Test Processing Research Articles

Assesmen Bangunan Gedung Dengan Metode Non Destructive Test (Ndt) Dan Destructive Test (Dt)

Existing building testing is carried out for various purposes that are likely to change the quality of a structure or because the building experiences or is indicated to have errors in workmanship or differences with technical specifications. Ideally, testing is carried out (non destructive) and (destructive test). The buildings used as test locations are the Faculty of Economics UNM, Tellu Cappa Postgraduate UNM, UNM Integrated Laboratory. The observation technique is to collect standards on direct implementation in the field and processing data obtained in the field. Based on the results of observations obtained the implementation method of schimdt hammer test and core drill data processing results schimidt hammer test building Faculty of Economics UNM for all elements obtained an estimated average compressive strength value of 459.4 kg / cm2, UNM Engineering Integrated Laboratory 445.3 kg / cm2, Tellu Cappa Postgraduate UNM 342.9 kg / cm2 While the average compressive strength of core drill samples Faculty of Economics UNM 32.89 MPa, Tellu Cappa Postgraduate UNM 30.06 MPa, UNM Integrated Laboratory 32.86 MPa. In conducting the test, pay attention to the condition of the structural elements or components that will be sampled.

Biodegradable Magnesium Alloys for Personalised Temporary Implants.

The objective of this experimental work was to examine and characterise the route for obtaining demonstrative temporary biodegradable personalised implants from the Mg alloy Mg-10Zn-0.5Zr-0.8Ca (wt.%). This studied Mg alloy was obtained in its powder state using the mechanical alloying method, with shape and size characteristics suitable for ensuing 3D additive manufacturing using the SLM (selective laser melting) procedure. The SLM procedure was applied to various processing parameters. All obtained samples were characterised microstructurally (using XRD-X-ray diffraction, and SEM-scanning electron microscopy); mechanically, by applying a compression test; and, finally, from a corrosion resistance viewpoint. Using the optimal test processing parameters, a few demonstrative temporary implants of small dimensions were made via the SLM method. Our conclusion is that mechanical alloying combined with SLM processing has good potential to manage 3D additive manufacturing for personalised temporary biodegradable implants of magnesium alloys. The compression tests show results closer to those of human bones compared to other potential metallic alloys. The applied corrosion test shows result comparable with that of the commercial magnesium alloy ZK60.

Evaluation of the Adhesion between Aggregate and Asphalt Binder Based on Image Processing Techniques Considering Aggregate Characteristics.

Aggregate-asphalt adhesion plays an important role in the water stability of asphalt concrete. In various test standards of different countries, it is evaluated via the subjective judgment of testers using the boiling water test. The subjective judgment in the test method is detrimental to the accuracy of the adhesion evaluation. However, there is no quantitative evaluation method for the aggregate-asphalt adhesion in existing studies. Moreover, the effects of aggregate shape on adhesion are also not discussed and stipulated. Hence, an innovative method based on the Chinese boiling water test and image processing technique is put forward to quantificationally evaluate the aggregate-asphalt adhesion. Moreover, the effects of aggregate shapes on adhesion are also investigated via the proposed method from a view of aspect ratio and homogeneity. Results show that the peeling of the asphalt membrane on the aggregate surface is more serious as the complexity of the aggregate shape increases after the boiling water tests, while the effect degree gradually decreases. The effect of aspect ratio on the peeling status of asphalt membrane is lower than that of aggregate homogeneity.

Falling weight deflectometer dispersion curve method for pavement modulus calculation.

