Principles Of Organization Research Articles

Organizational Ethos: Empact on Work Performance of Employees

The objective of this study is to explore how organizational ethos affects employees' work performance. This study is based on meta-analysis research design and the literature review. Organizational principles, practices, and distinctive features of culture all contribute to the dimension of corporate culture. The foundational element of an organization's ethos is its value system. The corporate ethos fosters professionalism among the employees. Workplace performance was found to be positively impacted by four organizational ethos sub-elements: managing change, attaining goals, coordinating teamwork, and cultural strength. Organizational ethos has a significant impact on the operations, personnel, and productivity of a wide range of services. This study demonstrates that if employees are dedicated and has the same values as their organizations; their performance in attaining organizational objectives will be achieved. To enhance the overall performance of the workforce and the services, managers and executives are encouraged to foster a strong organizational ethos. The study's findings show that organizational ethos has a major impact on employee motivation, develops personal growth, influences communication, and enhances organizational values, group decision-making, and conflict resolution.

Assesing the Dynamics of Employee Benefits for Virtual and Flexible Work Arrangements of Obapack Company Limited, Ghana

The human resource of every organisation plays a crucial role in the organisation’s fortunes, as they apply other resources to achieve the aims of that organisation. In recent times, owing to the advent of the Covid-19 pandemic, the attention of researchers has been drawn to virtual or remote workers. Researchers note that flexible working conditions affect the performance of employees. Therefore, this study sought to examine the effect of flexible working arrangements on employees’ performance in Obapack Company Limited. In line with this, effect of FWA on organization commitments, job satisfaction, employee performance and work-life balance were examined. To achieve the aims of the study, a descriptive, quantitative cross-sectional design was adopted. The stratified sampling techniques were combined to recruit 70 virtual workers into the study, after which they completed questionnaires on the variables of the study. Descriptive analysis of the data was done using frequencies, percentages, means, and standard deviations in Statistical Product for Service Solution (SPSS) version 25.0. To further explore the relationship between FWA and employee benefits, inferential statistics, such as linear regression, was utilised. The main FWAs examined within the context of Obaapack Company were flexi-time, annualised hours, and homeworking. Flexible Working Arrangements affect job satisfaction, work-life balance and employees’ performance positively. However, FWA affect organizational commitments negatively. FWA should be encouraged in the company, especially, job-shared which much attention was not given to it. This will improve upon the satisfaction, work-life balance and employees’ performance. Furthermore, Obaapack Company Limited should include other factors such as motivation that also influence organizational commitment since FWA only do not boost the staff’s commitment. Lastly, employees should also observe and follow the organizational principles regarding FWA in order for them to have a work-life balance.

Always expect the unexpected: eye position modulates visual cortex excitability in a stimulus-free environment.

Stimuli that potentially require a rapid defensive or avoidance action can appear from the periphery at any time in natural environments. de Wit et al. (Cortex 127: 120-130, 2020) recently reported novel evidence suggestive of a fundamental neural mechanism that allows organisms to effectively deal with such situations. In the absence of any task, motor cortex excitability was found to be greater whenever gaze was directed away from either hand. If modulation of cortical excitability as a function of gaze location is a fundamental principle of brain organization, then one would expect its operation to be present outside of motor cortex, including brain regions involved in perception. To test this hypothesis, we applied single-pulse transcranial magnetic stimulation (TMS) to the right lateral occipital lobe while participants directed their eyes to the left, straight-ahead, or to the right, and reported the presence or absence of a phosphene. No external stimuli were presented. Cortical excitability as reflected by the proportion of trials on which phosphenes were elicited from stimulation of the right visual cortex was greater with eyes deviated to the right as compared with the left. In conjunction with our previous findings of change in motor cortex excitability when gaze and effector are not aligned, this eye position-driven change in visual cortex excitability presumably serves to facilitate the detection of stimuli and subsequent readiness to act in nonfoveated regions of space. The existence of this brain-wide mechanism has clear adaptive value given the unpredictable nature of natural environments in which human beings are situated and have evolved.NEW & NOTEWORTHY For many complex tasks, humans focus attention on the site relevant to the task at hand. Humans evolved and live in dangerous environments, however, in which threats arise from outside the attended site; this fact necessitates a process by which the periphery is monitored. Using single-pulse transcranial magnetic stimulation (TMS), we demonstrated for the first time that eye position modulates visual cortex excitability. We argue that this underlies at least in part what we term "surveillance attention."

Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community.

Multimodal neuroimaging grants a powerful in vivo window into the structure and function of the human brain. Recent methodological and conceptual advances have enabled investigations of the interplay between large-scale spatial trends - or gradients - in brain structure and function, offering a framework to unify principles of brain organization across multiple scales. Strong community enthusiasm for these techniques has been instrumental in their widespread adoption and implementation to answer key questions in neuroscience. Following a brief review of current literature on this framework, this perspective paper will highlight how pragmatic steps aiming to make gradient methods more accessible to the community propelled these techniques to the forefront of neuroscientific inquiry. More specifically, we will emphasize how interest for gradient methods was catalyzed by data sharing, open-source software development, as well as the organization of dedicated workshops led by a diverse team of early career researchers. To this end, we argue that the growing excitement for brain gradients is the result of coordinated and consistent efforts to build an inclusive community and can serve as a case in point for future innovations and conceptual advances in neuroinformatics. We close this perspective paper by discussing challenges for the continuous refinement of neuroscientific theory, methodological innovation, and real-world translation to maintain our collective progress towards integrated models of brain organization.

Picking Apart a Program Evaluation Committee: A Multiple Case Study Characterizing Primary Care Residency Program Evaluation Committee Structure, Program Improvement, and Outcomes.

As of 2014, the Accreditation Council for Graduate Medical Education (ACGME) mandates initiating a Program Evaluation Committee (PEC) to guide ongoing program improvement.However, little guidance nor published reports exist about how individual PECs have undertaken this mandate. To explore how four primary care residency PECs configure their committees, review program goals and undertake program evaluation and improvement. We conducted a multiple case study between December 2022 and April 2023 of four purposively selected primary care residencies (e.g., family medicine, pediatrics, internal medicine). Data sources included semi-structured interviews with four PEC members per program and diverse program artifacts. Using a constructivist approach, we utilized qualitative coding to analyze participant interviews and content analysis for program artifacts. We then used coded transcripts and artifacts to construct logic models for each program guided by a systems theory lens. Results: Programs adapt their PEC structure, execution, and outcomes to meet short- and long-term needs based on organizational and program-unique factors such as size and local practices. They relied on multiple data sources and sought diverse stakeholder participationto complete program evaluation and improvement. Identified deficiencies were often categorized as internal versus external to delineate PEC responsibility, boundaries, and feasibility of interventions. The broad guidance provided by the ACGME for PEC configuration allows programs to adapt the committee based on individual needs. However, further instruction on program evaluation and organizational change principles would augment existing PEC efforts.

Cellular plasticity in the breast cancer ecosystem.

The complex interplay between genetically diverse tumor cells and their microenvironment significantly influences cancer progression and therapeutic responses. This review highlights recent findings on cellular plasticity and heterogeneity within the breast cancer ecosystem, focusing on the roles of cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs). We discuss evidence suggesting that breast cancer cells exhibit phenotypic plasticity driven by both intrinsic genetic factors and external microenvironmental cues, impacting treatment responses and disease recurrence. Moreover, single-cell RNA sequencing studies reveal diverse subtypes of CAFs and TAMs, each with distinct functional gene expression programs and spatial organization within the tumor microenvironment. Understanding the hierarchical relationships and niche cues governing cellular phenotypes offers new opportunities for targeted therapeutic interventions. By elucidating the organizational principles of the tumor ecosystem, future therapies may target phenotypic states or entire cellular niches, advancing precision medicine approaches in breast cancer treatment.

Differential clustering of visual and choice- and saccade-related activity in macaque V3A and CIP.

