Priority In Countries Research Articles

Has COVID-19 changed carer's views of health and care integration in care homes? A sentiment difference-in-difference analysis of on-line service reviews

Closer integration of health and social care is a policy priority in many countries. The COVID-19 pandemic has reinforced the necessity of joining up health and social care systems, especially in care home settings. However, the meaning and perceived importance of integration for residents’ and carers’ experience is unclear and we do not know whether it has changed during the pandemic.Using unique data from on-line care home service reviews, we combined multiple methods. We used Natural Language Processing with supervised machine learning to construct a measure of sentiment for care home residents' and their relatives’ (measured by AFINN score). Difference-in-difference analysis was used to examine whether experiencing integrated care altered these sentiments by comparing changes in sentiment in reviews related to integration (containing specific terms) to those which were not. Finally, we used network analysis on post-estimation results to assess which specific attributes stakeholders focus on most when detailing their most/least positive experiences of health and care integration in care homes, and whether these attributes changed over the pandemic.Reviews containing integration words were more positive than reviews unrelated to integration in the pre-pandemic period (about 2.3 points on the AFINN score) and remained so during the first year of the pandemic. Overall positive sentiment increased during the COVID-19 period (average by +1.1 points), mainly in reviews mentioning integration terms at the beginning of the first (+2.17, p-value 0.175) and second waves (+3.678, p-value 0.027). The role of care home staff was pivotal in both positive and negative reviews, with a shift from aspects related to care in pre-pandemic to information services during the pandemic, signalling their importance in translating integrated needs-based paradigms into policy and practice.

Environmental Risk Assessment and Management in Industry 4.0: A Review of Technologies and Trends

In recent decades, concern with workers’ health has become a priority in several countries, but statistics still show that it is urgent to perform more actions to prevent accidents and illnesses related to work. Industry 4.0 is a new production paradigm that has brought significant advances in the relationship between man and machine, driving a series of advances in the production process and new challenges in occupational safety and health (OSH). This paper addresses occupational risks, diseases, opportunities, and challenges in Industry 4.0. It also covers Internet-of-Things-related technologies that, by the real-time measurement and analysis of occupational conditions, can be used to create smart solutions to contribute to reducing the number of workplace accidents and for the promotion of healthier and safer workplaces. Proposals involving smart personal protective equipment (smart PPE) and monitoring systems are analyzed, and aspects regarding the use of artificial intelligence and the data privacy concerns are also discussed.

Effectiveness of a complex intervention of group-based nutrition and physical activity to prevent frailty in pre-frail older adults (SUPER): a randomised controlled trial

The increasing prevalence of frailty with age is becoming a public health priority in countries with ageing populations. Pre-frailty presents a window of opportunity to prevent the development of frailty in community-dwelling older adults. This study aimed to examine the effectiveness of a complex intervention that combined a nutrition-based intervention and a physical activity intervention, along with the effectiveness of each intervention individually, to reduce physical frailty in pre-frail older adults over 2 years. In this single-blind, 2 x 2 factorial, randomised, controlled trial, we recruited pre-frail community-dwelling older adults in Aotearoa New Zealand via mail through general medical practices. To be eligible, participants had to be pre-frail according to self-reported FRAIL scores of 1 or 2, aged 75 years or older (or 60 years or older for Māori and Pacific Peoples), not terminally ill or with advanced dementia as judged by a general practitioner, able to stand, medically safe to participate in low-intensity exercise, and able to use kitchen utensils safely. Participants were randomly allocated to receive an 8-week Senior Chef programme (SC group), a 10-week Steady As You Go programme (SAYGO group), a 10-week combined SC and SAYGO intervention (combined group), or a 10-week social programme (control group), using computer-generated block randomisation administered through an electronic data capture system by local study coordinators. Assessors were masked to group allocation for all assessments. SC is a group-based nutrition education and cooking class programme (3 h weekly), SAYGO is a group-based strength and balance exercise programme (1 h weekly), and the social control programme was a seated, group socialising activity (once a week). Masked assessors ascertained Fried frailty scores at baseline, end of intervention, and at 6, 12, and 24 months after the programme. The primary outcome was change in Fried frailty score at 2 years. Intention-to-treat analyses were completed for all randomised participants, and all participants who had a high (≥75%) adherence were analysed per protocol. This study is registered at ANZCTR, ACTRN12614000827639. Between May 12, 2016 and April 9, 2018, we assessed 2678 older adults for eligibility, of whom 468 (17%) consented and completed baseline assessment, with a mean age of 80·3 years (SD 5·1) and a mean Fried score of 1·9 (1·2); 59% were women. We randomly allocated these participants into the four groups: 117 in the SC group, 118 in the SAYGO group, 118 in the combined group, and 115 in the control group; 318 participants attended the 24-month follow-up: 89 in the SC group, 78 in the SAYGO group, 73 in the combined group, and 78 in the control group. At the 24-month follow-up, there were no differences in mean Fried scores between the intervention groups and the control group. No adverse events were reported. The study did not find that the combined SC and SAYGO programme was effective in reducing frailty in pre-frail older adults. Although some short-term benefits were observed in each individual programme, there was no clear evidence of long-term impact. Further research is needed to evaluate combinations of group-based programmes for community-dwelling older adults to optimise their physical function. Health Research Council New Zealand and Ageing Well Challenge (Ministry of Business Innovation and Employment).

