Floating Micro-Balloons: An Innovative Approach

Abstract

The primary purpose of developing mechanism for delivering controlled-release medicines to the mouth is to hold on the medication as long as feasible in the body. The research and development of innovative medication systems of delivery has progressed scientifically and technologically in recent years. Tablets, capsules, pills, laminated films, floating microspheres, granules, and powders are examples of gastro-retentive dose forms. The homogeneous distribution of these dosage forms within the stomach, resulting in more consistent drug absorption and a lower risks of local discomfort, has made floating microballoons increasingly popular. So far, various approaches have been discovered for modification of these microballoons such as Floating system, System with high density, ion exchange resin, system with osmotic control, .expandable or swelling system and many more. These approaches play an important role as Compared to single-unit dose forms and such systems offer more advantages. Microballoons promote patient compliance by increasing medicine bioavailability, decreasing drug excretion, regulation of drug delivery. Micro-balloons are free-flowing spherical powders with a diameter of 1-1000 µm. Proteins or synthetic polymers are used to create it. The current pharmaceutical foundation of their design, advantages, limitations method of Formulation, classification, assessment procedure, factors affecting their formulation, and in vitro parameters are summarised in this review study.