The falling weight deflectometer (FWD) test is a common non-destructive testing method for evaluating the structural capacity of pavements. At present, data processing of the FWD test mainly focuses on the deflection data, while paying less attention to the deflection-time history. Because a FWD is equipped with impulse loads and geophones, which allow for the generation and capture of surface wave signal propagation, it is hypothesized that Rayleigh wave dispersion theory can be applied to calculate the modulus profile along the pavement depth by analysing the dispersive properties of the deflection signal measured during FWD tests. To test this hypothesis, we develop a new methodology for the FWD test and data analysis, referred to as the FWD dispersion curve method. We first introduce the concept of the new method, followed by an illustration of the procedure and the experimental set-up. Case studies on three concrete pavement segments are then presented to evaluate the effectiveness of the FWD dispersion curve method. Modifications to the existing FWD device are further recommended for the impact loading sources and signal collection process so that the modulus of a much shallower layer, such as the concrete slab and upper asphalt layers, can be obtained. This article is part of the theme issue 'Artificial intelligence in failure analysis of transportation infrastructure and materials'.

The Effect of Online Communication on Community Satisfaction Through Online Service Quality

Satisfaction of the public using public services is determined, among other things, by online communication and the quality of online services. This study aims to examine the effect of on-line communication and on-line services on community satisfaction; and examine the effect of online communication on community satisfaction through online service quality. The research population is the community using on-line services in the period of September 2021. The total sample is 98 people whose determination is based on the Lemeshow formula. Collecting data using a Likert scale questionnaire distributed to respondents. The data analysis technique uses the path test and data processing uses the SPSS Ver 22 program. The conclusion of the study is that the increase in public satisfaction of users of public services is determined, among other things, by on-line communication and on-line services. When the intensity of online communication and the quality of online services are increased, there will be an increase in the satisfaction of the people who use public services. In addition, the quality of online services also plays a significant role as a mediating variable for the effect of online communication on public satisfaction with public services.

Heap leaching of ion adsorption rare earth ores and REEs recovery from leachate with lixiviant regeneration

In this work, semi-industrial scale heap leaching of 200 t ion adsorption rare earth ores (IRE-ore) and rare earth elements (REEs) recovery from lixivium was first conducted. Biosynthetic citrate/(Na)3Cit, a typical microbial metabolite, was chosen as the lixiviant to conduct heap leaching. Subsequently, an organic precipitation method was proposed, which used oxalic acid to effectively recover REEs and reduce the production cost by lixiviant regeneration. The results showed that the heap leaching efficiency of REEs reached 98 % with a lixiviant concentration of 50 mmol/L and a solid-liquid ratio of 1:2. The lixiviant can be regenerated during the precipitation process, with REE yields and impurity aluminum yields of 94.5 % and 7.4 %, respectively. The residual solution can then be cyclically used as a new lixiviant after simple adjustment. High-quality rare earth concentrates with a rare earth oxide (REO) content of 96 % can be finally obtained after roasting. This work provides an eco-friendly alternative for IRE-ore extraction to solve the environmental issues caused by traditional technology. The results proved feasibility and provided a foundation for in situ (bio)leaching processes in further industrial tests and production.

Damage Characteristics of Asphalt Stabilized Macadam Under Freeze-thaw Action

In order to study the freeze-thaw resistance of asphalt stabilized macadam asphalt pavement in cold regions, the asphalt stabilized macadam specimens were subjected to freeze-thaw cycles at different times. Based on CT non-destructive testing and digital image processing technology, the change laws of porosity, void number and void equivalent diameter of asphalt stabilized macadam specimens were studied, so as to analyze the freeze-thaw damage characteristics of asphalt stabilized macadam from the micro level, The effect of adding 2% SBS modifier on the freeze-thaw resistance of asphalt stabilized macadam was studied. The results show that with the increase of freeze-thaw times, the porosity and the number of voids of asphalt stabilized macadam increases gradually, while the equivalent diameter of voids decrease first and then increase; The addition of 2% SBS can hinder the development of void connectivity and the generation of new voids, and improve the water damage resistance of asphalt stabilized macadam.

