Slow Wave Propagation Research Articles

Wearable Neurotechnology for the Treatment of Insomnia: The Study Protocol of a Prospective, Placebo-Controlled, Double-Blind, Crossover Clinical Trial of a Transcranial Electrical Stimulation Device

Sleep disruption and deprivation are epidemic problems in the United States, even among those without a clinically diagnosed sleep disorder. Military service members demonstrate an increased risk of insomnia, which doubles after deployment. This study will investigate the ability of a translational device, Teledyne PeakSleep™ (Teledyne Scientific & Imaging, Durham, NC, USA), to reduce sleep onset latency and the time spent awake after sleep onset, with improvement in the subjective benefits of sleep for patients with insomnia by enhancing the brain rhythms within the frontal lobe implicated in slow wave generation. During this crossover trial, patients will use the wearable neurotechnology prototype headband, which delivers < 14 min of frontal short duration repetitive–transcranial electrical stimulation over a 30 min period immediately before trying to fall asleep. Using active stimulation versus a sham paradigm, we will compare actigraphy data, physiological data, and subjective sleep measures against a pre-treatment baseline in the same patient over the course of the 8-week study. If successful, PeakSleep™ could address the final common pathway in insomnia, namely the onset and maintenance of slow-wave sleep (SWS), and accordingly has the potential to enhance sleep onset in a wide range of individuals, most importantly warfighters in whom efficient sleep onset may be critical for operational success.

A Workflow for Creating Gastric Computational Models from SPARC Scaffolds

In-silico studies are an ideal medium to model and improve our understanding of the mechanisms underlying gastric motility in health and disease. In this study, a workflow to create computational models of the stomach was developed using SPARC scaffolds. Three anatomically based finite element method (FEM) models of the rat stomach incorporating experimental measurements of muscle layer thickness and fiber orientations across the stomach were developed: (i) 2D (surface) FEM model with no thickness, (ii) 3D (volume) FEM model with a fixed thickness across the longitudinal and circular muscle layers, and (iii) 3D (volume) FEM model with varying thickness across the longitudinal and circular muscle layers. The three FEM models were subsequently used in whole-organ slow wave simulations and the impact of anatomical details on the simulation outcomes was investigated. The 3D FEM model with varying thickness was the most computationally expensive, while the 2D FEM model provided the fastest solution (a 200 s simulation took 8 min vs. 38 h to solve). The spatiotemporal profiles of the slow wave activation and propagation in the three FEM models were in good agreement. The largest temporal difference of 1 s in cellular activation was observed between the 2D FEM model and the varying thickness 3D FEM model in the most distal-stomach regions. These FEM models and developed workflow will be used in in-silico studies to improve our understanding of the structure-function relationship in the stomach and identify the optimal parameters of electrical therapies, an alternative treatment for the motility disorders in the stomach. In addition, the developed workflow can be readily used to generate computational models of other organs using SPARC scaffolds.

Numerical assessment of ICRF-specific plasma-wall interaction in the new ITER baseline using the SSWICH-SW code

In 2023, switching the material on the first wall of ITER to tungsten (W) was recommended. In magnetic Fusion devices, waves in the Ion Cyclotron Range of Frequencies (ICRF) interact with the Scrape-Off Layer (SOL) via RF-sheath rectification. This contribution re-assesses this phenomenon close to the ITER ICRF antenna, focusing on the ICRF-specific gross erosion of W from the antenna port sides. Our quantitative estimates rely on predictive multi-2D numerical simulations of the ICRF antenna environment using the SSWICH-SW code. They combine Slow Wave propagation from the antenna mouth to the SOL, the excitation of RF oscillations in the sheath voltages at the antenna port sides and a subsequent DC biasing of the SOL. Maps of the parallel RF electric field at the antenna mouth, from the antenna code TOPICA, excite the system. Our simulations cover more than four decades in the local densities near the antenna. Since both the sputtering and the local heat loads are proportional to the local particle fluxes, the most intense Plasma-Wall Interaction is found for high local density, with or without ICRF waves. In these conditions, larger margins also exist for coupling the ICRF power. We tested several operational trade-offs between these two constraints. The simulated target plasma contains 2% of neon ions. These are efficient at sputtering W, already at low accelerating voltages. Consequently, although the RF-sheath rectification sufficiently amplifies the local sputtering at the antenna port for a detection using visible spectroscopy, the ICRF-induced increment of the gross W production represents at worse 22% of the W source expected from thermal sheaths over the eighteen out-board mid-plane ports. An upper bound, independent of our main assumptions, is proposed for this enhancement factor. This moderate expected global increase questions the ability to detect ICRF-specific W contamination of the plasma core, even at the planned maximal ICRF power.

