Proliferation Of Blood Vessels Research Articles

A « tipical » but rare cause of neck pain

•Not available for clinical flashcards. A 34-year-old man with medical history of familial deafness presented to the emergency department for an acute left cervicalgia and painful jaw for one week. He reported a context of recent physical effort because of house moving. He had already performed a cervical echography, which showed a thickening of the wall of the left common carotid artery (panel A) without disturbance of the vascular flow on Doppler (panel B). At presentation, vital parameters were normal with symmetrical blood pressure measurement, and no fever. Clinical examination, in particular neurological examination, was normal. Electrocardiogram was unremarkable. Biological tests showed a normal C-reactive protein value (4.4 mg/L), normal troponin, and search was negative for anti-neutrophil cytoplasmic antibodies, anti-nuclear antibodies (titer at 1:80) and anti-DNA antibodies. Finally, cervical angio-CT-scan eliminated a carotid dissection and revealed a perivascular infiltration surrounding the left common carotid artery with a thickened carotid wall (panel C). All these elements were suggestive of transient perivascular inflammation of the carotid artery (TIPIC) syndrome, also known as carotidynia or Fay syndrome (Image). Fay first described carotidynia in 1927 as an atypical neuralgia. Historically characterized by the association of unspecific clinical signs like tenderness and pain at the level of the carotid bifurcation, this entity was controversial and it is still unrecognized as a distinct pathology [[1]Lecler A Obadia M Savatovsky J Picard H Charbonneau F Menjot de Champfleur N et al.TIPIC syndrome: beyond the myth of carotidynia, a new distinct unclassified entity.Am J Neuroradiol. 2017; 38: 1391-1398Crossref PubMed Scopus (41) Google Scholar]. A recent multi-centric cases series of 47 patients proposed a new definition based on four criteria: a) presence of acute pain overlying the carotid artery, which may or may not radiate to the head, b) eccentric perivascular infiltration on imaging, c) exclusion of another vascular or non-vascular diagnosis with imaging, d) improvement within 14 days either spontaneously or with anti-inflammatory treatment [[1]Lecler A Obadia M Savatovsky J Picard H Charbonneau F Menjot de Champfleur N et al.TIPIC syndrome: beyond the myth of carotidynia, a new distinct unclassified entity.Am J Neuroradiol. 2017; 38: 1391-1398Crossref PubMed Scopus (41) Google Scholar]. The pathogenesis of the TIPIC syndrome remains unclear, cardiovascular, inflammatory or autoimmune origins are suspected [[2]Taniguchi Y. Horino T. Hashimoto K. Is carotidynia syndrome a subset of vasculitis?.J Rheumatol. 2008; 35: 1901-1902PubMed Google Scholar]. The two major differential diagnosis for carotid involvement are carotid dissection and vasculitis, notably Takayasu's arteritis or giant cell arteritis. Only one study reported a histologically evaluation and found proliferation of small blood vessels, low-grade of lymphocytic infiltration and early fibrosis. These histological finding were not specific but were different from the histological aspect of abscess wall, granulation tissue or vasculitis like giant cells arteritis [[3]Upton P.D. Smith J.G. Charnock D.R. Histologic confirmation of carotidynia.Otolaryngol Head Neck Surg. 2003; 129: 443-444Crossref PubMed Scopus (54) Google Scholar]. Our patient did not receive any treatment and he recovered in seven days. TIPIC syndrome is a rare but not serious condition, which usually improves spontaneously. However, it is important to recognize in order to avoid over-medicalization.

The Use of Beta-Blockers in Hereditary Hemorrhagic Telangiectasia-Related Epistaxis: A Systematic Review.

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease affecting 1 in 5000 individuals. Epistaxis is seen in more than 90% of patients with HHT. Severe recurrent epistaxis can significantly decrease quality of life and may be resistant to standard treatment measures. Dysregulation of angiogenesis has been shown to cause the proliferation of abnormal blood vessels. As such, antiangiogenic treatments have been investigated including beta-blockers. A systematic review of the efficacy of beta-blockers in topical treatment of epistaxis in patients with HHT based on epistaxis duration, frequency, and severity. A systematic search was performed using the PubMed, Embase via Ovid, and Cochrane databases. The Preferred Items for Systematic Reviews and Meta-Analyses guidelines were followed. Studies that measured the efficacy of beta-blocker treatment of epistaxis in patients with HHT were included for qualitative analysis. Five studies (3 randomized controlled trials and 2 case series) with a total of 132 patients were included. Administration (systemically or topically via a spray or gel) of timolol and propranolol showed mixed evidence of improvement in epistaxis frequency, severity, and duration when compared with control groups. The evidence for propranolol appears more promising than timolol. There are significant limitations in the included studies, and further investigation with larger longitudinal or randomized prospective trials is recommended. The available evidence suggests that beta-blocker treatment may have a positive effect on HHT-related epistaxis.

