Development Process Research Articles

Experimental study on backward erosion piping of a double-layer dike foundation under variable exit geometries

Double-layer dike foundation is composed of a weakly permeable overlying clay layer and a highly permeable underlying sand layer, which is one of the most common stratum types in dike engineering with the highest probability of catastrophic damage, and the main danger is backward erosion piping. Existing research on backward erosion piping of double-layer dike foundation has not fully considered the influence of the exit on the erosion process. Therefore, a self-designed test device is used to assess the influences of the size, position and type of different exits, and the circular exit is connected with the slot exit via the exit area to explore the critical identification conditions and the pipe development mechanism toward the upstream direction under different exit geometry conditions. The results show that both the local and global hydraulic gradients borne by the exit are inversely proportional to the exit area and are less notably affected by the location of the exit. The development process of slot exit pipes differs from that of circular exit pipes, and pipes are usually developed alternately at the two corners of the exit near the upstream end and then converge into one pipe. The average pipe depth and width are proportional to the exit size and the seepage length. With increasing average pipe area of the slot exit, pipes develop more rapidly after head enhancement, and the damage to the dike foundation increases.

Preventing retraumatisation in torture survivors during surgical care: results of a guideline-development project and qualitative study exploring healthcare providers’ experiences

ObjectivesInsufficient training and the absence of guidelines increase the risk of retraumatisation in torture survivors during surgical procedures. This study aims to develop guidelines to mitigate this risk and gather...

Visible-light-driven Bi2WO6/biochar composite photocatalyst efficiently degrades 17α-ethinylestradiol (EE2) and 17β-estradiol (E2) under persulfate synergy

Biochar (BC) composite photocatalysts have attracted much attention by virtue of their high efficiency in removing endocrine disruptors (EDCs). However, there has been a lack of systematic research on the mechanism and constitutive relationship of BC on photocatalysts, which has seriously impeded the development process in this field. In this study, Bi2WO6–BC2% composite photocatalysts were prepared by microwave-assisted hydrothermal method and used for degradation of 17α-ethinylestradiol (EE2) and 17β-estradiol (E2) in conjunction with persulfate synergy (PS). The removal rate of EE2 and E2 by Bi2WO6–BC2% was as high as 99.41 % (12 min) and 97.84 % (15 min), respectively. Systematic studies have shown that BC enhances the catalytic activity mainly through the following ways, increasing the specific surface area of the photocatalytic system, enriching the types of functional groups, enhancing the separation ability of photogenerated electron–hole pairs, and promoting the concentration of active free radicals. The results of the phytotoxicity experiments showed that compared to the EE2 or E2 pollutant solutions, the stem and root lengths of V. radiata increased by 93.63 % and 389.58 % in EE2 metabolites, and by 117.35 % and 160.38 % in E2 metabolites. Similarly, the stem and root lengths of P. vulgaris increased by 80.08 % and 174.91 % in EE2 metabolites, and by 188.92 % and 345.75 % in E2 metabolites. This work not only fills the gap in the study of the mechanism of action of BC, but also provides a green catalyst with very excellent photocatalytic efficiency and detoxification properties.

The role of emotion in urban development decision-making: A qualitative exploration of the perspectives of decision-makers

People's feelings about their neighbourhoods are important for health, but they may be undervalued in urban development decision-making. This study explores how decision-makers understand and respond to residents' emotions. Reflexive thematic analysis was conducted on a secondary dataset consisting of 123 interviews with influential professionals in urban development decision-making. We developed three themes and one subtheme: ‘(mis)understanding residents’ emotions', ‘neglecting the health impact of positive emotions’, ‘avoidance of emotion in community engagement’ and ‘sanitized emotions’. We recommend decision-makers engage directly with residents' emotions during urban development processes to ensure healthier place-making.

Design and Characterization of a Wearable Inertial Measurement Unit.

