Application Of Procedure Research Articles

Antibacterial UV-Curable Gel with Hydroxyapatite Nanoparticles for Regenerative Medicine in the Field of Orthopedics

The development and analysis of the properties of a new material based on UV-curable acrylate monomers with silicon-containing hydroxyapatite and zinc oxide nanoparticles as an antibacterial component and gelatin was carried out. Using this material in orthopedics and dentistry is very convenient because it covers any surface geometry of metal implants and hardens under ultraviolet light. In this work, sorption properties, changes in porosity, and mechanical properties of the material were investigated. The conditions for obtaining hydroxyapatite (HA) nanoparticles and the presence of silicon oxide nanoparticles and organic for the shell in an aqueous medium were studied for the pH of the medium, the sequence of administration and concentration of the material components, as well as antibacterial properties. This polymer material is partially resorbable. That supports not only the growth of bone cells but also serves as a protective layer. It reduces friction between organic tissues and a metal implant and can be a solution to the problem of the aseptic instability of metal implants. The material can also be used to repair damaged bones and cartilage tissues, especially in cases where the application and curing procedure is performed using laparoscopic methods. In this work, the authors propose a simple and quite cheap method for obtaining material based on photopolymerizable acrylates and natural gelatin with nanoparticles of HA, zinc oxide, and silicon oxide. The method allows one to obtain a composite material with different nanoparticles in a polymer matrix which retain the requisite properties needed such as active-sized HA, antibacterial ZnO, and structure-forming and stability-improving SiO2 nanoparticles.

Legal Protection for Auction Winners Whose Items Are Still Held by The Debtor According to Law Number 4 of 2004 on Auctions

This research discusses the legal protection for auction winners whose items are still held by the debtor, analyzed based on Law Number 4 of 2004 on Auctions. An auction is one way to enforce creditors' rights against debtors who cannot fulfill their obligations. In this study, the author examines the provisions in Law Number 4 of 2004, and the applicable legal practices to provide an overview of the legal steps auction winners can take to obtain the items they have won. The research findings indicate that although the auction winner has the right to the items once the auction process is complete, there is a legal protection mechanism that must be followed to obtain those items, including through the execution of goods by the auction official. This study also highlights the importance of legal protection for auction winners so that the applicable procedures can effectively protect their ownership rights over the auctioned items.

PENANGGULANGAN PERNIKAHAN DI BAWAH TANGAN

Marriage is a very noble way to organize household life and offspring and get to know each other, so that it will open the way for mutual assistance. Marriage gives rise to the reciprocal rights and obligations of husband and wife that are arranged very neatly, as well as the rights and obligations between parents and children. In fact, not all Islamic societies follow the applicable procedures or rules. This can be seen from the fact that there are still some people who practice unpublished marriages or are called underhand marriages. Islamic law has raised the motives and purposes of marriage to a higher and nobler level. If previously guided by Islamic teachings the purpose of marriage was solely driven by biological needs and to continue life, then according to Islamic law it is raised with the motive of carrying out the sunnatullah on the basis of the aim of worshiping Allah SWT.

Legal Analysis of Re-Determination of Suspects Based on Tax Law (Case Study of Value Added Tax in the Cigarette Industry of Blitar, East Java, Indonesia)

Taxes are mandatory contributions that individuals and entities must fulfill to support state activities. One significant tax component is the Value-Added Tax (VAT), which substantially contributes to state revenue, including from the tobacco industry sector. However, violations of tax obligations, such as using fictitious tax invoices, often result in state financial losses. One critical case is the re-determination of suspects in a VAT matter involving the tobacco industry in Blitar during 2015-2016, which sparked debates over the legality of the legal procedures. This study employs a normative juridical method with a statutory and case approach to analyze legal procedures related to the re-determination of suspects. The findings indicate that the re-determination of suspects in this case failed to adhere to the principles of justice and applicable legal procedures. The re-determination was carried out without adequate evidence, utilizing previously processed evidence in court without an Eintracht verdict, making it premature and violating the ne bis in idem principle. This highlights that the applied legal procedures did not reflect proper legal practices. This study recommends enhancing the capacity of law enforcement officers to understand tax law and ensure objective judicial processes with valid evidence. Imitating the ultimum remedium principle and applying fair legal principles in tax cases are essential steps to create a better tax system and prevent future violations.