Profuse haematochezia related to Crohn’s disease: a rare case report

Background: Lower gastrointestinal bleeding (LGIB) can be caused by irritable bowel disease. Haematochezia is one of the LGIB symptoms. Profuse haematochezia is a rare complication in Crohn’s disease. Case Presentation: We reported a 24-year-old patient with profuse haematochezia with severe anaemia and hypovolemic shock. Anamnesis, physical examination and colonoscopy showed that haematochezia was caused by Crohn’s disease. Colonoscopy was done after the patient was hemodynamically stable with findings of external haemorrhoid and multiple ulcers with varying size (0.5–2 cm) on ascending colon, caecum and terminal ileum. The tissue histopathology of ileocecal junction indicated intestinal epithelia with partially eroded, crypts infiltrated by inflammatory cells, swollen lamina propria with proliferation and dilation of blood vessels indicting the Crohn’s disease. The patient then treated with Crohn’s disease medical therapy including low dose oral steroid, sulfasalazine and antibiotics. Clinical improvement was found on one week follow-up after discharge from hospital. Conclusion: Profuse haematochezia could be associated with Crohn’s disease and the comprehensive approaches should be taken to manage the Crohn’s disease with such presentation.

Cranioplasty after Two Giant Intraosseous Angiolipomas of the Cranium: Case Report and Literature Review.

Angiolipomas are rare, benign tumors resulting from the proliferation of adipose tissue and blood vessels, most frequently encountered subcutaneously at the upper limbs and trunk level. Due to their rarity, few cases of intraosseous angiolipomas are presented in the literature. The paper reports a 50-year-old female case with intracranial hypertension syndrome, frontal and parietal headache, nausea, and vomiting symptoms increasing in intensity. A CT exam revealed two hypodense expansive intraosseous formations/lesions. The first one was located in the projection of the frontal bone and the second one was placed on the left parietal bone. After further investigations, a two-stage procedure was considered. A frontal craniotomy with excision of the intraosseous tumor was performed in the first stage. In the second stage, a left parietal craniotomy was done with excision of the intraosseous tumor combined with a cranioplasty procedure. The patient had a favorable postoperative evolution with no symptoms or neurological deficits. This is among the few reported cases of intraosseous angiolipoma located at the cranium level and the first case report of two intraosseous angiolipomas situated on the same site. The medical recommendation was a complete surgical excision of the lesion followed by cranioplasty.

Efficient starvation therapy with three-pathway blocking in combination with PTT/CDT for TME reversal and tumor apoptosis

Single cancer starvation therapy (ST) strategy can’t achieve satisfactory anti-tumor effect, mainly due to the diversified nutritional sources of tumor cells. Herein, CuS@Axitinib-SiO2@2-Deoxy-D-glucose(2-DG)-CaCO3-RGD nanoparticles (CADCR NPs) were prepared for three-pathway blocking for efficient starvation therapy as well as reinforced photothermal therapy (PTT) and chemodynamic therapy (CDT). After CADCR NPs were targeted to tumor cells, CaCO3 was ruptured in the acidic environment, releasing Ca2+ to chelate glutamine and cutting off the glutamine metabolic pathway of the tumor. 2-DG was also released from mesoporous SiO2 and restrained the glycolytic pathway of tumor cells. In addition, under the thermal stimulus of near-infrared irradiation, axitinib was released from CuS NPs, which inhibited the proliferation of tumor blood vessels, ultimately inhibiting the aerobic respiratory pathway of tumor cells. Interestingly, CADCR NPs also showed potential to reshape the tumor microenvironment (TME) and promoted the transformation of macrophages from M2 to M1 type, increasing the expression of CD8+ T cells in the tumor site. In conclusion, CADCR NPs achieve severe tumor starvation by simultaneously interfering with three energy metabolic pathways, and further enhance tumor treatment with the aid of PTT, CDT, and TME improvement, which exhibits great potential for clinical cancer therapy.

Multiple angiolipoma of the hand, back, and abdomen; a case report.