Neurons in sensory and motor cortices tend to aggregate in clusters with similar functional properties. Within the primate dorsal ("where") pathway, an important interface between three-dimensional (3-D) visual processing and motor-related functions consists of two hierarchically organized areas: V3A and the caudal intraparietal (CIP) area. In these areas, 3-D visual information, choice-related activity, and saccade-related activity converge, often at the single-neuron level. Characterizing the clustering of functional properties in areas with mixed selectivity, such as these, may help reveal organizational principles that support sensorimotor transformations. Here we quantified the clustering of visual feature selectivity, choice-related activity, and saccade-related activity by performing correlational and parametric comparisons of the responses of well-isolated, simultaneously recorded neurons in macaque monkeys. Each functional domain showed statistically significant clustering in both areas. However, there were also domain-specific differences in the strength of clustering across the areas. Visual feature selectivity and saccade-related activity were more strongly clustered in V3A than in CIP. In contrast, choice-related activity was more strongly clustered in CIP than in V3A. These differences in clustering may reflect the areas' roles in sensorimotor processing. Stronger clustering of visual and saccade-related activity in V3A may reflect a greater role in within-domain processing, as opposed to cross-domain synthesis. In contrast, stronger clustering of choice-related activity in CIP may reflect a greater role in synthesizing information across functional domains to bridge perception and action.NEW & NOTEWORTHY The occipital and parietal cortices of macaque monkeys are bridged by hierarchically organized areas V3A and CIP. These areas support 3-D visual transformations, carry choice-related activity during 3-D perceptual tasks, and possess saccade-related activity. This study quantifies the functional clustering of neuronal response properties within V3A and CIP for each of these domains. The findings reveal domain-specific cross-area differences in clustering that may reflect the areas' roles in sensorimotor processing.

Navigating Leadership and Communication: A Study of Emerging Leaders in Indian Organizations

Introduction: The research explores the dynamic interplay between the leadership styles and communication strategies in Indian context. In order to understand the connection between leadership and communication this research will use SPSS. 
 Literature review: This section delves into unraveling the diverse spectrum of leadership styles that are prevalent in Indian organizations. The importance of the problem-solving and informational-sharing studies has emphasized the complexity of the evaluative steps that have guided the theoretical framework to enable the research methodology.
 Methodology: The primary quantitative methodology employs a survey tool which has been administered on the 55 participants. SPSS solution has recognised so many attributes that have benefitted the organizational outcomes. The application of correlation, descriptive analysis and ANOVA has accessorized the vital values by making qualitative and quantitative assessments yielding a broad perception.
 Findings: This section illuminates the prevalence of diverse leadership styles incorporating transformational leaderships. It adopts a clear and delicate model which places emphasis on women as key players to the economic emancipation of citizens. From the findings, it has been obtained that there is a significant relationship between employee commitment and organizational success which is -0.74 at 0.01 level of significance.
 Discussion: From the discussion section, it has been examined that for organizational practices and leadership developments, as a result of these actionable insights, the young leader in India has been able to initiate the social media revolution. Moreover, tailoring a clear and transparent organization has emerged as a common factor to acknowledge the quantitative approaches
 Conclusion: The conclusion restates the main findings, which would in turn conclude any contributions to food safety research which should be derived from the study. Moreover, the dynamics and organizations landscape has been considered to be increasingly successful in empowering the leaders by means of expertise irrespective of relevance. Such strategy works through the complex nature of Indian corporate and organizational paradigm principles, which provides the foundation for leadership development programs to be conducted in future among researchers broadly.
 

PRESERVING THE HEALTH OF THE ORGAN OF VISION IN CHILDREN: ORGANIZATIONAL PRINCIPLES

Background. The relevance of the study is due to the growing prevalence of ophthalmic pathology among children, in particular, the growing prevalence of refractive errors in early and older adolescence. The results of scientific research prove the presence of a direct correlation between the growth of the prevalence of ophthalmic pathology and the growth of the child's age and the amount of visual stress, which is primarily related to the educational process during school education. The effective organization of medical care should take into account modern medical and preventive technologies of early preventive intervention, as well as be comprehensive with the involvement of medical specialists (pediatric ophthalmologists, family doctors) and educators, family members, parents of the child for effective support and leveling of managed risk factors for the development of ophthalmic pathology.
 Aim: to study the modern organizational principles of preserving the health of eye care of children, to clarify the medical and social aspects of the formation of the burden of ophthalmic pathology from childhood in different countries of the world.
 Materials and methods. The materials for the research were publications of the results of modern scientific research on the study of medical and social aspects of preserving the ophthalmic health of children, the peculiarities of the organization of providing medical and preventive care to children with visual impairments. The methods for carrying out scientific research were: system approach and system analysis, as well as content analysis.
 Results of the study prove the prospects for the implementation of medical and preventive strategies in the provision of primary and specialized ophthalmic medical care, in view of the significant medical and social burden of ophthalmopathology, the distribution of nosologies by class of diseases of the eye and its accessory apparatus, which are most often found in certain age groups of the children's population, is presented. It has been proven that compliance with the optimal periodicity of medical and preventive examinations is necessary for the majority of ophthalmological nosologies diagnosed since childhood and involves long-term supervision. In children of preschool, preschool and early school age, efforts at early prevention and diagnosis of such ophthalmological nosologies as: refraction anomalies (astigmatism, hypermetropia, myopia) are justified. strabismus and amblyopia; accommodation disorders; lack of convergence. Untreated or untimely detected refraction anomaly, strabismus, amblyopia can lead to the development of irreversible loss of visual functions, blindness and even inhibition of the formation of the visual system with distorted perception of visual information, which without timely correction lead to the appearance of complications, progression of strabismus, decrease in visual acuity, amblyopia , asthenopia, headache and deterioration of general well-being.
 Conclusion. The important medico-social importance of disorders of visual functions in childhood is a serious problem for the health care system, public health and ophthalmology service, in particular. Reasoned expediency of applying measures to level the managed risk factors against the background of intersectoral interaction of doctors, educators, the child himself and his family. This approach allows you to prevent the negative impact of ophthalmic pathology on academic performance, activate physical development, and promote harmonious personality development.

