Primary Energy Research Articles

Financial stability and environment degradation in Turkey: evidence from fourier ARDL approach

This study investigates the impact of financial stability on environmental degradation in Turkey, controlling for economic growth, renewable energy consumption, and primary energy consumption between 1990 and 2019. The study employs various statistical methodologies, including LS Unit Root, Fourier ARDL, DOLS, and FMOLS tests. The findings reveal an inverse relationship between financial stability and environmental degradation. Both economic growth and primary energy consumption are found to exacerbate environmental degradation. This study recommends that policymakers incorporate financial stability into policies aimed at reducing CO2 emissions. Furthermore, it emphasizes the importance of investing in renewable energy infrastructure and the transportation sector to effectively mitigate environmental degradation.

Energy and environmental evaluation and comparison of a diesel-electric hybrid tractor, a conventional tractor, and a hillside mini-tiller using the life cycle assessment method

Currently, electrification, especially hybrid solutions, still represents the most promising option to improve energy efficiency, emissions, and productivity for agricultural machinery. Agricultural machinery in China's mountainous areas is represented by quantities of small conventional tractors and hillside mini-tillers (HMTs), which are highly fuel-intensive and polluting. Effective measures need to be taken to reduce their environmental impacts. Thus, a diesel-electric hybrid tractor (DHT) was designed and developed. The life cycle assessment (LCA) method was used to assess and compare the energy consumption and environmental impacts of the DHT, an internal combustion engine tractor (ICET), and an HMT in this study. Comparative results present that the ICET had the most contribution to acidification potential (AP), eutrophication potential (EP), and respiratory inorganics (RI), while the HMT created the most to primary energy demand (PED), global warming potential (GWP), and photochemical ozone creation potential (POCP). The DHT had the lowest contribution to six environmental impact indicators, 5.1%–68.9% lower than those of ICET and HMT. Among the six phases in the life cycle, the Pump-to-Wheel (PTW) phase consumed the most energy (65.9%–78.5%) and brought about the largest environmental impacts (54.2%–94.7%), followed by the Well-to-Pump (WTP) phase (4.0%–37.3%). Increasing the proportion of electricity generation from non-fossil fuels in 2030 showed positive effects on saving energy and reducing environmental impacts for the ICET, DHT, and HMT, with the DHT benefiting the most. Discoveries in this study can contribute to the research and development of the DHT and the electrification of small agricultural machinery.

Building Mass Optimization to Reduce Solar Radiation in High Rise Building by Using Parametric Approach

Buildings use 40% of global primary energy, therefore their design and use affect climate change. Building performance analysis can assist architects predict performance before construction with parametric design tools. Radiance can be reduced via a parametric mass, lowering cooling load and energy use. The study uses theoretical and computational research to explain, forecast, and analyze events, whereas parametric design optimizes complicated geometries using mathematical parameters and algorithms. Environmental analysis in Grasshopper with the Ladybug plugin uses Rhinoceros. This plugin provides solar radiation, and climate analysis capabilities. To determine the most energy-efficient building design, the research links independent and dependent variables such solar radiation intensity and building mass. The study uses Surabaya weather data and high rise buildings. The land is formed like a square, with a 15-degree slope to the north and is flanked by low-rise buildings. As a result, the location receives the most direct sunlight during the day. Then, solar radiation analysis. It helps optimize passive solar design solutions. According to the modelling results, solar radiation on the top and west sides are particularly large and dominant in 65.37 and 32.69 kWh/m2. Meanwhile, the north, east and south sides receive very little solar radiation. The following simulation considers the optimal direction, which is to extend west-east and face to the south. A multi-towered megastructure is a high-rise building that responds best to solar radiation. The total solar radiation value is 3,718,100 kWh. It can accommodate large spaces with large mass composition but relatively low total solar radiation values. The building towers provide shade to each other, thereby reducing direct radiation from the sun to the building. The sides of the building's podium are also shaded, so the top of the building is partially red.