Generation of Quasi-Electrostatic Slow Extraordinary Waves by Kappa Distribution with a Loss Cone

Generation of Quasi-Electrostatic Slow Extraordinary Waves by Kappa Distribution with a Loss Cone

Modelling of ICRH slow wave propagation and absorption in Wendelstein 7-X stellarator

Abstract The propagation and absorption of the slow waves in the three-ion plasma of the Wendelstein 7-X stellarator have been investigated by ray tracing. The aim of the study is to obtain a qualitative notion of the penetration into the plasma and absorption of the wave excited by the potential difference between the antenna conductors and the antenna box. It has been discovered that the rays propagate along the magnetic field lines over a significant distance, up to 6 m, from the antenna. They weakly, to a depth of 0.1 m, penetrate into the plasma. Absorption of the slow waves by electrons does not lead to the generation of the currents capable of affecting the plasma equilibrium. Most of the slow waves are absorbed beyond the region of ion-ion hybrid resonance in the zone of cyclotron resonance of He3 ions at the periphery of the plasma. The ICRH of the three-ion W 7-X plasma will be used to heat He3 ions to high energies and simulate the confinement of alpha particles in an optimized stellarator configuration. The presence of a source of hot He3 ions, which are poorly confined, at the periphery of the plasma can affect the experimental results.

Effect of area divergence and frequency on damping of slow magnetoacoustic waves propagating along umbral fan loops

ABSTRACT Waves play an important role in the heating of solar atmosphere; however, observations of wave propagation and damping from the solar photosphere to corona through chromosphere and transition region are very rare. Recent observations have shown propagation of 3-min slow magnetoacoustic waves (SMAWs) along fan loops from the solar photosphere to corona. In this work, we investigate the role of area divergence and frequencies on the damping of SMAWs propagating from the photosphere to the corona along several fan loops rooted in the sunspot umbra. We study the Fourier power spectra of oscillations along fan loops at each atmospheric height which showed significant enhancements in 1–2, 2.3–3.6, and 4.2–6 min period bands. Amplitude of intensity oscillations in different period bands and heights are extracted after normalizing the filtered light curves with low-frequency background. We find damping of SMAW energy flux propagating along the fan loop 6 with damping lengths $\approx 170$ and $\approx 208$ km for 1.5- and 3-min period bands. We also show the decay of total wave energy content with height after incorporating area divergence effect, and present actual damping of SMAWs from photosphere to corona. Actual damping lengths in this case increases to $\approx 172$ and $\approx 303$ km for 1.5- and 3-min period bands. All the fan loops show such increase in actual damping lengths, and thus highlight the importance of area divergence effect. Results also show some frequency-dependent damping of SMAW energy fluxes with height where high-frequency waves are damped faster than low-frequency waves.

Gastric slow-wave modulation via power-controlled, irrigated radio-frequency ablation.

Recently, radio-frequency ablation has been used to modulate slow-wave activity in the porcine stomach. Gastric ablation is, however, still in its infancy compared to its history in the cardiac field, and electrophysiological studies have been restricted to temperature-controlled, non-irrigated ablation. Power-controlled, irrigated ablation may improve lesion formation at lower catheter-tip temperatures that produce the desired localized conduction block. Power-controlled, irrigated radio-frequency ablation was performed on the gastric serosal surface of female weaner pigs (n = 5) invivo. Three combinations of power (10-15 W) and irrigation settings (2-5 mL min-1) were investigated. A total of 12 linear lesions were created (n = 4 for each combination). Slow waves were recorded before and after ablation using high-resolution electrical mapping. Irrigation maintained catheter-tip temperature below 50°C. Ablation induced a complete conduction block in 8/12 cases (4/4 for 10 W at 2 mL min-1, 1/4 for 10 W at 5 mL min-1, 3/4 for 15 W at 5 mL min-1). Blocks were characterized by a decrease in signal amplitude at the lesion site, along with changes in slow-wave propagation patterns, where slow waves terminated at and/or rotated around the edge of the lesion. Power-controlled, irrigated ablation can successfully modulate gastric slow-wave activity at a reduced catheter-tip temperature compared to temperature-controlled, non-irrigated ablation. Reducing the irrigation rate is more effective than increasing power for blocking slow-wave activity. These benefits suggest that irrigated ablation is a suitable option for further translation into a clinical intervention for gastric electrophysiology disorders.

