Prominent Databases Research Articles

Comparison of anesthesia methods for intra-arterial therapy of patients with acute ischemic stroke: an updated meta-analysis and systematic review

ObjectivesCurrently, there remains debate regarding the optimal anesthesia approach for patients undergoing intra-arterial therapy for acute ischemic stroke. Therefore, we conducted a comparative analysis to assess the effects of general anesthesia versus non general anesthesia on patient outcomes.MethodsThe research methodology entailed comprehensive searches of prominent databases such as the Cochrane Library, PubMed, Scopus, and Web of Science, covering the period from January 1, 2010, to March 1, 2024. Data synthesis employed techniques like risk ratio or standardized mean difference, along with 95% confidence intervals. The study protocol was prospectively registered with PROSPERO (CRD42024523079).ResultsA total of 27 trials and 12,875 patients were included in this study. The findings indicated that opting for non-general anesthesia significantly decreased the risk of in-hospital mortality (RR, 1.98; 95% CI: 1.50 to 2.61; p<0.00001; I2 = 20%), as well as mortality within three months post-procedure (RR, 1.24; 95% CI: 1.15 to 1.34; p<0.00001; I2 = 26%), while also leading to a shorter hospitalization duration (SMD, 0.24; 95% CI: 0.15 to 0.33; p<0.00001; I2 = 44%).ConclusionIschemic stroke patients who undergo intra-arterial treatment without general anesthesia have a lower risk of postoperative adverse events and less short-term neurological damage. In routine and non-emergency situations, non-general anesthetic options may be more suitable for intra-arterial treatment, offering greater benefits to patients. In addition to this, the neuroprotective effects of anesthetic drugs should be considered more preoperatively and postoperatively.

The implication of user-generated content in new product development process: A systematic literature review and future research agenda

This study aims to provide a comprehensive overview of the current state of user-generated content (UGC) research within the context of new product development (NPD). A systematic literature review (SLR) was conducted across three prominent databases, namely Web of Science, Scopus, and Science Direct, using keywords to identify relevant articles. 5585 of 13,381 articles were deemed relevant following the application of inclusion and exclusion criteria. These articles were then thoroughly analyzed to create a comprehensive review of the topic. The selection process involved evaluating the titles and abstracts of all publications that were discovered, and carefully choosing 136 articles for full-text review. From these, 58 articles were ultimately selected for detailed analysis in this study. The study highlights the role of UGC in augmenting NPD process and identifies potential areas for future research based on evidence derived from an SLR of articles published between 2012 and 2023. The research methodologies adopted in this paper involve descriptive analysis and TCM framework (T-themes, C-contexts, and M-methodologies). Finally, the article concludes by shedding light on its potential applications by providing four themes and highlighting the importance of future research in the field with five propositions.

Catalysts of choice: Unraveling the dynamics of housing preferences across diverse societal contexts – Evidence from literature

Housing preferences worldwide are shaped by a myriad of factors, reflecting the diverse and dynamic nature of societal needs and individual choices. The process of evaluating available housing options is intricately linked to underlying motivating factors, shaping individual preferences and decisions in response to evolving circumstances and environments. This comprehensive study delves into the intricate dynamics of housing preferences, examining the interplay of temporal-spatial relationships, psychological factors, social-cultural dimensions, and political-economic aspects. Employing bibliometric-based citation analysis techniques and social network analysis, the research offers a nuanced exploration of scholarly landscapes from 1967 to 2022 across prominent databases—Web of Science, Scopus, and Science Direct.This article undertakes a comprehensive analysis of the preferences within contemporary housing systems, offering insights into diverse dwelling choices and their determinants. The examination encompasses multifaceted considerations, contributing to an understanding of the intricate dynamics influencing housing preferences in varying societal contexts. The article also informs policymakers, urban planners, and researchers about the intricate dynamics influencing housing preferences worldwide, providing valuable guidance for addressing the evolving housing needs of diverse populations.

