Successful Program Research Articles

Systemic factors in modern renewable energy development across national income categories

The need for a more sustainable environment with reduced carbon emissions to preserve our climate necessitates increasing the renewable mix of total electric power generation. To achieve the goals set in the Sustainable Development Goals (SDGs) of the United Nations, various stakeholders including governments, investors, end-users, etc. need to duly play their part. However, there is still a need for a greater understanding of the systemic factors at local and global levels amongst the various stakeholders to better realize this objective. Some countries are already meeting their targets while others lag. This review article presents the key systemic factors influencing the success of renewable energy programs across national income categories. It discusses systems factors, national economies, energy capacities, and social effects, and examines the impact of policy instruments and targets on renewable energy deployment. The importance of national governments’ commitment to local targets is highlighted, along with the effects of policy development, planning, technologies, supply chains, etc.

Community Based Rehabilitation in People With Lower Limb Amputation: A Systematic Review

The purpose of this paper is to identify the intervention components, key actors and models of social innovation that can contribute to the improvement of health rehabilitation services from a biopsychosocial perspective, aimed at people with lower limb amputation in a situation of disability. Likewise, it aims to analyze the ways in which Community Based Rehabilitation (CBR) facilitates the elimination of barriers in rehabilitation services and promotes a better quality of life for people with disabilities. A systematic review of scientific literature for the period 2001 to 2019 was carried out, starting with a bibliometric analysis of publications found in the Web of Science and Scopus databases; followed by content analysis with NVivo 12 software. Among the findings, it was identified that the optimization of health services for the population with disabilities in emerging countries requires investment and training. In addition, the success and deficiencies in CBR programs were analyzed, since according to the systematic review, these are limited to the care of people with lower limb amputation in contexts of armed conflict.

Assessing the success of a research leadership programme for senior nurses and midwives: A mixed methods programme evaluation.

In 2018 the National Institute of Health and Care Research, United Kingdom, launched a 3-year Senior Nurse and Midwife Research Leader Programme to support nurse and midwifery research leaders to develop research capacity and capability within NHS organisations. We report the results of a service evaluation of the programme strengths, areas for improvement and achievement of programme aims. Partially mixed, concurrent mixed methods programme evaluation, including: (a) meeting evaluation (survey), (b) annual evaluation (survey) and (c) qualitative stakeholder interviews. Survey results were quantitatively analysed using descriptive statistics. Interviews were audio-recorded, transcribed, deductively coded using elements within the logic model and analysed using the seven-stage framework analysis method. Satisfaction with the programme was high (75%). The main perceived benefit of the programme was being part of a network. Challenges included accessing learning resources, lack of opportunity to network and lack of clarity about the programme aims. Meetings were evaluated as relevant and helpful (mean 93%), thought-provoking (92%), inspiring (91%), at the appropriate level (91%) and aligned with the programme aims (90%). All meetings were ranked as highly beneficial by attendees (92%). Stakeholder feedback on the programme success reflected the importance of leadership, the programme design and content, 'connection and community' and communication with and about the cohort. Overall, the anticipated programme aims were met, evaluating well from both the perspective of those on the programme and the wider stakeholder group. There has been a lack of investment in schemes to support research leadership development for nurses/midwives. A novel programme to support nursing/midwifery research leadership was positively evaluated. The programme is a useful model to support future capacity and capability building for nurses/midwives. The work is reported with reference to the SQUIRE 2 and SRQR checklists. No patient or public contribution.