Repurposing Drugs to Combat Drug Resistance in Leprosy: A Review of Opportunities.

Leprosy is caused by extremely slow-growing and uncultivated mycobacterial pathogens, namely Mycobacterium leprae and M. lepromatosis. Nearly 95% of the new cases of leprosy recorded globally are found in India, Brazil, and 20 other priority countries (WHO, 2019), of which nearly two-third of the cases are reported in India alone. Currently, leprosy is treated with dapsone, rifampicin, and clofazimine, also known as multi-drug therapy (MDT), as per the recommendations of WHO since 1981. Still, the number of new leprosy cases recorded globally has remained constant in last one-decade, and resistance to multiple drugs has been documented in various parts of the world, even though relapses are rare in patients treated with MDT. Antimicrobial resistance testing against M. leprae or the evaluation of the anti-leprosy activity of new drugs remains a challenge as leprosy bacilli cannot grow in vitro. Besides, developing a new drug against leprosy through conventional drug development process is not economically attractive or viable for pharma companies. Therefore, a promising alternative is the repurposing of existing drugs/approved medications or their derivatives for assessing their anti-leprosy potential. It is an efficient method to identify novel medicinal and therapeutic properties of approved drug molecules. Any combinatorial chemotherapy that combines these repurposed drugs with the existing first-line (MDT) and second-line drugs could improve the bactericidal and synergistic effects against these notorious bacteria and can help in achieving the much-cherished goal of "leprosy-free world". This review highlights novel opportunities for drug repurposing to combat resistance to current therapeutic approaches.

Internationalisation and Diversity in Preschool Teacher Education: Representations in Preschool Student Teachers’ Projects

Internationalisation of higher education has been a top priority in many countries for decades, yet teacher education programmes in Sweden have lower number of exchange students. This is predominantly ascribed to the Swedish national context of education and to the lack of conceptualisation of internationalisation and diversity among teacher educators in Sweden. The need to address issues of internationalisation and diversity is reinforced by the fact that many societies today are heterogeneous with high levels of linguistic and cultural diversity. This study examines conceptualisations of internationalisation and diversity in preschool teacher education at one Swedish university. Drawing from Stephen Ball’s writings on policy as text and policy as discourse, student preschool teachers are simultaneously regarded as policy workers that act upon policy and as subjects constructed by the same policy. Through 26 preschool student teachers’ undergraduate degree projects, the question “What is the problem represented to be?” is used to explore the projects. The results show that the projects reproduce prevailing discourses of internationalisation and diversity from content, literature, and policy. The findings show that to develop students’ conceptualisations of internationalisation and diversity, a reconceptualisation of the purposes and means of internationalisation in preschool teacher education is needed.

