PRF Group Research Articles

Efficacy of Genicular Nerve Radiofrequency Ablation Versus Intra-Articular Platelet Rich Plasma in Chronic Knee Osteoarthritis: A Single-Blind Randomized Clinical Trial

Chronic knee osteoarthritis is a common problem with increasing of the aging population. Pulsed radiofrequency and intraarticular platelet rich plasma injection are well evidenced beneficial modalities for pain alleviation in such groups of patients. The primary goal in this study was to compare the 2 modalities regarding pain alleviation evaluated by visual analog scale. The secondary goal focused upon the change of the Index of Severity for Osteoarthritis of the Knee by Lequesne. Single-blind randomized interventional clinical trial. University hospitals. Two hundred patients with chronic knee osteoarthritis were equally and randomly distributed into 2 groups. Group PRF received pulsed radiofrequency, whereas the group PRP received intraarticular platelet-rich plasma. The visual analog scale and index of severity of osteoarthritis were evaluated before intervention, after one week (for visual analog scale only), then after 3, 6, and 12 months. Visual analog scale was significantly lower in the PRF group compared to the PRP group at 6 and 12 months with P-values of 0.01 and 0.04, respectively. Regarding to the postinterventional index of severity of osteoarthritis, it was significantly lower in the PRF group than the PRP group with P-values of 0.001 at 3, 6, and 12 months follow-up. Physical and analgesic therapy were not included in data collection, and there was no control group. Pulsed radiofrequency of the genicular nerves can be considered superior to knee intraarticular platelet-rich plasma injection for sustained pain relief and the lower severity index in patients with chronic knee osteoarthritis.

Effect of prf on pain, swelling, trismus after surgical removal of impacted lower third molars

Objectives: The aim of this study is to evaluate the effects of PRF on reducing pain, swelling and trismus after surgical removal of impacted lower third molars. Materials and methods: A randomized controlled clinical trial with parallel design was performed on 47 healthy patients, with 55 mandibular wisdom teeth on both sides with similar difficulty index, having needs and indications for extraction. All patients had the same standardized extraction protocol at Department of Minor Oral Surgery in National Hospital of Odonto – Stomatology at HCM City. In the study group, patients’ blood was collected, centrifugated to produce PRF, which was then placed in the wisdom tooth sockets after surgery. In the control group, the tooth sockets were curetted and sutured as in normal protocol. Pain level was assessed according to VAS scale at 2, 4 and 6-hour time point after patients’ lower lips stopped feeling numb, and on the 1st, 3rd and 7th postoperative day; swelling was evaluated based on the measurements between facial landmarks; trismus was assessed based on the distance between incisal edges of upper central incisor and lower incisor during maximum mouth opening on the 3rd and 7th postoperative days. Data obtained were statistically analyzed. Results: The pain level of patients in the PRF group was significantly lower than that of the control group (p<0.05) on the 1st and 3rd postoperative days. The swelling level did not differ between the two groups at all time. There was less trismus in the PRF group compared to the control group at all times, but the difference was not statistically significant (p>0.05). Conclusion: This study suggests that using PRF can help reduce pain level and trismus after surgical extraction of impacted lower third molars and could be used routinely after third molar sugery extraction.

EFFECTS OF THE PLATELET-RICH FIBRIN (PRF) ON BONE DENSITY IN IMMEDIATE IMPLANT PLACEMENT AND LOADING IN ESTHETIC ZONE (A randomized Clinical Trial)

Aim of the study: The aim of this study is to evaluate the effect of PRF on bone density after immediate implant placement and loading in the esthetic zone. Introuduction: The present study was conducted to evaluate bone density using CBCT around immediately placed and loaded implants with the addition of PRF in the esthetic zone.The patients were selected from the out patient Dental Implant Clinic Faculty of Dentistry, Cairo University, based on inclusion and exlusion criteria. MATERIAL AND METHODS: Patients were divided in to two equal groups: Group A: Immediate implant placement and loading with PRF in jumping gap at site of unrestorable extracted teeth in esthetic zone. Group B: Immediate implant placement and loading without PRF in jumping gap at site of unrestorable extracted teeth in esthetic zone. After implant placement and loading CBCTs were taken at 0,3,6,9 month. Bone density was measured at 0, 3, 6, 9 month for both groups. The collected results were tabulated and statistically analyzed. Results: The results of this study showed that the PRF group had higher bone density and there was statistically significant difference between (PRF) and (no PRF) groups in bone density values in 3,6 and 9 months intervals.

