Proactive Interference Effects Research Articles

Detection of cerebrospinal fluid biomarkers changes of Alzheimer's disease using a cognitive stress test in persons with subjective cognitive decline and mild cognitive impairment.

Timely and accurate diagnosis of the earliest manifestations of Alzheimer's disease (AD) is critically important. Cognitive challenge tests such as the Loewenstein Acevedo Scales for Semantic Interference and Learning (LASSI-L) have shown favorable diagnostic properties in a number of previous investigations using amyloid or FDG PET. However, no studies have examined LASSI-L performance against cerebrospinal fluid biomarkers of AD, which can be affected before the distribution of fibrillar amyloid and other changes that can be observed in brain neuroimaging. Therefore, we aimed to evaluate the relationship between LASSI-L scores and CSF biomarkers and the capacity of the cognitive challenge test to detect the presence of amyloid and tau deposition in patients with subjective cognitive decline and amnestic mild cognitive impairment (MCI). One hundred and seventy-nine patients consulting for memory loss without functional impairment were enrolled. Patients were examined using comprehensive neuropsychological assessment, the LASSI-L, and cerebrospinal fluid (CSF) biomarkers (Aβ1-42/Aβ1-40 and ptau181). Means comparisons, correlations, effect sizes, and ROC curves were calculated. LASSI-L scores were significantly associated with CSF biomarkers Aβ1-42/Aβ1-40 in patients diagnosed with MCI and subjective cognitive decline, especially those scores evaluating the capacity to recover from proactive semantic interference effects and delayed recall. A logistic regression model for the entire sample including LASSI-L and age showed an accuracy of 0.749 and an area under the curve of 0.785 to detect abnormal amyloid deposition. Our study supports the biological validity of the LASSI-L and its semantic interference paradigm in the context of the early stages of AD. These findings emphasize the utility and the convenience of including sensitive cognitive challenge tests in the assessment of patients with suspicion of early stages of AD.

Comparing the effectiveness of verb-focused and particle-focused exercise formats on the recall and recognition of phrasal verbs

Phrasal verbs are important for successful communication and yet are incredibly challenging for language learners. The current study compared two exercise formats for the learning of phrasal verbs. One format draws attention to the verb, while the other brings into focus the particle. In the verb-focused format, students were asked to guess the missing verb before receiving feedback. In the particle-focused format, they were told to guess the missing particle before feedback was presented. The results of a cued-recall test showed that the recall of phrasal verbs was enhanced more effectively in the particle-focused format than in the verb-focused format, although this advantage diminished after one week. A multiple-choice test revealed no significant difference between the two methods in terms of their impact on the recognition of phrasal verbs. The current study also aimed to test the prediction of the episodic recollection hypothesis, which specifies that memory of the initial guess plays a critical role in the subsequent recall of the correct answer. It was also found that asking students to recall their initial guess moderated their performance in the posttest. Overall, the findings of the current study suggest that the particle-focused format boosts the memory of phrasal verbs and that to minimize the adverse effects of proactive interference, it is vital for students to remember their errors. This means that teachers would be advised to focus on exercises that provide the verb and encourage guessing of the particle.

Individual features of the temporal dynamics of inhibitory processes in visual short-term memory depending on the content of stimuli and memorization training

Introduction. Age-related changes in cognitive functions are caused by various processes: degrading inhibitory control, decrease in the volume of working memory, or a slowdown in the speed of thought processes. However, there is no unanimous opinion on the dynamics of these processes and their interactions yet. Based on this, our research goal became finding the temporal dynamics and individual relationship of the effects of proactive interference (Retrival-Induced Forgeting (RIF)) and learning to remember (Retrieval-Based Learning (RBL)) depending on the content of the presented stimuli as well as the age-related specifics of memorization when training the short-term visual memory. Materials and methods. Memory training was carried out in a mode independently organized by the study participants using a computerized memorization program in a proactive interference model, including five sessions of visual presentation of stimuli. University students participated in the first part of the study, aimed at clarifying the meaning of the content of two different sets of stimuli, (220 people, 20.4 ± 1.9 years old), whereas second part aimed to determine the age-related characteristics of visual short-term memory training in a group of students, (70 subjects, 21.7±2.5 years) and a group of elderly women (25 subjects, 64.4±6.3 years). Research results. The results of the memory trace retrieval analysis showed that the RIF effect dominates over the RBL effect regardless of the content of the stimuli, but at different rates of its development depending on the set of stimuli used. With significant individual diversity in the combination of memory strategies, the RIF effect dominated at the initial stage of stimulus presentation (67.6% of cases) and gradually replaced by RBL (56.2% in the fifth run of the experiment). Analysis of age-related characteristics of the effectiveness of short-term visual memory training showed that when it is independently organized, maintaining activity is observed in 32% of university students and 50% in the elderly group. Along with this. Only average of ten approaches to complete this task accompanied by a further decrease in the number of training participants. Comparison of the results of the first three training sessions revealed a significant increase in the memory index in both groups compared to the initial value and the presence of a RIF effect with a further more rapid increase in the efficiency of memorization in students. Conclusion. Proactive interference while memorization of visual stimuli repeatedly presented in five sessions, appears regardless of their content, age of the subjects and memorization training. The efficiency of memorization due to training grows faster in the group of students and accompanied by the combination of the RIF and RBL effects that is characterized by individual diversity without a significant effect on the final result of the memory retrieval.