Intention in coastal environments for agricultural usage: a review of design thinking approaches

Abstract Through a systematic and comprehensive literature review, this review navigates the landscape of existing research, unveiling connections, emerging trends, and opportunities for innovation within the domains of agricultural usage intention and design thinking within coastal development. The review’s synthesis underscores the pivotal role of design thinking principles in deciphering intentions for agricultural usage within coastal environments. The methodology is systematic, encompassing prominent databases and unfiltered searches. Through comprehensive exploration, the study offers a holistic perspective on the intricate dynamics between intentions for agricultural usage and design thinking within coastal environments. In the process of assembling articles for inclusion, prominent electronic databases such as Google Scholar, Scopus, and PubMed were utilized. In all, 635 articles were found during the preliminary screening. A total of 28 papers were found to be suitable for the systematic review after a thorough inspection. Amid this exploration, emerging trends and innovative methodologies, including geospatial analyses and immersive technologies, enrich our understanding of agricultural usage intentions. The review identifies research gaps and invites future inquiries, such as cultural nuances and the synergy between evolving design thinking paradigms and coastal realms. As a contribution to sustainable coastal development, this manuscript echoes the call for human-centric, design-driven strategies that resonate with diverse coastal stakeholders, ensuring a harmonious coexistence of agricultural pursuits and ecological preservation.

Effectiveness of Herbal medicines on male reproductive system: Evidence from meta-analysis

BackgroundThe increasing prevalence of male infertility has become a global concern. Traditional Chinese and Asian medicines have long been using herbal remedies to promote spermatogenesis. This study aimed to systematically explore the potential of herbal medicines and formulations to enhance the male reproductive function in humans. MethodsTwo prominent databases, MEDLINE and EMBASE, as well as scientific journals indexed in the Web of Science, were used for the literature search until October 2023. The studies included in the analysis focused on the impact of herbal medicines (Mucuna pruriens, Withania somnifera, Eurycoma longifolia, Panax ginseng, Lycopersicon esculentum, Crocus sativus, Vitis vinifera, Nigella sativa, Sesamum indicum, Curcuma longa, Lepidium peruvianum) and Chinese and Korean Polyherbal formulations (Shao-Fu-Zhu-Yu-Tang; 少腹逐瘀汤) on human serum reproductive hormone levels, semen parameters, and antioxidant enzymes. ResultsA total of 23 articles were deemed eligible for the review and meta-analysis, which included 1,194 men from seven countries (China, Korea, Iran, Peru, Japan, Malaysia, and India). Of these, 19 articles were analyzed for semen parameters. The use of herbal medicine increased seminal parameters, including semen volume during each ejaculation (standardized mean difference (SMD) = 0.89; 95 % CI: 0.52, 1.26), sperm concentration (SMD = 1.97; 95 % CI: 1.30, 2.64), total sperm count (SMD = 2.28; 95 % CI: 1.44, 3.11), sperm motility (SMD = 1.07; 95 % CI: 0.68, 1.46), and normal morphology (SMD = 1.47; 95 % CI: 0.62, 2.32). Additionally, 18 articles that analyzed sex hormone levels showed that treatment with herbal medicines favorably reduced serum prolactin (SMD = -0.70; 95 % CI: -1.13, -0.28) and FSH levels (SMD = -1.07; 95 % CI: -1.56, -0.56). Meanwhile, herbal medicines did not affect testosterone levels (SMD = 0.41; 95 % CI: -0.24, 1.06) and LH levels (SMD = 0.45; 95 % CI: -0.33, 1.23). Finally, six articles were analyzed for seminal biochemical and antioxidant profiles, and the results showed that herbal medicine increased the levels of ascorbic acid (SMD = 1.19; 95 % CI: 0.51, 1.86), corrected seminal fructose (SMD = 1.32; 95 % CI: 0.89, 1.76), superoxide dismutase activity (SOD) (SMD = 1.06; 95 % CI: 0.45, 1.68), and catalase activity (SMD = 0.91; 95 % CI: 0.69, 1.44) in seminal plasma. ConclusionHerbal remedies have been found to promote spermatogenesis by optimizing semen parameters, sex hormone levels, and antioxidant profiles. As a result, these treatments should be regarded as complementary approaches to male infertility.