Pulsed-field ablation: an alternative ablative method for gastric electrophysiological intervention.

Pulsed-field ablation (PFA) is an emerging ablative technology that has been used successfully to eliminate cardiac arrhythmias. As a nonthermal technique, it has significant benefits over traditional radiofrequency ablation with improved target tissue specificity and reduced risk of adverse events during cardiac applications. We investigated whether PFA is safe for use in the stomach and whether it could modulate gastric slow waves. Female weaner pigs were fasted overnight before anesthesia was induced using tiletamine hydrochloride (50 mg·mL-1) and zolazepam hydrochloride (50 mg·mL-1) and maintained with propofol (Diprivan 2%, 0.2-0.4 mg·kg-1·min-1). Pulsed-field ablation was performed on their gastric serosa in vivo. Adjacent point lesions (n = 2-4) were used to create a linear injury using bipolar pulsed-field ablation consisting of 40 pulses (10 Hz frequency, 0.1 ms pulse width, 1,000 V amplitude). High-resolution electrical mapping defined baseline and postablation gastric slow-wave patterns. A validated five-point scale was used to evaluate tissue damage in hematoxylin and eosin-stained images. Results indicated that PFA successfully induced complete conduction blocks in all cases, with lesions through the entire thickness of the gastric muscle layers. Consistent postablation slow-wave patterns emerged immediately following ablation and persisted over the study period. Pulsed-field ablation induces rapid conduction blocks as a tool to modulate slow-wave patterns, indicating it may be suitable as an alternative to radiofrequency ablation.NEW & NOTEWORTHY Results show that pulsed-field ablation can serve as a gastric slow-wave intervention by preventing slow-wave propagation across the lesion site. Stable conduction blocks were established immediately following energy delivery, faster than previous examples of radiofrequency gastric ablation. Pulsed-field ablation may be an alternative for gastric slow-wave intervention, and further functional and posthealing studies are now warranted.

Modeling the Propagation of Slow Magnetoacoustic Waves in a Multistranded Coronal Loop

We study the propagation properties of slow magnetoacoustic waves in a multithermal coronal loop using a 3D MHD model, for the first time. A bundle of 33 vertical cylinders, each of 100 km radius, randomly distributed over a circular region of radius 1 Mm, is considered to represent the coronal loop. The slow waves are driven by perturbing the vertical velocity (v z ) at the base of the loop. We apply forward modeling to the simulation results to generate synthetic images in the coronal channels of the Solar Dynamics Observatory/Atmospheric Imaging Assembly. Furthermore, we add appropriate data noise to enable direct comparison with the real observations. It is found that the synthetic images at the instrument resolution show noncospatial features in different temperature channels in agreement with previous observations. Time–distance maps are constructed from the synthetic data to study the propagation properties. The results indicate that the oscillations are only visible in specific channels, depending on the temperature range of the plasma existing within the loop. Additionally, the propagation speed of slow waves is also found to be sensitive to the available temperature range. Overall, we propose that the cross-field thermal properties of coronal structures can be inferred using a combination of numerical simulations and observations of slow magnetoacoustic waves.

Cerebral Gray Matter May Not Explain Sleep Slow-Wave Characteristics after Severe Brain Injury.

Sleep slow waves are the hallmark of deeper non-rapid eye movement sleep. It is generally assumed that gray matter properties predict slow-wave density, morphology, and spectral power in healthy adults. Here, we tested the association between gray matter volume (GMV) and slow-wave characteristics in 27 patients with moderate-to-severe traumatic brain injury (TBI, 32.0 ± 12.2 years old, eight women) and compared that with 32 healthy controls (29.2 ± 11.5 years old, nine women). Participants underwent overnight polysomnography and cerebral MRI with a 3 Tesla scanner. A whole-brain voxel-wise analysis was performed to compare GMV between groups. Slow-wave density, morphology, and spectral power (0.4-6 Hz) were computed, and GMV was extracted from the thalamus, cingulate, insula, precuneus, and orbitofrontal cortex to test the relationship between slow waves and gray matter in regions implicated in the generation and/or propagation of slow waves. Compared with controls, TBI patients had significantly lower frontal and temporal GMV and exhibited a subtle decrease in slow-wave frequency. Moreover, higher GMV in the orbitofrontal cortex, insula, cingulate cortex, and precuneus was associated with higher slow-wave frequency and slope, but only in healthy controls. Higher orbitofrontal GMV was also associated with higher slow-wave density in healthy participants. While we observed the expected associations between GMV and slow-wave characteristics in healthy controls, no such associations were observed in the TBI group despite lower GMV. This finding challenges the presumed role of GMV in slow-wave generation and morphology.