Current State, Challenges, and Opportunities of the School-Based Sexual and Reproductive Health Education in Indonesia: A Systematic Literature Review

Sexual and reproductive health education for adolescents remains crucial for Indonesia as it is home for more than 44 million teenagers as of 2022, in its way to anticipate demographic bonus in 2030. Government Regulation no. 61 of 2014 concerning Reproductive Health mandates sexual and reproductive health education in formal and informal education settings. By using a systematic literature review (SLR) method, this study assesses the current state of school-based sexual and reproductive health education in Indonesia. Findings reveal that the delivery of sexual and reproductive health education in Indonesian schools is fragmented, spread across various subjects such as Biology, Sports, Religious, Civic and Moral education classes, as well as extracurricular activities. Key stakeholders, including families, teachers, peers, and school principals, play crucial roles in shaping adolescents' understanding of reproductive health. However, challenges such as cultural taboos, easy access to potentially misleading online information, and inadequate teacher training hinder effective education. In addition, Comprehensive Sexual Education (CSE) has been suggested by WHO to be implemented and integrated in the core curriculum, with programs like SETARA pilot project showing promise in improving adolescent knowledge and attitudes towards reproductive health. However, the success of such programs requires cooperation from various stakeholders and a shift in societal norms regarding adolescent sexuality.

Radioactivity and GMO-Free Sterile Insect Technology for the Sustainable Control of the Invasive Pest Drosophila suzukii.

Drosophila suzukii (D. suzukii), commonly known as the spotted wing drosophila, is a highly invasive crop pest that is difficult to control using chemical insecticides. To address the urgent need for alternative and more sustainable control strategies, the sterile insect technique (SIT) is improved, which involves the release of sterilized male insects to mate with fertile conspecifics, thereby reducing the size of the pest population in the subsequent generation. The three critical aspects that influence the success of SIT programs in D. suzukii are addressed. First, an accurate and nondestructive method is established to determine the sex of individual insects based on the differential weight of male and female pupae. Second, conditions for X-ray sterilization are systematically tested and an optimal dose (90kV/40Gy) is identified that ensures the efficient production of sterile D. suzukii for release. Finally, the inherent thermosensitivity of D. suzukii males is exploited to develop a temperature-based sterilization technique, offering an alternative or additional SIT method for this pest. These advances will contribute to the development of a comprehensive and effective strategy for the management of D. suzukii populations, reducing their impact on agriculture and helping to safeguard crop yields.

Improving antibiotic prescribing to reduce antimicrobial resistance in UTIs: the IPAP‐UTI programme

Unchecked antimicrobial resistance is lethal and carries a high economic burden on the global economy. Primary care is central to the success of health service antibiotic stewardship programmes, as most of these infections are managed in the community. This article examines a pioneering programme that aims to reduce resistance to antibiotics commonly used to treat lower urinary tract infections.

Convex Approach to Real-Time Multiphase Trajectory Optimization for Urban Air Mobility

Electric vertical takeoff and landing technology has emerged as a promising solution to alleviate ground transportation congestion. However, the limited capacity of onboard batteries enforces hard time constraints for vehicle operations in a complex urban environment. Therefore, a constrained, real-time trajectory optimization method is necessary to enable safe and energy-efficient vehicle flight. Unfortunately, most existing trajectory optimization methods suffer from low computational efficiency, unpredictable convergence processes, and strong dependence on a good initial trajectory. In this paper, we employ a successive convex programming approach to solve the multiphase minimum-energy-cost electric vertical takeoff and landing vehicle trajectory optimization problem for urban air mobility applications. The main contribution is the development and validation of two novel convexification methods that find approximate optimal solutions to the multiphase nonlinear trajectory optimization problem in real time by solving a sequence of convex subproblems. Specifically, the first method transforms the original nonlinear problem into a sequence of second-order cone programming problems through a convenient change of variables and lossless convexification, while the second approach achieves a similar goal without the need for control convexification. The resulting convex subproblems can be solved reliably in real time by advanced interior point methods. The proposed methods are demonstrated through numerical simulations of two different urban air mobility scenarios and compared with the solution obtained from GPOPS-II, a state-of-the-art general-purpose optimal control solver. Our proposed sequential convex programming methods can obtain near-optimal solutions with faster computational speed than GPOPS-II.