Optimization of a real municipal sewage treatment plant using CRFSMA algorithm and a mathematical model

This study presents the development, calibration, and validation of a mathematical model tailored for biological wastewater treatment at an actual urban sanitation facility. Utilizing multi-criteria optimization techniques, the research identified the most effective MCO algorithm by assessing Pareto optimal solutions. The model incorporated three primary performance measures energy consumption, overall volume, mean quality of effluent, and optimized 12 process parameters. Three algorithms, CRFSMA, particle swarm algorithm, and adaptive non-dominated sorting genetic algorithm III, were rigorously tested using MATLAB. The CRFSMA method emerged as superior, achieving enhanced Pareto optimal solutions for three-dimensional optimization. Quantitative improvements were observed with a 14.8 % increase in wastewater quality and reductions in total nitrogen (TN), chemical oxygen demand (COD), total phosphorus (TP), and ammonium nitrogen (NH4+-N) concentrations by 0.95, 2.38, 0.04, and 0.14 mg/L, respectively. Additionally, the total cost index and overall volume were decreased, contributing to an 18.27 % reduction in overall volume and an 18.83 % decrease in energy utilization. The adapted anaerobic-anoxic-Oxic (A2O) framework, based on real-world wastewater treatment plants, demonstrated compatibility with observed effluent variables, signifying the potential for energy savings, emission reductions, and urban sanitation enhancements.

Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3.

Glucose is the primary energy source for most mammalian cells and its transport is affected by a family of facilitative glucose transporters (GLUTs) encoded by the SLC2 gene. GLUT1 and GLUT3, highly expressed isoforms in the blood-brain barrier and neuronal membranes, respectively, are associated with multiple neurodevelopmental disorders including epilepsy, dyslexia, ADHD, and autism spectrum disorder (ASD). Dietary therapies, such as the ketogenic diet, are widely accepted treatments for patients with the GLUT1 deficiency syndrome, while ameliorating certain symptoms associated with GLUT3 deficiency in animal models. A ketogenic diet, high-fat diet, and calorie/energy restriction during prenatal and postnatal stages can also alter the placental and brain GLUTs expression with long-term consequences on neurobehavior. This review focuses primarily on the role of diet/energy perturbations upon GLUT isoform-mediated emergence of neurodevelopmental and neurodegenerative disorders.

Occupancy Comfort Evaluation in Green Building Rating Tools in Malaysia: A Comparative Review

Passive design strategy is the approach that maximizing utilization of natural resources to achieve occupancy comfort which covers the thermal comfort, visual comfort and acoustic comfort while minimizing secondary energy usage. Adapting passive design strategy during building design-stage is beneficial in reducing energy load of the building for long term, furthermore to reduce the energy consumption in day to day building operation. Applying Green Building Rating Tools, GBRT promotes passive design strategy for non-residential building and will assist the building designer to comply with the local and international standard. The minimum requirement of occupancy comfort is captured in GBRT rating system with different approach and intension of the system. This review summarize the coverage of passive design strategy sectors for non-residential building in Malaysia by comparing three GBRT system namely Green Building Index, GBI NCNR, MyCREST ICSAS and GreenRE NRB system. GreenRE NRB seems more aggressive in occupancy comfort evaluation compared to GBI NCNR and MyCREST ICSAS. GreenRE allocates 48.7% of total marks focus on occupancy comfort aspect while GBI and MyCREST allocates 14% and 13.2% respectively from the total score. MyCrest had enforce the mandatory compliance of OTTV, RTTV and Uroof to meet baseline requirement as per MS1525:2019 with zero marks allocation. Based on marks percentage allocation, GBI and MyCrest prioritizing visual comfort while GreenRE give more focus on thermal comfort with higher marks allocation. All rating system give less focus on acoustic comfort. On average, 16.3% of marks covers the thermal comfort, 9% covers visual comfort and 1% cover acoustic comfort. GBI and MyCrest focus more on green building materials which covers the building lifecycle includes water management and waste disposal. All system contributes to Malaysia-UNFCCC ratification of Paris Agreement on 45% GHG reduction in longer runs.

The MET Family of Receptor Tyrosine Kinases Promotes a Shift to Pro-Tumor Metabolism.