Use of Social Media in Disaster Management: Challenges and Strategies

Studies on social media (SM) and disaster management (DM) have mainly focused on the adaptation, application, and use of SM in each stage of DM. With the widespread availability and use of SM, the effective utilisation of SM in DM is impeded by various challenges but not yet comprehensively researched. Therefore, this paper aims to identify the challenges as well as the strategies to overcome the challenges and categorises them into a classified model. This study adopts a systematic literature review to present and analyse the challenges and strategies for using SM in DM. Utilising prominent databases, 72 publications were carefully selected and analysed qualitatively using content analysis. The findings revealed four key challenges to its users: the spread of misinformation; insufficient human resources to manage SM use; the lack of trust in information and authorities; and the poor information quality and content of messages. This study identified several strategies to overcome challenges, which can be classified into three sectors of the SM community: individuals, organisations, and SM companies. These findings contribute to enhancing the effective utilisation of SM in DM by community practitioners. Furthermore, this study provides insight into the current status of knowledge and identifies the research gaps around SM in DM for future research.

Program Kombinasi Intervensi Stimulasi Motorik Oral dalam Meningkatkan Kesiapan Keterampilan Minum Per-Oral pada Bayi Prematur

This study aims to evaluate the efficacy of integrating multiple oral motor stimulation interventions in facilitating the readiness for oral feeding among premature neonates.. A systematic review methodology was adapted for this inquiry. Extensive literature searches were conducted across prominent databases, including PubMed, EBSCO, Sage Journal, Taylor &amp; Francis, Clinical Key for Nursing, and Proquest. A total of six articles, all randomized controlled trials, were selected and meticulously reviewed. The results of this systematic review indicate that the interventions employed include combinations of oral motor stimulation with supplementary nursing, kinesthetic tactile techniques, non-nutritive sucking (NNS), swallowing exercises, and sensorimotor stimulation. The findings suggest that these interventions are effective in enhancing oral feeding readiness by shortening the transition period to oral feeding and promoting breastfeeding fulfillment. Additionally, they have been shown to increase breastfeeding rates and reduce concurrently the duration of hospitalization. This research provides valuable insight for improving neonatal care and optimizing feeding practices. Keywords: Feeding Readiness, Oral Motor Stimulation, Premature Infants

Mapping the Landscape: A Bibliometric Analysis of Rating Agencies in the Era of Artificial Intelligence and Machine Learning

Abstract In the ever-evolving financial landscape, the integration of artificial intelligence (AI) and machine learning (ML) is revolutionising creditworthiness assessment. The vast body of literature on credit rating indicates a growing prevalence of these techniques in the rating processes. Although these methods boast high predictive accuracy, concerns about their robustness, equity, and explainability affect the confidence of various parties in rating agencies. This comprehensive study explores the dynamic intersection of these cutting-edge technologies with rating agencies, presenting an in-depth literature review employing a bibliometric analysis that uses the Bibliometrix and Biblioshiny packages from R. The paper makes a significant contribution by analysing the literature across three prominent databases: Web of Science, Scopus, and arXiv. The empirical findings indicate that despite a recent growing interest, the relatively limited number of documents implies that, while there is a wide literature about credit rating in general, when it comes to rating agencies, the literature is much more limited. This limitation may stem from a certain lack of transparency in the methods and processes used by rating agencies and the complex nature of these entities. The literature witnessed growth after the 2008 global financial crisis, where rating agencies faced significant criticism, and post-pandemic, indicating a need for more adaptable and precise ratings. The examination of the topic reveals a recent shift in focus within AI-driven rating agencies towards accountable governance. While traditional attention persists on artificial intelligence techniques and finance, the emerging emphasis on ethical considerations, societal impacts, and performance evaluation underscores a changing landscape. This transition underscores the growing importance of integrating ethical considerations and societal impacts into the operational frameworks of AI-powered rating agencies, emphasising the necessity for responsible and transparent decision-making practices.