COMPARISON BETWEEN THE EFFECTS OF THE PLATELET RICH FIBRIN (PRF) VERSUS XENOGRAFT ON PRIMARY STABILITY IN MANDIBULAR PREMOLARS IMMEDIATE IMPLANTS

Aim of the study: The aim of this study was to compare the regenerative potential of deproteinized bovine bone (xenograft) and platelet rich fibrin on implant primary stability in immediately placed mandibular premolar implants. MATERIAL AND METHODS: Twelve patients were selected from twenty five patients examined in the outpatient clinic of the implant clinic in Faculty Dentistry Cairo University The patients fulfilled the following criteria: Presence of non-restorable mandibular premolar tooth due to trauma, caries, root resorption, root fracture, endodontic or periodontal failure, Male or female patients between the ages of 30 to 50. And Patient with Sufficient bone volume, good oral hygiene and nonsmokers. Results: The results showed that the measurements of primary stability for immediately extracted sockets with PRF and implant placement were greater than that with the xenograft; there was a statistically significant difference between the PRF group and the control group regarding measurements of primary stability. The higher mean value was found in (PRF) group, while the lowest mean value was found in (Xenograft) group. Conclusion: From the results of the current study we can conclude that: PRF provides better primary implant stability than xenograft as space filling material. PRF is an effective material for management of jumping gap after immediately placed dental implants. Further studies are recommended for long term evaluation of PRFas space filling material.

Narrow Ridge Expansion for Implant Placement Using Ultrasonic Bone Surgery and Platelet Rich Fibrin With and Without Silk Fibroin.

ABSTRACT Object: To evaluate the effect of combined split-crest technique using ultrasonic bone surgery with platelet rich fibrin alone and in combination with silk fibroin for dental implant placement in narrow ridge. Subject and Methods: A total of 24 implants inserted in 18 patients with narrow ridge. Patients were assigned into one of the following 2 groups based on the graft material used. For group I, the peri implant gap was filled with silk fibroin mixed with PRF while for group 2 was filled with PRF only. All patients undergone a ridge splitting technique using piezoelectrical device and immediate implant placment. Assessments included measurements of the ridge width, implant stability and bone density. Results: The differences in implant stability measurements were non- significant in both groups at baseline however, at 6 months was statistically significant (P=0.001) in favor of silk fibroin group. Additionally, the differences in mean crest width measurements between both studied groups, were statistically non- significant at base line and immediately after surgery while silk fibroin group exhibited a statistically significant (P=0.010) increase in mean crest width measurements at 6 months. Moreover, silk fibroin group also showed higher and statistically significant (P=0.001) mean bone density measurements, at 6 months compared to PRF group. Conclusions: Compared to PRF alone, adding silk fibroin might provide a better reconstruction of ridge width, implant stability and bone density in the narrow ridge augmented with crest splitting and immediate implants.

The Use of Platelet Rich Fibrin and Nano Hydroxyapatite as Regenerative Treatment of Furcation Class II Defects (A Histomorphometric Study in Dogs)

Objectives: The aim of the present study was to evaluate the use of platelet rich fibrin and Nano-hydroxyapatite as a regenerative treatment in furcation class II defect. Material and methods: Eight young adult dogs was selected for the study; in each dog, class II furcation defects were surgically created in 4 premolars and were treated as follow: First was treated with Nano hydroxyapatite alone ; Second with PRF alone ; Third with Nano hydroxyapatite and PRF ; Fourth did not receive any additional treatment than debridement (controls). Results: histomorphometric analysis revealed that, the greatest amount of newly formed bone was observed in the (PRF+ NHA bone) group, followed by the PRF group, then the NHA group, with the least recorded in the control group. The difference was not statistically significant except in comparing (PRF+ NHA group) with control group (p=0.0035). Conclusion: The combined use of both PRF and Nano hydroxyapatite in treatment of furcation class II defects could accelerate healing processes, getting use of the synergic effect of the powerful inherent regenerative potential of PRF and Nano hydroxyapatite.