Sustainable development goal 14: To what degree have we achieved the 2020 targets for our oceans?

Since the adoption of the United Nations Sustainable Development Goals in 2015, the world oceans, to which a specific goal was assigned, have been high on the global agenda. At the national level, the ocean has received increasing consideration, with many coastal states and islands adopting blue economy strategies and frameworks, and putting the ocean at the centre of development. SDG 14: Life Below Water includes ten targets, four of which (14.2, 14.4, 14.5 and 14.6) expired in 2020. This paper presents the state of progress on these four targets that address marine protection and fisheries management. The study is based on an assessment of the indicators established by the United Nations for each target, using publicly available databases allowing to measure the achievement of the targets. The analysis shows that achievement of these four targets is meagre. Only two countries achieved three of the four targets, while no country achieved all four. Most countries were classified as far from achievement or having made low progress. Across the four targets, SDG 14.5 on marine protected areas saw the highest number of achievers but also a high number of countries still far from achievement. Europe and Oceania had the highest number of countries having performed well in terms of achievement while Africa and the Middle East showed the most countries with limited achievement. These results indicate that there is still a long way to go to achieve these four targets in 2030. To move towards achievement, more investment is needed towards priority countries that have seen limited achievement but also some adaptation might be needed in terms of monitoring processes. Finally, it seems useful at this point to reflect on what has been achieved and how countries, especially those facing various socio-economic and political challenges, can fully benefit from current processes towards implementing SDG 14.

Harnessing the Power of Labour Law and Social Security Law to Achieve the Goal of Formalizing Labour Markets in the BRICS Countries

The Declaration by the Labour and Employment Ministers of the BRICS countries, “Quality Jobs and Inclusive Employment Policies,” guarantees that formalization of labor markets is a global priority for the BRICS countries, as informal employment hampers productivity, potential economic growth and efforts to improve the welfare of populations worldwide. Taking into account this strategic goal, the authors analyze the informal employment processes in the BRICS countries and speculate on the transition from informal to formal employment. The article addresses the issues of inhomogeneous notional ranges used to define informal employment and recommends that the possibilities provided by labor legislation and government employment policy (such as increasing the number of formal working places and dynamic development of labor legislation directed at regulation of new employment forms) be used to tackle these issues. The potential of the social security right for achieving the goals of transition to a formal economy and social security coverage is characterized in detail; various legal forms of social security (for example, government social security, social insurance (mandatory as well as voluntary) and social support) are analyzed; and the possibilities of their application to informal workers in the BRICS countries are defined.

Determinants of Public Acceptance of the COVID-19 Vaccine: A Systematic Review

Background: The coronavirus disease 2019 (COVID-19) pandemic can be considered as a global unity that has forced all countries to work together to treat it. Consistent with ongoing efforts to reduce the prevalence of COVID-19, building a safe and effective vaccine against COVID-19, which is recognized as a major achievement, is a priority for many developed countries around the world. In this regard, we aimed to investigate the determinants of public acceptance of COVID-19 vaccine. Methods: In this review, published articles on the determinants of public acceptance of COVID-19 vaccine during 2020-2021 were reviewed. To obtain related scientific documents, the following keywords were searched in the title and abstract of published articles: Coronavirus 2019, COVID-19, and Vaccine acceptance, Resistance, Doubt, Vaccination, Determinants and Pandemics. Scientific databases such as Google Scholar, PubMed, Science Direct, Scopus and ProQuest were searched and all relevant English articles were listed. The PRISMA checklist was used to review and control the quality of articles. Results: Initially, 372 English articles were retrieved and finally 19 articles were finally selected for comprehensive review and data extraction. The results showed that most people were more receptive to vaccines that produce 90%-95% efficacy and safety levels. Also, being a woman, low age, low-income level, being single, low education and lack of trust in the government were among the factors that reduced the acceptance of people for the COVID-19 vaccine. The most common reasons for people not participating in the vaccination process were fear of vaccine side effects, lack of confidence in vaccine efficacy, and safety levels. Conclusion: Considering that a significant number of people in the world have a high acceptance of vaccines with 90%-95% safety levels. Measures need to be taken to speed up the vaccination process. Also, since most people are only afraid and anxious about the side effects caused by vaccines, it is necessary to increase people’s awareness and knowledge about the positive and negative consequences of vaccination.