Perioperative nutrition optimization: a review of the current literature†

Abstract Objective This article aims to elaborate the recent research status of perioperative nutrition optimization, in order to help clinical practice. Methods This study employed a comprehensive and systematic method to search prominent databases, including PubMed and Web of Science, using carefully selected keywords. Following meticulous screening, the inclusion of high-quality studies was prioritized, and a thorough review of the references was conducted to comprehensively analyze the latest evidence on perioperative nutrition optimization. Results The main contents include preoperative nutritional risk screening and assessment, nutritional support pathway, immune enhancing nutrition, preoperative and postoperative nutritional management, as well as personalized nutrition optimization strategies for specific populations (such as children, bariatric surgery patients, and cancer patients). Conclusions In clinical practice, the importance of perioperative nutrition should be emphasized, and personalized nutrition management plans should be developed based on the characteristics and needs of patients. Further research and promotion of perioperative nutrition optimization strategies will help improve the overall prognosis and quality of life of surgical patients.

Experimental approaches for induction of diabetes mellitus and assessment of antidiabetic activity: An in vitro and in vivo methodological review.

Diabetes mellitus poses a global health challenge, driving the need for innovative therapeutic solutions. Experimental methods play a crucial role in evaluating the efficacy of potential antidiabetic drugs, both in vitro and in vivo. Yet concerns about reproducibility persist, necessitating comprehensive reviews. This review aims to outline experimental approaches for inducing diabetes and evaluating antidiabetic activity, synthesizing data from authoritative sources and academic literature. We conducted a systematic search of prominent databases, including PubMed, ScienceDirect, and Scopus, to identify relevant articles spanning from 1943 to the present. A total of 132 articles were selected for inclusion in this review, focusing on in vitro and in vivo experimental validations of antidiabetic treatments. Our review highlights the diverse array of experimental methods employed for inducing diabetes mellitus and evaluating antidiabetic interventions. From cell culture assays to animal models, researchers have employed various techniques to study the effectiveness of novel therapeutic agents. This review provides a comprehensive guide to experimental approaches for assessing antidiabetic activity. By synthesizing data from a range of sources, we offer valuable insights into the current methodologies used in diabetes research. Standardizing protocols and enhancing reproducibility are critical for advancing effective antidiabetic treatments.

Exploring the significance of early life outdoor experiences: a scoping review of retrospective outdoor methods

ABSTRACT Outdoor programs have shown holistic health benefits for participants, with recent evidence indicating that these benefits can extend long after the conclusion of the program. The methods employed in retrospective studies exploring these outcomes are diverse, leading to many different approaches. Furthermore, only a few studies reference a theoretical framework guiding the authors’ approach. The primary objectives of this review were to (1) identify the purposes and outcomes from retrospective studies related to outdoor experiences, (2) summarize the methodological characteristics, and (3) compile reported methodological limitations. A Peer Reviewed Electronic Search Strategy (PRESS) was employed to search four prominent databases; Yielding 5206 candidate studies, from which 31 met the inclusion criteria. Data analysis revealed that there were four main study purposes and 22 unique outcomes. Retrospective, longitudinal, and follow-up were the three main methodological designs, with methods exhibiting significant variation and diversity. This review concludes with five suggestions for future research.

India's Silent Struggle: A Scoping Review on Postpartum Depression in the Land of a Billion Mothers.

