Prioritization Of Information Research Articles

Creation of a regional hazardous drug handling task force.

A regional task force of health-system pharmacy leaders was created to assist with successful adoption of United States Pharmacopeia (USP) general chapter <800>. A group of pharmacy leaders in the Kansas City region identified potential benefits to healthcare personnel and patients if hazardous drug handling procedures were standardized. A task force was created, a preimplementation survey was distributed, and meetings were held monthly to discuss sections of USP <800> identified as the most challenging to implement. The task force focused on an assessment of risk tool, hot topics, cleanroom design, and a detailed analysis of controversial medications. After the first year of meetings, a postimplementation survey was distributed, and the results were analyzed. The task force created significant value for the participants and achieved the goal of facilitating efficient USP <800> implementation resulting in greater compliance and consistency across the multiple health systems represented. Over 5,100 beds and 200 clinic sites were affected by this task force's efforts. Nearly three-fourths (73%) of respondents reported that the task force was "extremely helpful," and the majority (64%) of respondents adopted most or all (81%-100%) of the task force's assessment of risk choices. Prioritization of tasks, information sharing, and decision-making were areas where the individual leaders were most supported. Creating a structure to eliminate barriers and facilitate collaboration among regional pharmacy leaders provided a framework for successful implementation of USP <800> requirements. This interdependent leadership model produced innovative and standardized solutions and should be considered when addressing complicated initiatives that impact the profession.

Immediate self-information is prioritized over expanded self-information across temporal, social, spatial, and probability domains.

People construct self-representation beyond the experiential self and the self-concept can expand to interpersonal as well as intrapersonal dimensions. The cognitive ability to project oneself onto expanded selves in different time points and places plays a crucial role in planning and decision-making situations. However, no research to date has shown evidence explaining the early mechanism of how processing the experiential self-information differs from processing the expanded self-information across temporal, social, spatial, and probability domains. We report novel effects showing a systematic information prioritization toward the experiential selves (i.e., the self that is now, here, and with highest certainty) compared to the expanded selves (i.e., the self that is in the future, at a distant location, and with lower certainty; Experiments 1a, 2, and 3). Implicit prioritization biases lasted over time (Experiment 1b; i.e., 4 months) indicating a trait-like more than a state-like measure of individual differences. Different biases, however, did not consistently correlate with each other (Experiments 1a to 3) suggesting separate underlying mechanisms. We discuss potential links to the basic structure of self-representation and individual differences for implications.

POS-301 IMPROVING THE IDENTIFICATION AND MANAGEMENT OF KIDNEY DISEASE THROUGH AN INTEGRATED CLINICAL INFORMATION PLATFORM AND DECISION SUPPORT TOOL

Kidney disease in Australia disproportionally affects remote living Indigenous Australians, who experience end-stage kidney disease (ESKD) at rates up to 30 times higher than non-Indigenous Australians. In the Northern Territory the rates of kidney disease are particularly high, as are the concomitant diseases of diabetes and cardiovascular disease. Prevention and care coordination are severely challenged by a highly mobile population and rapid staff turnover in remote community health services. Patients with a high risk of developing kidney disease, and rapid progression to ESKD, are slipping through “the cracks” in our health system. To address this we designed and developed an integrated clinical information system for the early identification and risk stratification of people with chronic kidney disease using a rules-based engine. Territory Kidney Care (TKC) utilises a service orientated architecture that connects to existing primary and hospital based electronic health records, automatically and securely transferring relevant clinical information of select patients based on agreed criteria. The key functionality of the system is the ability to identify disease phenotype patterns from consolidated data, based on clinician defined algorithms. This facilitates timely recognition, prioritisation, and the ability to monitor progress and predict disease outcomes. We utilise an agile approach for algorithm development involving domain experts and evidence-based medicine. Algorithms used in the derived clinical decision support were tested and validated for efficiency and accuracy. TKC seamlessly consolidates primary and tertiary care information in real-time and derives clinically relevant summaries based on dynamic algorithm-based phenotyping. This allows automatic identification, prioritisation, and summation of relevant clinical information, augmenting clinical decision making. Significant time efficiencies have been demonstrated with a substantial reduction in administrative time in the collation and synthesis of complex information from multiple sources, reduction in requirement for remote community travel and earlier and targeted advice to the primary care provider in the management of complex conditions. Integrated systems of care which focus on prevention and care coordination, can slow the progression of kidney disease and reduce complications of inter-related illnesses such as diabetes and cardiovascular disease. TKC enhances primary health care with minimal resource impact, primarily because the system does not alter the primary health service user interface, require the adoption of additional technologies or completion of paper-based records.