The development and growth of cancer is fundamentally dependent on pro-tumor changes in metabolism. Cancer cells generally shift away from oxidative phosphorylation as the primary source of energy and rely more heavily on glycolysis. Receptor tyrosine kinases (RTKs) are a type of receptor that is implicated in this shift to pro-tumor metabolism. RTKs are important drivers of cancer growth and metastasis. One such family of RTKs is the MET family, which consists of MET and RON (MST1R). The overexpression of either MET or RON has been associated with worse cancer patient prognosis in a variety of tumor types. Both MET and RON signaling promote increased glycolysis by upregulating the expression of key glycolytic enzymes via increased MYC transcription factor activity. Additionally, both MET and RON signaling promote increased cholesterol biosynthesis downstream of glycolysis by upregulating the expression of SREBP2-induced cholesterol biosynthesis enzymes via CTTNB1. These changes in metabolism, driven by RTK activity, provide potential targets in limiting tumor growth and metastasis via pharmacological inhibition or modifications in diet. This review summarizes pro-tumor changes in metabolism driven by the MET family of RTKs. In doing so, we will offer our unique perspective on metabolic pathways that drive worse patient prognosis and provide suggestions for future study.

Strategizing CO2 emission commitments in mainland China by integrating the experiences of primary energy consumption structures from the European assemblage and the USA in 1971–2021

To fulfill CO2 emission commitments becomes strategic to meet energy demands of sustainable economic growth via adjusting primary energy consumption structure. This study analyzed energy efficiency and CO2 emission intensity in the top three world economies in the period 1971–2021 and attempted to optimize structure of primary energy consumption for the CO2 emission commitments in mainland China, reaching peak emission by 2030 and neutrality by 2060. Results indicated that the USA and the European 16 – countries had significant higher energy efficiency and lower CO2 emission intensity than mainland China (α = 0.05). Reducing coal consumption is an efficient measure to reduce CO2 emission from fossil energy in the structure. However, renewable energies are crucial for achieving CO2 emission neutrality. As predicted, mainland China might peak CO2 emission by 2030 at 14.7 × 109 ton CO2 with 278 × 1018 J of total primary energy consumption, and would neutralize CO2 emissions by 2060 from 184 × 1018 J of primary fossil energy in the consumption structure in 2030 with renewable energies, hydropower, and nuclear as planned. Findings of this study provide a practical strategy for fulfilling CO2 emission commitments in mainland China and might be applicable to the developing world.

Starch molecular structure and diabetes

Starch is a primary source of food energy for human beings. Its chain-length distribution (CLD) is a major structural feature influencing physiologically-important properties, such as digestibility and palatability, of starch-containing foods. Diabetes, which is of epidemic proportions in many countries, is related to the rate of starch digestion in foods. Isoforms of three biosynthesis enzymes, starch synthase, starch branching enzymes and debranching enzymes, control the CLDs of starch, which can be measured by methods such as size-exclusion chromatography and fluorophore-assisted carbohydrate electrophoresis. Fitting observed CLDs to biosynthesis-based models based on the ratios of the activities of those isoforms yields biosynthesis-related parameters describing CLD features. This review examines CLD measurement, fitting CLDs to models, relations between CLDs, the occurrence and management of diabetes, and how plant breeders can develop varieties to optimize digestibility and palatability together, to develop starch-based foods with both a lower risk of diabetes and acceptable taste.

Peak patterns and drivers of city-level daily CO2 emissions in China

Cities are the primary carbon emitters in China and play a critical role in achieving national and regional emission-reduction targets. However, because existing CO2 emission datasets are mostly limited to national and provincial levels and have significant time lags, there are few studies on urban emission patterns and drivers below the annual level. In this study, utilizing near-real-time daily CO2 emission data from Carbon Monitor Cities-China, we analyzed the seasonality and peak patterns of city-level emissions and conducted a decomposition of emission drivers by sector based on sociometric and natural factors. Our results indicated that most cities in China exhibited seasonal emissions, with peak emissions occurring during winter. However, heavily industrialized cities tend to produce high year-round emissions. The residential and power sectors are crucial for reducing emissions in winter-peaked cities, whereas the industrial and power sectors are the primary energy consumers in non-winter-peaked cities. The results of the decomposition analysis show that the emission structure of the service industry and the impact of temperature on power generation are the primary drivers of CO2 emissions during winter. The above analysis offers recommendations for developing emission-reduction policies for various types of cities. Service-based cities should concentrate their efforts on reducing emissions from tertiary industries, whereas energy-dependent cities should continue to focus on controlling emissions from secondary industries such as industry and power. In addition, both service-based and energy-dependent cities must address the significant impact of heating demands on emissions.