The treatment of V2 + V3 idiopathic trigeminal neuralgia using peripheral nerve radiofrequency thermocoagulation via the foramen rotundum and foramen ovale compared with semilunar ganglion radiofrequency thermocoagulation

ObjectivesTo compare the advantages and disadvantages of V2 + V3 idiopathic trigeminal neuralgia using peripheral nerve radiofrequency (RF) thermocoagulation (PRF) via the foramen rotundum (FR) and foramen ovale (FO) with those of semilunar ganglion RF thermocoagulation (GRF) under local anesthesia, for exploring a new and available surgical method for patients with V2 + V3 idiopathic trigeminal neuralgia. Patients and methods102 patients with V2 + V3 idiopathic trigeminal neuralgia were enrolled in this prospective randomized controlled clinical trial, and they were divided into the PRF and GRF group randomly (n = 51 in both groups). The outcome of pain relief was assessed using the Barrow Neurological Institute (BNI) pain score, and grouped as good (BNI Class I or II, no medication required) and bad (BNI Class III–V, medication required or failed). Recurrence was defined as a relapse to a previous lower level after attainment of any higher level of pain relief. The immediate effective rate, the 2-year postoperative effective rate, the 2-year postoperative recurrence rate, and the number of complications were observed and recorded. ResultsTheir basic conditions (age, gender ratio, side of pain, and disease duration) were similar. Furthermore, we found that the 2-year postoperative effective rate between them had no significant difference. By comparing the two groups, PRF group had the better immediate effective rate of the V2 branch and no severe complications such as corneal ulcer, however, GRF group had lower 2-year postoperative recurrence rate of the V3 branch and fewer facial swelling. ConclusionThe PRF surgery, like GRF, is another prospective treatment for V2 + V3 idiopathic trigeminal neuralgia by virtue of its excellent immediate effect, accurate positioning and high safety.

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Fatih Sultan Mehmet Education and Training Hospital, Istanbul, Turkey

Background: Postherpetic neuralgia (PHN) occurs in 9% to 34% of herpes zoster (HZ) patients, and the incidence of PHN is positively correlated with age. A number of patients suffer from poor therapeutic effects or intolerable side effects and need to accept minimally invasive analgesia. Objectives: This study aimed to investigate the effects of spinal cord stimulation (SCS) and pulsed radiofrequency (PRF) on the treatment of elderly patients with HZ-related pain persisting beyond the acute phase. Study Design: A prospective, randomized-controlled trial. Setting: Research was conducted at the National Pain Management and Research Center, ChinaJapan Friendship Hospital (Beijing, China). Methods: We selected 63 patients aged over 50 years with zoster-related pain of 1 to 6 months onset. They were randomly divided into an SCS group and a PRF group. In the SCS group, the stimulus electrodes were placed in the affected spinal ganglion segment of the epidural space for 2 weeks. In the PRF group, the radiofrequency needle was percutaneously punctured in the affected dorsal root ganglion. The main outcome measures were the Numeric Rating Scale (NRS-11) score, response rate, and complete remission rate. The secondary endpoint was defined as the use of analgesics and calcium channel antagonists. Results: The NRS-11 score in the SCS group decreased to 2.90 ± 1.83 (1 week post operation) and 4.37 ± 2.43 (24 weeks post operation), while that in the PRF group decreased to 3.13 ± 1.78 and 4.23 ± 2.64, respectively (compared with baseline, P < .001); there was no significant difference between the 2 groups (P > .05) . The effective rate of pain management was in the range of 56.67% to 81.25%, and the complete pain relief rate ranged from 37% to 71%. The number of patients still using analgesics and calcium channel antagonists after operation were significantly less than those pre-operation (P < .001). Univariate and multivariate logistic regression analyses showed that the operation method, age, gender, and course of disease did not affect surgical efficacy. Limitations: The main limitation of this study is that all the cases were from the same center. Conclusion: It therefore can be concluded that SCS and PRF can effectively relieve PHN. Key words: Spinal cord stimulation, pulsed radiofrequency, postherpetic neuralgia

Comparison of Alveolar Ridge Preservation with Autograft Cancellous Bone Transplant and PRF Following Canine Tooth Extraction in Dog