Meta-Analysis of the Problem of Rehabilitation of Chemically Dependent Persons in Russian and Foreign Literature

The article analyzes the domestic and foreign literature of recent years, aimed at studying the effectiveness of the rehabilitation process of chemically dependent persons. However, most of the results obtained by the researchers are not comparable with each other. Firstly, the reasons are related to differences in the theoretical approaches of the authors of the goals, objectives and mechanisms of the rehabilitation process, as well as the "blurring" of the effectiveness criteria. In Russian narcology the criterion for the success of the rehabilitation process is the persistence, duration and quality of the achieved remissions. As scientific and practical studies show, the persistence of remission is achievable when the period of abandonment of substance is complemented by a long rehabilitation period, thanks to which the individual's ability to function in society is restored. Foreign researchers who consider recovery as a "process", not as an "end point", come to the conclusion that after all the necessary stages of rehabilitation, it is necessary to provide constant long-term support. A significant amount of international research confirms the need for long-term support in the post-rehabilitation period. From the point of view of some Russian authors, rehabilitation is a multi-level process that includes an environment with a certain atmosphere in which both rehabilitators and specialists interact. However, there are currently no training manuals and recommendations that would collect and systematize scientific and practical information for specialists working in the field of rehabilitation of minors prone to substance use. In modern narcology it is necessary to improve the organizational principles and legislative framework of the entire system of rehabilitation process of chemically dependent persons.

Research of the optimization problem of structure hierarchical communication network with changing its parameters

The article is devoted to the study of the problem of optimizing the hierarchical structure of a multicommodity communication network with discrete flows when changing its important parameters, such as the capacity of network arcs in transport blocks and the size of the transport block for transportation of the discrete small-lot cargo or of the data transmission in a digital communication network. The network has three levels of hierarchy – a backbone, a zonal and an internal and four types of nodes - backbone nodes of the first, second and third types, forming the backbone and zonal levels of the network, and nodes of the fourth type, which subordinate to each backbone node and forming the internal levels of the network. Types of nodes differ from each other in terms of functionality. The main task of the study is to establish how the structure of the backbone network changes (the number and location of backbone nodes of the first, second, and third types), the flow processing and distribution scheme, and the technical and economic indicators of the network's functioning for different values of its parameters. The principles of organization of sorting and distribution of flows in a three-level network and its mathematical model are given. A mathematical model of the optimization problem of the backbone network structure and flow sorting and distribution scheme is formulated. Algorithms for solving the problem are based on the discrete analogue of the local descent method proposed by the authors earlier, when the neighborhoods of the metric space of possible solutions are chosen based on heuristic considerations, taking into account the specifics of the problem being solved. Computer modeling of the problem on a network containing 10 nodes at the specified change in the both parameters is carried out. The modeling was carried out on the example of the transport network of cargo transportation using a computer program that is part of the instrumental software of the Information and Analytical Decision Support System (IA DSS), which is being developed at the Institute of Telecommunications and Global Information Space of the National Academy of Sciences of Ukraine. An experimental study of solution the problem showed that the structure of the network is weakly dependent on the change in the carrying capacity of the arcs and the size of the transport block. The proposed computer technology for solving problem when the network parameters are changed allows you to interactively modeling various options of a network, changing the topology, hierarchical structure, flows, parameters and constraints of the model and from the set of the obtained solutions to choose a best option, taking into account the selected a goal function and the accepted constraints; calculate preliminary technical and economic indicators of the network's functioning, estimate the cost of additional resources and plan the amount of investment required for the modernization and construction of its structural elements, which ultimately makes it possible to increase the efficiency functioning of the network by optimizing use of its resources and reducing the operating costs for the processing and transportation of flows.

Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation

In this study, for the first time, we explored a dataset of functional magnetic resonance images collected during focused attention and open monitoring meditation before and after a five-day psilocybin-assisted meditation retreat using a recently established approach, based on the Mapper algorithm from topological data analysis. After generating subject-specific maps for two groups (psilocybin vs. placebo, 18 subjects/group) of experienced meditators, organizational principles were uncovered using graph topological tools, including the optimal transport (OT) distance, a geometrically rich measure of similarity between brain activity patterns. This revealed characteristics of the topology (i.e. shape) in space (i.e. abstract space of voxels) and time dimension of whole-brain activity patterns during different styles of meditation and psilocybin-induced alterations. Most interestingly, we found that (psilocybin-induced) positive derealization, which fosters insightfulness specifically when accompanied by enhanced open-monitoring meditation, was linked to the OT distance between open-monitoring and resting state. Our findings suggest that enhanced meta-awareness through meditation practice in experienced meditators combined with potential psilocybin-induced positive alterations in perception mediate insightfulness. Together, these findings provide a novel perspective on meditation and psychedelics that may reveal potential novel brain markers for positive synergistic effects between mindfulness practices and psilocybin.

Dissociable Contributions of the Medial Parietal Cortex to Recognition Memory.

Human neuroimaging studies of episodic memory retrieval routinely observe the engagement of specific cortical regions beyond the medial temporal lobe. Of these, medial parietal cortex (MPC) is of particular interest given its distinct functional characteristics during different retrieval tasks. Specifically, while recognition and autobiographical recall tasks are both used to probe episodic retrieval, these paradigms consistently drive distinct spatial patterns of response within MPC. However, other studies have emphasized alternate MPC functional dissociations in terms of brain network connectivity profiles or stimulus category selectivity. As the unique contributions of MPC to episodic memory remain unclear, adjudicating between these different accounts can provide better consensus regarding MPC function. Therefore, we used a precision-neuroimaging dataset (7T functional magnetic resonance imaging) to examine how MPC regions are differentially engaged during recognition memory and how these task-related dissociations may also reflect distinct connectivity and stimulus category functional profiles. We observed interleaved, though spatially distinct, subregions of MPC where responses were sensitive to either recognition decisions or the semantic representation of stimuli. In addition, this dissociation was further accentuated by functional subregions displaying distinct profiles of connectivity with the hippocampus during task and rest. Finally, we show that recent observations of dissociable person and place selectivity within the MPC reflect category-specific responses from within identified semantic regions that are sensitive to mnemonic demands. Together, by examining precision functional mapping within individuals, these data suggest that previously distinct observations of functional dissociation within MPC conform to a common principle of organization throughout hippocampal-neocortical memory systems.

Medico-biological aspects of physical training of students of higher education institutions

The article analyzes the medical and biological aspects of the physical training of students of higher education institutions. The organizational and methodical principles on which the innovative educational technology of implementing the health-forming orientation of modernized physical education is based are highlighted.
 It was established that the level of physical culture of young people is determined, first of all, by special education in this field, the perceived need to use physical exercises and other types of motor activity for the purpose of strengthening health and comprehensive self-improvement. On the basis of the analysis of a complex of literary sources, the goal of physical education is summarized, which consists in improving the health, education and education of student youth.
 The use of medical and biological aspects for the study of physical culture and health measures, where physical training is considered from the standpoint of the formation of skills of motor activity of the individual and the biological properties of the human body, is substantiated.
 The typological characteristics of the modern system of physical education in higher education institutions of Ukraine are determined; the interaction of medical, biological and cultural aspects of physical culture, which contribute to increasing the productivity of educational and physical culture and health activities, is scientifically substantiated.
 Medical-biological aspects include the study of health problems and the physical condition of people, their use for the study of physical culture and health measures is determined by the fact that physical training is considered from the point of view of the formation of motor activity and biological properties of the body.
 The specificity of the motivational and value component of the medical and biological training of future specialists was investigated on the basis of a questionnaire of higher education applicants.
 It has been proven that more attention should be paid to the promotion of sports and physical culture in the institution of higher education, to fully provide classrooms for classes with modern sports equipment and inventory, to actively include student youth in the process of physical education and mass sports events.