Motor Transfer and Proactive Interference in Cycling With a Noncircular Chainring.

Athletes must transfer their performance when changing equipment due to innovative developments in sports technology. This kind of transfer has received only moderate attention. The aim of this study was to examine whether a mechanical change in sports equipment disturbs an athlete's performance and affects biomechanical and neurophysiological parameters. Therefore, an experiment was conducted in which 36 participants in three groups pedaled at 70 rounds per minute on a cycling ergometer with a circular and a noncircular (NC) chainring. The dependent variables were the total variability of the cadence, torque effectiveness, and muscle cocontraction (electromyographic cocontraction) of four antagonistic acting muscle pairs. Data were recorded during an acquisition phase, a transfer phase, and a retention phase. The results revealed that practice on a circular chainring induces a positive transfer on the NC chainring for total variability without a proactive interference effect. Torque effectiveness did not change within or between groups during the acquisition, transfer, and retention phases. Torque effectiveness and electromyographic cocontraction were not affected when the chainrings were altered from Day 1 to Day 2. During the retention phase, electromyographic cocontraction was higher when using the NC chainring, but the difference was small in absolute terms. The results regarding transfer and proactive interference seem to be strongly dependent on the movement task and the change in sports equipment. Transfer from the circular to NC chainring indicates refined neuromuscular control and improved movement coordination.

Reactivation-induced memory integration prevents proactive interference in perceptual learning.

We acquire perceptual skills through experience to adapt ourselves to the changing environment. Accomplishing an effective skill acquisition is a main purpose of perceptual learning research. Given the often observed learning effect specificity, multiple perceptual learnings with shared parameters could serve to improve the generalization of the learning effect. However, the interference between the overlapping memory traces of different learnings may impede this effort. Here, we trained human participants on an orientation discrimination task. We observed a proactive interference effect that the first training blocked the second training at its untrained location. This was a more pronounced effect than the well-known location specificity in perceptual learning. We introduced a short reactivation of the first training before the second training and successfully eliminated the proactive interference when the second training was inside the reconsolidation time window of the reactivated first training. Interestingly, we found that practicing an irrelevant task at the location of the second training immediately after the reactivation of the first training could also restore the effect of the second training but in a smaller magnitude, even if the second training was conducted outside of the reconsolidation window. We proposed a two-level mechanism of reactivation-induced memory integration to account for these results. The reactivation-based procedure could integrate either the previously trained and untrained locations or the two trainings at these locations, depending on the activated representations during the reconsolidation process. The findings provide us with new insight into the roles of long-term memory mechanisms in perceptual learning.

Effects of proactive interference on olfactory memory in dogs.

Proactive interference (PI) occurs when memories of past events or stimuli intrude in the present moment, causing working memory (WM) errors. These errors are often measured through WM tests such as matching-to-sample (MTS). When the repetition of individual stimuli increases, there is a greater chance of these intrusions, and thus there can be a decrease in accuracy in such tasks. In two experiments, we explored the nature of PI on dog working memory. First, we manipulated the size of the set of odors (2, 6, trial-unique) used to construct each session to maximize (2-odor set) and minimize (trial-unique) within-session proactive interference during an olfactory MTS task. Matching-to-sample accuracy decreased with greater PI. Second, we adapted procedures originally designed for pigeons and rhesus macaques to determine the locus of PI in dogs. To test for proactive interference, probe trials were inserted into MTS sessions where sample odors from earlier trials reappeared as incorrect comparisons. Incorrect responses on these probe trials indicated proactive interference. These probe tests were conducted with a 0-s or 20-s retention interval in separate sessions. We found that dogs performed worse on the matching task when the source of interference (odor stimulus) was from the immediately preceding trial compared with when they were from trials further back in the session but only for the 0-s retention interval. These results are compared with previous work examining the effects of proactive interference on working memory in other species.