A simplified approach to modeling temperature dynamics in photovoltaic systems – Validation, case studies, and parametric analysis

This paper presents a simplified theoretical model for analyzing the temperature dynamics of photovoltaic (PV) modules. The model is built on an energy balance approach, considering solar irradiation as the primary energy input. It accounts for the conversion of solar power into electricity and the storage of thermal energy within the PV module, which subsequently increases the PV temperature leading to decay in its electrical efficiency. Heat loss from the top and bottom surfaces of the module, with variations for cooling techniques, is also included. The model is validated against three different experimental studies, demonstrating good agreement with the experimental temperature variations, with a maximum discrepancy ranging from 4 % to 16 %. This simplified model is then applied to two case studies: one representing typical daytime conditions and another simulating cold weather events. By comparing the PV temperature dynamics between the model and the experimental data, it is shown that the model accurately captures the dynamic response of the PV temperatures to changes in solar irradiation and ambient temperatures. Moreover, a parametric analysis is conducted to investigate the effects of key parameters on PV temperature and efficiency. Higher cooling rates from the bottom surface significantly boost electric power output, aligning closely with solar irradiance variations. Enhanced upper surface cooling, through increased convection, reduces PV temperature and thereby improves electric efficiency and power production. The PV temperature increases quasi-linearly with ambient temperature, especially at lower wind speeds, and decreases with higher wind speeds, eventually stabilizing at high values. Additionally, both ambient temperature and solar irradiance contribute to rising PV temperatures, with ambient temperature having a slightly greater effect. These findings underscore the critical role of cooling techniques in optimizing PV performance amidst varying environmental conditions.

The changing mix of fossil fuels used and the related evolution of CO2 emissions

To limit global climate change, ultimately it will be necessary to minimize the use of all fossil fuels for energy. Because the rate of CO2 emissions per unit of primary energy varies among the fossil fuels, it is useful to focus first on reducing the use of coal, the fuel with the most CO2 per unit of energy used. Although multiple factors are involved in the choice of which fuel will be used for a given purpose, data on CO2 emissions show that over the last 25 years there has been an evolution in the fraction of emissions away from coal and toward natural gas. That is, although total emissions have continued to increase globally, the fraction attributable to coal has been decreasing in many places. This is true for the global sum of emissions, for Annex I countries, and for all regions except Asia Pacific. The fraction of emissions from oil products has varied largely with growth in the contribution of petroleum transportation fuels. Focus on decreasing the sum of all fossil fuels is needed, especially among the major energy users in the Asia Pacific region, but progress in the decreasing relative use of coal is promising.

A systematic analysis of European markers of balanced environmental management under the conditions of economic circularity

The main task of the article is to research the role of balanced environmental management in the construction of a circular model of the European countries’ economy by using environmental and economic markers. It determines the level of environmental pollution and other environmental problems, including those caused by resource waste. It proposes a technological method of wastewater treatment from estrogen, microplastic particles and oil by using iron oxide. The rate of population for which secondary wastewater treatment is available and its importance for water efficiency under the conditions of significant water crisis in Europe was determined. The paper identifies the main indicators of economic losses of European countries that depend on climate change, because the weather anomalies have a significant impact on economic processes. It studies the dynamics of changes in the area of forested land according to FAO of the European G7 members, the current potential of forest resources of Ukraine and identifies the necessity of systematic electronic wood accounting. It is established that in the EU countries the practice of returning many types of raw materials to production after waste processing has long been accepted, and the need for the fastest possible introduction of innovative processing technologies is identified. Mathematical formulas for calculating the coefficient of cyclicality, circular use of materials and establishes the level of using cyclical materials by European manufacturers are derived. It is established that to identify the efficiency and dynamism of waste transformation, it is appropriate to use an indicator that measures the fraction of recycled household waste in the total volume of its generation. The article establishes the share of fossil fuels in the total available energy of European countries and analyses the dynamics of primary energy consumption based on the example of the Scandinavian countries. It identifies the level of revenues from environmental taxes in most European countries and their importance for the circular economy. It is recommended for Ukraine to study and use the experience of the European Union countries for construction its own model of circular economy based on the principles of balanced nature management and sustainable development.

Carbon-based brilliance: a novel approach to renewable energy in radiotherapy centers.