POSITIONING DENMARK’S NATIONAL TOURIST PRODUCT ON THE INTERNATIONAL TOURISM MARKET IN THE CONTEXT OF THE GLOBAL PANDEMIC

This study is devoted to the analysis of Denmark’s place in the world tourism market. The specialization of the country’s recreational economy is determined. Problem Statement and Purpose. The aim of the study is to assess Denmark’s competitive advantage in the international tourism market, current trends in domestic tourism destinations, especially in the context of the global pandemic, as well as identifying national priorities for the development of the Danish tourism industry. Data & Methods. The study was conducted on the basis of analysis of statistical reports and materials data of UNWTO and international platform Statista. Their analysis made it possible to create a series of graphic models and to identify current trends in the development of Danish domestic tourism. Results. Danish tourism policy is the direct responsibility of the Ministry of Industry, Business and Finance, which cooperates with other ministries on tourism-related issues, including the Ministry of Environment and Food, transport and housing, foreign affairs and culture. The Danish National Tourism Strategy sets out the main priorities for the development of the tourism industry, which include the development of the tourism industry and the active introduction of innovations and information technologies in the tourism sector, creating quality impressions of the country’s tourism product, developing the tourist infrastructure and simplifying tourist formalities. In the international tourism market Denmark places itself as a priority country for the development of domestic tourism. Thus, in 2019, 27.2 million internal visitors were registered. According to the experts’ projections, by 2028 the costs of local tourists will exceed those of foreign tourists – 85.4 billion DKK. In accordance with the National Strategy for the Sustainable Growth of Danish Tourism, the main drivers for its further promotion are the development of tourism destinations, the balance between the environmental, economic and social spheres, as well as increasing international competition in the field of tourism.

One-part alkali-activated binder produced from inertized asbestos cement waste

Owing to its carcinogenic potential and the environmental impacts associated with its disposal, the search for inertization technologies that enable the reuse of asbestos cement waste (ACW) is a priority in several countries. Among the proposed methods, optimized heat treatment is a promising methodology. However, there is a lack of studies aimed at the application of asbestos cement waste, even after proper treatment. Thus, this study investigates the potential use of heat-treated asbestos-cement waste (ACWT) as a precursor of one-part alkali-activated binders. Eleven formulations were established using the I-Optimal algorithm, strategically varying the mass fractions of ACWT, solid sodium metasilicate (SSM) with a molar ratio of SiO2/Na2O equal to 0.98, and water. These formulations served as the basis for the construction of models that relate the properties of pastes with the proportion of materials. The pastes were evaluated by isothermal calorimetry, X-ray diffraction, autogenous shrinkage, drying shrinkage, and compressive strength. The results show that the formulations with an SSM concentration of approximately 5% and molarities close to 1 M presented the best mechanical properties. The addition of SSM had a strong influence on the accumulated heat rate, with the formulations containing the activator showing superior mechanical behavior compared to the mixtures without the activator. Furthermore, the pastes without an activator exhibited lower drying shrinkage and chemical shrinkage. It was possible to verify that ACWT can be applied for the production of alkali-activated binders and that the statistical mixture design is an efficient method for predicting the evaluated properties.

How to Ensure the International Publication Activity of Russian Researchers: Risks, Development Opportunities, Threats.