Performance Analysis of Internet of Things Interactions via Simulation-Based Queueing Models

Numerous middleware application programming interfaces (APIs) and protocols were introduced in the literature in order to facilitate the application development of the Internet of Things (IoT). Such applications are built on reliable or even unreliable protocols that may implement different quality-of-service (QoS) delivery modes. The exploitation of these protocols, APIs and QoS modes, can satisfy QoS requirements in critical IoT applications (e.g., emergency response operations). To study QoS in IoT applications, it is essential to leverage a performance analysis methodology. Queueing-network models offer a modeling and analysis framework that can be adopted for the IoT interactions of QoS representation through either analytical or simulation models. In this paper, various types of queueing models are presented that can be used for the representation of various QoS settings of IoT interactions. In particular, we propose queueing models to represent message-drop probabilities, intermittent mobile connectivity, message availability or validity, the prioritization of important information, and the processing or transmission of messages. Our simulation models demonstrate the significant effect on delivery success rates and response times when QoS settings are varied.

Biologically Plausible Artificial Synaptic Array: Replicating Ebbinghaus' Memory Curve with Selective Attention.

The nature of repetitive learning and oblivion of memory enables humans to effectively manage vast amounts of memory by prioritizing information for long-term storage. Inspired by the memorization process of the human brain, an artificial synaptic array is presented, which mimics the biological memorization process by replicating Ebbinghaus' forgetting curve. To construct the artificial synaptic array, signal-transmitting access transistors and artificial synaptic memory transistors are designed using indium-gallium-zinc-oxide and poly(3-hexylthiophene), respectively. To secure the desired performance of the access transistor in regulating the input signal to the synaptic transistor, the content of gallium in the access transistor is optimized. In addition, the operation voltage of the synaptic transistor is carefully selected to achieve memory-state efficiency. Repetitive learning characterizing Ebbinghaus' oblivion curves is realized using an artificial synaptic array with optimized conditions for both transistor components. This successfully demonstrates a biologically plausible memorization process. Furthermore, selective attention for information prioritization in the human brain is mimicked by selectively applying repetitive learning to a synaptic transistor with a high memory state. The demonstrated biologically plausible artificial synaptic array provides great scope for advancement in bioinspired electronics.

The neural dynamics underlying prioritisation of task-relevant information

The human brain prioritises relevant sensory information to perform different tasks. Enhancement of task-relevant information requires flexible allocation of attentional resources, but it is still a mystery how this is operationalised in the brain. We investigated how attentional mechanisms operate in situations where multiple stimuli are presented in the same location and at the same time. In two experiments, participants performed a challenging two-back task on different types of visual stimuli that were presented simultaneously and superimposed over each other. Using electroencephalography and multivariate decoding, we analysed the effect of attention on the neural responses to each individual stimulus. Whole brain neural responses contained considerable information about both the attended and unattended stimuli, even though they were presented simultaneously and represented in overlapping receptive fields. As expected, attention increased the decodability of stimulus-related information contained in the neural responses, but this effect was evident earlier for stimuli that were presented at smaller sizes. Our results show that early neural responses to stimuli in fast-changing displays contain remarkable information about the sensory environment but are also modulated by attention in a manner dependent on perceptual characteristics of the relevant stimuli. Stimuli, code, and data for this study can be found at https://osf.io/7zhwp/.

Hospital Mortality and Resource Implications of Hospitalisation with COVID-19 in London, UK: A Prospective Cohort Study.