IntroductionAngiolipoma is a rare and benign variant of lipoma that usually occurs as single or multiple entities. The aim of this study is to present a case of multiple angiolipoma located in the hand, back, and abdomen.Case reportA 38-year-old male presented with multiple swellings in his body for a 6-year duration. Physical examination revealed 3 painless masses in the hands, back, and abdomen. Laboratory findings were normal and ultrasound (US) examination suggested multiple body lipoma. The patient was managed with total excision and histopathological examination confirmed the diagnosis of benign angiolipoma. No reoccurrence was observed upon follow-up.DiscussionAngiolipoma mainly composed of a mixture of proliferating blood vessels and mature adipose tissues, with a degree of vascularity much higher than that of a normal lipoma. It has a slow growing nature that it can be presented as single or multiple neoplasia. It is reported to be more common in the young adult population with male predominance.ConclusionAngiolipoma is a rare variant of lipoma. It rarely occurs in the hands, especially as a painless mass. Histopathology is required for definitive diagnosis.

A poly-l-lysine-bonded TEMPO-oxidized bacterial nanocellulose-based antibacterial dressing for infected wound treatment

Oxidized bacterial nanocellulose (O-BNC) is a favorable material to subdue bacterial infection because of the carboxylate content that not only has a weak antibacterial activity but also is capable of bonding electrostatically to polycationic antibacterial agents. In this study, the 2,2,6,6-Tetramethylpiperidinyloxy radical (TEMPO)-mediated oxidation of BNC was optimized to achieve high carboxylate content while retaining an acceptable tensile profile. To develop an O-BNC-based functional wound dressing, ε-poly-l-lysine (PLL) was then covalently bonded with O-BNC via 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) reaction after homogeneous distribution by ultrasonication. The antibacterial activity of the obtained wound dressing was significantly higher (p < 0.05), and no toxicity was observed. The infected full-thickness wounds of rats were healed faster (p < 0.05) covered by the dressing due to less inflammation, faster blood vessel proliferation, and epidermal layer formation. The material is an effective and promising functional dressing for the treatment of infected wounds.

Topical Polydeoxyribonucleotide Loaded in Hydrogel Formulation for Wound Healing in Diabetic Rats

Patients with diabetes mellitus experience delayed wound healing because of the uncontrolled glucose level leads to impaired cell proliferative function, poor circulation, decreased production and repair of new blood vessels. Polydeoxyribonucleotide (PDRN) is used in wound healing as a substance that stimulates tissue repair. A hydrogel is a reticular substance generally used as a dressing formulation to accelerate wound healing, and also used as a bio-applicable scaffold or vehicle. The aim of study is to investigate the effects of PDRN loaded in hydrogel on wound healing, in combination and separately, in an animal diabetic wound model.&#x0D; Methods: We studied the effects of PDRN in diabetes-related healing defect using an incisional skin-wound model produced on the back of male diabetic rats. A total of 36 wounds, were classified into 3 groups: a control group, a hydrogel-only group, a PDRN loaded in hydrogel combined-treatment group. All rats were assessed for changes in wound size and photographed on scheduled dates. The skin specimen sample of diabetic rat wound model were observed on 3, 7, 14 and 21 days after skin injury to measure tissue remodeling through histological evaluation of fibroblasts proliferation, and collagen production, also the number of blood vessels was measured in all specimens.&#x0D; Results: Differences in the decrease and change in wound size in the PDRN loaded in hydrogel group were more significant than those in the control and hydrogel single-treatment groups. Analysis of the fibroblasts proliferation, collagen production and number of blood vessels through histological examination showed a pattern of increase over time that occurred in PDRN loaded in hydrogel combined-treatment group.&#x0D; Conclusion: This experiment demonstrated improved wound healing using a PDRN loaded in hydrogel combined treatment compared to either two groups, resulting in a decrease in diabetic wound size and a shortening of the healing period

Therapeutic Effects of New Pulsed-Type Microneedling Radiofrequency for Refractory Facial Pigmentary Disorders.

Numerous treatments for pigmentary disorders have been used with variable outcomes. Recently, a new radiofrequency (RF) device with minimal pulse duration has been introduced. The aim of this study was to evaluate the efficacy and safety of a pulsed-type microneedling RF device for treatment of facial pigmentary disorders. Forty-four patients diagnosed with facial melasma or Riehl melanosis received 5 treatments with RF at 2-week intervals, and evaluation was performed at each visits, including 4 and 8 weeks after the last treatment. Treatment outcomes were evaluated by investigator global assessment, patient global assessment score, and skin biophysical parameters of erythema index, melanin index (MI), and transepidermal water loss. Gene array and immunohistochemical staining including melan-A, Fontana silver, CD44, basic fibroblast growth factor (bFGF), and periodic acid-Schiff were performed. Most of the patients showed clinical improvement. Erythema index, MI, and transepidermal water loss decreased after the first treatment. Histopathologic examination showed decrease of melanin pigment, melanophages, and blood vessel proliferation but thickened basement membrane after treatment. Expression of CD44 and b-FGF was decreased after treatment. There were no serious adverse events reported during the study. Pulsed-type microneedling RF could be a treatment option for facial pigmentary disorders.

