Following societal events involving air, such as haze and COVID-19, Chinese people’s need for air purifiers has skyrocketed. The matching degree between the appearance of air purifier and the user’s subjective preference becomes an important factor affecting the user’s purchase decision. In this paper, we utilize the portable desktop air purifier as an example of how to address customers’ perceptual needs in the air purifier’s product appearance design, based on the Kansei engineering. We established product sample space through market research and literature reading, extracted product design elements, collected perceptual image words, then used semantic difference method to measure users’ perceptual needs, and obtained key perceptual image words by factor analysis. Then partial correlation analysis is conducted on the results of the above methods to determine the translation link between design elements and perceptual image space, and a set of design methodologies for a portable desktop air purifier based on Kansei engineering was obtained. Finally, a genuine development project is used to validate the method’s practicality. The findings of this study not only aid in the design and development of air purifiers but also provide research ideas and methodologies for air purifier appearance design to fulfill the perceptual needs of consumers.