cross-resistance rates of Pseudomonas aeruginosa before and after the relocation of the hospital facility were calculated, and the rates were assessed using CRR diagrams. It was possible to confirm the effect of hospital relocation on antibiotic susceptibility of Paeruginosa in terms of changes in resistance and cross-resistance rates. The effect of the facility's relocation on cross-resistance rates was particularly notable with respect to β-lactam antibiotics: cross-resistance rates among β-lactams decreased substantially, represented as a large wedge-shaped change towards the origin on the CRR diagram. Rates of cross-resistance between classes of antibiotics with a different mechanism of antibiotic action changed little. Including cross-resistance rates in the routine monitoring of resistance and susceptibility rates practiced by a medical institution can provide a comprehensive insight into the dynamics of bacterial flora in the facility. CRR diagrams, which allow visualization of the status and changes in cross-resistance, not only provide a new perspective for clinicians, but they also contribute to the proper use of antibiotics and serve as a tool in the education of healthcare professionals and students about antibiotic resistance.

Study of Methicillin-Resistant Staphylococcus aureus colonization in the nose of medical staff in Sina and Imam Reza hospitals

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is known to be the most resistant pathogen in hospitals, which can infect both the health workers and patients. The most common site for colonization is the anterior part of the nose and throat. In order to prevent and control the infection and the role of medical personnel as a carrier for transmitting infection, the aim of this study was to determine the amount of nasal colonization with MRSA in the medical staff of Sina and Imam Reza Hospital in Tabriz. Methods: The present cross-sectional study evaluated 400 participants. From the entire medical staff of Sina and imam Reza hospitals in 2017 who were willing to participate in this study. Sterile swabs inserted in to the anterior region of the nose. Then swabs were immediately cultured in a laboratory in mannitol salt agar blood agar for 24 hours and incubated for 48 to 72 hours, to determine the MRSA strains, Cefoxitin disc method was used in Muller Hinton Agar culture media. Descriptive statistical methods and Chi2 test was used for statistical analyses. P value less than 0.05 was considered statistically significant. Results: 55% of the health care workers (220) were carriers of Staphylococcus aureus, mean age was 38.27 ± 8.72 years and 61.8% were male. Internal ward health care workers were common Staphylococcus aureus carriers and diabetes was the most common systemic disease. Out of 37.8% had a history of previous hospital admission and 87.2% had antibiotic use. Also, methicillin resistance was observed in out of 32.7% of subjects. Conclusion: Constant control of infectious agents and the use of Proper antibiotics can be effective in controlling carriers and even drug-resistant cases.

The prevalence and patterns of self-medication with antibiotics in Jordan: A community-based study.

Self-medication with antibiotics is one of the leading causes of antibiotic resistance and drug therapy problems, making antibiotic self-medication practices a global concern. Despite global efforts to limit these practices, self-medication with antibiotics remains prevalent in developing countries. This study aimed to investigate the prevalence and patterns of self-medication with antibiotics in Jordan and to compare the findings of self-medication practices with antibiotics with results from 2006. A cross-sectional community-based study used a convenient sampling technique and recruited a large sample from all over Jordan. Between February and April 2019 trained 5th-year pharmacy students recruited participants (eg, door to door) who had taken antibiotics in the preceding month. The questionnaire consisted of 14 questions that aimed to describe the patterns of self-medication with antibiotics. A total of 1928 participants took part in this study. Of the 1928 respondents, 40.4% reported having used an antibiotic without a prescription in the previous month. Participants who had self-medicated with antibiotics had primarily used them for sore throat and influenza. Self-medicated participants had obtained antibiotics primarily from pharmacies (57.2%) and relied primarily on pharmacists (34.8%) and their own previous experience (35.2%) for information on the proper use of antibiotics. The rate of self-medication with antibiotics in Jordan in 2019 (40.4%) had not changed significantly since 2006 (39.5%, P=.295). However, self-medication practices (eg, source of antibiotic supply and information) have changed over the year. The findings of this study revealed that the prevalence of self-medication with antibiotics in Jordan remains high. This is a significant concern that requires a quick response from the government authorities to develop a collaborative approach to stop the dispensing of antibiotics without a prescription.