Differential effects of proactive and retroactive interference in value-directed remembering for younger and older adults.

We are often presented with more information than we can remember, and we must selectively focus on the most valuable information to maximize memory utility. Most tests of value-based memory involve encoding and then being tested on a list of recently studied information. Thus, people are focused on memory for the current list and are encouraged to forget information from earlier lists. However, prior learning can influence later memory, in both interfering and beneficial ways, and there may be age-related differences in how younger and older adults are influenced by the costs and benefits of prior learning and interference. In the present study, we presented younger and older adults with words paired with point values to remember for a later test but rather than asking participants to only recall words from the just-studied list, participants were asked to recall all studied words on each recall test. Results revealed that younger adults were more likely to recall words from previous lists than older adults, indicating that older adults were more susceptible to retroactive interference. Moreover, although selectivity is often preserved in older adults when study-test cycles are independent, a buildup of proactive interference arising from previously studied words reduced memory selectivity in older adults. Thus, when presented with more information than one can remember, younger adults are better at combating interference and recalling valuable information, while older adults may engage in selective forgetting of prior lists to enhance a "present-focused" form of memory, possibly as a result of impaired inhibitory control. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Proactive stress interference mechanism and its application in the Mahu oil area, Junggar basin

There exists a large horizontal principal stress difference (11–38 MPa) in the tight conglomerates in the Mahu oil area, China. It is difficult to form a complex fracture network via hydraulic fracturing under these conditions. To improve reservoir stimulation, the fracture formation mechanism of the complex conglomerate fracture networks was explored. Based on the geomechanics theory of fracture formation, the mechanism of the “stress wall” formed by fracturing in horizontal wells was analyzed in this paper. The inhibitory effect of the stress wall on the formation of tensile and shear fractures was studied. The reason for the decrease in the stress difference coefficient caused by fracturing fluid was analyzed through numerical simulation, which suggested that the complexity of a fracturing network is mainly controlled by the interference of externally applied stress and the reduction in the coefficient of internal stress difference. In this paper, innovative technologies were developed by proactively introducing stress interference in the application of the Ma131 small-well-spacing pilot area. The core technologies include optimization of the 3-D staggered small-well-spacing pattern, and synergetic optimization of multiple elements and zipper fracturing. The positive effects of proactive stress interference on improving fracturing volume, reserve utilization rate and recovery were discussed. Based on the concept of proactive stress interference, the “serial fracturing mode” of horizontal wells was proposed to reduce drilling and fracturing interference and improve the development effect.

Cognitive flexibility in the wild: Individual differences in reversal learning are explained primarily by proactive interference, not by sampling strategies, in two passerine bird species.

Behavioural flexibility allows animals to adjust to changes in their environment. Although the cognitive processes that explain flexibility have been relatively well studied in psychology, this is less true for animals in the wild. Here we use data collected automatically during self-administered discrimination-learning trialsfor two passerine species, and during four phases (habituation, initial learning, first reversal and second reversal) in orderto decompose sources of consistent among-individual differences in reversal learning, a commonly used measure for cognitive flexibility. First, we found that, as expected, proactive interference was significantly repeatable and had a negative effect on reversal learning, confirming that individuals with poor ability to inhibit returning to a previously rewarded feeder were also slower toreversal learn. Second, to our knowledge for the first time in a natural population, we examined how sampling of non-rewarding options post-learning affected reversal-learning performance. Sampling quantity was moderately repeatable in blue tits but not great tits; sampling bias, the variance in the proportion of visits to each non-rewarded feeder, was not repeatable for either species. Sampling behaviour did not predict variation in reversal-learning speed to any significant extent. Finally, the repeatability of reversal learning was explained almost entirely by proactive interference for blue tits; in great tits, the effects of proactive interference and sampling bias on the repeatability of reversal learning were indistinguishable. Our results highlight the value of proactive interference as a more direct measurement of cognitive flexibility and shed light on how animals respond to changes in their environment.