The utilization of inertial measurement units as wearable sensors is proliferating across various domains, such as health care, sports, and rehabilitation. This expansion has produced a market of devices tailored to accommodate very specific ranges of operational demands. Simultaneously, this growth is creating opportunities for the development of a new class of devices more oriented towards general-purpose use and capable of capturing both high-frequency signals for short-term, event-driven motion analysis and low-frequency signals for extended monitoring. For such a design, which combines flexibility and low cost, a rigorous evaluation of the device in terms of deviation, noise levels, and precision is essential. This evaluation is crucial for identifying potential improvements and refining the design accordingly, yet it is rarely addressed in the literature. This paper presents the development process of such a device. The results of the design process demonstrate acceptable performance in optimizing energy consumption and storage capacity while highlighting the most critical optimizations needed to advance the device towards the goal of a smart, general-purpose unit for human motion monitoring.

Analyzing Parametric Influences Driving Age-Associated Changes in Absorption using a PBPK-GSA Approach

The advanced age population may be susceptible to an increased risk of adverse effects due to increased drug exposure after oral dosing. Factors such as high-interindividual variability and lack of data has led to poor characterization of absorption's role in pharmacokinetic changes in this population. Physiologically based pharmacokinetic (PBPK) models are increasingly being used during the drug development process, as their unique qualities are advantageous in atypical scenarios such as drug-drug interactions or special populations such as older people. Along with relying on various sources of data, auxiliary tools including parameter estimation and sensitivity analysis techniques are employed to support model development and other applications. However, sensitivity analyses have mostly been limited to localized techniques in the majority of reported PBPK models using them. This is disadvantageous, since local sensitivity analyses are unsuitable for risk analysis, which require assessment of parametric interactions and proper coverage of the input space to better estimate and subsequently mitigate the effects of the phenomenon of interest. For this reason, this study seeks to integrate a global sensitivity analysis screening method with PBPK models based in PK-Sim® to characterize the consequences of potential changes in absorption that are often associated with advanced age. The Elementary Effects (Morris) method and visualization of the results are implemented in R and three model drugs representing Biopharmaceutical Classification System classes I-III that are expected to exhibit some sensitivity to three age-associated hypotheses were successfully tested.

UV-activated calcium peroxide system enables simultaneous organophosphorus degradation, phosphate recovery, and carbon fixation

Advanced oxidation processes are a desirable technology for treatment of contaminants of emerging concern. Nevertheless, conventional advanced oxidation of organophosphorus compounds releases inorganic phosphate, posing downstream concerns related to eutrophication. For this reason, we evaluated the ultraviolet light-activated calcium peroxide (UV/CaO2) system for effective treatment of organophosphorus compounds and concurrent capture of the mineralization products, phosphate. The degradation mechanisms, reaction kinetics, and mineralizations were assessed to determine the overall efficiency and performance of the UV/CaO2 process. Knowledge gaps related to photocatalysis in the UV/CaO2 system were not only addressed, but also leveraged to identify unique advantages for removal of organophosphorus compounds and their degradation products. Experimental results confirmed that the UV/CaO2 system effectively mineralized organophosphorus compounds and recovered inorganic phosphate; additionally, collaborative carbon fixation performance of the system reveals the potential of carbon utilization. These outcomes were facilitated by the alkaline environment generated by CaO2. The recovered solids contained most of the phosphorus and carbon from the parent compounds. Ultimately, these findings provide transformative, new insights into the development and application of advanced oxidation processes that prevent downstream concerns related to mineralization products, especially inorganic phosphorus and carbon.