Antibiotic eye drops prescription patterns by orthokeratology practitioners in China and the development of antibiotic usage guidelines

PurposeTo investigate antibiotic eye drops prescribing patterns of contact lens practitioners in Mainland China for orthokeratology (ortho-k) patients and to develop guidelines for their use. MethodsA questionnaire on their antibiotic prescribing habits was administered to eye care practitioners (ECP) involved in ortho-k lens fitting nationwide via an official online account. Multiple logistic regression models were used to assess the relationships between prescribing habits and demographics. ResultsA total of 555 ECP completed the survey, of whom 50.5 % were optometrists (non-medical degree). About 30 % of the respondents routinely prescribed antibiotic eye drops for prophylactic use before and/or after commencement of ortho-k treatment. Forty one percent of the respondents dispensed antibiotics to patients for emergency use without giving written instructions, 48.5 % used antibiotic eye drops to wet fluorescein strips during ortho-k lens fitting, and 44.9 % considered treating corneal infiltrate(s) with antibiotics to be appropriate. A set of guidelines, including when to use antibiotic eye drops during ortho-k lens treatment and their proper use, stratified by different corneal conditions, was developed. ConclusionsInappropriate use of antibiotic eye drops appeared to be common among ortho-k practitioners in Mainland China. Taking into account deficiencies and errors identified from the survey, a set of guidelines based on best practice was developed and can serve to provide advice for proper use of antibiotics in ortho-k practice.

Quasiexperimental intervention study protocol to optimise the use of new antibiotics in Spain: the NEW_SAFE project

IntroductionCeftaroline, tedizolid, dalbavancin, ceftazidime-avibactam and ceftolozane-tazobactam are novel antibiotics used to treat infections caused by multidrug-resistant pathogens (MDR). Their use should be supervised and monitored as part of an antimicrobial...

ANTIBIOTIC USE IN SLOVENIAN HOSPITALS

Abstract: Motivation/Background: Antibiotics are commonly overused and misused what increase the emergence of resistant organisms, side- effects and costs. To assess the appropriate use of antibiotics many methods are available. The aim of the present study is to find correlation between antibiotic use and case mix index (CMI) in Slovenian hospitals. Method: In retrospective study (in the years between 2004 and 2013) we correlated the total consumption of antibiotics for systemic use and CMI. Weighted linear regression test analysis was performed to determine correlation between defined daily dose (DDD) / 100 admissions and DDD / 100 bed-days and CMI. Results: The total antibiotic consumption in all included hospitals was in mean 317.69 DDD / 100 admissions and 58.88 DDD / 100 bed days, respectively. CMI range were from 1.25 to 3.55. A significant correlation between consumption expressed in DDD / 100 admissions and CMI (p = 0.028) and DDD / 100 bed days and CMI (p =0.008) was found. Conclusions: Thus, detailed analysis of correlations between DDD of antibiotics and CMI may constitutes a proper use of antibiotics.

New York State dairy farmers' perceptions of antibiotic use and resistance: A qualitative interview study.

Antibiotic resistance is a global problem affecting both human and animal health. Ensuring the strategic and effective use of antibiotics is paramount to combatting the emergence and spread of resistance. This study explored New York State (NYS) dairy farmers’ perceptions regarding antibiotic use in dairy farming and antibiotic resistance. Dairy farmers’ perceptions were assessed through semi-structured, in-person interviews. Twenty interviews with farm owners and/or managers of 15 conventional and five USDA certified organic dairy farms with 40 to 2,300 lactating cows were conducted. Thematic analysis was used to assess, compare and contrast transcripts for farmers’ characterization of their beliefs, values, and concerns. Conventional dairy farmers had a low level of concern about the possible impacts of on-farm antibiotic resistance on human health and believed their antibiotic use was already judicious. Generally, they believed their cattle’s health would suffer if antibiotic use were further curtailed. Conventional farmers expressed frustration over the possibility of more stringent governmental, milk cooperative, buyer, or marketer requirements for antibiotic use and associated animal welfare in the future. They attributed expanding regulations in part to misinformed consumer preferences, that farmers felt were influenced by the marketing of organic dairy products. Organic dairy farmers were generally more concerned about issues related to antibiotic resistance than conventional farmers. Both conventional and organic farmers placed emphasis on disease prevention through herd health management rather than treatment. In conclusion, the conventional NYS dairy farmers in this study were skeptical of the need for and benefits of reduced antibiotic use on their dairy farms. Interventions for farmers, delivered by a trusted source such as a veterinarian, that provide training about proper antibiotic use practices and information of possible financial benefits of refining antibiotic use may hold promise.