Processes Of Reparative Regeneration Research Articles

Experimental Morphologic Substantiation of Exogenous Nitric Monoxide Use for Gunshot Wounds Treatment

Influence of exogenous nitric monoxide (NO) on the process of reparative regeneration of gunshot wounds was evaluated during experimental morphologic study. Object of the study were 120 white rats. Use of NO-therapy for the treatment of experimental gunshot wounds normalized microcirculation, activated macrophages, increased proliferation and synthetic activity of fibroblasts, decreased dystrophic and necrotic changes in the wound tissues envirement. It also decreased secondary necrosis and, hence, promoted synthesis, maturation and remodeling of granulation tissue. The data obtained showed that NO-therapy could be recommended for clinical application to treat gunshot wounds in inflammatory and proliferative stages.

Cytological study of ischemic damage in rat kidney

Reparative regeneration in different periods following nephrectomy and the application of low-dose radiation has been studied by means of light and electron microscopy. Experimentally induced ischemia resulted in the destruction of renal corpuscles, the perishing of tubular epithelial cells, and the proliferation of connective tissue. Reparative regeneration is based on aseptic inflammation and its phase duration depends on the extent of organ injury. In nephrectomized rats, reparative regeneration is accompanied by necrosis and the deposition of calcium in the cortical substance. Calcium plays an important role in kidney metabolism and its increased content is characteristic of degenerative changes. The experiments showed that the use of low-dose radiation does not accelerate the process of reparative regeneration in rat kidney.

Experimental study of reparative regeneration processes in the wound treated with bioactive dressings.

Quantitative and structural functional analysis of granulation tissue cells during treatment with protein-polysaccharide dressing Collahit F was carried out. The preparation effectively cleansed the wound from detritus, prevented secondary infection due to stimulation of the functional activity of macrophages and due to the effect of its antiseptic component (furagin), and stimulated proliferative activity of fibroblasts and granulation tissue microvessels on day 5 of treatment, thus promoting repair processes in the wound.

Effect of ultrasound on the strength of metal fixing pins for fractured bones

Ultrasound is used successfully in traumatology and orthopedics to regulate the processes of reparative regeneration of injured bones [1-5]. In cases, however, where the fractured parts of an injured bone are adjusted and held in the correct position by metal fixing pins, the danger arises of a migration of the reinforcing constructions under the influence of mechanical oscillations. The ultrasound can also have a negative influence on the mechanical properties of the metal from which the fixing pin is made. 1Khl8N9T steel is most frequently used for this purpose. The combination of elements of which the steel is composed provides the predisposition for a labile austenitic structure. An increase in brittleness of the pin and a decrease in its mechanical strength disturb the stable fixation of the injured bone and lead to complications such as slow consolidation or the formation of a false joint. According to our sources these phenomena have not yet been studied. On the other hand, a solution of these problems is of great importance for practical medicine, which has stimulated us to carry out the present study.

Effect of rhythm of administration of 1,2-dimethylhydrazine on its carcinogenic activity

The influence of alpha-fetoprotein of man, dog and cat on the processes of reparative regeneration of the skin and long tubular bones was studied. alpha-fetoprotein was shown to stimulate regenerative processes by forming young connective tissue, but had no strong species specificity. Commercial preparation of human alpha-fetoprotein proved to possess maximum physiological activity in comparison with other alpha-fetoproteins under study.