High-energy pacing inhibits slow-wave dysrhythmias in the small intestine.

The motility of the gastrointestinal tract is coordinated in part by rhythmic slow waves, and disrupted slow-wave patterns are linked to functional motility disorders. At present, there are no treatment strategies that primarily target slow-wave activity. This study assessed the use of pacing to suppress glucagon-induced slow-wave dysrhythmias in the small intestine. Slow waves in the jejunum were mapped in vivo using a high-resolution surface-contact electrode array in pigs (n = 7). Glucagon was intravenously administered to induce hyperglycemia. Slow-wave propagation patterns were categorized into antegrade, retrograde, collision, pacemaker, and uncoupled activity. Slow-wave characteristics such as period, amplitude, and speed were also quantified. Postglucagon infusion, pacing was applied at 4 mA and 8 mA and the resulting slow waves were quantified spatiotemporally. Antegrade propagation was dominant throughout all stages with a prevalence of 55 ± 38% at baseline. However, glucagon infusion resulted in a substantial and significant increase in uncoupled slow waves from 10 ± 8% to 30 ± 12% (P = 0.004) without significantly altering the prevalence of other slow-wave patterns. Slow-wave frequency, amplitude, and speed remained unchanged. Pacing, particularly at 8 mA, significantly suppressed dysrhythmic slow-wave patterns and achieved more effective spatial entrainment (85%) compared with 4 mA (46%, P = 0.039). This study defined the effect of glucagon on jejunal slow waves and identified uncoupling as a key dysrhythmia signature. Pacing effectively entrained rhythmic activity and suppressed dysrhythmias, highlighting the potential of pacing for gastrointestinal disorders associated with slow-wave abnormalities.NEW & NOTEWORTHY Glucagon was infused in pigs to induce hyperglycemia and the resulting slow-wave response in the intact jejunum was defined in high resolution for the first time. Subsequently, with pacing, the glucagon-induced dysrhythmias were suppressed and spatially entrained for the first time with a success rate of 85%. The ability to suppress slow-wave dysrhythmias through pacing is promising in treating motility disorders that are associated with intestinal dysrhythmias.

Measurement and Analysis of In Vivo Gastroduodenal Slow Wave Patterns Using Anatomically-Specific Cradles and Electrodes.

Bioelectrical 'slow waves' regulate gastrointestinal contractions. We aimed to confirm whether the pyloric sphincter demarcates slow waves in the intact stomach and duodenum. We developed and validated novel anatomically-specific electrode cradles and analysis techniques which enable high-resolution slow wave mapping across the in vivo gastroduodenal junction. Cradles housed flexible-printed-circuit and custom cradle-specific electrode arrays during acute porcine experiments (N = 9; 44.92 kg ± 8.49 kg) and maintained electrode contact with the gastroduodenal serosa. Simultaneous gastric and duodenal slow waves were filtered independently after determining suitable organ-specific filters. Validated algorithms calculated slow wave propagation patterns and quantitative descriptions. Butterworth filters, with cut-off frequencies (0.0167 - 2) Hz and (0.167 - 3.33) Hz, were optimal filters for gastric and intestinal slow wave signals, respectively. Antral slow waves had a frequency of (2.76 ± 0.37) cpm, velocity of (4.83 ± 0.21) mm·s-1, and amplitude of (1.13 ± 0.24) mV, before terminating at the quiescent pylorus that was (46.54 ± 5.73) mm wide. Duodenal slow waves had a frequency of (18.13 ± 0.56) cpm, velocity of (11.66 ± 1.36) mm·s-1, amplitude of (0.32 ± 0.03) mV, and originated from a pacemaker region (7.24 ± 4.70) mm distal to the quiescent zone. Novel engineering methods enable measurement of in vivo electrical activity across the gastroduodenal junction and provide qualitative and quantitative definitions of slow wave activity. The pylorus is a clinical target for a range of gastrointestinal motility disorders and this work may inform diagnostic and treatment practices.