Objective- Due to its specific position, the canine tooth is more exposed to the injuries, fractures and pulp necrosis. In these cases, the damaged teeth are usually pulled out. The root of this tooth is very large and sometimes extends over the premolar teeth. To extract it, a large amount of alveolar bone tissue should be harvested. Moreover, the cavity remains very large, which results in forming a cavity after repairing. It can be very effective in the form of closure of the mouth and lips.Design- Experimental studyAnimals- five adult male dogs Procedures- In this research, five dogs were selected and their maxillary canine teeth in right and left (10 teeth in total) were surgically removed. Then the right dental cavity was filled with insulin PRF and the left one filled with autograft cancellous bone chips. Three weeks after the surgery, the cavity was sampled for histopathological examination. Factors such as epithelialization rate, fibroplasia, fibrotic reaction and intensity of inflammation were studied. Results- The average score obtained from histological studies implies that epithelialization in PRF group is significantly higher than the other group, and there is no significant difference in other parameters.Conclusion and Clinical Relevance- Since PRF preparation is easy, it is not painful and risky for the patient and does not require any special care after the surgery. Therefore, it is used preferably.

REGENERATION OF OPEN ROOTAPEX IN AN IMMATURE ANTERIOR TEETH

Introduction- Aim of the study was to find out the efficiency of three protocols in terms of patient compliance, technique sensitivity & also the clinical and radiographic result with time required. Methods: standard access was done and working length was determined keeping 1mm short of the radiographic apex and minimal biomechanical preparation 17% ethylene diamine tetra-acetic acid. Root canals were irrigated using 3% NaOCI following final rinse of normal saline. The triple antibiotic paste was delivered into the canal space using paste carriers as an intracanal medicament. A sterile cotton pellet placed over the medicament and the access cavity were sealed using a cavity temporary restoration for three weeks. Visits were then rescheduled to check for infection and response to the initial treatment was assessed. None of the cases showed persistent signs/symptoms of infection. After satisfactory clinical and radiographic evidence of healing, the cases were randomly assigned to the experimental groups of blood clot, PRP and PRF; for the regenerative endodontic procedures to be carried out. Result: statistically significant difference was observed where PRP and PRF group showed superior results than blood clot group, Conclusion: use of autologous scaffolds like the platelet concentrates, Platelet-rich Fibrin and Platelet-rich Plasma, accelerates the regeneration process in an immature necrotic permanent teeth.

Evaluation of Injectable platelet rich fibrin for the management of Tempromandibular joint internal derangement. (clinical evaluation)

Temporomandibular joint (TMJ) disorders are utterly described by joint dysfunction and/or pain. Temporomandibular joint internal derangement is the most frequently reported temporomandibular disorder. Several methods have been used for the management of TMJ internal derangement ranging from conservative occlusal splints and physiotherapy, to minimally invasive arthrocentesis and to open joint invasive surgical procedures. All of which aim to restore function and relief affected joints pain. Current study aimed on clinically evaluating the effect of using injectable platelet rich fibrin as an injection drug in the temporomandibular joint following arthrocentesis procedure. Results of our study revealed that the injectable PRF group was superior to the normal arthrocentesis group in pain relief, rapidity and amount of regain of the maximum mouth opening and in the resolution of the joint noise. Concluding that intra-articular PRF injection of the TMJ was a significantly effective treatment method for the treatment of internal derangement of the temporomandibular joint.

Platelet-Rich Fibrin Improves Fat Graft Survival Possibly by Promoting Angiogenesis and Adipogenesis, Inhibiting Apoptosis, and Regulating Collagen Production

Platelet-rich fibrin (PRF) can promote fat graft survival, but limited data are currently available, and the underlying mechanism of this effect has not yet been explained. The aim of this study was to explore the mechanism by which PRF promotes fat graft survival, from the aspects of angiogenesis, adipogenesis, cellular apoptosis, and collagen production. Nude mice were randomly assigned to a PRF group (subcutaneously injected with PRF and fat in the ratio of 1:5 by volume) and a control group (subcutaneously injected with normal saline and fat in the ratio of 1:5 by volume). On days 0, 3, 7, 14, 21, and 28 after transplantation, graft samples (n = 12) were obtained for quantification of target growth factors. In weeks 1, 2, 3, and 4 after transplantation, graft samples (n = 12) were obtained for the following evaluations. The volume and weight retention rates were calculated; gene and protein expression of vascular endothelial growth factor A (VEGF-A), peroxisome proliferator-activated receptor γ (PPAR-γ), COL1-A1, and BAX were evaluated; hematoxylin & eosin staining, Masson's trichrome staining, α smooth muscle actin staining, and perilipin-1 staining were performed to evaluate graft survival. After transplantation, the concentrations of growth factors produced by the fat increased to varying degrees, and the addition of PRF made these concentration changes ever greater. Compared with the control group, the PRF group had a higher volume and weight retention rate, a higher expression level of VEGF-A and PPAR-γ, a lower expression level of COL1-A1 and BAX, a higher vessel density, less fibrosis, and more viable adipocytes. PRF can promote autocrine function of the grafted fat to produce more growth factors. It greatly increased fat retention rate, possibly by promoting vascularization and adipogenic differentiation, inhibiting cellular apoptosis, and regulating collagen production.

