Background: Motorcycle and car riders in Indonesia have a very high population. This results in the rider's body being in a prolonged static position every day while driving. Motorcycle and car riders are forced to drive a vehicle for at least 1 – 2 hours a day. Prolonged sitting positions can result in some musculoskeletal pain. This study aims to analyze the use of vehicles, both motorcycles and cars, in terms of driving duration and determine the incidence of musculoskeletal pain. Methods: This research uses a descriptive research design with a cross-sectional analysis. The data source for this research is primary data obtained by interviewing and using a questionnaire that refers to the Nordic Body Map to map musculoskeletal pain complaints felt by participants while driving. Results: The total population was 124 people, however, only 88 samples were willing to be research subjects in this study. The results shown that more than 60 percent of respondents felt musculoskeletal pain in their bodies because of driving. Driving for more than 3 hours a day is one of the factor causing the musculoskeletal pain. From the data that has been obtained, it can be seen that musculoskeletal pain is felt in almost all parts of the body. Furthermore, pain in the lower back and neck was the most painful area of the body that felt by the most respondents. The upper back/shoulder is also a part of the body that feels pain almost the same as the neck. Conclusion: Vehicle drivers, both motorcycles and cars, have quite a large percentage of experiencing musculoskeletal pain complaints. The parts of the body that experience the most of musculoskeletal pain complaints are the low back, neck and upper back or shoulders.