Possibilities for inclusion of Bulgarian protected areas on the IUCN Green List

The most successful approach to conserving biodiversity is the development of a worldwide network of protected areas that are effectively managed through various tools and criteria. The latest global project for management quality of protected areas is the IUCN Green List Standard. It offers an instrument for regular assessment and implementation of protected area management efficiency. Listed sites gain recognition as a good example in nature preservation, international promotion, know-how, access to and exchange of global expertise, support and financial resources for good conservation outcomes. Bulgaria has a well-developed network of protected areas and participates in international programs with several nature sites. Joining the Green List program could influence national policy and actions for further excellence of the national network and its effective management, as well confirm Bulgarian commitment to global conservation efforts. The aim of this study is to assess the possibilities for including sites from the Bulgarian protected areas network on the IUCN Green List, identifying sites, ready to complete the application phase and be credible candidates for inscription. A review of the Bulgarian protected areas network was done and an evaluation, corresponding to the application phase of the Green List, of 49 natural sites (three national parks, 11 nature parks and 35 managed reserves) showed that the best potential candidates for the Green List are the administrations of Central Balkan National Park, Bulgarka Nature Park, Persina Nature Park and Belasitsa Nature Park. It is recommended that they start an application procedure and join the IUCN network.

The Effectiveness of Spinal Manipulative Therapy in Treating Spinal Pain Does Not Depend on the Application Procedures: A Systematic Review and Network Meta-analysis.

OBJECTIVE: To assess whether spinal manipulative therapy (SMT) application procedures (ie, target, thrust, and region) impacted changes in pain and disability for adults with spine pain. DESIGN: Systematic review with network meta-analysis. LITERATURE SEARCH: We searched PubMed and Epistemonikos for systematic reviews indexed up to February 2022 and conducted a systematic search of 5 databases (MEDLINE, EMBASE, CENTRAL [Cochrane Central Register of Controlled Trials], PEDro [Physiotherapy Evidence Database], and Index to Chiropractic Literature) from January 1, 2018, to September 12, 2023. We included randomized controlled trials (RCTs) from recent systematic reviews and newly identified RCTs published during the review process and employed artificial intelligence to identify potentially relevant articles not retrieved through our electronic database searches. STUDY SELECTION CRITERIA: We included RCTs of the effects of high-velocity, low-amplitude SMT, compared to other SMT approaches, interventions, or controls, in adults with spine pain. DATA SYNTHESIS: The outcomes were spinal pain intensity and disability measured at short-term (end of treatment) and long-term (closest to 12 months) follow-ups. Risk of bias (RoB) was assessed using version 2 of the Cochrane RoB tool. Results were presented as network plots, evidence rankings, and league tables. RESULTS: We included 161 RCTs (11 849 participants). Most SMT procedures were equal to clinical guideline interventions and were slightly more effective than other treatments. When comparing inter-SMT procedures, effects were small and not clinically relevant. A general and nonspecific rather than a specific and targeted SMT approach had the highest probability of achieving the largest effects. Results were based on very low- to low-certainty evidence, mainly downgraded owing to large within-study heterogeneity, high RoB, and an absence of direct comparisons. CONCLUSION: There was low-certainty evidence that clinicians could apply SMT according to their preferences and the patients' preferences and comfort. Differences between SMT approaches appear small and likely not clinically relevant. J Orthop Sports Phys Ther 2025;55(2):1-14. Epub 7 January 2025. https://doi.org/10.2519/jospt.2025.12707.

Fabrication of agglomerated WSe2-based rGO nanocomposite via a novel hydrothermal procedure for an energy conversion application

Fabrication of agglomerated WSe2-based rGO nanocomposite via a novel hydrothermal procedure for an energy conversion application

Halogenation-induced C-N bond activation enables the synthesis of 1,2-cis C-aryl furanosides via deaminative cyclization.