Investigation of the analgesic effect of platelet-rich fibrin on postoperative pain after mandibular impacted wisdom tooth extraction

ObjectivePlatelet-rich fibrin (PRF) is a second-generation platelet concentrate. PRF has been the subject of both basic and clinical studies and has seen clinical application throughout the world with a focus on its tissue regeneration effect; however, few reports have focused on PRF's postoperative pain-relieving effect. Therefore, we prospectively examined the postoperative pain-relieving effect of PRF following tooth extraction. PatientsAmong the patients who visited the Oral and Maxillofacial Surgery Department at the our hospital from April 2016 to March 2018, there were 14 male and 18 female subjects who met the inclusion criteria. ResultsThere were no significant differences in the average Visual Analog Scale (VAS) value between the PRF group and control group at the day of tooth extraction and day 2 after surgery, but at days 3 and 4 after surgery, the PRF group showed a significantly lower VAS value than the control group. ConclusionsThe present study proved the short-term efficacy of PRF immediately after surgery (within 1 week after surgery) for relieving pain.

Different Regenerative Responses of Two Platelet Concentrates in the Treatment of Human Periodontal Infrabony Defects: A Clinico-Radiographic Study.

Background:Platelet concentrates usage in the treatment of intrabony defects has been improved due to advancement of research. Many generation of platelet concentrates were used, but research regarding advanced platelet-rich fibrin (A-PRF) regarding periodontal treatment is scanty.Aim:The purpose of the study was to evaluate and compare PRF and A-PRF in the treatment of human periodontal infrabony defects (IBDs) both clinically and radiographically.Materials and Methods:Twenty-eight patients having IBDs were divided into Group A (PRF) and Group B (A-PRF). Clinical parameters such as plaque index, gingival index, probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline and 3 and 6 months and radiographic examination at baseline and 6 months were also recorded to evaluate defect fill, resolution, and change in the alveolar crest height. Then, all the data were tabulated in a Microsoft Excel sheet and subjected to statistical analysis. Mean and standard deviations of the clinical and radiographic parameters were calculated, and unpaired t-test was performed to assess intergroup comparison at different time intervals.Results:Intragroup comparison showed statistically significant improvement in PPD and CAL at 3 and 6 months while statistically significant improvement was observed in mean defect fill and resolution in Group B.Conclusion:Individually, both the materials have shown promising results. However, statistically, PRF group (Group A) showed better treatment outcome in terms of bone fill and A-PRF group (Group B) in terms of soft tissue healing.

Comparison of GTR, T-PRF and open-flap debridement in the treatment of intrabony defects with endo-perio lesions: a randomized controlled trial.

Background Titanium- prepared platelet rich fibrin (T-PRF) is an autologous hemo-component with a high concentration of platelets that also incorporates leukocytes, and growth factors into the dense fibrin matrix and can be used as a healing biomaterial. This study assesses the adjunctive use of T-PRF in intrabony defects (IBDs) with open flap debridement (OFD) in comparison with guided tissue regeneration (GTR) as a gold standard and OFD alone as a control. Material and Methods A total of 45 patients (15 per group) were randomized as either T-PRF (test group), GTR (test group), or OFD alone (control group) sites. Probing depth (PD), clinical attachment level (CAL), and IBD were recorded. The radiographic depth of IBD was also measured. Primary outcomes assessed were changes in PD, CAL, and radiographic IBD that were assessed at the beginning and nine months later. Results The PRF and GTR group showed significant improvement in clinical parameters compared with the OFD alone (control group) at nine months. While there were no significant differences in PD and CAL between test groups (T-PRF and GTR groups), the significant difference was found in radiographic IBD depth. Conclusions T-PRF may give similar successful results as GTR in the treatment of IBDs with endo-perio lesions. Key words:Flap surgery, guided tissue regeneration, intrabony defects, periodontitis, root canal therapy.