Open data platforms: Design principles for embracing outlaw innovators

Open data platforms freely provide citizens with access to public data, thus enabling improved governance transparency, enhanced public services, and increased civic engagement. However, unlocking the potential of this digital transformation strategy requires that public institutions manage the tension between public and private interests. Furthermore, even when public institutions break down traditional barriers for citizens’ access to data, the potential users often lack the knowledge to leverage it in meaningful ways. Open data platforms therefore tend to fall short of expectations. Leveraging a 10-year action design research study (ADR) in the Swedish Transport Administration (STA), this paper develops design principles for creating value-generating open data platforms in the public domain. The ADR project was initiated to assist STA in its efforts to deal with outlaw innovators who scraped train data from different websites to develop travel apps. Through three iterative design cycles that eventually led to the formation of a new open data platform, the outlaw innovators increasingly became valued partners in the digital transformation process. Theorizing this development process, this paper offers three design principles that provide guidance to public institutions aspiring to digitally transform by making public data accessible. We also reflect upon how these institutions might mitigate the risks associated with partnering with outlaw innovators in the pursuit of an open data strategy.

A wafer-level characterization method of thin film transverse piezoelectric coefficient evaluation

Accurate measurement of the piezoelectric property of thin films is critical for thin film process development and device design optimization. In this paper, we proposed a wafer-level thin film characterization method that provides a non-destructive, single-side measurement solution for evaluating and in-process monitoring the transverse piezoelectric coefficient (e31,f). The e31,f of piezoelectric films was determined by measuring the deflection of circular electrode induced by the converse piezoelectric effect, with the electrodes fabricated on top of piezoelectric thin film on a silicon substrate. The constitutive equation of the unimorph plate reveals a quadratic dependence of top electrode deflection (δ) on the radius (r), which was subsequently utilized to calculate the e31,f while considering the electrode edge effect. Determined by non-constant variations of |δ/r2| from finite element method (FEM) simulation results, the electrode edge effect leads to the specification of electrode size and substrate thickness for evaluating piezoelectric coefficient. A comprehensive FEM simulation analysis of the influence of wafer size and electrode location on the accuracy of the proposed method demonstrated its reliability for wafer-level characterization. The e31,f measurement results of single-crystal (s-PZT) and polycrystalline PZT (p-PZT) exhibit good agreement between the proposed wafer-level method and the die-level cantilever method. These results demonstrated that the proposed single-side wafer-level method provides a reliable measurement technique for e31,f characterization of piezoelectric thin film.

Design and Optimization of Molecularly Imprinted Polymer Targeting Epinephrine Molecule: A Theoretical Approach.

Molecularly imprinted polymers (MIPs) are a growing highlight in polymer chemistry. They are chemically and thermally stable, may be used in a variety of environments, and fulfill a wide range of applications. Computer-aided studies of MIPs often involve the use of computational techniques to design, analyze, and optimize the production of MIPs. Limited information is available on the computational study of interactions between the epinephrine (EPI) MIP and its target molecule. A rational design for EPI-MIP preparation was performed in this study. First, density functional theory (DFT) and molecular dynamic (MD) simulation were used for the screening of functional monomers suitable for the design of MIPs of EPI in the presence of a crosslinker and a solvent environment. Among the tested functional monomers, acrylic acid (AA) was the most appropriate monomer for EPI-MIP formulation. The trends observed for five out of six DFT functionals assessed confirmed AA as the suitable monomer. The theoretical optimal molar ratio was 1:4 EPI:AA in the presence of ethylene glycol dimethacrylate (EGDMA) and acetonitrile. The effect of temperature was analyzed at this ratio of EPI:AA on mean square displacement, X-ray diffraction, density distribution, specific volume, radius of gyration, and equilibrium energies. The stability observed for all these parameters is much better, ranging from 338 to 353 K. This temperature may determine the processing and operating temperature range of EPI-MIP development using AA as a functional monomer. For cost-effectiveness and to reduce time used to prepare MIPs in the laboratory, these results could serve as a useful template for designing and developing EPI-MIPs.