MENINGOANGIOMATOSIS AND ANGIOMATOUS MENINGIOMA: QUIZ IN DIFFERENTIAL DIAGNOSIS. A SERIES OF CASES

Meningoangiomatosis is a rare benign lesion characterized by proliferation of blood vessels and meningothelial cells, often fusiform, which is sometimes accompanied by cortical dysplasia. Proliferation of vascular cells, pronounced cellularity and reactive gliosis may be misdiagnosed by a pathologist as invasive angiomatous meninigioma, which may lead to the postoperative radiation therapy. Immunohistochemical examination can help in the differentiation and exclusion of other diseases, such as meningioma and schwannoma. There are certain histopathological and clinical features of angiomatous meningioma, i.e. meningiomas whose vascular component exceeds 50 % of the total tumor area. Accurate differential diagnosis of meningoangiomatosis and angiomatous meningioma is important, since the correct recognition of pathology will not lead to overly aggressive postoperative treatment, as radiation therapy or chemotherapeutic treatment as in the case of meningioma.

MiRNA-21-HIF-1α-VEGF Axis Is Associated with Myopic Choroidal Neovascularization in Guinea Pigs

Introduction: Myopic choroidal neovascularization (CNV) often causes serious damage to central vision. The mechanisms behind it remain unclear. Method: In this study, monocular form deprivation was applied to induce high myopia, and 532-nm laser was employed to induce CNV in guinea pig. The development of neovascularization was measured comprehensively by fundus fluorescein angiography, optical coherence tomography and hematoxylin and eosin staining. Gene expression was detected by real-time polymerase chain reaction and immunohistochemistry. Results: The proliferation of new blood vessels increased with time and peaked at 21 days. At each time point after laser photocoagulation, the incidence of CNV was higher in form-deprived myopia (FDM) group than in control group. Myopic CNV started earlier and decreased more slowly. The obvious continuous fluorescein leakage could last as long as 1 month. The expressions of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) increased and peaked at 14 days in both groups after laser photocoagulation. Moreover, after laser photocoagulation, miR-21 expression was upregulated in both groups, reached a peak at 7 days, with a level much higher in FDM group. In addition, miR-21 expression was positively correlated with VEGF and HIF-1α expression in both groups. Conclusion: miR-21 correlated with HIF-1α-VEGF signaling pathway may promote CNV formation in high-myopia guinea.

Assessment of angiogenic potential of mesenchymal stem cells derived conditioned media from various oral sources

Abnormal angiogenesis hamper blood vessel proliferation implicated in various biological processes. This study investigates the angiogenic potential of conditioned media (CM) of mesenchymal stem cells derived from different oral sources.

Kimura's disease involving the conjunctiva

A 50-year-old female presented with gradually increasing, pink nodular lesion on the temporal bulbar conjunctiva of the left eye, noticed in the past 15 days. She denied any history of trauma or similar episodes in the past or concurrent systemic illness. The lesion did not change after a 2-weeks long topical steroid course. It was then surgically excised. Histopathological analysis revealed lymphoid follicles with proliferating blood vessels lined up by plump endothelial cells with mixed infiltrate containing numerous eosinophils. Based on these findings, diagnosis of Kimura's disease (KD) was established. KD is a rare, chronic inflammatory disorder of possible allergic or autoimmune etiology which has been rarely described in conjunctiva.

TREATMENT OF ORAL HEMANGIOMAS USING SCLEROTHERAPY: A CONSERVATIVE APPROACH- CASE REPORT.

Most of the vascular tumors in the maxillofacial region are hemangiomas. Hemangiomas are basically benign lesions of a vascular origin characterized microscopically by proliferation of blood vessels. The congenital hemangioma is often present at birth and may become more apparent throughout life. They are probably developmental rather than neoplastic in origin. They can cause esthetic and functional impairment, depending on location. Despite their benign origin and behavior, hemangiomas in the oral cavity are always of clinical importance to the dental profession and require appropriate clinical management as sometimes it is associated with complications like bleeding and ulceration. Treatment is primarily dependent on correct diagnosis of the lesion and on its anatomic location. This case report presents a case of hemangioma in the edentulous region of maxillary right molar in 47-year-old male and its treatment using sclerosing agent.