1,2-cis C-Aryl furanosides are prevalent in nature and exhibit significant biological activities. The 1,2-cis configuration is less favorable in terms of stereoelectronic and steric effects, making the synthesis of this type of skeleton highly challenging. Traditional methods for the synthesis of 1,2-cis C-aryl furanosides usually require complicated protection manipulations, resulting in lengthy synthetic routes and low overall efficiency. Here, we report a simple and highly applicable procedure for the synthesis of 1,2-cis C-aryl furanosides from unprotected aldoses via Petasis reaction and subsequent deaminative cyclization. Unprotected aldose mediated Petasis reactions yield linear 1,2-trans 1-aryl polyhydroxy amines. Halogenation of the amine motif activates the conventionally inert C-N bond and triggers the key stereoinvertive intramolecular substitution process, affording 1,2-cis C-aryl furanosides with excellent chemo- and diastereoselectivity. This procedure does not require the use of any sensitive reagents, and can be conducted in one-pot without precautions against oxygen or moisture, offering a streamlined approach to 1,2-cis C-aryl furanoside natural products and bioactive agents.

ANALYSIS OF MUI FATWA AND MINISTRY OF TRADE POLICY ON BOYCOTT PRODUCTS IN INDONESIA

The prolonged conflict between Palestine and Israel has made several parties more aggressively support Palestine. One form of Indonesia's support for Palestine is the issuance of the Indonesian Ulema Council (MUI) fatwa No 83 of 2023 on the Law of Supporting the Palestinian Struggle. Unlike the MUI, the Ministry of Trade did not issue any decree regarding the prohibition of Israeli boycott products entering Indonesia, as long as they follow the applicable procedures. This research method uses a literature study to collect data and information from books, journals, articles, and related news. The purpose of this research is to analyze the fatwa of MUI and the Ministry of Trade regarding the boycott of Israeli products circulating in Indonesia, as well as the response and attitude of the community regarding this matter. The result of this research shows that the boycott of Israeli products is a form of indirect support of the Indonesian people, namely with the MUI fatwa, which urges as much as possible to avoid transactions and use of products affiliated with Israel and that support colonialism and Zionism. Unlike the MUI, the Ministry of Trade does not prohibit any product from circulating and being traded in Indonesia as long as it follows the applicable rules. This also has an impact on the decline of Indonesia's economic level. The Ministry of Commerce, MUI, and the governments concerned should clarify and affirm the decisions made regarding the Israeli boycott of products in Indonesia.

Use of the Baidu Index to Analyze Spatiotemporal Characteristics of Online Attention to Adult Education

Purpose: This study aims to analyze the spatiotemporal evolution of public attention to "adult education" over the past decade. Methods: Using Baidu Index data from January 1, 2014, to November 1, 2024, we examined search trends, demand distribution, and user characteristics through trend research, demand mapping, and user profiling. Results: The online search index for adult education shows a fluctuating upward trend, with peaks in April and October each year. Demand mapping indicates interest in areas such as adult college entrance exams, self-study exams, educational institutions, exam schedules, registration, major selection, tuition, and application procedures. User profiling reveals higher attention from males aged 30~39 in Guangdong Province. Conclusion: Changes in online attention to adult education correlate closely with career aspirations, policy announcements, and social contexts.

Multi-environment and multi-parameter screening of stability and coating efficiency of gold nanoparticle bioconjugates in application media

Gold nanoparticles (AuNPs) and their biocompatible conjugates find wide use as transducers in (bio)sensors and as Nano-pharmaceutics. The study of the interaction between AuNPs and proteins in representative application media helps to better understand their intrinsic behaviors. A multi-environment, multi-parameter screening strategy is proposed based on asymmetric flow field flow fractionation (AF4)-multidetector. Citrate-coated AuNPs ( AuCIT, 25.1 ± 0.2 nm) and PEG-coated AuNPs (AuPEG, 38.3 ± 0.8 nm) were employed with albumin as a model system. Attention was put in investigating the influence of Au/BSA mass ratios, that allowed to identify the yield-maximizing (1:1) and product-maximizing (2.5:1) conditions for the generation of AuNPs-protein conjugates. Furthermore, bioconjugate properties were thoroughly assessed across various saline media with different pH and ionic strengths. While AuNPs with PEG coating exhibit greater stability at high salinities, such as 30 mM, their conjugates are less stable over time. In contrast, although bare AuNPs are significantly affected by pH and salt concentration, once conjugates are formed, their stability surpasses that of the conjugates formed with AuPEG. The developed methodology can fill the vacancy of standard reference quality control (QC) procedures for bioconjugate synthesis and application in (bio)sensors and Nano-pharmaceutics, screening in a short time many combinations, easily scaling up to the semi-preparative scale or translating to different bioconjugates.

