The solubility of zinc-chloride (ZnCl2) in different concentrations of hydrochloric acid have been experimentally studied. Solubility for anhydrous ZnCl2 was found to be the highest in 3–6 M hydrochloric acid solution. Elevating the temperature of the solvent further increased solubility albeit with diminishing returns above 50 °C when the evaporation of hydrochloric acid increases. The best solubility was found to be 26.1 ± 1.17 M in 6 M hydrochloric acid at 50 °C. This information is important for further studies which will be aimed at producing and testing a liquid target for the irradiation of [68Zn]ZnCl2 solution in hydrochloric acid. The testing will involve pressure, irradiation time, acquired activity and other parameters. In the current paper we only describe the experimental results for the solubility measurements for ZnCl2 in different hydrochloric acid concentrations, 68Ga production is not carried out yet.