Integrated vermicompost and blended NPSB inorganic fertilizer are needed to improve the soil's fertility status, which can raise output and revenue. Thus, the purpose of the experiment was to ascertain how major physicochemical properties of the soil at Bako were affected by the application of blended NPSB fertilizer and vermicompost. Factorial combinations of four levels of vermicompost (0, 2, 4 and 6 tons ha<sup>-1</sup>) and four levels of NPSB blended inorganic fertilizer (0, 50, 100 and 150 kg ha<sup>-1</sup>) were laid out in Randomized Complete Block Design (RCBD) with three replications. The interaction of vermicompost and NPSB blended inorganic fertilizer had significant effects on ear diameter, grain yields, and harvest index and cob weight. The maximum grain yield (7503.7 kg ha<sup>-1</sup>) was obtained from application of blended NPSB fertilizer at the rate of 100 kg NPSB ha<sup>-1</sup> and 4 tons ha<sup>-1</sup> vermicompost rate with a net profit of 104850 birr and 6143% MRR with values to cost ratio of 3.47 birr profit per unit investment for midland maize production at Bako. Therefore, it can be said that the application of 100 kg NPSB ha<sup>-1</sup> and 4 t vermicompost ha<sup>-1</sup> was shown to be superior in terms of both grain yield and economic advantage, and it is therefore tentatively advised for use. To come to a definitive decision, the experiment needs to be repeated across a number of years, as this study was only conducted during one season at one site.