Specialist resident education is a level of professional development to improve the professional qualifications of specialist doctors, which is a tough and stressful process. Medical personnel who treat patients exposed to COVID-19 experience burnout. This study was to determine the risk of burnout in anesthesiology residents and intensive care as a frontline during the COVID-19 pandemic era. The research design was an observational analytic study that was cross-sectional towards residents who served in the Special Isolation Room of Dr. Soetomo Surabaya. The sample in this study used total sampling and obtained 35 respondents. The statistical test used multiple linear regression. Each research subject was given an online Maslach Burnout Inventory (MBI) questionnaire assessment of the Maslach Burnout Inventory (MBI) questionnaire given before serving in the Special Isolation Room (Pre-RIK), post-assignment (Post-RIK) in the Special Isolation Room and post Self Isolation (Post-ISOMAN). Burnout study in resident Anesthesiology and Intensive Care at Dr. Soetomo in the prevention of COVID-19 in Pre-RIK showed that 3 people had a burnout of 9.37% and 32 people had no burnout at 90.63%. At Post-RIK there were 3 burnouts (9.37%) and 32 people (90.63%) without burnout. In Post-ISOMAN there was 1 burnout (2.85%) and without burnout of 34 people (97.15%). In the study, it was found that resident receipts in 2019 experienced more burnout, compared to resident at the end of the year.