Background Coronavirus disease 2019 (COVID-19) had a significant impact on the National Health Service in the United Kingdom (UK), with over 35 000 cases reported in London by July 30, 2020. Detailed hospital-level information on patient characteristics, outcomes, and capacity strain is currently scarce but would guide clinical decision-making and inform prioritisation and planning. Methods We aimed to determine factors associated with hospital mortality and describe hospital and ICU strain by conducting a prospective cohort study at a tertiary academic centre in London, UK. We included adult patients admitted to the hospital with laboratory-confirmed COVID-19 and followed them up until hospital discharge or 30 days. Baseline factors that are associated with hospital mortality were identified via semiparametric and parametric survival analyses. Results Our study included 429 patients: 18% of them were admitted to the ICU, 52% met criteria for ICU outreach team activation, and 61% had treatment limitations placed during their admission. Hospital mortality was 26% and ICU mortality was 34%. Hospital mortality was independently associated with increasing age, male sex, history of chronic kidney disease, increasing baseline C-reactive protein level, and dyspnoea at presentation. COVID-19 resulted in substantial ICU and hospital strain, with up to 9 daily ICU admissions and 41 daily hospital admissions, to a peak census of 80 infected patients admitted in the ICU and 250 in the hospital. Management of such a surge required extensive reorganisation of critical care services with expansion of ICU capacity from 69 to 129 beds, redeployment of staff from other hospital areas, and coordinated hospital-level effort. Conclusions COVID-19 is associated with a high burden of mortality for patients treated on the ward and the ICU and required substantial reconfiguration of critical care services. This has significant implications for planning and resource utilisation.

How does positive mood modulate time-based event expectancy?

In the present study, we investigated how positive mood affects the formation of time-based event expectancies. After positive or neutral mood inductions, participants performed a binary choice response task in which two target stimuli (circle and square) and two pre-target intervals (800 and 1600ms) appeared equally often. One of the targets was paired with the short interval and the other target with the long interval in 90% of the trials. We found that participants from the positive and neutral groups showed markedly different behavioral patterns of time-based expectancy. The time-based expectancy was restricted to shorter intervals for the positive group and to longer intervals for the neutral group. We propose that positive mood increases attentional prioritization of information that is temporally closer to us.

Occurrence and spatial distribution of legacy and novel brominated flame retardants in seawater and sediment of the South China sea.

The occurrence and spatial distribution of polybrominated diphenyl ethers (PBDEs) and novel brominated flame retardants (NBFRs) in seawater and surficial sediment samples (N=19 and 45, respectively) from the South China Sea (SCS) in 2018 were investigated, and the correlation between BFRs and site parameters (total organic carbon, depth, etc.) were assessed by principal component analysis. The concentration ranges of ΣPBDEs in seawater and sediments were 0.90-4.40ng/L and 0.52-22.67ng/g dry weight (dw), respectively, while those of ΣNBFRs were 0.49-37.42ng/L and 0.78-82.29ng/g dw, respectively. BDE-209 and decabromodiphenyl ethane were the predominant BFRs, accounting for 38.65% and 36.94% in seawater and 26.71% and 68.42% in sediments, respectively. Notably, tris(2,3-dibromopropyl)isocyanurate and 2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine, seldomly detected in aquatic matrices worldwide, were detected for the first time in the study area, and their relatively high levels and detection frequencies indicate the ubiquitous application of these NBFRs in the Pearl River Delta. Zhuhai and Jiangmen are the main sources of NBFRs in the SCS. Preliminary risk assessment on NBFRs using hazard quotient indicates low to medium risks to marine organisms at some sites. The occurrence of NBFRs in the SCS highlights the prioritization of more toxicological information on these compounds.

Prioritization and Interference of Emotional Information in Briefly Presented Scenes: Selection Advantage for Positive Emotional Scenes

Previous studies have repeatedly demonstrated the attentional prioritization of emotional information over neutral information. However, the parsing of interference from negative and positive stimuli has not received the same attention. In the study reported here, we examined the effect of real-world visual scenes of neutral, positive, and negative valence, as well as the effect of both high- and low-arousal (differentially categorized based on their arousal and valence ratings) on scene gist identification. Using a partial-report paradigm, participants were asked to report the gist of a post-cued scene from a briefly-presented array of four scenes. Scene gist identification performance was significantly higher for positive scenes, regardless of arousal, than for negative scenes. All emotional scenes, regardless of valence and arousal, interfered with reporting the gist of neutral scenes. The findings support the hypothesis that emotional scenes more often interfere with processing of neutral scenes and are selectively attended to during briefly-presented scene arrays. Moreover, the results suggest that the identification and the interference of positive, high-arousal scenes are prioritized in visual information processing.