Legal Analysis of the Authority of Military Judges in the Procedural Law of Examination of Connectivity in Corruption Cases

In order to uphold law enforcement, especially in the field of criminal law, the law distinguishes between civilians and the military. The problem that arises now is what if a criminal act is committed by the military together with civilians, which in its development is called a connectivity case. The corruption case that occurred in Indonesia involving the military and civilians that has been decided by the Connectivity Court is the Corruption Case of the Indonesian Army Compulsory Savings from 2013 to 2020 with the Defendant from the Military, namely Brigadier General TNI (Ret.) Yus Adi Kamrullah, S.E., M.Sc., and from the civilian party Ni Putu Purnamasari which caused the state a loss of Rp. 127,000,000,000,- (one hundred and twenty seven billion rupiah), and the corruption case of the 123 East Longitude Orbit Slot Satellite Procurement Project/Floater Satellite Procurement between the Indonesian Ministry of Defense in 2012 to 2021 involving the military and civilians with the Defendant Rear Admiral (Ret.) Agus Purwoto, and from the civilian side the Defendants Arifin Wiguna and Surya Cipta Witoelar which caused the state a loss of Rp.453,094,059,540.68 (four hundred fifty three billion ninety four million fifty nine thousand five hundred forty point sixty eight cents). The purpose of this study is to determine the implementation of handling corruption criminal cases through connectivity courts in Indonesia and the authority of military judges in connectivity courts and to determine the resolution of connectivity criminal cases in corruption crimes committed by civilians and military personnel in both cases in the Connection Court. The study uses a normative legal research method. The data used are secondary and primary data, then the data is processed and presented in the form of a literature study. The analysis used is deskriftif juridis and fersfektif analysis. The results of the study indicate that the process of handling connectivity cases in corruption cases of connectivity has been partially carried out in accordance with the applicable criminal procedure law (KUHAP) and the defendants are legally and convincingly guilty of committing corruption together in accordance with Article 2 Paragraph (1) in conjunction with Article 18 of Law Number 31 of 1999 as amended by Law Number 20 of 2001 in conjunction with Article 55 Paragraph (1) ke-1 of the Criminal Code.

TINJAUAN PROSES PERUBAHAN NAMA DI PENGADILAN SEBAGAI HAK INDIVIDU YANG DI CATATKAN NEGARA

Name change is an individual right guaranteed by the government, allowing every citizen to manage their personal identity according to their wants and needs. This process must be carried out through formal legal procedures, as stipulated in Law Number 24 of 2013 concerning Population Administration. This study aims to analyze the implementation of name change procedures in Indonesia, focusing on Stipulation number 14/Pdt.P/PN Pbg, which rejected a name change application due to non-compliance with legal procedures. The research method used in the preparation of this study is the normative juridical approach, which specifically focuses on the analysis of norms or the application of principles in applicable law. Based on Law Number 24 of 2013, name changes require a stipulation from the district court according to the applicant's domicile. In addition, Presidential Regulation No. 96/2018 stipulates that the recording of a name change must be accompanied by a copy of the court decision, an extract of the civil registration certificate, a family card, an electronic identity card, and travel documents for foreign nationals. The applicant's application in Stipulation No. 14/Pdt. P/PN Pbg was rejected in relation to the name change application due to non-compliance with applicable legal procedures. The applicant had made several identity changes at the Population and Civil Registration Office without going through the court process, which clearly violated the existing provisions.