Health System Responses to Address Treatment Gaps of Unsuppressed Adolescents on HIV Treatment in Public Primary Health Care Facilities in Windhoek, Namibia.

Adolescents living with HIV (ALHIV) face unique challenges that result in persistent gaps in achieving and maintaining suppressed viral load. Although effective evidence-based interventions to address treatment gaps in adolescents are readily available, health systems in resource-constrained, high HIV prevalence settings are challenged to implement them to achieve epidemic control. Here, we describe the health system responses to address the treatment gap of unsuppressed ALHIV on antiretroviral therapy in Windhoek, Namibia. We conducted a qualitative descriptive and exploratory study in Windhoek between June and October 2023. Nineteen purposively selected key informants, ranging from pediatric HIV program managers to healthcare providers, were interviewed. In-depth interviews were audio-recorded and transcribed verbatim. The transcripts were uploaded to ATLAS.ti and subjected to thematic analysis. The four main themes elucidated challenges related to adherence and retention as well as health system responses in the form of interventions and support programs. The predominant adherence and retention challenges faced by ALHIV were mental health issues, behavioral and medication-related challenges, and inadequate care and social support. The health system responses to the identified challenges included providing psychosocial support, peer support, optimization of treatment and care, and the utilization of effective service delivery models. Key health system support elements identified included adequately capacitated human resources, efficient medication supply chain systems, creating and maintaining an enabling environment for optimum care, and robust monitoring systems as essential to program success. The health system responses to address the remaining treatment gaps of unsuppressed ALHIV in Windhoek are quite varied and, although evidence-based, appear to be siloed. We recommend harmonized, multifaceted guidance, integrating psychosocial, treatment, care, and peer-led support, and strengthening client-centred differentiated service delivery models for unsuppressed adolescents.

Healthcare workers’ perspectives on a prescription phone program to meet the health equity needs of patients in the emergency department: a qualitative study

ObjectivesPeople experiencing homelessness and marginalization face considerable barriers to accessing healthcare services. Increased reliance on technology within healthcare has exacerbated these inequities. We evaluated a hospital-based prescription phone program aimed to reduce digital health inequities and improve access to services among marginalized patients in Emergency Departments. We examined the perceived outcomes of the program and the contextual barriers and facilitators affecting outcomes.MethodsWe conducted a constructivist qualitative program evaluation at two urban, academic hospitals in Toronto, Ontario. We interviewed 12 healthcare workers about their perspectives on program implementation and outcomes and analyzed the interview data using reflexive thematic analysis.ResultsOur analyses generated five interrelated program outcomes: building trust with patients, facilitating independence in healthcare, bridging sectors of care, enabling equitable care for marginalized populations, and mitigating moral distress among healthcare workers. Participants expressed that phone provision is critical for adequately serving patients who face barriers to accessing health and social services, and for supporting healthcare workers who often lack resources to adequately serve these patients. We identified key contextual enablers and challenges that may influence program outcomes and future implementation efforts.ConclusionsOur findings suggest that providing phones to marginalized patient populations may address digital and social health inequities; however, building trusting relationships with patients, understanding the unique needs of these populations, and operating within a biopsychosocial model of health are key to program success.

Study to Determine the Barriers in the Implementation of the National Program for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases, and Stroke in Satara District, Maharashtra: A Stakeholder’s Perspective

