In connection with the development of urbanization, the protection of cities and the environment, issues of restoring the ecological balance become an urgent issue. The scale and intensity of product development in Azerbaijan enhance the anthropogenic impact on the nature of the regions. Such an effect is manifested in the pollution of soils with industrial, household waste, chemical fertilizers, the burning of hydrocarbons, the emission of harmful substances in the water and vehicles into the environment. Like in the whole world and in Azerbaijan, such negative processes are no exception. In this regard, the environmental problems of cities and urban agglomerations around the world are in the focus of attention of specialists and scientists. The presented article considers environmental and geographic problems that arose as a result of air emissions in 8 cities of Azerbaijan. The historical properties of studying atmospheric pollution in cities are analyzed, ecogeographic methods for studying atmospheric pollution of cities are identified, environmental pollutants of large cities and the ecogeographic properties of their influence are considered. The ecological properties of the geographical condition, meteorological climatic conditions in air pollution, aerospace research in the study of atmospheric pollution in large cities and the effect of pollution on the health of the population of large cities are studied. The transport system of cities, their geography, and the effect of emissions of harmful, poisonous substances into the atmosphere by vehicles on public health were also noted. Based on the methods for predicting atmospheric air pollution in large cities and the non-linear regression technique, a mathematical model of ecogeographic forecasting of air pollution is applied. Comprehensive indicators and the level of air pollution in unfavorable conditions for urban agglomerations are determined.