A prospective study of the effect of functional endoscopic sinus surgery on the recovery of olfactory function in patients with chronic rhinosinusitis with nasal polyposis

Objective:To investigate the efficacy of functional endoscopic sinus surgery（FESS） in the treatment of olfactory dysfunction in patients with chronic rhinosinusitis with nasal polyps （CRSwNP） , at the same time, it provides an evidence for the prognosis evaluation of olfaction and the clinical application of oERPs to evaluate the plasticity of olfaction cortex. Methods:From October 2021 to October 2022, 45 patients with CRSwNP who underwent FESS nine-step standardized treatment in our department were recruited as the research subjects, divided into 22 patients with eosinophilic CRSwNP（ECRS）and 23 patients with non-eosinophilic CRSwNP（nECRS）. VAS-olfactory dysfunction （VAS-OD） score, SNOT-22 olfactory score, Sniffin' Sticks test and oERPs collection and processing were performed before the operation. All items were evaluated again 3 months after the operation. Results:VAS-OD and SNOT-22 olfactory score were significantly lower in all CRSwNP patients after the operation than those before the operation[F（1, 43） =357.429, P<0.001; F（1, 43） =185.657, P<0.001], the scores of T, D, I and TDI scores in Sniffin' Sticks test were significantly higher than those before the operation[F（1, 43） =126.302, P<0.001; F（1, 43） =311.301, P<0.001; F（1, 43） =131.401, P<0.001; F（1, 43） =295.885, P<0.001]; The decrease of VAS-OD and SNOT-22 olfactory score in the ECRS group was smaller than that in the nECRS group[F（1, 43） =4.825, P=0.033; F（1, 43） =9.916, P=0.003], T, D and TDI scores were significantly lower in nECRS group than those in nECRS group[F（1, 43） =6.719, P=0.013; F（1, 43） =4.890, P=0.032; F（1, 43） =4.469, P=0.040]; There was a positive correlation between preoperative eosinophil-to-lymphocyte ratio（ELR） and SNOT-22 olfactory score and how much it changes（r=0.455, P=0.002; r=-0.414, P=0.005）, a negative correlation between T, TDI score and how much they change respectively（r=-0.431, P=0.003; r=-0.385, P=0.009; r=-0.383, P=0.010; r=-0.316, P=0.035）. The latency of P3 was significantly shorter after operation than that before operation in all CRSwNP patients[F（1, 14） =24.840, P<0.001], however, the amplitude has no significant surgical effect. Conclusion:FESS could significantly improve the olfactory function of CRSwNP patients, while changes in plasticity may occur in the olfactory cortex. In addition, the preoperative peripheral blood eosinophil granulocyte level can predict the postoperative olfactory improvement.

Investigation of processes in the WLTC test of a passenger car with a diesel engine

The tests were carried out in accordance with the WLTP (Worldwide Light Duty Test Procedure), on a passenger car with a compression ignition engine. The analysis was conducted doe the following variables: vehicle speed, exhaust emission rate and fuel consumption volumetric rate. The subject of the research are exhaust emission components that are harmful to the health of living organisms: carbon monoxide, hydrocarbons and nitrogen oxides, as well as greenhouse gases. The research results have shown a very large range of values for carbon monoxide, organic compounds and nitrogen oxides emission rate characteristics. The average distance-specific emissions values of carbon monoxide, organic compounds and nitrogen oxides were very small and were in line with the Euro 6 requirements within a large margin. Correlation studies of the measured variables were conducted – between vehicle speed and exhaust emission rate as well as volumetric fuel consumption rates, and between exhaust emission rates and volumetric fuel consumption rates. Dimensionless statistical characteristics of the measured variables were determined, such as: extreme values, range, mean value, median, standard deviation, kurtosis, skewness and coefficient of variation. The coefficient of variation analysis made it possible to assess that the most dynamic properties could be observed in organic compounds emission rate, followed by carbon monoxide and nitrogen oxides emission rates, and finally – the vehicle speed. The vehicle speed histogram was characterized by relative uniformity apart from the dominance of the idle speed. Histograms of exhaust emission rate variables were most frequently dominated by small values.