This (AI)n’t fair? Employee reactions to artificial intelligence (AI) in career development systems

AbstractOrganizations increasingly implement AI for career development to enhance efficiency. However, there are concerns about employees’ acceptance of AI and the literature on employee acceptance of AI is still in its infancy. To address this research gap, integrating justice theory, we investigate the effects of the deciding entity (human, human and AI, and AI) and the impact of the data source (internal data, external data), on employees’ reactions. Using a scenario-based between-subject design, displaying a common situation in organizations (N = 280) and an additional causal-chain-approach (N = 157), we examined whether a decrease of human involvement in decision making diminishes employees’ perceived fairness and satisfaction with the career development process and increases their perceived privacy intrusion. Although we also considered other data sources to moderate the proposed relationships, we found no support for interaction effects. Finally, fairness and privacy intrusion mediated the influence of the deciding entity and data source on turnover intention and employer attractiveness, while satisfaction with the process did not. By addressing how the employees react to AI in career development–showing the negative reactions, our study holds considerable relevance for research and practice.

Publication trends of Leber congenital amaurosis researches: a bibliometric study during 2002-2022

AIM: To analyze the changes in scientific output relating to Leber congenital amaurosis (LCA) and forecast the study trends in this field. METHODS: All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science (WOS) database. We analyzed the quantity (number of publications), quality (citation and H-index) and development trends (relative research interest, RRI) of published LCA research over the last two decades. Moreover, VOSviewer software was applied to define the co-occurrence network of keywords in this field. RESULTS: A total of 2158 publications were ultimately examined. We found that the focus on LCA kept rising and peaked in 2015 and 2018, which is consistent with the development trend of gene therapy. The USA has contributed most to this field with 1162 publications, 56 674 citations and the highest H-index value (116). The keywords analysis was divided into five clusters to show the hotspots in the field of LCA, namely mechanism-related, genotype-related, local phenotype-related, system phenotype-related, and therapy-related. We also identified gene therapy and anti-retinal degeneration therapy as a major focus in recent years. CONCLUSION: Our study illustrates historical research process and future development trends in LCA field. This may help to guide the orientation for further clinical diagnosis, treatment and scientific research.

Reimagining faculty development: A paradigm shift from content to transformative learning processes

Background Faculty development programs in health professional education traditionally emphasise theories, principles, and effective teaching practices. However, the efficacy of these strategies in instigating meaningful changes in instructional practices has come under scrutiny. Methods This qualitative research aims to enhance our understanding and support of educators’ ongoing learning and growth. Employing a transformative learning lens, the study explored the experiences, professional development practices, and responsibilities of clinical educators who participated in a faculty development course. Utilising Mezirow’s transformative learning theory as a framework, this research investigated the transformative journey of educators, analysing reflective pieces from 144 participants. Results The study findings revealed shifts in pedagogical approaches, ranging from the recognition of a haphazard teaching style to the intentional integration of evidence-based methods and pedagogical philosophies. The thematic analysis identified key stages in the transformative process, illuminating educators’ commitment to structured teaching, self-directed learning, and continuous improvement. Conclusion This research has contributed valuable insights into how faculty development programs can stimulate reflective practices and transformative learning in health professional education. The article argues for the centrality of transformative learning processes in faculty development, presenting an intriguing perspective on sustainable and impactful professional growth. Trends across learning experiences are presented, accompanied by practical recommendations. The implications of the research for clinical educators, administrators, and developers of formal faculty professional development programs are also discussed.

Efficacy of gaseous ozone and UVC radiation against Candida auris biofilms on polystyrene surfaces

