The article considers a number of socio-legal and criminological problems that have arisen in Ukraine as a result of the spread of the global pandemic COVID-19, which has become a challenge to the epidemic security and social wellbeing of mankind. It is emphasized that the most severe consequence of this pandemic is high mortality. Along with this, a number of negative consequences for the vital activity of society have been formed in various spheres (for example, in the sphere of human rights, legal regulation of public relations, state economy, social life and information space, state of law and order). The spread of the coronavirus pandemic in the world and the introduction of quarantine measures of varying sever- ity contributed to a certain degree of restriction of constitutional rights, freedoms and legitimate interests of human and citizen (eg freedom of movement, free choice of residence, right to leave Ukraine, right to health, medical care, the right to hold meetings, rallies, marches and demonstrations, the right to conduct business, etc.). The main directions of legal regulation of counteracting the spread of COVID-19 and overcoming the consequences caused by the epidemic in various spheres of public life are: prevention of the emergence and spread of coronavirus disease; providing treatment for coronavirus disease; providing state support in various spheres and socio-economic rights of citizens in connection with the spread of coronavirus disease; strengthening legal responsibility for violating quarantine rules. It is emphasized that the inconsistency of legislative changes in the regulation of responsibility for violation of quarantine rules has caused a number of law enforcement problems. It is established that the degree of correlation of coronavirus disease with the state of socio-economic development in Ukraine is ambiguous. In the socio-psychological sphere of Ukrainian society the main consequence of the spread of the COVID-19 pandemic is the strengthening of the state of social isolation. A natural consequence of social isolation is an increase in the danger of infodemic chaos. The main changes in the state of law and order of the state are determined. It is noted that quarantine measures and increased social interest in overcoming the COVID-19 pandemic and its consequences have contributed to the emergence of new types of criminal behavior and the adaptation of existing ones to new conditions.