Abstract Background: The Government of India started the National Program for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases, and Stroke (NPCDCS) in 2009, which was implemented in Satara district since 2014. To identify gaps and difficulties in the implementation of this program, the present study was planned with the following objective. Objectives: The objective of this study was to determine the barriers in the implementation of the NPCDCS program from a stakeholder’s perspective. Methodology: This facility-based cross-sectional study was conducted in different health facilities (30), and 96 staff working for the NPCDCS program were interviewed using a pretested and semi-structured questionnaire. Informed consent was drawn from stakeholders. The study was approved by the Institutional Ethics Committee. Statistical analysis was carried out using the SPSS version 20. Results: While 96 responders were interviewed, with a mean age of 36.55 years, 82.3% were women among them. The majority of them were working as ASHA (39.6%). Among them 73 (76.0%) had more than 3 years of program experience; however, most of them had contractual jobs, 64 (87.7%). Among perceived barriers satisfaction with the number of staff provided for the program, 60 (62.5%), satisfaction with the training of human resources, 47 (41.7%), and supply of medicine to facility, 38 (39.6%), were predominant. Conclusion: For effective implementation of NPCDCS, focusing on the supply of good-quality medicine in ample quantity is a must; lack of which will definitely push the beneficiaries away. Providing repetitive essential training to the program health workers will improve program staff performance. Increasing the number of staff provided for the program will help stakeholders to give more time toward this program, particularly to improve service delivery and ensure program success.

Robotic-assisted coronary artery bypass grafting: how I teach it.

The first robotic cardiac operation was performed more than two decades ago. This paper describes the distinct steps and components necessary for teaching robotic-assisted minimally invasive direct coronary artery bypass (R-MIDCAB). It also provides a general overview of the surgical robotic setup and ways to troubleshoot potential complications. The focus of robotic training is not only on the surgeon but includes an entire dedicated cardiac team and administrative institutional support. This team approach ensures that R-MIDCAB can be performed safely and reproducibly. Meticulous planning, incremental learning, and teamwork are the main factors leading to program success and optimal patient outcomes. Robotic-assisted internal mammary artery (IMA) harvesting and coronary revascularization via a small, anterior mini-thoracotomy has provided an alternative to sternotomy in selected patients with coronary artery disease (CAD). Benefits include less postoperative atrial fibrillation, fewer blood transfusion, less time in the operating room (OR), less ventilatory support, fewer strokes, decreased intensive care unit stay and shortened postoperative length of stay all of which manifests as a decrease in institutional resource utilization. Recent data show that R-MIDCAB and hybrid coronary revascularization provides good long-term outcomes. In addition to patient satisfaction, there is an additional overall cost benefit to R-MIDCAB over traditional sternotomy coronary artery bypass grafting (CABG), secondary to decreased hospital length of stay. Robotically harvesting the IMA, operating on a beating heart, and performing anastomoses through a small incision all require advanced training and incremental learning. Increased experience generally leads to shortened surgical times and fewer complications.

Development of an integrated and differentiated tahfidz teaching module to improve Quran memorization for students at MI Plus Al-Fatimah Sukorejo Bojonegoro

Teaching modules are independent curriculum frameworks that replace traditional lesson plans. The independent curriculum teaching module, which serves as a replacement for the RPP, has a diverse format that encompasses learning material/content, teaching methods, interpretation, and evaluation techniques. These modules are designed systematically and engagingly to meet the desired success indicators. The primary goal of developing teaching modules is to provide teachers with instructional tools that can guide them effectively in the teaching process. Teachers are given the autonomy to choose or modify the provided modules by the government to better match their students' characteristics or to create their own modules tailored to their students' needs. The developed teaching modules include integrated modules for tahfidz subjects at Madrasah Ibtidaiyah Plus Al-Fatimah, differentiated modules for tahfidz subjects at Madrasah Ibtidaiyah, guidelines for developing tahfidz teaching modules, instruments for developing these modules, and evaluation tools for assessing the module development process. This research and development (R&D) approach aims to create integrated and differentiated tahfidz teaching modules specifically for MI Plus Al-Fatimah. These modules cover the tahfidz teaching program, implementation guides, and evaluation instruments to assess the program's success. The development process involves the principal to ensure that students can achieve the target of memorizing four juz within six years at the madrasah ibtidaiyah level. The development stages include determining learning strategies and media, producing the modules, and creating assessment tools. This phased approach ensures that the integrated and differentiated tahfidz teaching modules are effective and meet the educational goals of the institution.