Drivers’ User-interface Information Prioritization in Manual and Autonomous Vehicles

This study investigated what information items should be presented to drivers in future autonomous vehicles by comparing how preferences regarding information differ from those in the current manual-driving environment. A survey of 29 in-vehicle information items was conducted among 156 participants, who drove a virtual indoor simulator in both manual- and autonomous-driving modes. In all, 29 items of in-vehicle information were classified into three tasks. The primary driving task had mobility as its core value, secondary driving tasks were activities that played supportive roles in vehicular movements (e.g., car accident notifications, wipers), and tertiary driving tasks included non-driving activities. The results indicated that drivers place less priority on receiving secondary task-related information and greater priority on tertiary driving task information in the autonomous mode of driving compared to the manual driving environment. Second, females have a higher preference for information in both modes of driving, whereas males demonstrated a higher incremental level for information in the autonomous environment. Third, older drivers and those in their 20s should be given the highest priority in information dissemination. This study is useful as it can provide a basic guideline for designers of user experiences and user interfaces.

Revisiting the prioritization of emotional information in iconic memory.

In this replication study, the previously reported prioritization of emotional stimuli in iconic memory (Kuhbandner et al. 2011. Psychol. Sci. 22, 695–700. (doi:10.1177/0956797611406445)) was reinvestigated. Therefore, recall from iconic memory was measured for sets of visual images that were briefly presented in the periphery of the visual field. Using a partial-report technique, a central arrow presented at varying delays after the images was pointing to the location of the to-be-recalled target. In the direct replication (experiment 1, n = 41), participants were asked to verbally report the cued image (note that the entire planned sample size could not be reached owing to the COVID-19 pandemic), and in an extension experiment (experiment 2, n = 55), iconic memory was tested using a visual recognition test. Both experiments demonstrated prioritized selection of emotional targets from iconic memory, with higher verbal recall and visual recognition accuracy for negative and positive targets compared to neutral targets. In addition, we found that the presence of emotional distractors in the set interfered with the selection of neutral targets, thus confirming a trend that was observed in the original study. Exponential decay curves further revealed that both target and distractor valence primarily affected initial availability (in case of verbal recall) and attentional selection, whereas the decay of iconic memory with increasing cue delay was less sensitive to the emotional meaning.

A dual mechanism underlying retroactive shifts of auditory spatial attention: dissociating target- and distractor-related modulations of alpha lateralization

Attention can be allocated to mental representations to select information from working memory. To date, it remains ambiguous whether such retroactive shifts of attention involve the inhibition of irrelevant information or the prioritization of relevant information. Investigating asymmetries in posterior alpha-band oscillations during an auditory retroactive cueing task, we aimed at differentiating those mechanisms. Participants were cued to attend two out of three sounds in an upcoming sound array. Importantly, the resulting working memory representation contained one laterally and one centrally presented item. A centrally presented retro-cue then indicated the lateral, the central, or both items as further relevant for the task (comparing the cued item(s) to a memory probe). Time–frequency analysis revealed opposing patterns of alpha lateralization depending on target eccentricity: A contralateral decrease in alpha power in target lateral trials indicated the involvement of target prioritization. A contralateral increase in alpha power when the central item remained relevant (distractor lateral trials) suggested the de-prioritization of irrelevant information. No lateralization was observed when both items remained relevant, supporting the notion that auditory alpha lateralization is restricted to situations in which spatial information is task-relevant. Altogether, the data demonstrate that retroactive attentional deployment involves excitatory and inhibitory control mechanisms.

Rapid Public Information and Situational Awareness After the November 26, 2019, Albania Earthquake: Lessons Learned From the LastQuake System

The use of LastQuake information system, its app, the associated Twitter account and to a lesser extent the EMSC’s websites have been analysed for the 7-days following the Nov. 26, 2019 M6.4 Albania destructive earthquake to evaluate what can be improved and how crowdsourcing of information and monitoring of both use and absence of use of the app can contribute to rapid situational awareness. The mainshock and its numerous felt aftershocks triggered a strong public desire for information which in turn led to rapid and massive adoption of the LastQuake app by up to 5% of the country’s population. The constant flow of new app users created a stress test of the app’s crowdsourcing features and led to errors in the association of felt reports with their appropriate earthquake. However these errors had no identifiable impact supporting the conclusion that the curation mechanisms currently in place are efficient. The rapid succession of felt aftershocks contributed to these errors by making information related to the mainshock difficult to access within hours of its occurrence, especially for new users who were not attuned to the app. This revealed that prioritization of information within the app layout is lacking and is an important requirement during these kinds of events. LastQuake has been shown to be a powerful tool for rapid situational awareness. The possibility of damage was detected within 8 min of the mainshock earthquake by a lack of LastQuake app activity close to the epicenter. This possibility was then gradually strengthened as new data became available and was finally confirmed by the reception of the first geo-located pictures of structural damage and building collapse within 60-70 min. Direct exchanges on Twitter were appreciated by eyewitnesses and were reported to reduce their anxiety. Questions mainly focused on the possible evolution of the seismicity. Attempts to debunk prediction claims were difficult and we report on how this could be eased and possibly made more efficient by the use of a clear concise, pre-prepared statement in the local language explaining the state of scientific knowledge and the difference between prediction, early warning or forecasts.

