Research Progress Research Articles

Application and progress of nomograms in gastric cancer

Gastric cancer, as one of the malignant tumors with a significant disease burden globally, emphasizes the importance of early diagnosis and personalized treatment for improving patient prognosis. In recent years, clinical prediction models (CPMs) have played a crucial role in predicting disease risks, assisting medical decision-making, and evaluating clinical prognosis and benefits as tools for risk–benefit assessment. Nomograms, as an important visualization form of clinical prediction models, have been increasingly applied in tumor-related research. Numerous studies have constructed multiple nomogram models by integrating clinical, pathological, laboratory, imaging data, and genetic characteristics, providing an accurate and effective tool for predicting the risk of gastric cancer, early diagnosis, treatment response assessment, and prognosis analysis. This article aims to review the current clinical applications and research progress of nomograms in gastric cancer, with the goal of providing robust references and theoretical support for clinical practice.

Review of pretreatment and analytical methods for environmental endocrine disruptors: Phthalates.

Phthalates, known as phthalate esters (PAEs), are among the most ubiquitous pervasive env7ironmental endocrine disruptors (EEDs), extensively utilized globally in various facets of modern life due to their irreplaceable role as plasticizers. The exponential production and utilization of plastic goods have substantially escalated plastic waste accumulation. Consequently, PAEs have infiltrated the environment, contaminating food and drinking water reservoirs, posing notable threats to human health. This review provides a comprehensive overview of research advancements in PAE detection and identifies key focal points from 2000 to 2022, utilizing the Web of Science Core Collection. Sample pretreatment and analytical methodologies for PAEs are examined based on bibliometric analysis findings. Pretreatment methods mainly include dispersive solid-phase extraction (DSPE), magnetic solid-phase extraction (MSPE), molecularly imprinted solid-phase extraction (MISPE) and solid-phase microextraction (SPME). Laboratory analytical methods such as gas chromatography (GC), liquid chromatograph (LC) and immunoassay have been described. Additionally, a discussion on the advantages and challenges of rapid on-site detection methods, in comparison to traditional approaches, is presented in alignment with the evolving demands of PAEs detection. Based on the current research progress, future studies can focus on the demand of rapid detection of PAEs.

Single-Cell RNA-Sequencing Analysis Provides Insights into IgA Nephropathy

IgA nephropathy (IgAN) is currently the most common primary glomerular disease worldwide, and early diagnosis and intervention contribute significantly to improving outcomes and reducing the incidence of renal failure. The pathogenesis of IgAN remains incompletely understood. In recent years, the rapid development of single-cell RNA-sequencing (scRNA-seq) technology has provided the high-resolution and rich data necessary to elucidate disease characteristics and enabled the analysis of complex interactions between individual cells and cell types. The application of scRNA-seq in IgAN successfully revealed the landscape of immunological features, including peripheral blood B-cell and Th-cell activation, cytotoxic T-cell depletion, and renal infiltrating cell subtypes, as well as the crucial role of mesangial cells and endothelial cells in the early stage of kidney injury, and also revealed the extensive intercellular interactions between renal cells. Here, we discuss the research progress of scRNA-seq technology in IgAN. These scRNA-seq profiles help us to understand the complex molecular mechanisms of IgAN and develop biomarkers and specific therapeutic strategies.

The role of ubiquitination and deubiquitination in cancer lipid metabolism

The ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome. Lipid metabolism plays a crucial role in cellular energy metabolism and is closely associated with the occurrence and development of cancers. Recent research indicates that cancer lipid metabolism is regulated by intracellular proteins, including ubiquitination modifications. This review will explore the role of ubiquitination in regulating cancer lipid metabolism, summarize the latest research progress, and propose potential therapeutic strategies.

Research progress in diagnosis and treatment of psychogenic pseudosyncope in children.

Psychogenic pseudosyncope is one of the primary causes of transient loss of consciousness in children and adolescents, essentially classified as a conversion disorder that significantly impacts patients' quality of life. Clinically, psychogenic pseudosyncope shares certain similarities with vasovagal syncope in terms of pre-syncope symptoms and triggers, making it sometimes difficult to differentiate and easily misdiagnosed. Therefore, placing emphasis upon the characteristics of psychogenic pseudosyncope is crucial for early identification and treatment, which holds significant importance for the mental and psychological health of children and adolescents. In the present review, we aimed to address psychogenic pseudosyncope with clinical features, diagnosis, and treatment.