Raising environmental awareness through community-based efforts to clean and preserve the Karang Mumus river, Samarinda City

River pollution, particularly from littering, has long plagued Samarinda City. The Karang Mumus River exemplifies this challenge, with heavy downstream debris and a lack of upstream catchment areas leading to seasonal flooding. This pollution significantly reduces the community's quality of life and hinders sustainable development efforts. To address this, a community service program was initiated to raise environmental awareness through cleaning and maintaining the Karang Mumus River. The program utilized outreach methods to educate the "Save Karang Mumus" (SKM) community about the river's functions and proper environmental practices in the surrounding area. The activity culminated in a river cleaning initiative. Notably, post-program participants expressed a willingness to actively participate in future river cleaning efforts organized by GMSS-SKM. This positive outcome demonstrates the program's success in raising awareness about the importance of protecting the Karang Mumus River environment.

Determining the Factors Influencing the Success of Sports Entertainment Programs using Big Data Analysis : Focussing on “A Clean Sweep”

PURPOSE This study aimed to identify the factors influencing the success of the sports entertainment program “A Clean Sweep” using big data analysis.METHODS Text mining, sentiment analysis, TF-IDF, connection centrality, and semantic network analysis were conducted using the social big data analysis program Textom and social network analysis program Ucinet6. The research period was limited from June 6, 2022 to November 30, 2023.RESULTS The factors determining success were entertainment programs, Monday, OTT, and independent league. The events and marketing factors were extracted, and A Clean Sweep X Kelly, A Clean Sweep X Mom love, cheering song, uniforms, and direct viewing day influenced success. The new hire factors were rookie draft, Young-Mook Hwang, Sung-Joon Won, and Hyun-Soo Jeong. Positive (such as good, fun, looking forward to, best, and funny) and negative (such as esoteric, regrettable, shocking, dislike, and uncomfortable) emotional factors were also extracted. The extracted star marketing factors were directors (Seung-Yup Lee, Sung-Geun Kim) and players (Dae-Ho Lee, Geun-Woo Jung, Hee-Kwan Yoo, Moon-Ho Kim, Yong-Taek Park, Taek-Geun Lee).CONCLUSIONS We were able to identify the success factors of “A Clean Sweep”, which we hope will contribute to the revitalization of professional baseball as well as sports entertainment programs.

Can High Involvement of Roma Parents Combat the Impact of Poverty? Resilience and Parental Involvement in the Success of Roma Students at School from the Students’ Perspective

RESEARCH OBJECTIVE: A recurring question in Romani studies is why it is difficult to achieve breakthrough successes in inclusion programs. These programs focus mainly on school subjects, although the role of parents is crucial to solving the problem. This study, therefore, concerns parents and their roles in school success. THE RESEARCH PROBLEM AND METHODS: The purpose of this study is 1) to reveal how Roma and non‑Roma pupils perceive their parents’ involvement (PI) and 2) to come closer to explaining how PI affects students’ school success under the control of other variables. The analysis sheds light on the views of children of Roma and non‑Roma parents in Hungary. Cross‑tabulation analysis and linear regression analysis were applied. THE PROCESS OF ARGUMENTATION: The database called Discovery of Hidden Value of Mentoring (DHVM) was analysed, which includes data from 13–14‑year‑old students (N = 206; 31.1% Roma, 68.9% non‑Roma). RESEARCH RESULTS: For all school‑based and home‑based PI indicators apart from one (parent–teacher conferences), Roma and non‑Roma parents showed the same results. A student’s disadvantaged financial situation most strongly determined their level of school success, overriding the compensatory effect of PI. The variance explained by the regression model was 30.4%, and the model was significant (F(7) 5.18, p < 0.001). CONCLUSIONS, RECOMMENDATIONS, AND APPLICABLE VALUE OF RESEARCH: Although financial disadvantage overrides the compensatory effect of PI on school careers and political entities need much action to improve people’s financial situation, schools and families cannot look only to the outside for solutions. The most significant finding of the research is that there is a hidden resource to improve the school success of Roma pupils, namely PI. Based on the results, the schools are recommended to conduct the partner cooperation with parents, because together they can increase the children’s future opportunities and resilience.