Training on Survey Techniques and Data Processing for Mapping Areas for Young Surveyors

Surveys and Mapping are skills in recording and collecting data and information regarding resources (both natural, social and cultural) based on an adequate area with remote sensing technology. The low interest of young surveyors in exploring surveys and mapping. This is because the surveyors consider that developing expertise in using testing equipment and processing survey and mapping data is quite difficult and expensive. HIMATESI is a student association whose members are young researchers, young surveyors or final year students. Partners realize the need for increased understanding of survey techniques. Universities answer partner problems by providing knowledge about survey technique training and data processing for area mapping as well as tricks for dealing with problems in area measurement free of charge. Community service activities in the form of training on survey techniques and data processing for area mapping are held to provide information about the introduction and use of survey tools such as waterpass, theodolite and Autocad and goggle map applications. The method used in the implementation of this training is lighting, discussion and practice. The results of this training were able to increase participants' knowledge of the use of survey technique tools and data processing for area mapping as well as tricks in overcoming problems in the field regarding area measurement and mapping so that it is hoped that participants will be able to implement the knowledge gained in field implementation later.

Physics-Based Modelling for On-Line Condition Monitoring of a Marine Engine System

The engine system is critical for a marine vehicle, and its performance significantly affects the efficiency and safety of the whole ship. Due to the harsh working environment and the complex system structure, a marine system is prone to have many kinds of novelties and faults. Timely detection of faults via effective condition monitoring is vital for such systems, avoiding serious damage and economic loss. However, it is difficult to realize online monitoring because of the limitations of measurement and health monitoring methods. In this paper, a marine engine system simulator is set up with enhanced sensory placement for static and dynamic data collection. The test rig and processing for static and dynamic data are described. Then, a physics-based multivariate modeling method is proposed for the health monitoring of the system. Case studies are carried out considering the misfire fault and the exhaust valve leakage fault. In the misfire fault test, the exhaust gas temperature of the misfired cylinder dropped from the confidence interval 100–150 °C to 70–80 °C and the head vibration features decreased from the confidence interval 900–1300 m/s2 to around 200–300 m/s2. For the exhaust valve leakage fault, the engine body vibration main bearing impact RMS increased nearly 10 times. Comparisons between the model-predicted confidence interval and measured data reveal that the proposed model based on the fault-related static and dynamic features successfully identified the two faults and their positions, proving the effectiveness of the proposed framework.

IDENTIFICATION OF PADDY DISEASE ALONG ITS PROCESSING TIME

Most tropical and subtropical nations in the world eat rice as their main meal. This involves hectare-sized paddy fields, whose upkeep and care becomes a tiresome undertaking for the farmers. The caregivers are unable to recognize ailments and are unable to finish the time-consuming task of crop care in a timely manner. This research offers a suggestion for a rapid identification of paddy into unhealthy plants as a result of this laborious operation. The purpose of this work is to offer a system for diagnosing and detecting paddy illness based on performance testing and image processing methods. The system, which was developed in C++ and tested using a dataset of contaminated leaf images, is used. The several varieties of spotted leaves caused by paddy disease are provided in this dataset. Image acquisition, pre-processing, feature extraction, and performance measurement are the system's four key processes. These steps each conduct their own tasks. In addition, this research provides a definitive description of the paddy illness. The image is shrunk and made grayscale in the first phase because it is the procedure for carrying out the subsequent actions. The sick areas are then divided into groups and given labels. As a result, the processing time and signal-to-noise ratio are calculated and summarized in the last phase. According to the study's findings, the suggested system can accurately and efficiently identify and categorize paddy disease in plants.

Processing speed and memory test performance are associated with different brain region volumes in Veterans and others with progressive multiple sclerosis.