2D WS2 monolayer preparation method and research progress in the field of optoelectronics.

Two-dimensional Transition Metal Dichalcogenides (2D TMDs) have garnered significant attention in the field of materials science due to their remarkable electronic and optoelectronic properties, including high carrier mobility and tunable band gaps. Despite the extensive research on various TMDs, there remains a notable gap in understanding the synthesis techniques and their implications for the practical application of monolayer tungsten disulfide (WS2) in optoelectronic devices. This gap is critical, as the successful integration of WS2 into commercial technologies hinges on the development of reliable synthesis methods that ensure high quality and uniformity of the material. In this study, we present a comprehensive overview of the synthesis techniques for monolayer WS2, focusing on mechanical stripping, Atomic Layer Deposition (ALD), and Chemical Vapor Deposition (CVD). We highlight the advantages of each method, such as the uniform growth achievable with ALD at low temperatures and the capability of CVD to produce large-area, high-quality monolayers. Additionally, we summarize the performance of WS2 in various electronic and optoelectronic applications, including field-effect transistors (FETs), photodetectors, and logic devices. Our findings indicate that with ongoing advancements in film uniformity, compatibility with existing semiconductor processes, and the long-term stability of WS2-based devices, there is a promising trajectory for the transition of 2D WS2 from laboratory research to practical applications. This work not only addresses the existing gaps in the literature but also underscores the potential of WS2 to significantly impact the future of optoelectronic technologies.&#xD.

Research progress regarding endocannabinoid system involvement in pain modulation and electroacupuncture analgesia

Pain is a subjective and unpleasant sensation that significantly impacts the daily lives of individuals. Chronic pain represents one of the most challenging public health issues, and ensuring effective pain management is a fundamental right of individuals and a sacred duty of healthcare providers. Cannabis, one of the earliest recognized medicinal plants, contains cannabinoids, which are non-opioid substances that modulate nociceptive responses. Electroacupuncture (EA), characterized by its low-risk and well-tolerated nature, is pivotal in pain management. The endocannabinoid system consists of endocannabinoids, cannabinoid receptors, and enzymes involved in endocannabinoid synthesis, degradation, and transport. Recently, the role of the endocannabinoid system in pain development and EA analgesia has attracted considerable research attention. Studies have highlighted the role of the endocannabinoid system in various types of pain, including inflammatory pain, neuropathic pain, and cancer-related pain, as well as in EA analgesia. This study aims to review the mechanisms of endocannabinoid system involvement in pain modulation and EA analgesia to provide insights to inform clinical approaches to pain management. Graphical abstract: http://links.lww.com/AHM/A150.

A Comprehensive Review of Riverbank Filtration Technology for Water Treatment

Riverbank filtration (RBF) technology has been applied and investigated worldwide for water supplies due to its sustainable water quantity guarantee and reliable quality improvement. In this work, the development history, application status, research progress, and technical overview of RBF are reviewed and summarized. RBF usually uses rivers, lakes, and groundwater as raw water, with a few cases using seawater. Nitrogen removal in RBF systems primarily occurs through key geochemical processes such as adsorption, denitrification, organic nitrogen mineralization, and dissimilatory nitrate reduction to ammonium (DNRA). For the attenuation of emerging contaminants in groundwater environments, key processes such as filtration, adsorption, and biotransformation play a crucial role, and microorganisms are essential. Based on a discussion of the advantages and disadvantages, we proposed the research prospects of RBF. To further enhance the water-supply safety and security with RBF, the mechanisms of surface water and groundwater interaction, pollutant removal, and blockage; the impact of capturing surface water on the stability of river ecosystems; and the coupling and synergistic effect of RBF with other water treatment technologies should be deeply investigated.