Postpartum emotional issues, including postpartum blues, postpartum psychosis, and postpartum depression (PPD), affect many mothers worldwide. The prevalence of postpartum blues ranges from 300 to 750 per 1,000 mothers, while postpartum psychosis has a prevalence of 0.89-2.6 cases per 1,000 births. PPD affects 100-150 new mothers per 1,000 births, and its prevalence can go above 25% globally. Depression in mothers can have long-lasting impacts on children and the next generation, affecting their growth, development, and relationships. However, the condition of PPD is frequently misdiagnosed, and women who suffer from it do not receive treatment. There is a lack of solid systematic evidence that looks at the overall burden of PPD and the risk factors that are associated with it in India. The awareness of PPD is critical in managing the symptoms and seeking professional support, and studies are needed to evaluate and assess the situation in India. This study is a systematic literature review with a scoping review approach aimed at providing existing evidence on the awareness and prevalence of PPD in India. The search strategy for the electronic bibliographic search included a list of related terms and factors of awareness and prevalence of PPD. The search encompassed six prominent databases. The assessment tools used in studies from 2012 to 2023 study the factors using the Postpartum Depression Literacy Scale (PoDLiS) and the Edinburgh Postpartum Depression Scale, which measure the awareness and prevalence of PPD. The study found a significantly low volume of studies conducted in India to determine the prevalence of PPD. The materials or studies accessible are hospital-based research with a minimal number of samples. The reported prevalence rate of postpartum depression (PPD) in India varies across different studies, ranging from 4% to 48.5%. Among mothers who gave birth either naturally or by cesarean section in a hospital setting, one study reported the lowest prevalence rate (4%). The prevalence of PPD among women in India is estimated to be 18% based on the average score across all research. A study that evaluated the moms in the community found that PPD was prevalent in new mothers at a rate of 21.5%. There are three studies, in particular, that focus on how aware people are of PPD. Two studies found that 54% of the family members of postpartum moms and women undergoing tertiary pediatric care are aware of PPD. Many studies point to the lack of social support as a significant risk factor for mental health complications after delivery. History of depression, anxiety, adverse life events, partner abuse, low economic status, complications at childbirth, and a traumatic childbirth experience are some of the associated factors identified in the studies. Studies have also shown that women who undergo a cesarean section have a higher risk of developing PPD than those with a vaginal delivery.

Therapeutic Interventions for Diabetes Mellitus-Associated Complications.

Diabetes Mellitus (DM) is an alarming health concern, affecting approximately 537 million people worldwide. As a leading cause of morbidity and mortality, DM demands a comprehensive understanding of its diverse pathophysiological mechanisms and disease progression. This traditional review has consolidated literature on the pathogenesis of hyperglycemia, its progression into complications, and advances in optimal treatment strategies. The literature in the last two decades has been reviewed using several keywords, including "diabetes," "diabetes-associated complications", "novel therapeutic interventions for diabetes-associated diseases", "phyto-extracts as antidiabetic drugs", etc. in prominent databases, such as PubMed, Scopus, Google Scholar, Web of Science, and ClinicalTrials.gov. We have discussed macrovascular and microvascular complications, such as atherosclerosis, cardiovascular disease, Peripheral Arterial Disease (PAD), stroke, diabetic nephropathy, retinopathy, and neuropathy, as well as various pharmacological and non-pharmacological interventions that are currently available for the management of DM. We have also focused on the potential of natural products in targeting molecular mechanisms involved in carbohydrate metabolism, insulin production, repair of pancreatic cells, and reduction of oxidative stress, thereby contributing to their antidiabetic activity. Additionally, novel therapeutic approaches, like genetic, stem cell, and immunomodulatory therapies, have been explored. We have also discussed the benefits and limitations of each intervention, emerging research and technologies, and precision medicine interventions. This review has emphasized the need for an improved understanding of these advancements, which is essential to enhance clinicians' ability to identify the most effective therapeutic interventions.