The article deals with the problems of the publication activity of Russian scientists in connection with the growing sanctions pressure. In the changed international conditions, the Russian strategy of international publishing activity needs to be revised and reassessed risks. The article proposes a number of measures to support the international publication activity of Russian researchers and to preserve the recognition of Russian research in the world. Firstly, this is the creation of specialized journals, regulated by the Russian scientific communities themselves. The inclusion of journals in the quality lists should take place on the decision and at the initiative of the Russian research communities, carried out by their professional associations. Secondly, it is necessary to organize the accounting of collective and individual monographs in leading Russian publishing houses, as well as series of scientific preprints, publications in publication knowledge bases and archives (as decided by specialized research communities). Thirdly, it is necessary, if possible, to preserve international private scientific contacts, transferring their center, if necessary, to those countries and organizations that did not support the international sanctions. Fourthly, international institutional contacts should be refocused on the remaining friendly countries and organizations, procedures for registering and maintaining such relations should be simplified, as well as transfer their management toscientific and educational organizations in Russia. Fifth, it is necessary to develop a network of joint graduate schools with friendly foreign graduate schools in priority countries and regions of the world, encouraging joint conferences and publications is a possible tool to counter the exclusion of young researchers in general, from international contacts and publication activity.

Integrated Evaluation of Innovative Development of the New EU Member States and Other EU Countries

This study investigates the problem of estimating various aspects and qualitative features of innovative development. A new methodological approach to comprehensively assessing the polystructural nature of modern innovative development in the new EU member states and other EU countries is proposed, which allows us to identify growth points and promising areas to increase their innovative development. Aspects such as information adaptability, innovative orientation, and synergetic efficiency are considered. The analysis is based on a logical evaluation of indicators that characterize science, technology, and the digital society in accordance with the data presented in the public domain, from which the main indicators that characterize these three aspects of the EU’s innovative development were selected. According to the algorithm of the matrix method for the new EU member states and other EU countries, the maximum (reference) value was chosen for each indicator and the coefficient of compliance with the reference value of a particular indicator was calculated. As a result, integrated indicators of assessing information adaptability, innovative orientation, and synergetic efficiency and the integrated indicator of innovative development of the EU countries were calculated, which allowed us to rate them. The innovative development of the economies of the EU countries differs significantly in some indicators and aspects. The assessment and comparison of innovative development at the national level depends on many factors but is primarily determined by public policy and national priorities of a particular country. That is why a promising direction of increasing the innovative development of all EU countries should be, first of all, the further development of their mutual exchange of technologies based on the existing integration scientific and technical potential.

The Prevalence, Directionality, and Dyadic Perpetration Types of Intimate Partner Violence in a Community Sample in Portugal: a Gender-Inclusive Inquiry.

Intimate partner violence (IPV) is a major concern across the world, and its prevalence assessment has been a priority in numerous countries. However, data about IPV prevalence in Portugal is scarce and not up-to-date. This study aims to estimate IPV prevalence in Portugal. A community sample of 1392 adults (77.4% female, mean age = 34.95 years, SD = 12.80) was collected through a web-based survey, between March and June of 2020. Participants completed a sociodemographic questionnaire and the Conflict Tactic Scales-2 (CTS-2). Accounting for all forms of IPV, a past-year prevalence of 64.4% and 64.6% were found, for victimization and perpetration, respectively. Regarding gender or sexual orientation, no significant differences were found in the past-year or the lifetime prevalence, neither concerning frequency. Directionality and dyadic concordance types were analyzed and showed that most violence was bidirectional. Having perpetrated violence in previous intimate relationships was the most influential factor when predicting past-year perpetration or victimization. Other significant predictors were age, being victimized before 15 years old, cohabitation with the intimate partner, and drug use, but the last two were only significant for victimization. Findings support the idea that IPV is a relevant phenomenon, regardless of gender and sexual orientation. It is the first nationwide, gender-inclusive study to do so in Portugal. Studies based on different samples might provide important evidence to prevent hasty conclusions about IPV prevalence and patterns and to guide empirically driven policies.