A novel EWMA-based adaptive control chart for industrial application by using hastings approximation

Control charts are commonly used for process monitoring under the assumption that the variable of interest follows a normal distribution. However, this assumption is frequently violated in real-world applications. In this study, we develop an adaptive control chart based on the exponentially weighted moving average (EWMA) statistic to monitor irregular variations in the mean of the Truncated Transmuted Burr-II (TTB-II) distribution, employing Hastings approximation for normalization. We propose a continuous function for the adaptation of the smoothing constant. The performance of the proposed TTB-II distribution is compared with multiple existing distributions, including TB-II, TB-III, TB-XII, B-II, B-III, and B-XII, to demonstrate its competitive advantages. The run-length profiles, including the average run-length (ARL) and the standard deviation of run-length (SDRL), are computed under various parameter settings. The effectiveness of the proposed chart is evaluated using Monte Carlo (MC) simulations in terms of run-length profiles. The practical implementation of the proposed chart is demonstrated with a real dataset, illustrating the design and application procedures.

Light-Inducible Deformation of Mitochondria in Live Cells.

Mitochondria are dynamic organelles with constantly changing morphologies. Despite recent reports indicating that mechanical cues modulate mitochondrial morphologies and functions, there is a lack of methods that can exclusively and precisely exert mechanical forces to and deform mitochondria in live cells. Therefore, how mitochondria sense and respond to mechanical forces remains largely elusive. Optogenetic methods open up new venues for remote and precise manipulation of intracellular activities using light, providing an unprecedented opportunity to establish targeted mechano-stimulation toward mitochondria. This chapter describes the development of a novel optogenetic approach to optically mechanostimulate and induce the deformation of mitochondria. In this approach, light-gated protein-protein heterodimerization recruits force-generating molecular motors to the outer mitochondrial membrane, enabling direct exertion of mechanical force on mitochondria. Details for the design, application, and experimental procedures are laid out in this chapter. This method presents a mitochondria-specific mechano-stimulator for studying the correlation between mitochondrial morphology and functions as well as mitochondrial mechanobiology.

Study on Discharge Dynamics and Droplet Characteristics of Various Nozzle Types for Pesticide Application

This research is aimed at reducing the environmental impact and increasing the efficiency of pesticide application by examining the effects of nozzle type and operating pressure on spray characteristics and discharge rate. Prevalent challenges of applying pesticides had been the subject of prior studies, but the relationships between nozzle types [flat fan, hollow cone, and flower (8-hole)] and operating pressures (2, 3 and 4 kg cm-2) were not widely recognized for greenhouses. This research gap necessitated an experimental approach, measuring spray deposition and discharge rate across three nozzles using a Malvern Spraytec droplet analyzer and spray patternator. Specific surface area (SSA), volume mean diameter [D(4,3)], Sauter mean diameter [D(3,2)], droplet size distribution (Dv10, Dv50, and Dv90), span were characterized and measured. Data were analyzed using analysis of variance (ANOVA) and Tukey's Honest Significant Difference (HSD) tests to determine significant difference between factors for nozzle selection. The results showed that increasing working pressure of flat fan nozzle from 2 to 4 kg cm-2 led to smaller droplets sizes, with Dv10, Dv50 and Dv90 decreasing from 85.61 to 66.41 µm, 165.33 to 142.80 µm, and 424.83 to 376.16 µm, respectively. Increase in SSA correspondingly from 0.387 to 0.524 m² cc-1, indicates more surface area available per unit volume of pesticides. It was found that with increase in discharge rate from 1045.69 to 1360.01 mL min-1, there was a significant increase in pesticide volume delivered. These findings provide important information for enhancing pesticide application procedures by highlighting the significance of carefully choosing operating pressures and nozzle types to establish a balance between spray efficacy and environmental considerations.

