ABSTRACT With advances in digitization, there have been heightened concerns about online privacy in developing countries, in particular, the privacy of personal health information (PHI) as these are shared among various stakeholders. To understand these concerns, this study explores the impacts of individuals’ characteristics, experiences, and perceptions on PHI privacy concerns (PHIPC) in the healthcare setting of a developing country, Ghana. Using data from 276 individuals, the results show individuals are less concerned about PHI collection, but more concerned about the management of their PHI once it is collected (e.g. errors, secondary use, and unauthorized use). The results further indicate that the factors influencing PHIPC are differentiated for the collection and management of PHI. While gender, age, health status, and privacy risk perceptions impact PHI collection concerns, PHI management concerns are impacted by privacy orientation, computer experience, and trust in healthcare providers. Implications for research and practice are discussed.