Cognitive dysfunction and brain atrophy are both common in progressive multiple sclerosis (MS) but are seldom examined comprehensively in clinical trials. Antioxidant treatment may affect the neurodegeneration characteristic of progressive MS and slow its symptomatic and radiographic correlates. This study aims to evaluate cross-sectional associations between cognitive battery components of the Brief International Cognitive Assessment for Multiple Sclerosis with whole and segmented brain volumes and to determine if associations differ between secondary progressive (SPMS) and primary progressive (PPMS) MS subtypes. The study was based on a baseline analysis from a multi-site randomized controlled trial of the antioxidant lipoic acid in veterans and other people with progressive MS (NCT03161028). Cognitive batteries were conducted by trained research personnel. MRIs were processed at a central processing site for maximum harmonization. Semi-partial Pearson's adjustments evaluated associations between cognitive tests and MRI volumes. Regression analyses evaluated differences in association patterns between SPMS and PPMS cohorts. Of the 114 participants, 70% had SPMS. Veterans with MS made up 26% (n = 30) of the total sample and 73% had SPMS. Participants had a mean age of 59.2 and sd 8.5 years, and 54% of them were women, had a disease duration of 22.4 (sd 11.3) years, and had a median Expanded Disability Status Scale of 6.0 (with an interquartile range of 4.0-6.0, moderate disability). The Symbol Digit Modalities Test (processing speed) correlated with whole brain volume (R = 0.29, p = 0.01) and total white matter volume (R = 0.33, p < 0.01). Both the California Verbal Learning Test (verbal memory) and Brief Visuospatial Memory Test-Revised (visual memory) correlated with mean cortical thickness (R = 0.27, p = 0.02 and R = 0.35, p < 0.01, respectively). Correlation patterns were similar in subgroup analyses. Brain volumes showed differing patterns of correlation across cognitive tasks in progressive MS. Similar results between SPMS and PPMS cohorts suggest combining progressive MS subtypes in studies involving cognition and brain atrophy in these populations. Longitudinal assessment will determine the therapeutic effects of lipoic acid on cognitive tasks, brain atrophy, and their associations.

SENSORY ANALYSIS OF STARCH GARUT UTILIZATION (MARANTHA ARUNDINACEA L.) AS SUBSTITUTION MATERIAL FOR WHEAT FLOUR IN MAKING PASTA

The purpose of this study was to determine the effect of arrowroot starch substitution on pasta making. The benefit of this research is that it can determine the effect of arrowroot starch substitution in the panelist preference level in starch content. The formulations used are arrowroot starch P1 50% and flour 50%, P2 arrowroot starch 70% and wheat flour 30%, P3 arrowroot starch 100 and wheat flour 0%. The parameters observed were sensory test of color, aroma, taste, texture and starch content. Data processing of hedonic test uses kruskawalis test analysis and duncan follow-up test. Starch content test data were analyzed using Analysis of Variance (ANOVA) the use of arrowroot starch as a substitution material affected the aroma and texture. Starch levels have decreased due to processing. The best treatment in the hedonic test process of arrowroot paste processing was obtained by adding 50% starch formulation and 50% flour while in starch carbohydrate test was obtained by adding 100% starch and 0% flour.

Thermal fatigue testing with repeatable temperature cycles on thermomechanical simulator

This paper presents two thermal fatigue tests developed to simulate the typical thermal fatigue behavior of hot-work tools and rolls. The tests are carried out on a Gleeble 1500D thermomechanical simulator with computer-controlled heating and cooling of the test specimens. In the first test, internal cooling of the specimens is performed, and in the second test, external cooling is performed. This allows constant test conditions and the collection of reliable experimental data on the thermal fatigue behavior. The internally cooled test rig is used for testing the thermal fatigue properties of bulk materials. Indefinite chill double-poured cast iron is used to present the basic capabilities of the test. At the material, the cracks take flattened graphite–cementite pathways. The external cooling test rig, on the other hand, is designed for comparative testing of four surfaces simultaneously. Thus, the capabilities of the second test are presented in the comparative testing of three different laser-welded functionally graded material surface layers and the basic H13 tool steel, simultaneously. The highest thermal fatigue resistance is shown by the weld with the lowest silicon (Si) content. Quantitative evaluation of thermal fatigue resistance as well as following of degradation processes in both tests is enabled.