The growth and attachment of highly resistant biofilms on/to polymer-based surfaces, including reusable medical devices is a significant health concern in infection control. The increasing prevalence of the multidrug-resistant yeast, Candida auris, has recently garnered immense interest as a contributor to healthcare-associated infections. In this study, we investigate the potential of disinfection processes (ozone, UVC, and ozone + UVC) to inactivate C. auris biofilms (NCPF 8971), grown on polystyrene surfaces. A bespoke decontamination chamber is used to expose the substrate for 20–60 mins, corresponding to ozone doses between 1000 and 3000 ppm.min and UVC doses between 2864 and 11,592 mJ/cm2, respectively. The performance of these 3 treatment methods against the biofilms and vegetative/planktonic cells of the organism is comparatively evaluated. While complete inactivation (> 8 log10 reduction, CFU/mL) of the vegetative cells is observed within 40 mins by all methods, the biofilms proved considerably difficult to inactivate. Only 3.3 log10 reduction was achieved using ozone for 40 min, whereas 7.2 log10 reduction was obtained using UVC for 40 min. A hybrid application of ozone and UVC improved the decontamination efficacy compared to their independent applications (i.e., ozone only and UVC only). Scanning electron microscopy results yielded new insights into the inactivation mechanisms; thus providing the needed foundation for newer developments in oxidation-based processes for biofilm mitigation and control.

Experimental Study on Explosion Characteristics and Consequences for Homogeneous and Inhomogeneous Methane-Air Mixtures within a Kitchen

ABSTRACT Owing to the effect of a non-uniform concentration distribution, natural gas leakage explosion accidents usually cause different degrees of damage inside residential kitchens. According to the similarity principle, a reduced-scale experiment setup of a kitchen was established. Uniform and non-uniform explosion experiments for methane-air mixtures with concentrations of 7.7%, 9.5%, and 11.2% were performed. The flame propagation behavior and pressure evolution characteristics were analyzed for homogeneous and inhomogeneous methane-air mixtures. In addition, two dimensionless coefficients, namely macroscopic and directional non-uniformity coefficients, were introduced to quantify the uneven distribution of gas concentration within the kitchen. Furthermore, the flame development process and pressure evolvement characteristics were compared between homogeneous and inhomogeneous methane-air mixtures in a fuel-lean, chemical equivalence concentration and fuel-rich state. The results show that the macroscopic non-uniformity coefficients are 0.0998, 0.0653, and 0.0571 on the fuel-lean, chemical equivalence concentration and fuel-rich conditions, respectively. It indicates that the greatest non-uniformity of methane concentration distribution within the kitchen is represented on the fuel-lean condition. The concentration gradient could obviously reduce the explosion overpressure in the fuel-lean condition, whereas it would not significantly decrease the explosion overpressure in the chemical equivalence concentration or fuel-rich condition. It means that the greater the non-uniformity coefficient is, the more significant the effect on the overpressure peak is.

Ultra-sensitive detection of cadmium and lead in water using crown ether gel electromembrane extraction coupled with miniaturized electrochemical system

This study presents the development of an electrochemical technique combined with gel electromembrane extraction (G-EME) for the simultaneous detection of cadmium and lead in environmental water samples. Crown ether (18C6) was added to the gel as a complexing agent and cationic carrier. The electrochemical responses were evaluated using differential pulse anodic stripping voltammetry (DPASV) across various pH levels and deposition times. The most sensitive response (acetate buffer pH 4, deposition time 90 s) was selected for the development of the G-EME process. By applying a 30 V electrical potential across the gel membrane containing 1 % (w/v) of 18C6 for 10 min, positively charged Cd2+ and Pb2+ ions migrated from the donor phase (pH 5.0) through the 18C6@gel membrane (pH 5.0) into the acceptor phase (pH 5.0). This resulted in a linear range from 0.3 to 5 µg/L for Cd2+ and 0.5 to 5 µg/L for Pb2+, with detection limits of 0.10 µg/L and 0.19 µg/L, respectively— up to 120 times more sensitive than direct electrochemical measurements. Furthermore, the proposed technique maintained selectivity for cadmium and lead, despite the presence of other potential heavy metal ions in the environment.