Aktivitas harian lumba-lumba hidung botol Indo-Pasifik (Tursiops aduncus) rehabilitasi di Umah Lumba, Teluk Banyuwedang, Bali

Study on the daily activities of confiscated animals prior to be released is very important for the success of an animal release program. This research focuses on confiscated bottlenose dolphins Tursiops aduncus which were rehabilitated in Umah Lumba, Banyuwedang Bay, Pejarakan Village, Gerokgak District, Buleleng, Bali, and aims to determine the daily activities of bottlenose dolphins in Umah Lumba prior to be released in North Bali waters. Observations of daily activities was carried out by using the focal animal sampling method with instantaneous recording on three individual bottlenose dolphins in Umah Lumba. This study showed that there were several activities that support life in the wild, namely the absence of tail clapping activity, as well as the locomotion and breathing activities increased optimally. Likewise, it was also recorded the activities that indicated the optimal condition of their physiological state, such as a minimal sneezing activity and recorded jumping activity as one of the foraging strategies carried out by dolphins in their natural habitat. Those activities are improvements towards optimal conditions ahead of release from the observation conducted at the beginning of the rehabilitation period.

Perceptions and outcomes of a nationwide remote pharmacy mentorship program

AbstractIntroductionMentorship is crucial for professional development in health care. However, the outcomes of national remote mentorship programs in pharmacy remain largely unexplored. This study evaluates the perceptions and experiences of student pharmacists, residents, fellows, and nontrainee pharmacists in such a program.ObjectivesThis study aimed to assess the perceptions and outcomes of a nationwide remote pharmacy mentorship program designed for student pharmacists, residents, and fellows. It explores the efficacy, benefits, and barriers within a national pharmacy professional organization mentorship program.MethodsThe mentor and mentee experiences in the American College of Clinical Pharmacy (ACCP) Ambulatory Care Practice and Research Network (PRN) from program years 2019–2022 were assessed using an anonymous online survey, employing a mixed‐methods approach. The survey featured quantitative Likert scale and qualitative free‐response questions. In addition, publicly available online sources provided data for postprogram placement outcomes of learner participants in the program. Summary statistics were computed from the quantitative data, and content analysis was applied to the qualitative data.ResultsOf the 356 invited program participants, 48 mentors (32.7%) and 18 mentees (8.6%) responded to the survey. Most respondents agreed or strongly agreed on the program's effectiveness, contributing to a high postprogram placement rate in residencies and ambulatory care positions, emphasizing the program's success in supporting career progression. Respondents recognized significant benefits like career development and professional satisfaction. Notable demographic disparities, especially in age, gender, and race, were observed among participants. The study also identified logistical challenges that impeded the program's full potential.ConclusionDespite limitations, including a low number of responses, the study revealed that remote mentorship may positively affect professional development and well‐being. The data supports the program‐impacted respondent involvement and professional growth. Moreover, these findings suggest the need for further research to address the program barriers and disparities in participation.

The Role of Social Capital and Technology Adaptation: A Performance Study of Water Supply and Sanitation Managers

This research aims to describe the role of social capital, technology adaptation, and the performance of group administrators at Kpspams in East Java Province. The location of this research was 170 Kpspams throughout the East Java region with reasonable functioning classifications. Kpspams in the East Java region was chosen as the research location because East Java is the province with the highest Kpspams functional status nationally. The time required to collect data is approximately 2 (two) months. The population in this study were Kpspams administrators throughout the East Java region who had an excellent functioning classification totaling 1016. The sampling technique used a probability sampling technique, a proportional random sampling method based on the same proportion for each group, so the sample determined in this study was 170 Kpspams members—East Java region. The research results show that the social capital variable was not able to significantly increase the value of each indicator of the management performance variable but technology adaptation has a significant positive effect on management performance as a consideration in improving management performance and sustainability of Kpspams in East Java Province. The contribution of this research is expected to be an input to overcome a problem that is being faced, especially in the aspect of program success at Kpspams in East Java Province and its development. The advice that can be given in this research is the development of several previous studies with distinctive characteristics not found in previous research, namely giving rise to a new dimension in the form of technological adaptation as a variable in the Kpspams research object.