Employee moonlighting: a review and research agenda

PurposeThis paper aims to present a literature review on the emerging field of employee moonlighting, which refers to holding more than one job at a time. It also attempts to integrate the literature on employee moonlighting and present the related research themes.Design/methodology/approachThis is a systematic literature review (SLR) using the basic guidelines of SLR. A search string is designed, and the prominent database is searched. The results are screened based on self-designed inclusion and exclusion criteria. The qualitative analysis of selected 89 research studies uses inductive thematic analysis and proposes a framework.FindingsThe outcome of the present study consists of a conceptual framework, themes and sub-themes related to employee moonlighting, propositions, and the pictorial representation of the overall outcome. The four key themes that emerged are determinants and traits of moonlighting intentions, the impact of moonlighting on employer and employee, policy, and economic implications, respectively.Originality/valueThe study provides insight into the factors that lead to moonlighting intentions and activity. The managers can understand and analyze these factors and can formulate policies to streamline the moonlighting activity with the organizational goals and for the company’s benefit. Academic scholars can adopt some research ideas from the themes and gaps suggested and can work on them in the near future.

LEVERAGING WORKFORCE ANALYTICS FOR SUPPLY CHAIN EFFICIENCY: A REVIEW OF HR DATA-DRIVEN PRACTICES

This study explores the pivotal role of HR analytics in enhancing supply chain management (SCM) efficiency, marking a significant shift from traditional HR practices to data-driven decision-making. The main objective was to bridge the gap between HR analytics and SCM performance, highlighting the transformative potential of integrating advanced data analysis in workforce management to optimize supply chain operations. Employing a systematic literature review and content analysis methodology, this research meticulously analyzed peer-reviewed articles, conference papers, and scholarly books from prominent databases. The search strategy was comprehensive, incorporating a broad spectrum of relevant keywords to ensure the inclusion of significant studies that address the integration of HR analytics into SCM. Key findings underscore the transformative power of HR analytics in SCM, revealing that data-driven HR practices significantly contribute to operational efficiency, strategic decision-making, and enhanced competitive advantage. Advanced analytical tools, such as AI, machine learning, and predictive analytics, have been identified as critical in optimizing workforce performance and aligning human capital with supply chain objectives. The study concludes with actionable recommendations for practitioners, leaders, and policymakers, emphasizing the importance of robust data governance, cross-functional collaboration, and the development of analytics competencies. It also outlines emerging challenges and opportunities in leveraging workforce analytics, suggesting directions for future research, particularly in exploring the strategic impacts of HR analytics on supply chain resilience and sustainability. This research contributes to the growing body of knowledge on the strategic integration of HR analytics in supply chain management, offering a roadmap for organizations seeking to enhance supply chain efficiency through data-driven HR practices. Keywords: HR Analytics, Supply Chain Management, Data-Driven Decision-Making, Workforce Optimization.

Managing hypertriglyceridemia for cardiovascular disease prevention: Lessons from the PROMINENT trial.

Numerous epidemiological studies have shown that hypertriglyceridemia is a significant risk factor for cardiovascular diseases (CVD). However, large clinical studies on triglyceride-lowering therapy have yielded inconsistent results. In the current review, we reassess the importance of triglyceride-lowering therapy in preventing CVD based on previous literature and the recently published findings of the PROMINENT trial. This narrative review is based on literature and public documents published up to November 2023. Meta-analyses of trials on peroxisome proliferator-activated receptor α agonists and triglyceride-lowering therapy, including the PROMINENT trial, have indicated that triglyceride-lowering therapy can reduce CVD events. Mendelian randomization studies have also indicated that triglyceride is indeed a true risk factor for coronary artery disease, leaving no doubt about its relationship to CVD. Meanwhile, the negative results from the PROMINENT trial were likely due to the insufficient triglyceride-lowering effect, slight increases in low-density lipoprotein cholesterol and apolipoprotein B, and the inclusion of mostly high-intensity statin users as target patients. It is unlikely that adverse events counteracted the effectiveness of pemafibrate on outcomes. Additionally, pemafibrate has shown positive effects on non-alcoholic fatty liver disease and peripheral artery disease. Although the PROMINENT trial did not demonstrate the significance of pemafibrate as a triglyceride-lowering therapy in a specific population, it does not necessarily negate the potential benefits of treating hypertriglyceridemia in reducing CVD events. It is necessary to explore appropriate populations that could benefit from this therapy, utilize data from the PROMINENT trial and other databases, and validate findings in real-world settings.