Coexisting fast–slow dendritic traveling waves in a 3D-array electric field coupled neuronal network

Coexistence of fast and slow traveling waves without synaptic transmission has been found in hhhippocampal tissues, which is closely related to both normal brain activity and abnormal neural activity such as epileptic discharge. However, the propagation mechanism behind this coexistence phenomenon remains unclear. In this paper, a three-dimensional electric field coupled hippocampal neural network is established to investigate generation of coexisting spontaneous fast and slow traveling waves. This model captures two types of dendritic traveling waves propagating in both transverse and longitude directions: the N-methyl-D-aspartate (NMDA)-dependent wave with a speed of about 0.1 m/s and the Ca-dependent wave with a speed of about 0.009 m/s. These traveling waves are synaptic-independent and could be conducted only by the electric fields generated by neighboring neurons, which are basically consistent with the in vitro data measured experiments. It is also found that the slow Ca wave could trigger generation of fast NMDA waves in the propagation path of slow waves whereas fast NMDA waves cannot affect the propagation of slow Ca waves. These results suggest that dendritic Ca waves could acted as the source of the coexistence fast and slow waves. Furthermore, we also confirm the impact of cellular spacing heterogeneity on the onset of coexisting fast and slow waves. The local region with decreasing distances among neighbor neurons is more liable to promote the onset of spontaneous slow waves which, as sources, excite propagation of fast waves. These modeling studies provide possible biophysical mechanisms underlying the neural dynamics of spontaneous traveling waves in brain tissues.

Vectorgastrogram: dynamic trajectory and recurrence quantification analysis to assess slow wave vector movement in healthy subjects

Functional gastric disorders entail chronic or recurrent symptoms, high prevalence and a significant financial burden. These disorders do not always involve structural abnormalities and since they cannot be diagnosed by routine procedures, electrogastrography (EGG) has been proposed as a diagnostic alternative. However, the method still has not been transferred to clinical practice due to the difficulty of identifying gastric activity because of the low-frequency interference caused by skin–electrode contact potential in obtaining spatiotemporal information by simple procedures. This work attempted to robustly identify the gastric slow wave (SW) main components by applying multivariate variational mode decomposition (MVMD) to the multichannel EGG. Another aim was to obtain the 2D SW vectorgastrogram VGGSW from 4 electrodes perpendicularly arranged in a T-shape and analyse its dynamic trajectory and recurrence quantification (RQA) to assess slow wave vector movement in healthy subjects. The results revealed that MVMD can reliably identify the gastric SW, with detection rates over 91% in fasting postprandial subjects and a frequency instability of less than 5.3%, statistically increasing its amplitude and frequency after ingestion. The VGGSW dynamic trajectory showed a statistically higher predominance of vertical displacement after ingestion. RQA metrics (recurrence ratio, average length, entropy, and trapping time) showed a postprandial statistical increase, suggesting that gastric SW became more intense and coordinated with a less complex VGGSW and higher periodicity. The results support the VGGSW as a simple technique that can provide relevant information on the “global” spatial pattern of gastric slow wave propagation that could help diagnose gastric pathologies.

Multithermal apparent damping of slow waves due to strands with a Gaussian temperature distribution

Context. Slow waves in solar coronal loops are strongly damped, but the current theory of damping by thermal conduction cannot explain some observational features. Aims. We investigated the propagation of slow waves in a coronal loop built up from strands of different temperatures. Methods. We considered the loop to have a multithermal, Gaussian temperature distribution. The different propagation speeds in different strands led to a multithermal apparent damping of the wave, similar to observational phase mixing. We used an analytical model to predict the damping length and propagation speed for the slow waves, including in imaging with filter telescopes. Results. We compared the damping length due to this multithermal apparent damping with damping due to thermal conduction and found that the multithermal apparent damping is more important for shorter period slow waves. We quantified the influence of instrument filters on the wave’s propagation speed and damping. This allowed us to compare our analytical theory to forward models of numerical simulations. Conclusions. We find that our analytical model matches the numerical simulations very well. Moreover, we offer an outlook for using the slow wave properties to infer the loop’s thermal properties.

