Promote Patient Compliance Research Articles

Revolutionizing Transdermal Patches: Navigating Clinical Challenges and Technological Progress

ransdermal patches, conceived to extend drug release, enhance bioavailability, and foster patient adherence, witnessed their inaugural approval by the USFDA in the 1980s. These patches, varying in size, constitute medicinal formulations with one or more active components that permeate the bloodstream through the skin. This review undertakes a comprehensive examination of recent strides in transdermal patch technology, encompassing critical facets such as their merits and demerits, advancements in microneedle technology, the evolution of transdermal patch generation, the integration of Artificial Intelligence, and the role of 3D printing technology. Additionally, the focus is placed on USFDA-approved patches. Various literature databases viz. Science Direct, PubMed, and Web of Sciences were explored for this research. The review furnished insights into the application of 3D printing technology in the fabrication of transdermal patches and disseminated information on USFDA-approved patches. The exploration delved into diverse strategies aimed at augmenting the efficiency of drug delivery and promoting patient compliance. Major transdermal products being marketed with details of their active substance have been discussed. Various applications of artificial intelligence in drug delivery have been summarized. It may be summarized that transdermal patch technology is not a thing of the past but a technology to stay and meet the demands of drug delivery in the present and future.

Cubosomes: An Emerging and Promising Drug Delivery System for Enhancing Cancer Therapy.

Cancer and other diseases can be treated with cubosomes, which are lyotropic nonlamellar liquid crystalline nanoparticles (LCNs). These cubosomes can potentially be a highly versatile carrier with theranostic efficacy, as they can be ingested, applied topically, or injected intravenously. Recent years have seen substantial progress in the synthesis, characterization, regulation of drug release patterns, and target selectivity of loaded anticancer bioactive compounds. However, its use in clinical settings has been slow and necessitates additional proof. Recent progress and roadblocks in using cubosomes as a nanotechnological intervention against various cancers are highlighted. In the last few decades, advances in biomedical nanotechnology have allowed for the development of "smart" drug delivery devices that can adapt to external stimuli. By improving therapeutic targeting efficacy and lowering the negative effects of payloads, these well-defined nanoplatforms can potentially promote patient compliance in response to specific stimuli. Liposomes and niosomes, two other well-known vesicular systems, share a lipid basis with cubosomes. Possible applications include a novel medication delivery system for hydrophilic, lipophilic, and amphiphilic drugs. We evaluate the literature on cubosomes, emphasizing their potential use in tumor-targeted drug delivery applications and critiquing existing explanations for cubosome self-assembly, composition, and production. As cubosome dispersion has bioadhesive and compatible features, numerous drug delivery applications, including oral, ocular, and transdermal, are also discussed in this review.

Comparative Evaluation of Cefixime Microspheres Utilizing a Natural Polymer and a Synthetic Polymer

Background:: Microspheres are naturally biodegradable, free-flowing powders with a particle size of less than 200 micrometres that are comprised of proteins or synthetic polymers. Using microspheres is a reliable strategy to ensure that the drug is accurately delivered to the target area and that the right concentration is kept there without having any unfavourable side effects. Objective:: The objective of the present study was to create a sustained-release cefixime trihydrate microsphere delivery system employing natural and synthetic polymers as a carrier and increase therapeutic effectiveness. Methods:: Due to the simplicity of processing, the solvent injection method was used to create microspheres. Microspheres were created with this technology using the sustained-release polymer, sodium alginate, and active material (drug). The compatibility of components with the drug was evaluated using XRD and FT-IR. In an in-vitro release research, the dissolving medium was phosphate buffer at pH 6.8. For the kinetic analysis of the drug release mechanism, graphs for zero-order, first-order, Higuchi's, Korsmeyer-Peppas, and Hixson-Crowell models were also created. Results:: The best formulation was chosen from the batches, and in-vitro cefixime trihydrate release studies for various microspheres containing cefixime trihydrate in phosphate buffer (pH 7.4) for 8 hours were performed. The dissolution profiles of formulations F4 and F8 showed that the formulation, including xanthan gum, F8, released 55.01% more medication in 8 hours than the formulation using HPMC, F4. X-ray diffraction, swelling index of drug-laden microspheres, and Scanning Electron Microscopy were used to evaluate formulation F8. The graphs for zero-order, first-order, Higuchi's, Korsmeyer-Peppas, and Hixson- Crowell models were plotted, and the optimised batch was discovered to match Higuchi's drug release kinetics with an R2 value of 0.990. Conclusion:: Cefixime trihydrate microspheres can be utilized as a new drug delivery technology to minimize dose frequency and, as a result, to promote patient compliance.