A review of Moroccan Medicinal Plants Used in the Treatment of Hypertension

The incidence of hypertension is very high in human societies and its treatment is the most important priority in many countries. Knowledge of the plants that are used may provide insight on their properties, for further exploration. This study aimed to collect the knowledge on traditional medicine for the treatment of hypertension in different regions of Morocco. We reviewed 145 research publications based on data from the six explored regions of Morocco published until August 2021 in various journals. This was achieved using literature databases: Google, Google Scholar, PubMed, Medline, Science Direct and Researchgate. The findings of this study indicated that 23 plants have been reported to possess antihypertensive activities in in vivo / in vitro experiments, while 81 plants had not been studied for such an activity. Plants from the Lamiaceae, Asteraceae and Apiaceae families were used most often. Leaves were the plant parts used most often. Decoction was the main preparation method. Twenty three plants have been explored experimentally for their antihypertensive activity. This review provides baseline data for plant species used to treat hypertension in Morocco and provides new areas of research on the antihypertensive effect of these plants.

Antimicrobial Resistance Research Collaborations in Asia: Challenges and Opportunities to Equitable Partnerships.

Antimicrobial Resistance is recognized as a major threat to global health security. The WHO Southeast Asia region is dubbed a “global hub for AMR emergence”, as it runs the highest risk for AMR emergence among all WHO regions in Asia. Hence, there is a need for Asia-centric, collaborative AMR research aligned with the true needs and priorities of the region. This study aimed to identify and understand the challenges and opportunities for such collaborative endeavors to enhance equitable partnerships. This qualitative study adopted an interpretative approach involving a thematic analysis of 15 semi-structured interviews with AMR experts conducting research in the region. The study identified several factors influencing research collaborations, such as the multi-dimensional nature of AMR, limited or lack of funds, different AMR research priorities in Asian countries, absence of Asia-centric AMR leadership, lack of trust and, unequal power relationships between researchers, and the negative impact of the COVID-19 pandemic in research collaborations. It also identified some opportunities, such as the willingness of researchers to collaborate, the formation of a few networks, and the prioritization by many academics of the One Health paradigm for framing AMR research. Participants reported that the initiation of stronger cross-discipline and cross-country networks, the development of Asia-centric AMR leadership, flexible research agendas with shared priorities, transparent and transferable funds, and support to enhance research capacity in LMICs could assist in developing more equitable collaborative research in Asia.

Exploring country priorities and contextual considerations for implementing national cancer control plans (NCCP) among participants of International Cancer Control Partnership (ICCP) ECHO.

1581 Background: Promoting NCCP implementation by low- and middle-income countries (LMICs) is key to addressing inequities in cancer outcomes and the global burden of cancer. We explored contextual factors that may influence implementation of NCCP priorities in LMICs. Methods: Seven countries participated in the 2021 International Cancer Control Partnership ECHO (R) geared toward creating a community of practice to inform NCCP implementation. Using qualitative methods, we conducted focus group discussions (FGDs) with country teams who were asked to identify NCCP priorities and provide contextual considerations around implementing these in the 12-months program. FGDs were audio-recorded, transcribed, double-coded, and underwent thematic analysis. Results: Thirty-three participants from 6 Sub-Saharan African countries and 1 country in Asia took part in 7 FGDs, including 14 physicians, 9 non-governmental organizations, 6 Ministry of Health/NCCP and 4 cancer registry representatives. All seven country teams (100%) prioritized cancer early detection, especially for cervical (71%) and breast (57%) cancer, including by educating primary care clinicians (57%) and general population (43%) about cancer signs and symptoms. Related contextual factors included late-stage diagnosis of cancer (43%) and low knowledge about cancer among primary care clinicians and the general population (29% each), respectively. Finding resources for implementation of NCCP priorities was important given lack of funding (57% each). Harmonizing programs and building partnerships for implementation (57%) was prioritized given perceived fragmentation of efforts and benefit of leveraging limited resources (29% each). Improving access to treatment (43%) was a priority given a lack of oncology specialists (29%) and unaffordable treatment (14%). Improving access to palliative care (43%), including by writing guidelines (29%), was prioritized due to late-stage diagnosis and insufficient access to palliative care (14% each). Improving cancer registry data was essential for NCCP program planning (43% each), while cancer research (43%) was key to answering specific questions related to cancer registry data (14%) and program impact (29%). Additional contextual considerations for making progress on these priorities dicussed by country teams included leveraging existing programs (100%) and learning from other countries and ICCP technical experts (57% each). Conclusions: There were similarities in country NCCP priorities and contextual factors affecting implementation. These results allow for future exploration of how LMIC country teams implement NCCPs and examine the value of communities of practice promoted by ICCP and facilitated by ECHO, towards improving cancer outcomes.