Systematic refinement of surrogate modelling procedure for useful application to building energy problems

Systematic procedures for applying surrogate model development to building energy problems have limited adoption and struggle to incorporate advancements in broader machine learning research. This work demonstrates an iterative approach that encompasses: Establishing clear, consistent baseline performance thresholds. Assembling a comprehensive set of domain-relevant evaluation metrics, including rigorous bounds on error and emphasis on regions of interest within the broader problem space. Characterizing and adapting the problem space using sub-sampling and pre-processing techniques. Accounting for variability, randomness and complexity in the building energy problem definition, data sampling and surrogate model training. Refining the metamodel decision space defining the neural network architecture and training algorithms, and explored by hyperparameter optimization methods. In addition to demonstrating improved performance predicting aggregate annual heating and cooling demands for an illustrative office case, accuracy, bias and bounds on error were all brought within domain-relevant thresholds for net zero regions of interest. Highlights Iterative refinement of surrogate modelling procedure for building energy problems Consideration of complexity and variability in energy data, problem and surrogate Addition of key dimensions to performance evaluation useful for domain application Greatly improved predictive value for net zero building energy regions of interest Systematic shift in hyperparameter tuning towards deep learning configurations

Analisis Yuridis Terhadap Permohonan Perwalian Dalam Pengurusan Izin Jual Tanah Anak Di Bawah Umur

In general, a child is someone who is not yet an adult or is not married. It is not possible for children under this age to carry out legal actions by themselves. For all legal actions, minors are under the authority of the Guardian. To sell land and buildings with the condition that parents act as guardians, you must apply for guardianship and apply for a permit to sell property for minors in the District Court. The purpose of writing this thesis is to understand the application procedures and responsibilities of guardians in processing permits to sell assets of minors in the District Court. This research uses a normative juridical approach, namely, it is carried out by examining theoretical concepts and statutory regulations related to this writing. The data source for this research is a secondary data source, namely data obtained through literature study. The method used in data analysis is a qualitative method, namely interpreted logically and systematically and then conclusions are drawn. The results of this research show that the application submission process consists of: first, the administrative stage, namely: the applicant brings the application letter, submits the case files to the first desk to register the application, pays the down payment, the First Desk Officer submits the SKUM and a copy of the application. Second, the trial stage, namely: The Panel of Judges reads the petition along with the evidence and grants the petitioner's petition. The guardian's responsibility is to make a list of the child's assets under his or her control and record all changes in assets used for the child's benefit until the end of the guardianship period.

PENGELOLAAN ALAT PELINDUNG DIRI PADA KARYAWAN DI INDUSTRI PUPUK

factors in maintaining occupational safety and health. This study aims to find out how to manage personal protective equipment (PPE) in the fertilizer industry, with indicators including identification of PPE needs and requirements, training, use, maintenance, storage of PPE, management in disposal or destruction, and PPE coaching. The results of this study show that the fertilizer industry has managed PPE very well in accordance with applicable procedures and regulations. This is proven through observations and interviews conducted by researchers with several informants. PPE needs and requirements have been well identified and support adequate standards. Before use, the PPE is double-checked to ensure that the PPE used is in accordance with what has been coordinated with the operator. Based on the interviews, the informants admitted that there were no obstacles in the identification and selection process of PPE. The same is true for training, use, maintenance, and storage of PPE that has been managed regularly and routinely. However, in use and maintenance, more emphasis is placed on employees through periodic inspections. Management in disposal and destruction is carried out in stages and follows procedures and regulations for the destruction of PPE that can no longer be used. PPE coaching is carried out in accordance with the established guidelines, including ensuring proper use by workers. Thus, this study concludes that the fertilizer industry has succeeded in managing PPE well in accordance with applicable procedures and regulations.

Analisis Kesalahan Morfologi dalam Penulisan Caption dan Komentar di Salah Satu Postingan Akun Instagram @official.kpk

The purpose of this study was to analyze language errors in the morphological category in captions and comments in one of the @official.kpk posts. The research method used is descriptive with a qualitative approach to describe the existence of errors or mistakes in writing captions and comments according to the procedures for analyzing language errors. The data source in this study is the @official.kpk Instagram post. on November 6, 2024. The data collection technique used was the purposive sampling technique to determine the data sample. Other data collection techniques used in this study were literature studies, documentation, and discourse analysis. The object data used was one post in the form of captions and comments. Data processing was carried out by collecting words that contained errors or mistakes, especially in the morphological category such as affixation or reduplication, then grouped. After grouping the data sources, the researcher conducted an analysis by analyzing using an analysis table and in accordance with applicable procedures. In the results and discussion section, it can be concluded that from one post that the researcher took, there were many errors and mistakes in the comments column, totaling 18 errors and mistakes.