Dissociating the effects of delay and interference on dog (Canis familiaris) working memory.

Delayed matching-to-sample (dMTS) is commonly used to study working memory (WM) processes in non-humans. Previous procedures for studying dog WM, including versions of the dMTS, did not separate the impact of delay and interference on memory performance. These studies were also limited to auditory and spatial stimuli, neglecting dogs' dominant sensory modality (i.e., olfaction). Therefore, we designed the first olfactory dMTS in dogs, with systematically varied delays and number of odors in a session, to dissociate the effects of delay and within-session proactive interference on dog WM. Dogs (n = 5) initially trained on matching-to-sample with 48 odors, with a zero-second delay, were tested on four delay lengths (0, 30, 60, and 90s), counterbalanced across three, trial-unique, sessions. Although there was a slight decrease in accuracy across delays, dogs performed above chance on delays up to 60s, suggesting a WM duration of at least 60s. To explore the effect of within-session proactive interference on WM duration, the size of the stimulus set was reduced to six and two odors. There was no effect on the memory function with six odors compared to the trial-unique sessions. However, the interference caused by the two-odor set was enough to decrease accuracy at each delay length. These findings suggest that forgetting in dog working memory for odors can be simultaneously influenced by delay and within-session proactive interference.

Neural Underpinnings of Proactive Interference in Working Memory: Evidence From Patients With Unilateral Lesions.

Proactive interference in working memory refers to the fact that memory of past experiences can interfere with the ability to hold new information in working memory. The left inferior frontal gyrus (LIFG) has been proposed to play an important role in resolving proactive interference in working memory. However, the role of white matter pathways and other cortical regions has been less investigated. Here we investigated proactive interference in working memory using the Recent Probes Test (RPT) in 15 stroke patients with unilateral chronic lesions in left (n = 7) or right (n = 2) prefrontal cortex (PFC), or left temporal cortex (n = 6). We examined the impact of lesions in both gray and white matter regions on the size of the proactive interference effect. We found that patients with left PFC lesions performed worse overall, but the proactive interference effect in this patient group was comparable to that of patients with right PFC lesions, temporal lobe lesions, and controls. Interestingly, the size of the interference effect was significantly correlated with the degree of damage in the extreme/external capsule and marginally correlated with the degree of damage in the inferior frontal occipital fasciculus (IFOF). These findings suggests that ventral white matter pathways connecting the LIFG to left posterior regions play a role in resolving proactive interference in working memory. This effect was particularly evident in one patient with a very large interference effect (>3 SDs above controls) who had mostly spared LIFG, but virtually absent ventral white matter pathways (i.e., passing through the extreme/external capsules and IFOF). This case study further supports the idea that the role of the LIFG in resolving interference in working memory is dependent on connectivity with posterior regions via ventral white matter pathways.

Dissociating the effects of distraction and proactive interference on object memory through tests of novelty preference.

Encoding information into memory is sensitive to distraction while retrieving that memory may be compromised by proactive interference from pre-existing memories. These two debilitating effects are common in neuropsychiatric conditions, but modelling them preclinically to date is slow as it requires prolonged operant training. A step change would be the validation of functionally equivalent but fast, simple, high-throughput tasks based on spontaneous behaviour. Here, we show that spontaneous object preference testing meets these requirements in the subchronic phencyclidine rat model for cognitive impairments associated with schizophrenia. Subchronic phencyclidine rats show clear memory sensitivity to distraction in the standard novel object recognition task. However, due to this, standard novel object recognition task cannot assess proactive interference. Therefore, we compared subchronic phencyclidine performance in standard novel object recognition task to that using the continuous novel object recognition task, which offers minimal distraction, allowing disease-relevant memory deficits to be assessed directly. We first determined that subchronic phencyclidine treatment did not affect whisker movements during object exploration. Subchronic phencyclidine rats exhibited the expected distraction standard novel object recognition task effect but had intact performance on the first continuous novel object recognition task trial, effectively dissociating distraction using two novel object recognition task variants. In remaining continuous novel object recognition task trials, the cumulative discrimination index for subchronic phencyclidine rats was above chance throughout, but, importantly, their detection of object novelty was increasingly impaired relative to controls. We attribute this effect to the accumulation of proactive interference. This is the first demonstration that increased sensitivity to distraction and proactive interference, both key cognitive impairments in schizophrenia, can be dissociated in the subchronic phencyclidine rat using two variants of the same fast, simple, spontaneous object memory paradigm.