Toward a systematic accessibility review process for English language proficiency tests for young learners

In order to make assessments as widely accessible as possible, including to young learners from diverse backgrounds with a wide range of individual needs and characteristics, some developers of standardized tests have resorted to offering accessibility tools (e.g., magnifying/zoom) and accommodations (e.g., extended response time) to test takers. These solutions have some limitations stemming from the fact that they are retroactively applied to tests. One possible avenue to meet the accessibility needs of diverse students is to proactively address accessibility in the development of test content for all learners. In this article, we report on the development and piloting of a systematic accessibility review process intended for all test content at an organization producing large-scale standardized English proficiency tests for elementary and secondary education students in the United States. We describe the theoretical and research foundations related to fairness, accessibility, and universal design that guided our development of the accessibility review process followed by the process used to develop the tool. The application of the accessibility checklist to a kindergarten English language proficiency assessment is described in detail. Finally, we share some considerations for how the accessibility checklist could be used in other assessment development contexts.

The feasibility and acceptability of integrating hepatitis C and HIV diagnostic testing on centralized molecular laboratory platforms in Myanmar.

In Myanmar, 1.3 million people have been exposed to hepatitis C (HCV). However, public sector access to viral load (VL) testing for HCV diagnosis remains limited; ten near-point-of-care (POC) devices are available nationally. Myanmar's National Health Laboratory (NHL) has surplus capacity on centralized molecular testing platforms used for HIV diagnostics, presenting an opportunity for integrating HCV testing to expand overall testing capacity. This pilot assessed the operational feasibility and acceptability of HCV/HIV integrated testing implemented with a comprehensive package of supportive interventions. HCV VL samples were collected prospectively from consenting participants at five treatment clinics and tested at Myanmar's NHL (October 2019-February 2020) on the Abbott m2000. To optimize integration, laboratory human resources were bolstered, staff trainings were offered, and existing laboratory equipment was serviced/repaired as needed. Diagnostics data during the intervention period were compared against HIV diagnostics data in the seven months prior. We conducted three time and motion analyses at the laboratory and semi-structured interviews with laboratory staff to assess time needs and program acceptability. 715 HCV samples were processed during the intervention period with an average test processing time of 18 days (IQR: 8-28). Despite adding HCV testing, average monthly test volumes were 2,331 for HIV VL and 232 for early infant diagnosis (EID), comparable to the pre-intervention period. Processing times were 7 days for HIV VL and 17 days for EID, also comparable to the pre-intervention period. HCV test error rate was 4.3%. Platforms utilization increased from 18.4% to 24.6%. All staff interviewed were supportive of HCV and HIV diagnostics integration; suggestions were made for broader implementation and expansion. With a package of supportive interventions, integration of HCV and HIV diagnostics on a centralized platform was operationally feasible, did not adversely impact HIV testing, and was acceptable to laboratory staff. In Myanmar, integrated HCV VL diagnostic testing on centralized platforms may be an important addition to existing near-POC testing in expanding national testing capacity for HCV elimination.

Anxiety in Medical Students: In Terms of the Influence of Efficacy Aspects and Emotional Intelligence

BACKGROUND: Anxiety is a condition, especially for students who have just entered the lecture period. Students usually feel anxious, especially medical students. Learning for students is assessed from several aspects, such as affective aspects and emotional intelligence. Efficacy aspects are aspects related to a person’s attitudes and behavior, while emotions are the ability to manage feelings in this case being able to motivate yourself. AIM: The aim of this study is to find out the relationship between efficacy aspects and emotional intelligence with anxiety for 1st-year medical students of the Faculty of Medicine, Universitas Baiturrahmah, Padang. METHODS: The design of this study was cross-sectional with a correlation analytic approach. The research population is students of the faculty of medicine with 135 samples using the total sampling technique. Univariate data analysis is presented in the form of frequency distribution and percentage and bivariate analysis using Pearson test and data processing using SPSS version 16.0 computerized program. RESULTS: The results of this study show that there is no relationship between anxiety and efficacy aspects with a positive and no significant value, r = 0.3 p = 0.09 and there is a significant relationship between anxiety and emotional intelligence, and a p-value of (0.04), a positive correlation with a Pearson’s strength value of r = 0.7. In the efficacy aspect, the highest category was 92 people (68.1%), the most emotional intelligence was moderate, namely, 86 people (63.7%), and the most anxiety was in the normal category, namely, 116 people (85.9%). CONCLUSION: There is a significant relationship between anxiety and emotional intelligence with a strong correlation, and there is no significant relationship between anxiety and efficacy aspect.