Explaining individual differences in infant visual sensory seeking.

Individual differences in infants’ engagement with their environment manifest early in development and are noticed by parents. Three views have been advanced to explain differences in seeking novel stimulation. The optimal stimulation hypothesis suggests that individuals seek further stimulation when they are under‐responsive to current sensory input. The processing speed hypothesis proposes that those capable of processing information faster are driven to seek stimulation more frequently. The information prioritization hypothesis suggests the differences in stimulation seeking index variation in the prioritization of incoming relative to ongoing information processing. Ten‐month‐old infants saw 10 repetitions of a video clip and changes in frontal theta oscillatory amplitude were measured as an index of information processing speed. Stimulus‐locked P1 peak amplitude in response to checkerboards briefly overlaid on the video at random points during its presentation indexed processing of incoming stimulation. Parental report of higher visual seeking did not relate to reduced P1 peak amplitude or to a stronger decrease in frontal theta amplitude with repetition, thus not supporting either the optimal stimulation or the processing speed hypotheses. Higher visual seeking occurred in those infants whose P1 peak amplitude was greater than expected based on their theta amplitude. These findings indicate that visual sensory seeking in infancy is explained by a bias toward novel stimulation, thus supporting the information prioritization hypothesis.

Choices in a key press decision-making task are more optimal after gaining both aiming and reward experience.

When presented with two different target-penalty configurations of similar maximum expected gain (MEG), participants prefer aiming to configurations with more advantageous spatial, rather than more advantageous gain parameters-perhaps due to the motor system's inherent prioritisation of spatial information during movements with high accuracy demands such as aiming. To test this hypothesis, participants in the present studies chose between target-penalty configurations via key presses to reduce the importance of spatial parameters of the response and performance-related feedback. Configurations varied in spatial (target-penalty region overlap) and gain parameters (negative penalty values) and could have similar or different MEG. Choices were made without prior aiming experience (Experiment 1), after aiming experience provided information of movement variability (Experiment 2), or after aiming experience provided information of movement variability and outcome feedback (Experiment 3). Overall, configurations with advantageous spatial or gain parameters were chosen equally (Both-Similar condition) in all experiments. However, average behaviour at the group level was not reflective of the behaviour of most individual participants with three subgroups emerging: those with a value preference, distance preference, or no preference. In Experiments 1 and 2, these individual differences cannot be explained by MEG differences between configurations or participants' movement variability, but these variables predicted choice behaviour in Experiment 3. Further in the Both-Different condition, participants only selected the larger MEG configuration at a level above chance when both variability and outcome information were given prior to the key press task (Experiment 3). In sum, the data indicate that prioritisation of spatial information did not emerge at the group level when performing key presses and more optimal behaviour emerged when information regarding movement variability and outcome feedback were given.

Distinct neural substrates underlying target facilitation and distractor suppression: A combined voxel-based morphometry and resting-state functional connectivity study

Selective attention, the ability to filter relevant from a sea of sensory information, relies on the prioritization of goal-relevant information (target facilitation) and the suppression of goal-irrelevant information (distractor suppression). Although several lines of evidence have shown that target facilitation and distractor suppression were mediated by distinct mechanisms, the underlying neural substrates remain unclear. To address this question, we acquired structural and resting-state magnetic resonance imaging scans, as well as behavioral data from a modified Posner cueing task. Specifically, the location of a target (Target Cue, TC) and a distractor (Distractor Cue, DC) was either cued in advance to separately trigger target facilitation and distractor suppression, or no predictive information was provided, serving as a baseline. We combined voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analyses to explore the neural correlates of behavioral benefits, yielding the following results. First, behavioral data showed faster responses to TC and DC conditions compared to baseline, the benefits of which were named TC-benefit and DC-benefit. Second, the VBM analysis revealed that the gray matter volume (GMV) in the superior frontal (SFG) and postcentral gyrus inversely correlated with individual TC-benefit, while the GMV in the superior parietal lobe, middle frontal gyrus, and angular gyrus inversely correlated with individual DC-benefit, indicating that target facilitation and distractor suppression was associated with the GMV of distinct and distributed regions in the frontoparietal cortex. Third, the rsFC analysis with the SFG as a seed region further found distinct patterns of rsFC for target facilitation and distractor suppression. Specifically, individual TC-benefit were positively correlated with distributed connections between the SFG and brain regions, mainly within the ventral attention and somato-motor network; but individual DC-benefit were positively correlated with centralized connections between the SFG and brain regions, mainly within the frontoparietal, dorsal attention and ventral attention network. Finally, a multiple linear regression analysis showed that the GMV and rsFC could jointly explain individual differences in TC- and DC-benefit. Taken together, these results provided neural evidence for different structural and functional substrates underlying target facilitation and distractor suppression.