Memory Impairment in Relapsing-Remitting Multiple Sclerosis Using a Challenging Semantic Interference Task.

Objective: Episodic memory is frequently impaired in Multiple Sclerosis (MS), but the cognitive characteristics and neuropsychological processes involved remain controversial. Our aim was to study episodic memory dysfunction in MS, using the LASSI-L, a novel memory-based cognitive stress test that uses a new paradigm that capitalizes on semantic interference.Methods: Cross-sectional study in which 93 patients with MS (relapsing-remitting) and 124 healthy controls were included. The LASSI-L test was administered to all participants, as well as a comprehensive neuropsychological battery including a selective reminding test. MS patients were divided into two groups, with cognitive impairment (CI-MS) and cognitively preserved (CP-MS).Results: Reliability of the LASSI-L test was high (Cronbach's alpha 0.892) and there were less ceiling effects. MS patients scored lower than controls on all LASSI-L subtests, except for maximum storage of the initial target items (CRA2). Effect sizes were moderate-large. A delay in learning, difficulties in retroactive semantic interference, failure to recover from proactive semantic interference, and delayed recall were the most frequent findings in MS patients. Scores associated with maximum storage capacity, and retroactive semantic interference were the most strongly associated with cognitive impairment and employment status.Conclusion: We found that deficits in maximum learning, difficulties in recovery from the effects of proactive semantic interference and retroactive semantic interference are three important breakdowns in episodic memory deficits among patients with MS. The LASSI-L showed good psychometric and diagnostic properties. Overall, our study supports the utility of the LASSI-L, as a new cognitive test, useful for neuropsychological assessment in MS in clinical and research settings.

Effects of low-gamma tACS on primary motor cortex in implicit motor learning

In the primary motor cortex (M1), rhythmic activity in the gamma frequency band has been found during movement planning, onset and execution. Although the role of high-gamma oscillatory activity in M1 is well established, the contribution of low-gamma activity is still unexplored. In this study, transcranial alternating current stimulation (tACS) was used with the aim to specifically modulate low-gamma frequency band in M1, during an implicit motor learning task. A 40 Hz-tACS was applied over the left M1 while participants performed a serial reaction time task (SRTT) using their right hand. The task required the repetitive execution of sequential movements in response to sequences of visual stimuli. Sequential blocks were interleaved by a random block, which served as interference to sequence learning. Sham and 1 Hz tACS were used as control. Task performance was examined before, during and after tACS (pre-, online- and post-phase, respectively). Furthermore, cortical reactivity of M1 was assessed in the pre- and post-tACS phases, by measuring motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS).Compared to sham and pre-tACS, the 40 Hz stimulation applied during SRTT slowed down response times in blocks that required retrieving previously learned sequences, after performing the random block. In addition, M1 cortical reactivity was selectively inhibited following 40 Hz-tACS, as quantified by reduced MEP amplitude. These results show that low-gamma tACS delivered over M1 during motor learning enhanced susceptibility to interference generated by the random sequence (i.e., proactive interference effect). Importantly, only low-gamma stimulation produced long-lasting effects on M1 cortical reactivity.

Experimental Effects of Acute Exercise in Attenuating Memory Interference: Considerations by Biological Sex.

Background and Objectives: The objective of this experiment was to evaluate the effects of acute exercise on memory interference and determine if this potential relationship is moderated by sex. Materials and Methods: A randomized controlled experiment was conducted (N = 40), involving young adult males (n = 20) and females (n = 20) completing two counterbalanced visits (exercise and no exercise). The exercise visit involved an acute (15 min), moderate-intensity bout of treadmill exercise, while the control visit involved a time-matched seated task. Memory interference, including both proactive interference and retroactive interference, involved the completion of a multi-trial memory task. Results: In a factorial ANOVA with the outcome being List B, there was a main effect for condition (F(1,38) = 5.75, P = 0.02, n2p = 0.13), but there was no main effect for sex (F(1,38) = 1.39, P = 0.24, n2p = 0.04) or sex by condition interaction (F(1,38) = 1.44, P = 0.23, n2p = 0.04). Conclusion: In conclusion, acute moderate-intensity exercise was effective in attenuating a proactive memory interference effect. This effect was not moderated by biological sex.