The energy produced from other sources which does neither come from fossil fuels nor contribute in the production of any greenhouse effects that causes climate changes is called as 'Alternative Energy'. Since our world's primary energy sources such as coal, oil and natural gases are exploited to a greater extent, we are in an urge to switch to an alternative energy. Scattered radiation, a common byproduct in radiation therapy and diagnostic radiology, presents a unique opportunity in the realm of alternative energy. As a potential source of interference, scattered radiation can be repurposed to contribute to sustainable energy solutions. Addressing the issue of scattered radiation wastage and utilizing it for alternative energy, an activated carbon-based solar cell emerges as a solution. This solar cell, a conventional one in which cadmium Telluride is replaced by coconut shell based carbon material, has the potential in producing a significant amount of electrical energy by utilizing scattered radiation from radiotherapy and radiology machines. Furthermore, this activated carbon based-material undergoes thorough characterization into various teletherapy and radiology machines, and it can be seamlessly integrated into clinical practices.

Threshold displacement in the tungsten-carbon system

ABSTRACT Threshold displacement energies (Ed) of carbon and tungsten in tungsten carbide (WC), W2C, tungsten and diamond are predicted using molecular dynamics. The spatial dependence of Ed is probed by considering a geodesic projection of a symmetrically distinct arc of crystallographic directions for each lattice site. Further, the definition of threshold displacement is explored by making the distinction between atomic displacement ( E ¯ d disp ) and defect formation ( E ¯ d def ). Predicted values of E ¯ d def compare favourably to experimental observations for tungsten and tungsten carbide. Results confirm that E ¯ d def and E ¯ d disp are strongly structure dependent. Differences between E ¯ d disp and E ¯ d def are commensurate with rapid defect recombination within the timeframe of the simulations for some species and structures but not universally. The probability of displacement and defect formation as a function of primary knock-on energy is also reported. Previously developed models for the average displacement of the primary knock-on atom based on kinetic energy and momentum-dependent drag terms are generally found to provide a useful level of approximation. Anisotropy is investigated and results highlight differences due to structures.

Near-infrared polarity fluorescent probe for wash-free imaging lipid droplets and the application in the diagnosis of non-alcoholic fatty liver tissue

Lipid droplets (LDs), as primary cellular energy storage organelles, play essential roles not only in energy conservation but also in inflammatory responses, apoptosis, and the progression of diseases such as non-alcoholic fatty liver disease (NAFLD). Studies indicate that alterations in the polarity of LDs are closely linked to pathological factors like oxidative stress, ferroptosis, and lipophagy. Therefore, developing biological probes for precisely monitoring LDs polarity is crucial for understanding these biological phenomena and devising new therapeutic strategies. In this context, we synthesized four fluorescent probes (CNL1-CNL4) to precisely monitor the polarity of LDs using triphenylamine and carbazole derivatives as electron donors and isophorone and benzopyranonitrile units as electron acceptors, employing intramolecular charge transfer (ICT) mechanism. Our findings demonstrated that all four probes exhibited high sensitivity and specificity for polarity changes. Probes CNL2 and CNL4 were sensitive to polarity, and their maximum fluorescence intensity and maximum emission wavelength demonstrated a good linear relationship with polarity parameters within a certain range. Biological experiments demonstrated that both CNL2 and CNL4 possess excellent wash-free imaging capabilities and superior LDs targeting abilities but also enable dynamic monitoring of LDs and respond well to changes in LDs polarity under varying concentrations of oleic acid stimulation. Due to its longer emission wavelength (>650 nm), boasting excellent photostability, and featuring a larger Stokes shift (≈168 nm in acetonitrile), probe CNL4 was selected for further studies. Furthermore, probe CNL4 effectively monitors changes in LDs polarity under conditions of ferroptosis and oxidative stress. It has shown potential in the diagnosis of NAFLD tissue and during the process of lipophagy, highlighting its value in disease diagnostics and biological research. These findings not only deepen our understanding of the mechanisms underlying NAFLD progression but also provide new tools for diagnosing and treating related diseases.

Energy and economic analysis of energy efficiency actions in surgery rooms: A dynamic analysis

This research proposes several measures designed for reducing the primary energy consumption of operating rooms, but at the same time complying with the stringent regulations governing operating rooms. In particular, this study proposes a novel control strategy for the air handling unit serving the surgery rooms, along with two innovative layouts designed for decreasing the thermal energy demand. Note that the two proposed novel layout involves the adoption of a round-around-coil and a recovery heat pump, in order to recover the waste heat of the air stream leaving the user. The simulation model of the operating room and of its heat, ventilation, and air conditioning systems plant are developed using the TRNSYS18 environment. The performance of the air handling unit and heat pumps are calibrated against the manufactured data. The case study consists of a real surgery theatre including three operating rooms. This facility is located in Naples, south of Italy. The operating room is served by a dedicated air handling unit, integrated with a heat pump providing heating and cooling energy, as well as a humidifier. All proposed layouts demonstrated high performance, reducing primary energy consumption by roughly 22–26%, with a simple payback period lower than one year. All the proposed layouts are able to significantly reduce the specific primary energy consumption of the selected operating rooms. In fact, the specific energy consumption decreases from 1.883 kWh/m2 to 1.452–1.383 kWh/m2.