JAK inhibition synergistically potentiates BCL2, BET, HDAC, and proteasome inhibition in advanced CTCL

AbstractCutaneous T-cell lymphoma (CTCL) is a malignancy of skin-homing T lymphocytes that is more likely to involve the peripheral blood in advanced stages. For such patients with advanced disease, there are few available systemic treatment options, and prognosis remains poor. Exome sequencing studies of CTCL have suggested therapeutic targets, including within the JAK/STAT pathway, but JAK inhibition strategies may be limited by patient-specific mutational status. Because our recent research has highlighted the potential roles of single and combination approaches specifically using BCL2, bromodomain and extra-terminal domain (BET), and histone deacetylase (HDAC) inhibition, we aimed to investigate the effects of JAK inhibition on CTCL cells and established CTCL cell lines when paired with these and other targeting agents. Peripheral blood malignant CTCL isolates exhibited differential responses to JAK inhibition, with JAK2 expression levels negatively correlating to 50% inhibitory concentration (IC50) values. Regardless of single-agent sensitivity, JAK inhibition potentiated malignant cell cytotoxicity in combination with BCL2, BET, HDAC, or proteasome inhibition. Combination inhibition of JAK and BCL2 showed the strongest potentiation of CTCL cytotoxicity, driven by both intrinsic and extrinsic apoptosis pathways. JAK inhibition decreased expression of BCL2 in the high-responder samples, suggesting a putative mechanism for this combination activity. These results indicate that JAK inhibition may have major effects on CTCL cells, and that combination strategies using JAK inhibition may allow for more generalized cytotoxic effects against the malignant cells from patients with CTCL. Such preclinical assessments help inform prioritization for combination targeted drug approaches for clinical utilization in the treatment of CTCL.

Seagrass habitat in Tarawa Lagoon, Kiribati: Service benefits and links to national priority issues

This paper presents a review around seagrass habitat in Tarawa Lagoon, Kiribati and explores the links between seagrass occurrence and the national priority issues of climate change, urban development, human health, nearshore fisheries, threatened species, ocean policy, research capacity and awareness. The contribution of healthy seagrass habitats to many aspects of these national issues is often overlooked and there is need to establish the knowledge gaps and priority actions that can enable mitigation of issues that impact on valuable seagrass resources and their management. Research data on seagrass habitats in Kiribati, and the wider Pacific Island region, is limited and this hinders informed decisions at local, national and regional levels. We present a comprehensive review on seagrass within a national context to aid prioritisation and uptake of information for resource owners, and wider stakeholders, in Kiribati while acknowledging local expertise. The paper highlights data and knowledge gaps that if addressed, will provide information useful to Kiribati nationals, communities and government stakeholders. Recommendations for actions that fill these gaps and build understanding of seagrass resources in Kiribati are provided.

Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder

Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retain information rather than on the attention-dependent stages of encoding and retrieval. The current study uses a visual short-term memory binding task, measuring both behavioral and electrophysiological responses to characterize WM encoding, binding and retrieval comparing ADHD and non-ADHD matched adolescents. ADHD exhibited poorer accuracy and larger reaction times than non-ADHD on all conditions but especially when a change across encoding and test displays occurred. Binding manipulation affected equally both groups. Encoding P3 was larger in the non-ADHD group. Retrieval P3 discriminated change only in the non-ADHD group. Binding-dependent ERP modulations did not reveal group differences. Encoding and retrieval P3 were significantly correlated only in non-ADHD. These results suggest that while binding processes seem to be intact in ADHD, attention-related encoding and retrieval processes are compromised, resulting in a failure in the prioritization of relevant information. This new evidence can also inform recent theories of binding in visual WM.