Background Speech Disrupts Working Memory Span in 5-Year-Old Children

The present study tested the effects of background speech and nonspeech noise on 5-year-old children's working memory span. Five-year-old typically developing children (range = 58.6 to 67.6 months; n = 94) completed a modified version of the Missing Scan Task, a missing-item working memory task, in quiet and in the presence of two types of background noise: male two-talker speech and speech-shaped noise. The two types of background noise had similar spectral composition and overall intensity characteristics but differed in whether they contained verbal content. In Experiments 1 and 2, children's memory span (i.e., the largest set size of items children successfully recalled) was subjected to analyses of variance designed to look for an effect of listening condition (within-subjects factor: quiet, background noise) and an effect of background noise type (between-subjects factor: two-talker speech, speech-shaped noise). In Experiment 1, children's memory span declined in the presence of two-talker speech but not in the presence of speech-shaped noise. This result was replicated in Experiment 2 after accounting for a potential effect of proactive interference due to repeated administration of the Missing Scan Task. Background speech, but not speech-shaped noise, disrupted working memory span in 5-year-old children. These results support the idea that background speech engages domain-general cognitive processes used during the recall of known objects in a way that speech-shaped noise does not.

Особенности когнитивного статуса студентов с нарушением слуха: значение для инклюзивного образования

Specificity of intelligence, attention and memory were studied in students with hearing impairment (26 individuals). This group shown less indicators of verbal intelligence and speed of selection of visually presented information as compared to the normal hearing group (28 individuals). Higher index of figurative and spatial intelligence, comparing to the verbal component of intelligence in the group with hearing impairments indicate the development of compensatory effect in visual functions. The smaller effect of proactive interference with a greater time of executive control in students with hearing impairments compared with the control group indicates a lack of development of the inhibitory functions of the prefrontal cortex.

The variability puzzle in human memory.

Memory performance exhibits a high level of variability from moment to moment. Much of this variability may reflect inadequately controlled experimental variables, such as word memorability, past practice and subject fatigue. Alternatively, stochastic variability in performance may largely reflect the efficiency of endogenous neural processes that govern memory function. To help adjudicate between these competing views, the authors conducted a multisession study in which subjects completed 552 trials of a delayed free-recall task. Applying a statistical model to predict variability in each subject's recall performance uncovered modest effects of word memorability, proactive interference, and other variables. In contrast to the limited explanatory power of these experimental variables, performance on the prior list strongly predicted current list recall. These findings suggest that endogenous factors underlying successful encoding and retrieval drive variability in performance. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Acute Cardiovascular Exercise on Proactive Memory Interference

The present experiment evaluated the temporal effects of exercise on memory performance after an antecedent distractor. We aimed to evaluate if exercise could attenuate a proactive interference (PI) effect. The present study was a within-subject, counterbalanced, randomized controlled design. Participants completed four laboratory visits including (1) a control visit, (2) exercising (15-min brisk walking) prior to memory encoding, (3) exercising during memory encoding, and (4) exercising after memory encoding. The PI assessment included a word-list trial, including a competing stimuli trial (list A), followed by recall of a second word trial (list B), with performance on list B serving as the outcome measure. The visit that involved exercise occurring prior to the memory task had the highest number of words recalled for list B. Specifically, for the control, before, during, and after visits, respectively, the mean (SE) number of recalled words were 5.9 (0.4), 6.4 (0.3), 6.1 (0.5), and 5.8 (0.3). These differences, however, did not reach statistical significance. Acute exercise did not statistically attenuate proactive memory interference.

Impact of ageing on problem size and proactive interference in arithmetic facts solving.

Arithmetic facts (AFs) are required when solving problems such as "3 × 4" and refer to calculations for which the correct answer is retrieved from memory. Currently, two important effects that modulate the performance in AFs have been highlighted: the problem size effect and the proactive interference effect. The aim of this study is to investigate possible age-related changes of the problem size effect and the proactive interference effect in AF solving. To this end, the performance of young and older adults was compared in a multiplication production task. Furthermore, an independent measure of proactive interference was assessed to further define the architecture underlying this effect in multiplication solving. The results indicate that both young and older adults were sensitive to the effects of interference and of the problem size. That is, both interference and problem size affected performance negatively: the time needed to solve a multiplication problem increases as the level of interference and the size of the problem increase. Regarding the effect of ageing, the problem size effect remains constant with age, indicating a preserved AF network in older adults. Interestingly, sensitivity to proactive interference in multiplication solving was less pronounced in older than in younger adults suggesting that part of the proactive interference has been overcome with age.