Genetic-epigenetic aspects of infertility in women with long-COVID-19

The aim of the study is to determine the genetic and epigenetic features of infertile patients with long-term COVID-19 in order to clarify the risk factors for the failure of assisted reproductive technologies (ART) use. Materials and methods. The MTHFR (C677T, A1298С), RFC-1 (G80A) and BHMT (G742A) gene polymorphisms and the methylation of ESR1 gene was performed. 40 patients (main group) with infertility due to long-term COVID-19 were examined: the subgroup 1 - 25 women in whom the use of ART was ineffective, the subgroup 2 - 15 patients with effective use of ART. The control was taken from literary sources: for RFC (G80A), MTHFR (C677T) and MTHFR (A1298C) polymorphisms - 35 Ukrainian women without infertility and reproductive losses; for BHMT (G742A) - 60 people of the Ukrainian population. The methods of variational statistics were used, in particular the Fisher test with a significance level of p<0.05. Results. Patients of the main group have a higher frequency of the homozygous genotype of the MTHFR gene polymorphism (C677T) on the mutant T allele (20.0% vs. 3.2%; p<0.05). When ART is unsuccessful, the TT genotype is 4 times greater (28.0% vs. 6.7%; p<0.05). A study by genotypes of MTHFR polymorphism (A1298C) did not reveal a significant difference. Patients of the main group `have a higher frequency of the mutant allele A of the RFC gene (G80A) (80.0% vs. 51.4%; p<0.05). No significant difference was found depending on the success rate of ART. The frequency of BHMT gene polymorphism (G742A) in the main group did not differ from that in the Ukrainian population, however, in the case of unsuccessful ART, it was observed less often and only in the heterozygous variant (40.0% vs. 66.6%; p<0.05). The analysis of pairwise intergenic interaction revealed the highest frequency of the combination of AAGA for the MTHFR (A1298C)+BHMT (G742A) pair - 35.0% and GAAA for the RFC (G80A)+MTHFR (A1298C) pair - 30.0% in the main group. Hypermethylation of the promoter region of the ESR1 gene is observed in 20 (50.0%) patients of the main group: in 17 (68.0%) women of the subgroup 1 versus 3 (20.0%) women of the subgroup 2 (p<0.05). Conclusions. The genetic and epigenetic conditioning of the success of ART programs in infertility associated with long-term COVID-19 has been revealed, which opens up new diagnostic and therapeutic opportunities for identifying factors predisposing to unsuccessful ART treatment and increasing the effectiveness of such treatment by correcting disorders of folic acid metabolism, hyperhomocysteinemia and the estrogens receptor apparatus. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the women was obtained for the research. The authors declare no conflict of interest.

Amyloid-related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid-modifying therapy.

Amyloid-related imaging abnormalities, were originally described by dementia care experts. The wider use of aducanumab and now lecanemab warrant broader understanding by the health care provider continuum. The optimal care approach for patients with Alzheimer's dementia, treated with amyloid-targeted therapy, includes proper clinical diagnosis, complication surveillance, specific imaging protocols, expert specialty consultation, integrated treatment strategies, and proper facility system planning. Improved awareness and understanding of amyloid-modifying therapy, both benefits and potential complications, among the health care provider continuum is paramount to the success of complex care programs. Specifically, recognition of treatment high risk, high benefit groups, and the interface of concurrent antiplatelet and anticoagulation. This integrated acute, specialty, and primary care approach should improve patient care quality and outcome.