Navigating the Sustainable Business Model: A Comprehensive Bibliometric Analysis at the Intersection of circular economy and innovation management in the Era of the Fourth Industrial Revolution

This study aims to comprehensively analyze the Intersection of the circular economy and innovation management during the fourth industrial revolution, uncovering evolving trends and influential contributors. Design/methodology: Using the Biblioshiny web app, this pioneering research conducts a bibliometric analysis to review the Circular Economy and innovation management literature, quantify scientific output, and identify mathematical advances. Findings: This study provides quantitative insights into the progress of circular economy research and innovation management toward creating sustainable business models and provides a map of evolving trends, thematic developments and influential contributors. The practical implications of these findings offer businesses and managers valuable insights and guide them through fundamental, driving, and emerging thematic trends. It also advises them to focus on motor and basic themes for strategic decision-making in designing sustainable business models. Social consequences: By fostering active engagement with evolving trends, this research contributes to the ongoing circular economy and innovation management discourse, potentially leading to social well-being, prosperity, and progress. Authenticity/value: This pioneering study is an in-depth bibliometric analysis of the Intersection of circular Economy and innovation management, which provides unique insights and quantitative assessments of scientific outputs and thematic trends and improves the orientation of innovation management toward sustainable circular rather than linear models. Therefore, it adds considerable value to the existing literature

Absolute Paleointensity Estimates from Precambrian India and the Long-Term Thermal Evolution of the Earth

Summary Despite significant progress in paleomagnetic research over the last century, the origin, evolution, and long-term behavior of the geomagnetic field remains poorly understood. One significant open question is when and how the inner core nucleated. Since geomagnetic field behavior is intrinsically linked to the thermal evolution of the core, scientists have turned to the global paleointensity record to search for proxies for inner core nucleation. From this record, two signals have been identified as possible indicators of inner core nucleation: (1) A spike in magnetic field strength between 1.5–1.0 Ga, and (2) an initially strong, but gradually decreasing field strength that resulted in a weak dynamo in the Ediacaran. Although both these hypotheses are vastly different, they do have one common challenge hindering rigorous testing: A paucity of paleointensity data. This is especially true for the Precambrian time period for which well-preserved outcrops are scarce and weathering/alteration is nearly inescapable. Despite making up almost 90% of Earth's history, data from this super eon comprises <10% of the global paleointensity database. This lack of data for most of Earth's history represents a considerable gap in our knowledge and greatly impedes our ability to understand the origin and evolution of our planet and its magnetic field. In an effort to fill in this gap, we performed paleointensity experiments on Precambrian-aged mafic dikes from India (Malani Igneous Suite and Bastar, Dharwar, and Bundelkhand cratons) with ages ranging from ∼740 Ma to ∼2.36 Ga. To monitor thermal alteration and minimize the effects of non-ideal grain sizes, the Thellier method following the IZZI protocol was used. Successful results were obtained for samples from the Bundelkhand (∼740 Ma) and Bastar (∼1.89 Ga) cratons. The Bastar results fall in a ∼40 Myr gap in the database and corroborate field trends predicted by the Monte Carlo axial dipole moment model (MCADAM), which suggests that intensity values were moderately low (2–4 × 1022 Am2) in the middle Paleoproterozoic. The Bundelkhand result suggests that the field may have been rapidly decaying in the late Tonian to early Cryogenian.

The impact of antimony on all-inorganic lead-free perovskites: progress in optical advancement and applications.

The incorporation of Sb3+ ions into all-inorganic halide lead-free perovskites bestows them with remarkable photoluminescence characteristics, including an extensive color tuning range, elevated photoluminescence quantum yield (PLQY), and reversible color transitions, which hold significant promise for applications in light-emitting diodes, anti-counterfeiting encryption technologies, and photodetectors. Sb3+ ions not only create new optical absorption channels but also can be integrated into these materials as activators or sensitizers to modulate the bandgap and band structure. This review focuses on the optical properties of Sb3+ ion-doped lead-free halide perovskites while examining potential energy transfer pathways across various doping systems. It reviews the recent research progress of Sb3+ ion-doped lead-free perovskites within different frameworks, addressing influencing factors, strategies for enhancing PL intensity, and prospective applications. Ultimately, it outlines the challenges that lie ahead and proposes viable solutions for further exploration of Sb-doped lead-free perovskites.