Barbed sutures and skin adhesives improve wound closure in hip and knee arthroplasty.

This study aimed to formulate evidence-based recommendations for optimising wound management in hip and knee arthroplasty by exploring alternative methods such as barbed sutures and skin adhesives. A Delphi panel, comprising seven orthopaedic surgeons, one musculoskeletal infectious disease specialist, and one health economics expert, was convened to evaluate the use of barbed sutures and skin adhesives for wound closure in hip and knee arthroplasty. Two systematic reviews informed the development of questionnaires, with panelists ranking their agreement on statements using a 5-point Likert scale. Consensus was achieved if ≥75% agreement. Unresolved statements were revisited in a second round. Consensus was reached on 11 statements, providing evidence-based recommendations. The expert panel advocates for a multilayer watertight technique using barbed sutures to prevent surgical site infections (SSI), reduce complications, shorten surgical times, optimise resources and improve cosmetic appearance. For skin closure, the panel recommends topical adhesives to decrease wound dehiscence, enhance cosmetic appearance, promote patient compliance, prevent SSIs, and optimise resources. The Delphi consensus by Italian total joint arthroplasty experts underscores the pivotal role of barbed sutures and skin adhesives in optimising outcomes. While guiding clinical decision-making, these recommendations are not prescriptive and should be adapted to local practices. The study encourages further research to enhance current evidence. Level III.

A sustainable artificial-intelligence-augmented digital care pathway for epilepsy: Automating seizure tracking based on electroencephalogram data using artificial intelligence.

Scalp electroencephalograms (EEGs) are critical for neurological evaluations, particularly in epilepsy, yet they demand specialized expertise that is often lacking in many regions. Artificial intelligence (AI) offers potential solutions to this gap. While existing AI models address certain aspects of EEG analysis, a fully automated system for routine EEG interpretation is required for effective epilepsy management and healthcare professionals' decision-making. This study aims to develop an AI-augmented model for automating EEG seizure tracking, thereby supporting a sustainable digital care pathway for epilepsy (DCPE). The goal is to improve patient monitoring, facilitate collaborative decision-making, ensure timely medication adherence, and promote patient compliance. The study proposes an AI-augmented framework using machine learning, focusing on quantitative analysis of EEG data to automate DCPE. A focus group discussion was conducted with healthcare professionals to find the problem of the current digital care pathway and assess the feasibility, usability, and sustainability of the AI-augmented system in the digital care pathway. The study found that a combination of random forest with principal component analysis and support vector machines with KBest feature selection achieved high accuracy rates of 96.52% and 95.28%, respectively. Additionally, the convolutional neural networks model outperformed other deep learning algorithms with an accuracy of 97.65%. The focus group discussion revealed that automating the diagnostic process in digital care pathway could reduce the time needed to diagnose epilepsy. However, the sustainability of the AI-integrated framework depends on factors such as technological infrastructure, skilled personnel, training programs, patient digital literacy, financial resources, and regulatory compliance. The proposed AI-augmented system could enhance epilepsy management by optimizing seizure tracking accuracy, improving monitoring and timely interventions, facilitating collaborative decision-making, and promoting patient-centered care, thereby making the digital care pathway more sustainable.

A Review on: Formulation and Evaluation of Herbal Medicated Chewing Gum

One portable method of medicine delivery is chewing gum. It may be used to provide medications orally, either systemically or locally. In recent years, significant progress has been made in research and technology related to the oral medication administration route. Medicated chewing gum has gained international attention throughout the year due to its ability to promote patient compliance in both pediatric and geriatric patients as well as the general population. The Mayan Indians used to clean their teeth and refresh their breath by chewing tree resin from the sapodilla tree a thousand years ago. Over the course of the year, herbal chewing gum has been more widely accepted as a medication delivery method. Herbal chewing gum today contains a number of substances. A variety of characteristics, including color, stickiness, hardness, and in vitro drug release, are assessed for the prepared product. Chewing gum can be utilized as a portable medication delivery mechanism for oral drug administration, both systemic and local. The majority of people find chewing gum to be enjoyable. Medicated gum preparations frequently require organic solvents to solubilize the active ingredients, and it can be challenging to remove these organic solvents from the finished product.

