Profile Of Breast Disease Research Articles

Profile of Breast Diseases in Eastern Nepal

Background & Objectives: Breast problems, benign or malignant are common in occurrence worldwide. Breast problems can present themselves in a number of ways like breast pain, nipple discharge, cystic lesions and more commonly a lump. Breast diseases are under reported and cancer is one of the leading causes of mortality in women. This prospective study was undertaken with an aim to study the profile of various breast diseases in eastern Nepal.Materials & Methods: This is a prospective study of women with breast diseases conducted from March 2011 to February 2012. Inclusion criteria were women irrespective of age with breast diseases with or without complaints. Exclusion criteria were women having breast abscess and mammary fistula.Results: Out of 125 breast diseases 39 cases (31%) had malignancy and 86 cases (69%) had BBD. The overall mean age for BBD was 25.9 years, with range of 10-60 years. The mean age for malignant breast diseases was 45.6 years, with range of 28-67 years. All of the cases had breast lump as their presenting complaints whether they came out benign or malignant. 52.8% had no significant pain associated with lump; in malignant cases 35.8% had pain associated with lump. In benign cases 68.7% had no perceptible change in lump size. On ultrasound scan, 69% of the lesions were designated benign compared to 31% malignant features. FNAC resulted in 68% lesions to be classified as of benign nature and 32% as malignant /suspicious malignancy.Conclusion: BBD constituted 69% of breast diseases, and mostly fibroadenoma and FCC/FCD and commonest malignant lesion was infiltrating ductal carcinoma. The BBD peaked at the age of 21-30 years.

Profile of Breast Diseases in Post Pubertal Women Assessed By Clinical Breast Examination - A Community Based Study in Rural Pondicherry.

Breast diseases in women, whether benign or malignant, are very commonly encountered. Benign diseases are under reported and cancer is one of the leading causes of mortality in women. This study was undertaken with an aim to study the profile of various breast disease in the community. In this observational study all the post pubertal women residing in the selected village (n=1000) were included. The study was done from September 2013 to August 2015. A thorough history taking was done with the help of a predesigned proforma followed by a clinical breast examination and further investigation at our hospital if necessary. It was found in this study that mastalgia, both cyclical and non-cyclical as well as lumps were a common finding in the general population. Significant proportions of women were found to be in the peri-menopausal age group. Median age of menarche was 13 years; menopause was 45 years. The average age at first childbirth was 21 years with 1 year being the median duration of breast-feeding. A total of 128 women (1 in 8) had positive symptomatology with 94 (1 in 11) of them having a breast disease on examination. One was diagnosed with breast cancer. The prevalence of cyclical mastalgia was 1 in 11, non-cyclical mastalgia 1 in 34, fibroadenosis 1 in 23 and fibroadenoma 1 in 100. The awareness regarding risk factors and the availability of screening program was very poor. The average age of presentation of mastalgia was 34 years; fibroadenosis was 35 years and fibroadenoma 29 years. None of the women interacted with or had consulted a practitioner regarding mastalgia as it was not perceived to be a sign of malignancy and did not cause any significant discomfort. It was thus concluded from this study that benign breast diseases are a common occurrence in the general population. Breast cancer continues to be diagnosed only at later stages owing to lack of awareness and inadequately structured screening program. The concept of self-breast examination seems to be poorly understood. CBE is more fruitful with subsequent radiological and histopathological investigation, if warranted.