Lobular capillary hemangioma of palatal mucosa of an infant

Hemangiomas are common tumors characterized microscopically by massive proliferation of blood vessels predominantly blood capillaries. The congenital hemangioma is often present at birth and may become more apparent throughout life. They are probably developmental rather than neoplastic in origin. Although they are seen in head and neck, they are rarely reported in the oral cavity, especially those associated to palatal mucosa. This case report presents a case of a rare capillary hemangioma of palatal mucosa in a 2 months old infant.

Inflammatory myo-fibroblastic tumor of appendix: A rare clinical entity.

IntroductionInflammatory myo-fibroblastic tumor of appendix is one of the rarest clinical findings and less has been described in the literatures. So, we aimed to present the clinical case that we encountered at our institute.Presentation of a caseA 29-year-old lady presented with history of pain at the periumbilical area for one day which shifted to right iliac fossa. Clinical examination revealed tenderness and rebound at right iliac fossa with increased total leucocyte count and ultrasonography abdomen showed swollen appendix. Intraoperatively, a lump around 4 × 3 cm was evident at the tip of appendix with cut section revealing pus along with fecalith. Appendectomy was done with no spillage of the content within the peritoneal cavity. Histopathology revealed inflammatory myo-fibroblastic tumor of appendix. Patient is on regular follow up.DiscussionInflammatory myo-fibroblastic tumor of appendix is one of the rarest clinical findings that mimics malignancy. Presentation could be that of acute appendicitis and in most instances, diagnosis is made intraoperatively. Surgical removal is the mainstay of treatment with regular follow up of the patient for chances of recurrences. Histologically, edematous stroma consisting of inflammatory infiltrates composed of lymphocytes, plasma cells, eosinophils and focal formation of lymphoid follicles along with the proliferation of scattered spindle to ovoid cells with proliferating blood vessels with unremarkable over lying epithelium is evident. Myo-fibroblastic origin can be confirmed by immunostaining with smooth muscle specific vimentin and actin.ConclusionInflammatory myo-fibroblastic tumor of appendix can present with features of acute appendicitis and may mimic malignancy. Appendectomy with regular follow up is mandated if such clinical cases are encountered.

Haemangioma of the Distal Palm treated by Surgical Excision – A Case Report

Vascular anomalies are broadly classified as either vascular tumours or vascular malformations. Haemangiomas come under vascular tumours and are the fourth most common tumor of the hand and consist primarily of proliferating blood vessels within the soft tissue. The common symptoms include progressive enlargement of the lesion and throbbing pain. Haemangiomas are readily compressible, poorly defined, bluish, subcutaneous masses that distended when the venous return was obstructed and contracted when the extremity was elevated. Plain radiographs will show a soft tissue mass and the typical calcification of phleboliths may be seen. The treatment of haemangiomas is surgical excision with the ligation of the tributory vessels to decrease the chances of recurrence. Here, we report a case of a haemangioma of the hand which was surgically excised.

Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models.

Malignant pleural mesothelioma (MPM) is a highly malignant disease that develops after asbestos exposure. Although the number of MPM cases is predicted to increase, no effective standard therapies have been established. The novel radiosensitizer α-sulfoquinovosyl-acylpropanediol (SQAP) enhances the effects of γ-radiation in human lung and prostate cancer cell lines and in animal models. In this study, we explored the radiosensitizing effect of SQAP and its mechanisms in MPM. The human MPM cell lines MSTO-211H and MESO-4 were implanted subcutaneously into the backs and thoracic cavities of immunodeficient KSN/Slc mice, then 2 mg/kg SQAP was intravenously administered with or without irradiation with a total body dose of 8 Gy. In both the orthotopic and ectopic xenograft murine models, the combination of irradiation plus SQAP delayed the implanted human MSTO-211H tumor growth. The analysis of the changes in the relative tumor volume of the MSTO-211H indicated a statistically significant difference after 8 Gy total body combined with 2 mg/kg SQAP, compared to both the untreated control (P = 0.0127) and the radiation treatment alone (P = 0.0171). After the treatment in each case, immunostaining of the harvested tumors revealed decreased cell proliferation, increased apoptosis and normalization of tumor blood vessels in the SQAP- and irradiation-treated group. Furthermore, hypoxia-inducible factor (HIF) 1 mRNA and protein expression were decreased, indicating reoxygenation in this group. In conclusion, SQAP improved hypoxic conditions in tumor tissue and may elicit a radiosensitizing effect in malignant mesothelioma models.