The Safety of Cold-Chain Food in Post-COVID-19 Pandemic: Precaution and Quarantine.

Since the outbreak of coronavirus disease-19 (COVID-19), cold-chain food contamination caused by the pathogenic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has attracted huge concern. Cold-chain foods provide a congenial environment for SARS-CoV-2 survival, which presents a potential risk for public health. Strengthening the SARS-CoV-2 supervision of cold-chain foods has become the top priority in many countries. Methodologically, the potential safety risks and precaution measures of SARS-CoV-2 contamination on cold-chain food are analyzed. To ensure the safety of cold-chain foods, the advances in SARS-CoV-2 detection strategies are summarized based on technical principles and target biomarkers. In particular, the techniques suitable for SARS-CoV-2 detection in a cold-chain environment are discussed. Although many quarantine techniques are available, the field-based quarantine technique on cold-chain food with characteristics of real-time, sensitive, specific, portable, and large-scale application is urgently needed.

Stability and Numerical Simulations of a New SVIR Model with Two Delays on COVID-19 Booster Vaccination

As COVID-19 continues to threaten public health around the world, research on specific vaccines has been underway. In this paper, we establish an SVIR model on booster vaccination with two time delays. The time delays represent the time of booster vaccination and the time of booster vaccine invalidation, respectively. Second, we investigate the impact of delay on the stability of non-negative equilibria for the model by considering the duration of the vaccine, and the system undergoes Hopf bifurcation when the duration of the vaccine passes through some critical values. We obtain the normal form of Hopf bifurcation by applying the multiple time scales method. Then, we study the model with two delays and show the conditions under which the nontrivial equilibria are locally asymptotically stable. Finally, through analysis of official data, we select two groups of parameters to simulate the actual epidemic situation of countries with low vaccination rates and countries with high vaccination rates. On this basis, we select the third group of parameters to simulate the ideal situation in which the epidemic can be well controlled. Through comparative analysis of the numerical simulations, we concluded that the most appropriate time for vaccination is to vaccinate with the booster shot 6 months after the basic vaccine. The priority for countries with low vaccination rates is to increase vaccination rates; otherwise, outbreaks will continue. Countries with high vaccination rates need to develop more effective vaccines while maintaining their coverage rates. When the vaccine lasts longer and the failure rate is lower, the epidemic can be well controlled within 20 years.

Ongoing symptomatic COVID-19 – practical advice: A review

Studying the consequences of COVID-19 is a global priority in various countries around the world. The term long-covid or ongoing symptomatic COVID-19 should include situations with clinical manifestations of the disease lasting more than 4 but less than 12 weeks from the onset of the disease. The most urgent problem today remains the management of patients with persistent symptoms of past COVID-19.

Some Historical Aspects of the Establishment and Development of the “Vor V Zakone” E Bis Institute

Abstract Organized crime is the most dangerous type of criminal activity because organized crime associations run the criminal environment and commit various types of serious criminal acts. The fight against organized crime is, therefore, a priority for individual countries as well as for the world community as a whole. To combat this phenomenon, the United Nations adopted the Convention against Transnational Organized Crime on November 15, 2000, which has been ratified by many countries around the world. In addition, one of the types of organized crime is the so-called “thieves in law” institute, which originated in the former Soviet Union and is known around the world as the Russian mafia, namely the Russian term “Vory v Zakone”, which means “thieves in law”. means. Today, their criminal activities are widespread in many countries. We believe that in order to fight against this criminal association, it is necessary to study the history of its emergence and development. That is why our goal is the so-called. A study of the history of the institute of “thieves in law” and some peculiarities.