Advances in Drug Formulation Technology: Enhancing Bioavailability and Patient Compliance

Drug formulation technology is continuously evolving to improve the efficacy and patient experience of pharmaceuticals. This paper explores recent advancements in drug formulation techniques aimed at enhancing drug bioavailability and promoting patient compliance. By addressing challenges related to drug solubility, stability, and delivery, these innovations have the potential to revolutionize drug development and patient care. This paper provides an overview of these advancements, their mechanisms, and their impact on the pharmaceutical industry and healthcare.

Recent Development of Novel Drug Delivery of Herbal Drugs

Abstract Objective As plants are nature's panacea, mankind has used them for food and healing since the dawn of time. Currently, there are worldwide initiatives targeted at finding herbal treatments in plants and promoting them using a reliable drug delivery system for people. The fundamental idea underlying it is that each disease's cure can be found in nature. But the distribution of herbal medications also needs to be modified in order to promote patient compliance, achieve sustained discharge, etc. Key Findings Due to challenges with processing, standardisation, extraction, and identification, herbal medications traditionally could not convince scientists to modify novel drug delivery systems. Advanced approaches can be used to prevent toxicity, improve stability, increase the bioavailability of herbal formulations, and prevent physical and chemical deterioration. The various drug delivery systems indicated in this article are phytosomes, liposomes, nanoparticles, microspheres, microemulsions, niosomes, dendrimers, etc. Summary In order to enhance the delivery of herbal drugs by increasing their therapeutic benefits and reducing their toxicity, the need for innovative drug delivery systems has increased. This review provides information on numerous strategies used to increase the efficacy and safety of phytomedicines, as well as employing novel formulations. Conclusion By minimising toxicity and eliminating the need for repeated administration to overcome noncompliance, novel drug delivery systems increase therapeutic value. enhanced bioavailability, etc.

Floating Micro-Balloons: An Innovative Approach

The primary purpose of developing mechanism for delivering controlled-release medicines to the mouth is to hold on the medication as long as feasible in the body. The research and development of innovative medication systems of delivery has progressed scientifically and technologically in recent years. Tablets, capsules, pills, laminated films, floating microspheres, granules, and powders are examples of gastro-retentive dose forms. The homogeneous distribution of these dosage forms within the stomach, resulting in more consistent drug absorption and a lower risks of local discomfort, has made floating microballoons increasingly popular. So far, various approaches have been discovered for modification of these microballoons such as Floating system, System with high density, ion exchange resin, system with osmotic control, .expandable or swelling system and many more. These approaches play an important role as Compared to single-unit dose forms and such systems offer more advantages. Microballoons promote patient compliance by increasing medicine bioavailability, decreasing drug excretion, regulation of drug delivery. Micro-balloons are free-flowing spherical powders with a diameter of 1-1000 µm. Proteins or synthetic polymers are used to create it. The current pharmaceutical foundation of their design, advantages, limitations method of Formulation, classification, assessment procedure, factors affecting their formulation, and in vitro parameters are summarised in this review study.

A review of medicines with sustained release

Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties for maximum therapeutic efficacy. The matrix regulates the rate at which the drug is released. Because it facilitates prolonged release, the major excipient in the formulation is a release retardant. The technology may promote patient compliance and efficiently treat chronic illnesses by decreasing the overall dosage and dosing schedule. The drug is supplied in this system via diffusion- and dissolution-controlled methods. The primary goal of this analysis is to provide comprehensive information on the sustained release system and to discuss the many selection criteria for medicines used in medication administration system

Management of obstructive sleep apnea and insomnia in a patient with complete and partial removable dentures

In this case, we assessed the feasibility of managing obstructive sleep apnea (OSA) with an oral appliance (OA) for an edentulous patient. Given that promoting patient compliance with continuous positive airway pressure (CPAP) is challenging, OA therapy could improve patient adherence and quality of life. A 56-year-old male with a medical history of moderate OSA and insomnia was referred to our center by a sleep physician for OA therapy. He reported intolerance to CPAP with different types of masks and nasal pads. Upon clinical examination, the patient had a fully edentulous maxilla and three healthy abutment teeth in the mandible. He wore a complete upper denture and a lower partial denture both day and night. We used a custom-made adjustable OA (semiedentulous design) for both dentures. During the last follow-up visit, a significant improvement in OSA indexes was observed. The patient's apnea[FIGURE DASH]hypopnea index (AHI) decreased from 11.8/h to 6.8/h, whereas his nadir oxygen saturation increased from 83% to 92%. The rapid eye movement (REM) stage of sleep drastically improved from 15.7% to 26.6%, and the respiratory disturbance index decreased from 40/h to 15.8/h at the REM stage. OA was an effective alternative to a tongue retainer device for a completely and partially edentulous patient refusing to comply with CPAP and unable to tolerate the tongue retainer device. Further studies with larger sample sizes using different OAs are recommended.