THE INFLUENCE OF ORGANIZATIONAL CULTURE ON THE LEADER AND TEAM FORMATION, MOTIVATING FACTORS FOR EMPLOYEES' WORK PERFORMANCE

The present article deals with the study of the issue of how the organizational culture affects the formation of the leader and the team, what factors are important for the motivation of employees. Whether the work to be performed is suitable for different means of motivation. Does the level of general satisfaction depend on pay? A good organizational culture is the main factor for the success of the organization. The organizational culture sets the framework for the participation and involvement of the employees, which leads to positive motivation in the organization. Organizational culture refers to the beliefs and principles of a particular organization. Organizational culture varies from one organization to another depending on leadership, motivation of employees and management. Organizational culture plays an important role in team building within a company. It affects how teams are structured, how team members interact and collaborate, and how they approach work. Unfortunately, there are still no clearly defined methods and standards for employee motivation in Georgia, professional training is also not regulated, there are no encouraging activities on the part of organizations that would contribute to the formation of a healthy corporate culture in Georgian companies. As important as it is to maintain a healthy organization, it is necessary to understand and study the importance of organizational culture. This topic becomes more relevant over time, so more leaders and supervisors understand that it is necessary to motivate employees and increase the level of their satisfaction. The formation of a strong organizational culture is very important for the successful functioning of the organization. Correctly selected culture helps the organization to form a strong company. It can be safely said that the organizational culture is the main aspect of the company, without it there will be complete chaos and great failure. It plays a significant role in the success of the company. Personally, I think this issue also adds relevance to the topic. Keywords: organizational culture, team, leader, employee, motivation, factors.

Virtual exhibitions for scientific knowledge propagation

Scientific knowledge propagation is among the key functions of the Common Scientific Knowledge Digital Space (CSKDS), and the virtual exhibitions (VE) as an efficient instrument enable to accumulate heterogeneous scientific information on phenomena, events or scholars. The authors discuss the general issues and principles of VE organization, content selection, VE structure and main sections. Three VE types are specified, namely autonomous, remote and combined VE. Selection and content structuration methods are proposed for each of the types. The authors introduce extensibility and flexibility as VE characteristics. They also describe in detail the VE experience of the RAS Interdepartmental Supercomputer Center as a model CSKDS element. They describe the VE “Mrs. Penicillin” dedicated to Zinaida Vissarionovna Ermolyeva, a microbiologist who created the preparation of penicillin in the USSR in the late 1930s. The exhibition offers information about Ermolyeva, her scientific and pedagogical work.The study is accomplished at Russian Academy of Sciences Interdepartmental Supercomputer Center, branch of RAS Research Institute of System Analysis within the framework of the Government Order No. FNEF-2024-0014.

Projects of establishing the Peasant land bank and its organizational-legalprinciples of functioning

The purpose of the article is to characterize the process of formation and the first steps of the Peasant Land Bank (Selianskyi pozemelnyi bank), to identify and analyze various projects of the organization of a state institution for long-term crediting of the peasantry, which preceded the emergence of the Peasant Land Bank in 1882. Research methodology is based on the fundamental principles of historical research: historicism, systematicity, objectivity in the selection of facts and documents. Scientific novelty of the article lies in the analysis of projects for the formation of the Peasant Land Bank in the Russian Empire in the context of agrarian reforms of the late 19th and early 20th centuries. Organizational and legal aspects and principles of functioning of this bank, its role in the implementation of the government's agrarian policy are studied. The author examines the influence of credit activity of the Peasant Land Bank on the development of agriculture and formation of a class of wealthy peasants in the context of the modernization of agriculture. Conclusions. The establishment of the Peasant Bank, to a certain extent, can be considered as an important step in the direction of public opinion at that time. The concession, which over time was tried to be significantly reduced, was the establishment of numerous restrictions, which indicated the limited effectiveness of the bank's activities. These restrictions included a five million annual transaction limit, a small maximum loan size per person, and the ability to participate in transactions only by voluntary agreement between the seller and the buyer. It was also assumed the need for significant additional payments when purchasing, which were unaffordable for poorer peasants. These restrictions significantly limited the positive influence of the bank. It was noted that the main goal of the bank was realized in a residual way, in particular, due to political reasons and commercial principles that were the basis of its activity. In addition, crediting conditions were considered absurd, as they provided for the same interest rates as in commercial banks. A prospective promise was a change in the focus of the bank's activity to credit support for peasants who intended to farm on the acquired lands, in particular by providing “ameliorative” credit.