One-pot preparation of one-dimensional hierarchically porous carbon@SnO2 nanocomposites for flexible fabric-based supercapacitor electrodes

The design of functional energy storage materials with superior performances has become the focus topic with the growing energy crisis in recent years. Herein, porous carbon nanofibers@tin dioxide (PCNFs@SnO2) composites are prepared by one-pot electrospinning and followed by carbonization. The PCNFs@SnO2 possesses a hierarchically porous structure containing mesopores and micropores. The specific surface area is as high as ∼ 559.4 m2 g−1, and the total pore volume can reach 0.28 cm3 g−1. Meanwhile, the nonwoven fabric surface is coated with a silver layer through the screen printing technique to obtain silver-coated nonwoven fabric (SNF). Importantly, PCNFs@SnO2 and SNF are combined to obtain flexible fabric-based functional materials. As a primary energy application, the prepared PCNFs@SnO2/SNF electrode has a high mass specific capacitance of 583.1 F g−1 at 1 A g−1, a high area specific capacitance of 933 mF cm−2 at 1 mA cm−2, and a good rate capability (70 % at 10 A g−1). The supercapacitor device with two PCNFs@SnO2/SNF electrodes also shows outstanding cycling durability, capacitor retention is as high as ∼ 91.52 %, after 10000 charging/discharging cycles. In brief, our study may provide an innovative route for designing hierarchically porous one-dimensional carbon nanocomposites for supercapacitors with high performances.

Examining the non-linear impact of fossil and renewable energy consumption on Vietnam’s ecological footprint: insights from the asymmetric ARDL approach

Vietnam’s economy is rapidly growing, marked by an increasing reliance on fossil fuels and renewable energy sources, resulting in unsustainable consumption patterns. The primary objective is to investigate the implications of renewable and non-renewable resource consumption on the overall resource availability over the long term, as indicated by the ecological footprint. Furthermore, the study incorporates economic growth to examine the Environmental Kuznets Curve hypothesis in Vietnam. Methodologically, the study adopts the asymmetric Autoregressive Distributed Lag model, utilizing time-series data ranging from 1986 to 2022. The findings highlight that Vietnam’s economic growth still use more natural resources while compromising the overall ecological reserve. Furthermore, the research findings suggest that the Environmental Kuznets Curve hypothesis does not hold in the context of Vietnam. Specifically, the increasing share of primary energy sourced from fossil fuels is observed to coincide with an increase in demand in ecological footprint. In contrast, an increase in primary energy consumption from renewable sources demonstrates a marked reduction in natural resource demand over the long term. Several strategies are recommended to enhance the resilience of environmental resources, such as adopting new and energy-efficient technologies is necessary within the industrial sector, promote the utilization of renewable energy sources, enhance waste management systems, transition from conventional energy to renewable sources in both production and consumption and the formulation of legislation on renewable energy usage.

Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture

Neuronal activity undergoes significant changes during vigilance states, accompanied by an accommodation of energy demands. While the astrocyte-neuron lactate shuttle has shown that lactate is the primary energy substrate for sustaining neuronal activity in multiple brain regions, its role in regulating sleep/wake architecture is not fully understood. Here we investigated the involvement of astrocytic lactate supply in maintaining consolidated wakefulness by downregulating, in a cell-specific manner, the expression of monocarboxylate transporters (MCTs) in the lateral hypothalamus of transgenic mice. Our results demonstrate that reduced expression of MCT4 in astrocytes disrupts lactate supply to wake-promoting orexin neurons, impairing wakefulness stability. Additionally, we show that MCT2-mediated lactate uptake is necessary for maintaining tonic firing of orexin neurons and stabilizing wakefulness. Our findings provide both in vivo and in vitro evidence supporting the role of astrocyte-to-orexinergic neuron lactate shuttle in regulating proper sleep/wake stability.