Lupus anticoagulant in an elderly woman with dementia: a clinical case report with many questions and few answers

We describe the clinical case of an elderly woman with dementia, suffering from bilateral soleal venous thrombosis, despite antithrombotic prophylaxis, after orthopedic surgery. An isolated anti-cardiolipin antibodies positivity, however pre-existing for at least seven years, was found in a patient with previous cerebral ischemia and treated intermittently with aspirin. During the coronavirus disease 2019 (COVID-19) pandemic lockdown, to promote patient compliance, we practiced anticoagulant therapy with edoxaban: resolution of venous thrombosis was achieved. Longlasting medical treatment is discussed.

Remote Training of Dental Students and Professionals to Promote Cooperative Behavior in Patients with Intellectual and Developmental Disabilities.

Many individuals diagnosed with intellectual and developmental disabilities (IDD) are uncooperative during routine dental exams, leading to poor oral health in this population. Few studies have evaluated methodologies for preparing dental students and professionals to work effectively with patients diagnosed with IDD. In this study, experimenters used remote behavioral skills training (BST) to train dental students and professionals how to implement a practical intervention that included tell-show-do, contingent praise, and noncontingent reinforcement. Results suggested that group training conducted via videoconferencing was effective for teaching six of seven participants to implement the intervention in the absence of post-training feedback. This approach appears useful for quickly and efficiently training current and future dental professionals to implement behavior techniques to promote patient compliance.

Compliance with Lid Hygiene in Patients with Meibomian Gland Dysfunction.

PurposeTo evaluate the level and predictor of compliance with lid hygiene of the patients with meibomian gland dysfunction (MGD) by a specially designed and validated questionnaire.Patients and MethodsA cross-sectional, descriptive study was conducted among patients with symptomatic meibomian gland dysfunction visiting at Ramathibodi Hospital from April 2019 to December 2020. Dry eye symptom, fluorescein tear breakup time (TBUT), ocular surface staining, lid morphology, meibum quality, and meibum expressibility were evaluated. All patients were instructed to perform lid hygiene two times daily. Eight weeks after receiving the instruction, the patients were asked to complete a newly developed seven-item questionnaire to assess compliance. The associated factors limiting treatment adherence were evaluated. Proper statistical analyses were used to determine the relationships between compliance and non-compliance and a group of relevant baseline variables. P < 0.05 was considered to be statistically significant.ResultsA total of 77 patients were recruited into the study. Sixty-three patients (81.8%) were female. The mean age was 66.71 ± 8.17 years old (42–87 years). Good compliance with lid hygiene was reported by 42 patients (54.6%). Patient demographic factors or the number of concurrent systemic or ophthalmic drugs were not significantly different between the compliance and non-compliance groups. Some clinical signs, including the higher scores of meibomian gland expressibility and moderate to severe ocular surface staining, were significantly positively associated with lid hygiene compliance (χ2 = 10.13, P = 0.001 and χ2 = 10.48, P = 0.001, respectively). A lack of time was the most notable reason for non-compliance.ConclusionApproximately half of the patients with symptomatic MGD had good compliance with lid hygiene by the specific questionnaire. Appropriate patient education and optimization methods of lid hygiene may promote patient compliance.

High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury

Drug delivery systems with high content of drug can minimize excipients administration, reduce side effects, improve therapeutic efficacy and/or promote patient compliance. However, engineering such systems is extremely challenging, as their loading capacity is inherently limited by the compatibility between drug molecules and carrier materials. To mitigate the drug-carrier compatibility limitation towards therapeutics encapsulation, we developed a sequential solidification strategy. In this strategy, the precisely controlled diffusion of solvents from droplets ensures the fast in-droplet precipitation of drug molecules prior to the solidification of polymer materials. After polymer solidification, a mass of drug nanoparticles is embedded in the polymer matrix, forming a nano-in-micro structured microsphere. All the obtained microspheres exhibit long-term storage stability, controlled release of drug molecules, and most importantly, high mass fraction of therapeutics (21.8–63.1 wt%). Benefiting from their high drug loading degree, the nano-in-micro structured acetalated dextran microspheres deliver a high dose of methylprednisolone (400 μg) within the limited administration volume (10 μL) by one single intrathecal injection. The amount of acetalated dextran used was 1/433 of that of low drug-loaded microspheres. Moreover, the controlled release of methylprednisolone from high drug-loaded microspheres contributes to improved therapeutic efficacy and reduced side effects than low drug-loaded microspheres and free drug in spinal cord injury therapy.