A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity

Cell-based metabolomics provides multiparametric physiologically relevant readouts that can be highly advantageous for improved, biologically based decision making in early stages of compound development. Here, we present the development of a 96-well plate LC-MS/MS-based targeted metabolomics screening platform for the classification of liver toxicity modes of action (MoAs) in HepG2 cells. Different parameters of the workflow (cell seeding density, passage number, cytotoxicity testing, sample preparation, metabolite extraction, analytical method, and data processing) were optimized and standardized to increase the efficiency of the testing platform. The applicability of the system was tested with seven substances known to be representative of three different liver toxicity MoAs (peroxisome proliferation, liver enzyme induction, and liver enzyme inhibition). Five concentrations per substance, aimed at covering the complete dose-response curve, were analyzed and 221 uniquely identified metabolites were measured, annotated, and allocated in 12 different metabolite classes such as amino acids, carbohydrates, energy metabolism, nucleobases, vitamins and cofactors, and diverse lipid classes. Multivariate and univariate analyses showed a dose response of the metabolic effects, a clear differentiation between liver toxicity MoAs and resulted in the identification of metabolite patterns specific for each MoA. Key metabolites indicative of both general and mechanistic specific hepatotoxicity were identified. The method presented here offers a multiparametric, mechanistic-based, and cost-effective hepatotoxicity screening that provides MoA classification and sheds light into the pathways involved in the toxicological mechanism. This assay can be implemented as a reliable compound screening platform for improved safety assessment in early compound development pipelines.Graphical abstract

The impact of visual and motor skills on ideational apraxia and transcortical sensory aphasia

Background Patients with extensive left hemisphere damage frequently have ideational apraxia (IA) and transcortical sensory aphasia (TSA). Difficulty with action coordination, phonological processing, and complex motor planning may not be indicative of higher-order motor programming or higher-order complex formation. We report on the effects of IA and TSA on the visual and motor skill of stroke patients. Purpose The study aims to address the question of whether IA and TSA in bilingual individuals are the results of an error of motor function alone or due to a combined motor plus and cognitive dysfunction effect. Method Twelve bilingual patients (seven males, and five females) were diagnosed with IA and TSA, and are divided into two groups of six patients. Then, 12 healthy bilingual controls were evaluated for comparing with both groups. Bilingual aphasia testing (BAT) and appropriate behavioral evaluation were used to assess motor skills, including coordination, visual-motor testing, and phonological processing. Results Findings (pointing skills) show that the performance of the L1 and L2 languages are consistently significant (p < 0.001) in healthy individuals compared to the IA and TSA groups. Command skills for L1 and L2 languages were significantly higher in healthy individuals compared to IA and TSA controls (p < 0.001). Further, the orthographic skills of IA and TSA vs controls in both groups were significantly reduced (p < 0.01). Visual skills in the L1 language were significantly improved (p < 0.05) in IA and TSA patients compared to healthy controls after 2 months. Unlike orthographic skills which were improved in IA and TSA patients, languages in bilingual patients did not simultaneously improve. Conclusion Dyspraxia is a condition that affects both motor and visual cognitive functions, and patients who have it often have less referred motor skills. The current dataset shows that accurate visual cognition requires both cognitive-linguistic and sensory-motor processes. Motor issues should be highlighted, and skills and functionality should be reinforced along with the significance of treatment between IA and TSA corresponding to age and education. This can be a good indicator for treating semantic disorders.