73 Off-label use and safety of drug use in vascular anomalies

Abstract Primary Subject area Clinical Pharmacology and Toxicology Background Vascular anomalies (VA) represent a heterogeneous group of disorders associated with an abnormal development and proliferation of blood and/or lymphatic vessels displaying variable clinical presentations and severity. Infantile hemangiomas, venous, and lymphatic malformations, for example, are commonly encountered in children. Other, less frequent diagnostics include Klippel-Trenaunay syndrome and PIK-3CA-related overgrowth spectrum (PROS). Severe phenotypes can alter organ function and/or lead to pain and chronic functional impairment, and are associated with significant morbidity and mortality. Management includes surgical, interventional radiology, and pharmacologic modalities. Drugs are administered by systemic (e.g., oral, intravenous) or local (topical, intralesional) routes, or by sclerotherapy (endovascular or percutaneous venous, lymphatic, or arterial injection). Off-label drug use is common in pediatrics and in rare diseases, two characteristics applying to vascular anomalies (VA). Off-label use is associated with an increased risk of adverse drug reactions. Objectives To quantify off-label drug use in VA and assess its safety. Design/Methods A guidelines search was conducted to extract a list of drugs used in VA management. The labelling status and safety of each drug was assessed based on the product monograph, Micromedex, and the FDA data. A drug was considered to have significant safety concerns if a black box warning (the FDA’s most stringent warning dedicated to serious or life-threatening risks) or if a serious adverse drug reaction was reported in at least 1% of the patients (leading to hospitalization, congenital malformation, persistent or significant disability or incapacity, life-threatening condition, or death). Results Among 87 drugs, 13 were unlicensed and 73 off-label. Figure 1 describes the reason for considering the 73 drugs off-label. Among 74 licensed drugs, only the oral solution of propranolol hydrochloride (Hemangeol®) for the treatment of infantile hemangiomas (IH) is approved. 98.9% of the drugs are used off-label or unlicensed. Except infantile hemangioma, all other VA are exclusively treated with off-label drugs. Significant safety issues concerned 73% of the drugs and were more frequent among systemic than locally delivered drugs (Figure 2). Conclusion This first study determining the rate of off-label drug use in vascular anomalies shows that off-label drug use in VA is the rule and not the exception. Significant safety concerns are common. It is needed to carefully weigh risk and benefits for every patient when using systemic and local treatments carrying safety concerns. Patients and families should be openly informed and involved in the decision-making process.

A Rare Case of Cavernous Angiomatosis of the Uterus

Abstract Introduction/Objective Angiomatosis is a rare, non-neoplastic vascular malformation characterized by the proliferation of blood vessels which involve skin, soft tissue, and bone. Angiomatosis of the female genital tract is extremely rare with very few cases described in the English literature. Methods/Case Report We present a case of an unexpected finding of angiomatosis of the uterus and cervix in a 34- year-old nulliparous female with a history of abnormal uterine bleeding and dysmenorrhea of one year duration. Imaging studies showed an anteverted uterus measuring 9 cm × 6 cm × 5 cm with thickened irregular endometrium, blood clots within the endometrial cavity, and subserosal uterine fibroids. A subsequent endometrial curettage showed benign superficial endometrium. Hysterectomy was performed and histopathological examination revealed diffuse haphazardly arranged large vascular channels within the uterine wall and cervical stroma. A diagnosis of cavernous angiomatosis of the uterus and cervix was made. Results (if a Case Study enter NA) NA Conclusion Angiomatosis of the female genital tract is a rare vascular proliferation that tends to grow at a slow rate and cause heavy menstrual bleeding in otherwise healthy patients. Differential diagnoses of angiomatosis include other vascular tumors such as hemangiomas, lymphangioma, arteriovenous malformation and papillary endothelial hyperplasia. Clinical examination and investigations like hysteroscopy, endometrial curettage and ultrasonography may not help in accurate diagnosis. Definitive diagnosis relies heavily on histopathological examination. Treatment of symptomatic angiomatosis is purely surgical and in our case, was curative. Following treatment, recurrences can occur and appropriate surveillance is recommended. Malignant transformation have not been reported. It is important to be aware of this rare entity to make an accurate diagnosis.