Potential of membrane distillation for water recovery and reuse in water stress scenarios: Perspective from a bibliometric analysis

Climate change and related issues such as water scarcity and the urgent need for a transition to sustainable energy sources have motivated the development of novel processes and techniques that can be applied for water treatment, recovery and reuse. Among these emerging processes, membrane distillation in its different configurations has been extensively studied and reported in the literature. A bibliometric analysis was performed to investigate the research documents published in the scientific database Scopus until 2024, related to use of membrane distillation for water recovery and reuse. The main quantitative attributes of the research during this period were identified. The results of this analysis showed a very low scientific production until 2005, followed by a rapid exponential increase since then. The combined contribution of the two most productive countries (China and USA respectively) accounted for more than 41 % of the total number of publications, followed by Australia and Saudi Arabia, which occupied the third and fourth positions in the ranking. Chemical engineering was the most important subject category (57.4 % contribution), closely followed by environmental sciences. The review of the most cited documents and keywords showed that membrane wetting is one of the main drawbacks that can reduce the performance of membrane distillation and the use of innovative superhydrophobic, omniphobic or Janus membranes resulted an adequate solution to avoid this problem. Moreover, the desalination of seawater, brines and other highly saline solutions can be considered as the most studied application of membrane distillation. The consideration of the energetic aspects of membrane distillation and its coupling with other technologies were identified as relevant topics during the bibliometric network analysis. Special attention was given to the potential of membrane distillation for water recovery and reuse in the Chilean context of water stress for the production of drinking water and the treatment of domestic greywater and wastewater from mining and other industrial activities.

Social workers’ experiential accounts of complex intervention development for youth and families in practice settings

ABSTRACT We aimed to explore social workers’ experiential accounts of developing complex interventions for youth and families within practice settings. Social workers’ experience of developing interventions has not been leveraged in scientific research even though many complex interventions in use are developed by social workers in practice settings. Lack of insight into the intervention development process impairs our ability to link approaches to outcomes and thereby assess whether specific approaches produce interventions that are more successful than others. We conducted semi-structured interviews with 12 developers of seven complex interventions. Through qualitative content analysis we identified 11 categories of activities participants engaged in during the development process. Participants described engaging in a range of activities found in the scientific literature. However, participant engagement in development activities were motivated on different grounds and conducted at different stages than suggested by current intervention development frameworks. Contextual and organisational factors were important in shaping the final approach to intervention development. We recommend future research on intervention development from the practitioner perspective to further explore and validate these findings. We encourage practitioners to document important details in their intervention development work to build a literature base and guide other practitioners who engage in complex intervention development.

Temperature Control and Crack Prevention of High RCC Dam in Cold and Drought Area

A development process is introduced for a computation program to calculate the temperature and stress field of mass concrete based on the ANSYS® platform. The temperature control scheme of a high roller compacted concrete (RCC) dam in northern Xinjiang is optimized by using the simulation program. It is suggested that the concrete pouring temperature of the dam should not exceed 16°C and that water-pipe cooling should be adopted. The dam should be permanently heat preserved by 10 cm thick extruded polystyrene (XPS) extruded panels, and the top surface of the overwintering layer should be covered with an at least 14 cm thick thermal insulation quilt. During construction, the warehouse surface should be temporarily insulated with a 2 cm thick thermal insulation quilt. The causes of cracks in a particular dam section are simulated and analysed, and it is concluded that the cracks are mainly caused by the lack of thermal insulation of the warehouse surface during cold spells.

Epigenetic regulation of macrophage activation in chronic obstructive pulmonary disease.

Macrophages in the innate immune system play a vital role in various lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute lung injury and pulmonary fibrosis. Macrophages involved in the process of immunity need to go through a process of activation, including changes in gene expression and cell metabolism. Epigenetic modifications are key factors of macrophage activation including DNA methylation, histone modification and non-coding RNA regulation. Understanding the role and mechanisms of epigenetic regulation of macrophage activation can provide insights into the function of macrophages in lung diseases and help identification of potential therapeutic targets. This review summarizes the latest progress in the epigenetic changes and regulation of macrophages in their development process and in normal physiological states, and the epigenetic regulation of macrophages in COPD as well as the influence of macrophage activation on COPD development.