Objective: To explore whether different levels of ambulatory and office blood pressure (BP) and different hypertension phenotypes associate with differences of risk in diabetes and no-diabetes. Design and method: This analysis assessed outcome data from patients with complete data included in the Spanish Ambulatory BP (ABP) Monitoring Registry. The associations between office BP, mean, daytime and nighttime ABP and the risk in patients with diabetes and no-diabetes were explored. The effects of diabetes on mortality in different hypertension phenotypes compared with normotension were studied. Analyses were done with Cox regression analyses and adjusted for demographic and clinical confounders. Results: A total of 59,124 patients were recruited from 223 primary care centres in Spain. The majority had an office SBP >140 mmHg (36,700 patients), 23,128 (40.6%) patients were untreated. Diabetes was diagnosed in 10,935 patients (19.2%). Cardiovascular (CV) disease was present in 2,521 patients (23.1%) with and 4,616 (10.0%) without diabetes. Twenty-four-hour mean, daytime and nighttime ABP were associated with increased risk in diabetes and no-diabetes, whereas there was no clear association for office BP. While the relative association of BP with CV death risk was similar in diabetes compared to no-diabetes (mean interaction p=0.80, daytime interaction p=0.97 and nighttime interaction p=0.32), increased event rates occurred in diabetes for all ABP monitoring parameters for CV death and all-cause death. White-coat hypertension was not associated with risk for CV death (HR 0.86; 95% CI 0.72-1.03) and slightly reduced risk for all-cause death in no-diabetes (HR 0.89; 95% CI 0.81-0.98) but without significant interaction between diabetes and no-diabetes. Sustained hypertension and masked hypertension in diabetes and no-diabetes were associated with even higher risk. There were no significant interactions in hypertensive phenotypes between diabetes and no-diabetes (interaction p=0.26) and CV death risk, while, some interaction was present for all-cause death (interaction p=0.043) and non-CV death (interaction p=0.053). Conclusions: Diabetes increased the risk for all-cause death, CV, and non-CV death at every level of office and ABP. Masked and sustained hypertension confer the highest risk, while white-coat hypertension appears grossly neutral without interaction of relative risk between diabetes and no-diabetes.