Late-spiking retrosplenial cortical neurons are not synchronized with neocortical slow waves in anesthetized mice

Neocortical slow waves are critical for memory consolidation. The retrosplenial cortex is thought to facilitate the slow wave propagation to regions beyond the neocortex. However, it remains unclear which population is responsible for the slow wave propagation. To address this issue, we performed in vivo whole-cell recordings to identify neurons that were synchronous and asynchronous with slow waves. By quantifying their intrinsic membrane properties, we observed that the former exhibited regular spiking, whereas the latter exhibited late spiking. Thus, these two cell types transmit information in different directions between the neocortex and subcortical regions.

About one method for studying monitoring data for modeling potential seismic sources

Modeling a lumpy geological media using the theory of block structures and studying the conditions for the occurrence of resonance phenomena in the areas where blocks meet will make it possible to determine the locations of potential rearrangements associated with the development of natural disasters. In this paper we present a description of experimental data on the study of the Earth’s crust block structure used to construct a model for the propagation of slow deformation waves in the lithospheric structures of the region. Since the appearance of anomalies in the velocities of longitudinal waves indicates the emergence of geological rearrangements in the zone of a developing seismic event, a comprehensive method of active vibroseismic monitoring using a signal with linear frequency modulation and a harmonic signal is proposed to identify dilatant-type structures.

Ventilating noise barrier with slow wave propagation metamaterial

There has been rapid development of acoustic metamaterials over the past decades, which provide more flexible and effective alternatives to conventional acoustic applications in the field of noise insulation. Recent approaches resolve the conflict between noise insulation and ventilation with partially open meta-structures. Such a binary design eliminates the monopolar and dipolar modes, leading to a total reflection boundary. It holds huge potential in practical scenarios. More simple structures and a broader operating bandwidth are highly desirable to enhance its applicability. This work adopts a binary structure to tune the surface response: open areas with air and slow wave propagation layers with helical-structured metamaterial. These two phases alternate along the radial direction, forming a concentrically layered ventilating insulator. The numerically optimized metamaterial performs efficiently in a wide frequency band and has been validated through experiments.

A sonic black hole structure with perforated boundary for slow wave generation

Sonic black hole (SBH) allows for effective and broadband sound absorption in a retarding duct structure, in which two indispensable physical processes take place: wave retarding and energy dissipation. In this study, an SBH structure with perforated boundary (SBH-PB) is investigated, in which perforated acoustic boundaries are incorporated into the SBH to enhance the black hole effects through a simplified structural design. To predict acoustic performance and understand the physical mechanisms, this paper employs the transfer matrix method (TMM) to model and analyze the physics characteristics of an SBH-PB. Compared to the original form of SBH, the proposed SBH-PB is shown to entail better sound absorption owing to the increased energy dissipation by the small holes, while requiring a smaller number of inner rings. The validity of the TMM prediction is verified by experiments. Finally, the slow wave phenomenon in the retarding structure is also further studied and visualized by numerical simulation and experiment. The proposed structure holds promise for sound wave manipulation and the development of acoustic noise control devices.

Impact of Cortical Bone Thickness on the Parameters of Fast and Slow Ultrasound Wave based on 2-D Simulation

Quantitative Ultrasound (QUS) has been introduced to measure the quality of human bones using ultrasound and become one of the prevention methods for Osteoporosis diseases. Because of the porous composition inherent in human cancellous bone, the generation of both fast and slow waves occurs, and these waves exhibit a distinct association with the cancellous bone structure, particularly the extent of porosity. Nonetheless, the presence of these waves is also contingent upon the anisotropy of cancellous bone, and it is noteworthy that most human cancellous bones are enveloped by cortical bone, which may influence the parameters of the fast and slow waves. Therefore, the aim of this study is to perform a 2-Dimensional (2-D) simulation utilizing the through transmission (TT) measurement method. The primary focus is to examine the impact of cortical thickness on the parameters of both the fast and slow waves. The cortical thickness will be added to the cancellous bone models and the thickness will be varied. Then, the fast and slow wave parameters will be compared in terms of correlation coefficient to identify which wave is affected more. The result shows that the cortical thickness causes increasing in attenuation and velocity for both fast and slow waves. The increase in attenuation is due to sonometry effects while the different longitudinal velocities of water and bone material may contribute to the behaviors for phase velocity measurements. However, the fast wave shows more correlation with the cortical thickness for attenuation (R2 = 0.76) and phase velocity (R2 = 0.77) parameters. This is due to fast wave corresponding to the solid structure and increasing cortical thickness also increase the solid structure. Thus, analyzing fast waves against human cancellous bone, cortical bone thickness needs to be considered to ensure accurate measurements.