Organizational and methodological principles of orienteering competitions within the framework of the Shoulder-to-Shoulder All-Ukrainian School Leagues project

The article systematizes materials related to the organization and conduct of orienteering competitions in the conditions of a modern school. The authors focus on the fact that orienteering has a wide range of applications in various spheres of activity: sports, education, travel, military affairs. Special emphasis is placed on the practicality and accessibility of the use of this sport in competitions among schoolchildren. For the first time, an algorithm for organizing and conducting school orienteering competitions was developed.
 It is noted that the organization and conduct of orienteering competitions in wartime conditions has a number of peculiarities. Observance of safety measures, lack of methodical materials, as well as insufficient level of material and technical support of schools made it necessary to find available forms of organization of orienteering competitions. The result of the search was the development and approval of unified tasks that can be used at any location, even in the absence of a special map or scheme for orienteering. In addition, the authors suggested using the existing infrastructure (sports hall, school building, school yard) for orienteering competitions.
 Thanks to this research, a wide range of possibilities regarding the organization of trainings and competitions of the participants of the Shoulder-to-Shoulder All-Ukrainian School Leagues project was revealed. In addition, the developed methodical materials became the foundation of the educational and methodical film “Orienteering. The elementary level of education”, which was released in the second half of February 2024. This made it possible to expand access to methodological materials for a wide audience of specialists in the field of orienteering and physical education teachers.

TOR regulates variability of protein synthesis rates

Cellular processes are subject to inherent variability, but the extent to which cells can regulate this variability has received little investigation. Here, we explore the characteristics of the rate of cellular protein synthesis in single cells of the eukaryote fission yeast. Strikingly, this rate is highly variable despite protein synthesis being dependent on hundreds of reactions which might be expected to average out at the overall cellular level. The rate is variable over short time scales, and exhibits homoeostatic behaviour at the population level. Cells can regulate the level of variability through processes involving the TOR pathway, suggesting there is an optimal level of variability conferring a selective advantage. While this could be an example of bet-hedging, but we propose an alternative explanation: regulated ‘loose’ control of complex processes of overall cellular metabolism such as protein synthesis, may lead to this variability. This could ensure cells are fluid in control and agile in response to changing conditions, and may constitute a novel organisational principle of complex metabolic cellular systems.

The Left-Right Side-Specific Neuroendocrine Signaling from Injured Brain: An Organizational Principle.

A neurological dogma is that the contralateral effects of brain injury are set through crossed descending neural tracts. We have recently identified a novel topographic neuroendocrine system (T-NES) that operates via a humoral pathway and mediates the left-right side-specific effects of unilateral brain lesions. In rats with completely transected thoracic spinal cords, unilateral injury to the sensorimotor cortex produced contralateral hindlimb flexion, a proxy for neurological deficit. Here, we investigated in acute experiments whether T-NES consists of left and right counterparts and whether they differ in neural and molecular mechanisms. We demonstrated that left- and right-sided hormonal signaling is differentially blocked by the δ-, κ- and µ-opioid antagonists. Left and right neurohormonal signaling differed in targeting the afferent spinal mechanisms. Bilateral deafferentation of the lumbar spinal cord abolished the hormone-mediated effects of the left-brain injury but not the right-sided lesion. The sympathetic nervous system was ruled out as a brain-to-spinal cord-signaling pathway since hindlimb responses were induced in rats with cervical spinal cord transections that were rostral to the preganglionic sympathetic neurons. Analysis of gene-gene co-expression patterns identified the left- and right-side-specific gene co-expression networks that were coordinated via the humoral pathway across the hypothalamus and lumbar spinal cord. The coordination was ipsilateral and disrupted by brain injury. These findings suggest that T-NES is bipartite and that its left and right counterparts contribute to contralateral neurological deficits through distinct neural mechanisms, and may enable ipsilateral regulation of molecular and neural processes across distant neural areas along the neuraxis.