Lipid-liquid crystals for 2 months controlled risperidone release: In-vitro evaluation and pharmacokinetics in rabbits

In this study, a drug delivery system based on lipid liquid crystal (LLC) was developed for the long-term delivery of risperidone to improve psychological treatment. Optimal LLC formulation was achieved based on maximum release after 60 days with different ratios of phosphatidylcholine (PC) to sorbitol monooleate (PC: SMO), tween grade 80 (w/w %), and tocopherol acetate (TA) (w/w %) using the Box-Behnken method. In vitro and ex vivo studies, pharmacokinetics, and histopathological examination in rabbits were conducted to compare the optimal LLC with Risperdal CONSTA®. The optimum formulation containing the PC to SMO ratio of 58.6%, tween 0.82% w/w, and TA 3.6% w/w was selected because it had the highest drug release percentage (100%) during about two months. Polarized optical microscopy (POM) revealed HII mesophase with a 2-dimensional structure. Cell culture also revealed moderate cytotoxicity for LLC-risperidone. Pharmacokinetic data displayed that the optimal LLC created a more consistent drug serum level within 60 days, and histopathology results demonstrated slight to moderate damage in rabbits’ organs. Furthermore, the accelerated stability test confirmed optimum stability for LLC and risperidone. This study confirmed the better pharmacokinetic potentials of SMO-based LLC systems compared with Risperdal CONSTA®, which would promote patient compliance and obviate the difficulties of additional oral therapy.

Communicate with Elderly Patients in the Medical Visit: Doctors’ Service Experiences of a Regional Hospital in Taiwan

This study explored doctors’ medical service experiences while communicating with elderly patients. In this qualitative study, the researchers conducted semi-structured interviews with 20 doctors from a regional hospital in Taiwan. The findings revealed that: (a) By providing medical service, doctors can collect patient information more effectively by inquiring about the patients in dialects and guiding the patients’ family members; (b) It is more feasible in medical service of health education to speak slower and louder, apply relatable metaphors or imagery, and reassure the patients’ level of comprehension; (c) Emotional communication behaviors such as listening, patience, care, and psychological support, are key to establishing doctor-patient trust; (d) Allowing caregivers to participate in the communication process will help to establish good partnerships, thereby promoting patient compliance and increasing treatment efficacies in the medical service. The results can serve as a reference for the government and medical units to design medical service training programs for enhancing doctor-patient communication.

Modulating OPG and TGF-β1 mRNA expression via bioelectrical stimulation

BackgroundBone remodeling is a lifelong process that ranges from orthodontic tooth movement/alignment to bone damage/healing, to overall bone health. Osteoprotegerin (OPG) and transforming growth factor β1 (TGF-β1) are secreted by osteoblasts and participate in bone remodeling. OPG promotes bone remineralization and stabilization prominent in post-mechanical repositioning of the teeth in the dental alveolus. TGF-β1 participates in regulatory processes to promote osteoblast and osteoclast equilibrium. In the context of orthodontic tooth movement, post-treatment fixation requires additional, exogenous, stabilization support. Recent research showcases supplementary solutions, in conjunction to standard tooth fixation techniques, such as OPG injections into gum and periodontal tissues to accelerate tooth anchorage; however, injections are prone to post-procedure complications and discomfort. This study utilizes noninvasive bioelectric stimulation (BES) to modulate OPG and TGF-β1 as a novel solution to regulate bone remineralization specifically in the context of post-orthodontic tooth movement. PurposeThe aim of this study was to investigate a spectrum of BES parameters that would modulate OPG and TGF-β1 expression in osteoblasts. MethodsOsteoblasts were cultured and stimulated using frequencies from 25 Hz to 3 MHz. RT-qPCR was used to quantify changes in OPG and TGFb-1 mRNA expression. ResultsOPG mRNA expression was significantly increased at frequencies above 10,000 Hz with a maximum expression increase of 332 ± 8% at 100 kHz. Conversely, OPG mRNA expression was downregulated at frequencies lower than 1000 Hz. TGF-β1 mRNA expression increased throughout all stimulation frequencies with a peak of 332 ± 72% at 250 kHz. Alizarin Red tests for calcium, indicated that mineralization of stimulated osteoblasts in vitro increased 28% after 6 weeks in culture. DiscussionResults support the working hypothesis that OPG and TGF-β1 mRNA expression can be modulated through BES. Noninvasive BES approaches have the potential to accelerate bone remineralization by providing a novel tool to supplement the anchorage process, reduce complications, and promote patient compliance and reduce post-treatment relapse. Noninvasive BES may be applicable to other clinical applications as a novel therapeutic tool to modulate bone remodeling.