Exploration of the research hotspot and application rule of Tengligen in anti-digestive system tumor based on bibliometric analysis and data mining

Objective: Based on the systematic bibliometric and data mining of the literature on the anti-digestive system tumor of Tengligen, the state of research, research hotspots and medication rules in this field were explored. Methods: From January 2004 to October 2024, literature pertaining to Tengligen’s anti-digestive system tumor was obtained from the CNKI, Wanfang, and VIP databases. CiteSpace 6.3.R1 and VOSviewer 1.6.20 software were used to intuitively display the number of publications, authors, institutions, keywords and other information, and then analyzed. The medical record information of famous Chinese medicine treating digestive system tumors with prescriptions containing Tengligen was extracted, a database was established, and the association rule analysis and cluster analysis of Chinese medicine compatible with Tengligen were carried out by IBM SPSS Modeler18.0, SPSS Statistics 26.0 and other software. Results: There were 115 publications in all, and there was a growing tendency in the quantity of papers published in this area. There were 295 authors total, with 28 serving as key authors. The primary publishing institutions are Zhejiang Chinese Medicine University, the First Clinical School of Zhejiang Chinese Medicine University, and Nanjing University of Chinese Medicine. Seven core tags were obtained by keyword cluster analysis, and research focuses on the mechanism of action, extract of Tengligen, clinical efficacy, etc. A total of 41 prescriptions containing Tengligen were included, involving 125 Chinese medicines, among which Tengligen was the most associated with Fuling, Huangqi and Yiyiren, respectively. Cluster analysis showed that Tengligen, Ezhu, Yiyiren and Huangqi were the core prescriptions. Conclusion: The scientific knowledge graph directly shows the research progress and hot trends of Tengligen against digestive system tumors, analyzes the rule of its clinical application, and provides a cutting-edge perspective for new research.

Advances in the use of nanotechnology for treating gout.

Gout is a commonly occurring form of inflammatory arthritis caused by persistently elevated levels of uric acid. Its incidence rate rises with the increases of living standards and poor dietary habits, which has a considerable impact on the quality of life of the patients. Although there is a wide assortment of drugs available for the management of gout, the effectiveness and security of these drugs are limited by their poor chemical stability and insufficient targeting. Therefore, development of effective nanomedicine systems to overcome these problems and treat gout becomes a high priority. This review provides a detailed introduction research progress on developing advanced nanomedicines using polymers, hydrogel, nanocapsules, lipids, bionic vesicles, inorganic artificial organelles and electronically controlled conveyor systems carriers to improve gout therapy.

Research progress in unilateral moyamoya disease

Unilateral moyamoya disease (U-MMD) is a chronic vascular disease characterized by progressive stenosis and occlusion of the terminal end of the internal carotid artery and its main branches, resulting in the appearance of moyamoya-like blood vessels at the base of the brain. The etiology of U-MMD is unknown, it accounts for 9.7–17.8% of all moyamoya disease, and the family incidence is 5.5–13.3%. The clinical characteristics are similar to those of typical moyamoya disease, but there are some differences. U-MMD can progress to bilateral moyamoya disease with a median probability of 29.01% (ranging from 6.3 to 58.8%), and there are many risk factors that promote its development. Surgical treatment can effectively reduce the incidence of ischemic stroke and improve prognosis. However, the timing and indications for surgery require further investigation. This article reviews the latest research progress on the etiology, epidemiology, clinical and radiological characteristics, progression, treatment, and prognosis of U-MMD.

Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review).

Peptidyl‑prolyl cis‑trans isomerase NIMA-interacting 1 (Pin1) is a specific phosphorylated serine/threonine-proline cis-trans isomerase, which is involved in the regulation of a variety of physiological and pathological processes, including cell cycle progression, proliferation and apoptosis. Pin1 plays a key role in tumorigenesis and tumor development and it promotes the proliferation and metastasis of cancer cells by regulating the cell cycle, signaling pathways and the function of tumor suppressors. Upregulated expression of Pin1 is closely associated with a poor prognosis in several types of cancers. Thus, Pin1 is may have potential as a novel potential biomarker for tumor diagnosis and prognosis, as well as a promising anticancer target. The aim of the present review was to discuss the mechanism of Pin1 in tumors and recent research progress in this field.

