Abstract
Influence of exogenous nitric monoxide (NO) on the process of reparative regeneration of gunshot wounds was evaluated during experimental morphologic study. Object of the study were 120 white rats. Use of NO-therapy for the treatment of experimental gunshot wounds normalized microcirculation, activated macrophages, increased proliferation and synthetic activity of fibroblasts, decreased dystrophic and necrotic changes in the wound tissues envirement. It also decreased secondary necrosis and, hence, promoted synthesis, maturation and remodeling of granulation tissue. The data obtained showed that NO-therapy could be recommended for clinical application to treat gunshot wounds in inflammatory and proliferative stages.
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