Effectiveness of interpersonal psychotherapy in comparison to other psychological and pharmacological interventions for reducing depressive symptoms in women diagnosed with postpartum depression in low- and middle-income countries: A systematic review.

Effectiveness of interpersonal psychotherapy in comparison to other psychological and pharmacological interventions for reducing depressive symptoms in women diagnosed with postpartum depression in low- and middle-income countries: A systematic review.

Revealing the Path to a Green Economy: Insights and Recommendations for Sustainable Development in Malaysia

This study proposes a green economy framework leading to Malaysia's green economy roadmap and raising society's sustainability awareness. The framework has catered actionable insight into promoting a green economy to industrial sectors by integrating Environmental, social, and corporate governance (ESG) and Sustainable Development (SD) principles to improve Malaysia's achievement of Sustainable Development Goals (SDGs). This paper has critically analyzeda systematic review from 2209 journal articles indexed from two prominent databases, Scopus, and Web of Science. The data were analyzed using visualizing bibliometric networks and a computer-assisted qualitative method. The thematic pattern result was verified and strengthened using in-depth interviews with industrial business leaders. The result shows that establishing a green economy framework should align with a clear regulatory policy and incentives. This study provided a unique combination of proposing a green economy framework employing advanced analysis techniques and providing specific recommendations for the Malaysian context. Adopting the green economy framework led by integrated ESG, SD, and SDGs would lead to Malaysia's Shared Prosperity Vision 2030. The public listed companies should step ahead in adopting green economy frameworks.

Management of organophosphorus poisoning and the role of magnesium sulfate: A scoping review of literature.

Organophosphorus agents are easily absorbed via respiratory, gastrointestinal, and dermal routes, and inhibit the acetylcholine transferase enzyme (AChE), which is responsible for the majority of toxicity caused by organophosphates in the body. A comprehensive search was conducted across three prominent databases, namely Google Scholar, PubMed, and Science Direct, to identify relevant articles published. The search focused on the keywords "MgSO4" or "magnesium sulfate" in conjunction with "organophosphate" or "organophosphate poisoning." Inhibition of AChE results in the accumulation of acetylcholine (ACh) in synapses and stimulation of cholinergic receptors. Considering that several studies have shown the use of magnesium sulfate (MgSO4) in inhibiting the release of ACh in the central and peripheral sympathetic and parasympathetic synapses, this study was conducted to review the role of MgSO4 in the treatment of OP. The intravenous administration of MgSO4 exhibits favorable tolerability and clinical efficacy in alleviating cardiac toxicity associated with OP exposure.

Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade.

Recurrent aphthous stomatitis (RAS) refers to a sore and frequently recurring inflammation of the oral tissues, distinguished by the presence of small ulcers that cause significant discomfort and cannot be attributed to any underlying disease. Different treatments have been used for RAS. This review aims to provide a comprehensive overview of the treatment options over the past decade for recurrent aphthous stomatitis (RAS), encompassing both natural and synthetic treatments. It will utilize clinical efficacy studies conducted in vivo and in vitro, along with a focus on the pharmaceutical approach through advancements in drug delivery development. We conducted a thorough literature search from 2013 to 2023 in prominent databases such as PubMed, Scopus, and Cochrane, utilizing appropriate keywords of recurrent aphthous stomatitis, and treatment. A total of 53 clinical trials with 3022 patients were included, with 35 using natural materials in their research and a total of 16 articles discussing RAS treatment using synthetic materials. All the clinical trials showed that natural and synthetic medicines seemed to benefit RAS patients by reducing pain score, ulcer size, and number of ulcers and shortening the healing duration.