Design and in-vitro Evaluation of Float-adhesive Famotidine Microspheres by using Natural Polymers for Gastroretentive Properties

Abstract: Objectives: In the present investigation a novel oral drug delivery system was developed by combining two different techniques floating and mucoadhesive system so called floatadhesive, in order to obtain a controlled system that could remain in the stomach for prolonged period and release the drug in a controlled manner. Materials and Methods: Microspheres containing Famotidine were prepared by ionic gelation method using Mimosa pudica seed mucilage as a natural mucoadhesive polymer. Sodium alginate (SA) and chitosan (CS) were incorporated as drug release modifier. The microspheres were characterized by scanning electron microscopy and evaluated by employing shape and particle size, % drug entrapment efficiency, in vitro floating ability, in vitro mucoadhesion and in vitro drug release pattern. Results: The prepared microspheres were acceptably spherical with a mean particle size in the range of 334 ± 1.18 μm to 498 ± 1.12 μm. Drug entrapment efficiency was observed in the range of 72.82 ± 1.10% to 92.38 ± 1.20%. Formulations containing a combination of both mucilage and chitosan showed increased in vitro mucoadhesion and buoyancy as compared to formulations containing chitosan alone. In vitro drug release for all the formulations in 0.1N HCl was diffusion controlled gradually throughout 12 h and followed Higuchi’s and Korsmeyer Peppas kinetics. The mechanism of in vitro drug release was non-fickian type controlled by swelling and relaxation of the polymer. Conclusion: The developed microspheres have dual advantages of being floating and mucoadhesive to increase oral bioavailability and releasing drug in a controlled manner, to reduce the required frequency of administration thereby promoting patient compliance. Key words: Natural polymers, Mimosa pudica mucilage, Chitosan, Floating, Mucoadhesive, Float-adhesive, Ionic gelation.

Efficacy and Safety of Vitrectomy without Using Perfluorocarbon Liquids and Drainage Retinotomy Associated with Postoperative Positioning Based on Residual Subretinal Fluid for Rhegmatogenous Retinal Detachment.

Medical records of 75 eyes from 75 consecutive patients with uncomplicated rhegmatogenous retinal detachment (RRD) who underwent pars plana vitrectomy (PPV) were analyzed. Inclusion criteria were patients with RRD who underwent primary 23- or 25-gauge PPV with air, gas, or SiO tamponade and performed by a single surgeon, no use of perfluorocarbon liquids (PFCL) and drainage retinotomy, and follow-up ≥ six months. Exclusion criteria were patients who underwent previous vitreoretinal surgery, proliferative vitreoretinopathy (PVR) more than grade B, giant tears, and encircling band associated with PPV. The main endpoint was the anatomical retinal reattachment rate after a single surgical procedure. Secondary endpoints were best-corrected visual acuity (BCVA), postoperative retinal displacement, and intraoperative and/or postoperative complications. Primary anatomical success was achieved in 97.3% of cases using this modified surgical procedure. Retinal slippage occurred only in 28.2% of patients and it was not observed in all cases of macula-on RRD. The mean logMAR of the BCVA significantly improved in 92% of patients and no intraoperative complications were observed. The results suggest that complete subretinal liquid drainage is not mandatory for all RRD cases treated with PPV and that using PFCL and performing a drainage retinotomy are not essential in eyes with primary RRD and PVR less than grade B. Postoperative positioning after PPV for uncomplicated RRD based on the presence or absence of residual subretinal fluid at the end of surgery could limit the occurrence of postoperative retinal displacement, while promoting patient compliance.