Research progress of circRNAs in bone-related diseases

Circular RNAs (circRNAs) are non-coding RNAs that exist naturally in various eukaryotic organisms. The majority of circRNAs are produced through the splicing of exons, although there are a limited number that are generated through the circularization of introns. Studies have shown that circRNAs play an irreplaceable role in the pathogenesis, disease progression, diagnosis, and targeted therapy of motor system tumors (osteosarcoma), metabolic diseases (osteoporosis), and degenerative diseases (osteonecrosis of the femoral head, osteoarthritis, intervertebral disc degeneration). This review summarizes the advancements in circRNA detection techniques and the research progress of circRNAs in orthopedic diseases.

Trichosporon asahii: emerging challenges in pathogenesis and drug resistance.

Trichosporon asahii (T. asahii) is an opportunistic pathogenic fungus that often causes severe infections in immunosuppressed patients. Among Trichosporon species, T. asahii is the most pathogenic and lethal species. Current research faces challenges related to unknown pathogenic mechanisms, complex resistance mechanisms, insufficiently rapid and accurate diagnostic methods, and insufficient research on susceptibility to infection. These issues need to be explored in depth. This review summarizes research progress on the origin and classification of T. asahii, its virulence factors and pathogenic mechanisms, epidemiological characteristics, infection modes, diagnostic methods, drug treatment options, and drug resistance mechanisms. Traditional culture combined with molecular biology techniques, such as polymerase chain reaction and gene sequencing, has improved the accuracy and speed of detection. Treatment relies mainly on azole antifungal drugs and amphotericin B; however, patients are facing the problem of drug resistance. New techniques, such as gene knockout and gene sequencing, have identified resistance mechanisms, thus supporting the development of novel antifungal drugs. In summary, an in-depth study of T. asahii will aid in developing more effective diagnostic and therapeutic methods and improve patient prognosis.

40 years of JET operations: a unique contribution to fusion science

Abstract During its 40 years of operations, the Joint European Torus (JET) tokamak has consistently pushed the physics and engineering boundaries of fusion research, providing the scientific community with a unique testing ground for theories and innovative ideas. This paper covers a selection of remarkable contributions of JET to various fields of tokamak science, from transport and plasma heating studies to plasma-wall interaction and D-T experiments, and their impact on the fusion research progress.

T-2 Toxin Nephrotoxicity: Toxic Effects, Mechanisms, Mitigations, and Future Perspectives.

T-2 toxin is a highly toxic fungal toxin that threatens humans and animals' health. As a major detoxifying and metabolic organ, the kidney is also a target of T-2 toxin. This article reviews T-2 toxin nephrotoxicity research progress, covering renal structure and function damage, nephrotoxicity mechanisms, and detoxification methods to future research directions. T-2 toxin damages kidney structure, causing renal dysfunction. The nephrotoxicity mechanism of T-2 toxin involves multiple factors including oxidative stress, endoplasmic reticulum stress, mitophagy, inflammatory responses, and apoptosis, which are intertwined and interdependent. Current detoxification strategies mainly involve reducing T-2 toxin in feedstuff and using antioxidant substances, but both have limits. Future research should focus on renal cells sensitivity to T-2 toxin, exploring key molecules in T-2 toxin's nephrotoxicity, renal injury's impact on other organs, and better detoxification methods. This review aims to guide future research and underpin T-2 toxin-induced nephrotoxicity prevention and treatment.

Optimization of Forward Osmotic Dewatering on Resource Utilization of Microalgae: A Review

Microalgae have attracted wide attention due to their extensive application potential. Dewatering is a necessary work for the application of microalgae, especially in biofuel production, where forward osmosis (FO) research is relatively advanced but still faces technical bottlenecks hindering large-scale commercialization. Based on the current research in recent years, the research progress in the causes and control of membrane fouling, the development of membrane materials and optimization of membrane structure, and the energy saving and efficiency of the process are reviewed in this paper. We found that different species of algae have direct effects on membrane fouling. Chlorella vulgaris has a low membrane fouling trend, but the mechanisms of fouling need further investigation. The material development and structure optimization of membranes are the main research methods to reduce membrane fouling, but there are still some defects, such as complicated preparation and low water flux, which are difficult to apply on a large scale. The research progress of reducing costs by using seawater, urine, fertilizer, etc. as new draw solutions (DS) is reviewed. At present, many aspects of FO microalgae dewatering technology are still not well understood, and future research should focus on scaling up the existing technologies.