Recent advancements in Mechanical Engineering, particularly in areas such as thermo-fluids and system design, have spurred the need for comprehensive discussions on the development of associated sciences and their diverse applications worldwide. This initiative aimed to foster global awareness among researchers, including those who participated in our inaugural conference, ICTFSD 2022, and others from India and abroad eager to join our collaborative platform for exchanging ideas and showcasing local innovations. Thus, the Department of Mechanical Engineering at Birla Institute of Technology, Mesra, Ranchi (India) organized the 2nd International Conference on Thermo-Fluids and System Design (ICTFSD) 2024 on April 4-5, 2024. The conference convened experts from academic institutions, research organizations, industries, and policymakers to facilitate in-depth interactions. Keynote speakers from India, the US, and Europe delivered talks on various applications within these fields. The conference was heavily supported through financial assistance from the Science and Engineering Research Board (SERB), Government of India. Partial financial support was also received from private partners viz. ANSYS Inc., Entuple Technologies and COMSOL Multiphysics Pvt. Ltd. ICTFSD 2024 aimed to promote industry-relevant research in academic and research institutions, establishing networks for collaborative research and development. It identified emerging research areas while showcasing high-quality papers spanning both emerging and traditional fields. All conference papers underwent rigorous peer review by a technical committee, with select papers earmarked for publication in the Journal of Physics Conference Series, IOP Publications. The conference conveners and organizing secretaries, who also served as Editors of the Conference Series, extend gratitude to the Morressier team and the IOP publications team for helping us in the entire review and publication process. We especially acknowledge the valuable inputs of the expert reviewers for their pivotal role in quality check of the manuscripts. We would like to extend our sincere appreciation to all the conference sponsors, whose financial contributions were instrumental in making the event a success. Appreciation also goes to all researchers who contributed papers and participated in ICTFSD 2024, the eminent guests who took their valuable time to join us in the event, as well as to the faculty and staff of our department whose efforts ensured the conference’s success. Looking ahead, we envision continued success for the ICTFSD conference series. List of ICTFSD 2024 Organising Committee is available in this Pdf.