Clinicohistopathological evaluation of breast masses and profile of breast diseases in Eritrea: a case of poor concordance between clinical and histological diagnos

Background: Profile of breast disease varies with sex and age with predominance of cancers in older females. For patients presenting with breast masses, triple assessment using clinical, radiological and histological methods is desirable, with the latter considered to be the golden standard. Little information is available on the features of breast diseases in Eritrea. Objective of the study: To investigate the profiles of breast diseases, and to determine the concordance between clinical and histological diagnoses so as to develop evidence based policies and cost effective management guidelines for the disease Methods: This was a retrospective study of 89 patients presenting with clinical diagnosis of breast masses from 1st January 2006 to 31st December 2006. Biopsies taken from the patients were histologically examined and reported by one pathologist from the National Health Laboratory of the Ministry of Health, Asmara, Eritrea. Results: The majority of cases were women (96.6%). The age at presentation ranged from 16 to 86 years. About half of the sample 43 (49.4%) had clinical diagnosis of breast cancer. The study found that, the concordance rates between clinical diagnosis and histological diagnosis were lower for carcinoma and benign lesions 46.5% and 80% respectively. Three quarters of the fibroadenomas were found in women younger than 36 years. Conclusion: Benign breast lesions and carcinomas were common in females, with the former being more prevalent in women less than 36 years and the latter in women older than 50 years of age respectively, which is consistent with other reports. Because of relatively low concordance between clinical and histological diagnosis, findings from this report recommend that all patients with breast masses undergo biopsy and histological examination.

Profile of breast disease in patients with mastalgia audit of breast clinic in Mosul

Objective: In the medical encyclopedia ;Mastodynia, mastalgia or mammalgia are names for a medical symptom that means - pain in the breast .This common problem seen in the west, finds little mention in our country and our literature. The purpose of this study is to report the pattern of various breast diseases amongst women presenting with mastalgia (breast pain) in Mosul breast clinic emphasizing their assessment and hoping to initiate further studies on their natural profile. Patients and methods: A retrospective study of 682 female patients with mastalgia. From the Breast Clinic in Al Jamhoory Teaching Hospital in Mosul between Aug 2002 - March 2004. Records of six hundred eighty two patients with breast pain with or without lumpiness utilizing Cardiff daily breast pain chart filled by the patients were reviewed. Their mean age was about 38 years. All patients were examined clinically and by ultrasound (probe7.5MHz). Mammography and histopathological examination were done to those with equivocal and suspicious clinical and ultrasonographic results.Results: Cyclical breast pain was reported in 422 patients (62%), normal breast nodularity in 154 (22%), inflammatory lesions in 40 (6%), benign breast pathology in 56 (8%), benign tumours in 6(less than 1%) and malignant tumours in 4 (less than 1%).Conclusions: Breast pain is a common problem in the breast clinic. This study showed that cyclical breast pain and nodularity represent the commonest conditions followed by benign and inflammatory lesions. Breast pain needs to be evaluated as with many other medical problems, by good history (including breast pain chart) and examination. This to be followed by imaging (as the age implies) and histopathological assessments. Surgeons evaluating breast pain should have more rational criteria in using further sophisticated, expensive and invasive tests. Key words: breast; mastalgia; profile.

Does hormone replacement therapy increase the frequency of breast atypical hyperplasia in postmenopausal women? Results from the Bouches du Rhone district screening campaign

It is thought that the risk of atypical hyperplasia (AH) increases with age, particularly among postmenopausal women. Three hypotheses were investigated to try to explain this phenomena: use of hormone replacement therapy (HRT), increased breast cancer screening and improvements in radiological quality. Data were collected from the Bouches du Rhône breast cancer screening programme database and from the pathological registry of all women operated on for breast diseases in the district. The AH incidence rate was studied using a Poisson regression analysis. The change in the profile of breast diseases was explored through studying changes in the proportion of AH among benign lesions and malignant diseases. The AH incidence rate significantly increased over time (13.6% per year). The proportion of AH among the benign diseases increased with time and was significantly higher for HRT users (Odds Ratio (OR)=2.05; 95% Confidence Interval (CI): 1.43–2.93). While AH decreased with age among HRT non-users, it increased among users as a proportion of both benign and malignant lesions. The AH incidence rate significantly increased among pre- and postmenopausal women. Our study suggests that this increase is partly explained by the incidental discovery of these lesions by mammography and partly by a real increase of the disease among HRT users.