Autologous Platelet Rich Fibrin Glue Local Application at Fracture Line in Treatment of the Mandibular Angle Fractures

Objective: The aim of this study was to evaluate the application of platelet rich fibrin on the outcome of mandibular fracture. Methods: This prospective study was carried on 16 patients with mandibular angle fracture with a mean age of 35 years, PRF was applied on fracture line after reduction. Results: significantly higher mean of bone density was recorded in PRF group in first and third months postoperatively. Conclusion: PRF seems to be attributed to enhance and accelerate bone formation.

Effects of leukocyte- and platelet-rich fibrin associated or not with bovine bone graft on the healing of bone defects in rats with osteoporosis induced by ovariectomy.

To evaluate the healing of critical size defects (CSDs) in calvaria of rats with osteoporosis induced by ovariectomy and treated with leukocyte- and platelet-rich fibrin (L-PRF) associated or not with bovine bone graft (XENO). A total of 32 rats underwent a bilateral ovariectomy procedure. After 3months, one 5mm in diameter CSD was created in the middle of the calvaria of each animal. In group C, defect was filled with blood clot only. In PRF, XENO, and PRF-XENO groups, defects were filled with 0.1ml of L-PRF, 0.1ml of XENO, and a mixture of 0.1ml of L-PRF plus 0.1ml of XENO, respectively. L-PRF compressed clots were used to cover the defects in PRF and PRF-XENO groups. Animals were submitted to euthanasia at 30 postoperative days. Histomorphometric, microtomographic, and immunohistochemical analyses were performed. PRF-XENO group presented greater amount of neoformed bone (NB) when compared with XENO group, as well as higher expression of vascular endothelial growth factor (VEGF), osteocalcin (OCN), and bone morphogenetic protein (BMP-2/4) (p<.05). PRF group presented increased amount of NB and higher expression of VEGF, OCN, BMP-2/4, and Runt-related transcription factor 2 (RUNX-2) when compared with group C (p<.05). (a) The isolated use of L-PRF clot can improve bone neoformation in CSDs in rats with osteoporosis induced by ovariectomy, but seems to lead to decreased amount of bone neoformation when compared to the isolated use of XENO; (b) L-PRF potentiates the healing of XENO in rats with osteoporosis induced by ovariectomy.

High-Voltage, Long-Duration Pulsed Radiofrequency on Gasserian Ganglion Improves Acute/Subacute Zoster-Related Trigeminal Neuralgia: A Randomized, Double-Blinded, Controlled Trial

Background: Trigeminal postherpetic neuralgia is a severe neuropathic pain and often refractory to existing treatment, it develops secondary to herpes zoster-infected Gasserian ganglion. Therefore, it is important to prevent the transition of acute/subacute zoster-related pain to trigeminal postherpetic neuralgia. Despite numerous studies, the optimal intervention that reduces trigeminal postherpetic neuralgia incidence is still unknown. Objectives: This study aimed to evaluate the efficacy and safety of high-voltage, long-duration pulsed radiofrequency (PRF) on the Gasserian ganglion in patients with acute/subacute zosterrelated trigeminal neuralgia. Study Design: Prospective, randomized, double-blinded study. Setting: Department of Pain Medicine, the First Affiliated Hospital of China Medical University. Methods: Ninety-six patients with acute/subacute zoster-related trigeminal neuralgia were equally randomly assigned into 2 groups. The electrode needle punctured the Gasserian ganglion guided by computed tomography in every patient. High-voltage, long-duration PRF at 42°C for 900 seconds was applied in the PRF group (n = 48). It was also applied in the sham group (n = 48) without radiofrequency energy output. The therapeutic effects were evaluated using a visual analog scale (VAS) and the 36-Item Short Form Health Survey (SF-36) at different time points. The average dosage of pregabalin (mg/d) administrated within the first month after treatment was also recorded. Results: The postprocedure VAS scores in the PRF group were significantly lower than those in the sham group at different time points after treatment (P &lt; 0.01). The SF-36 scores, which included physical functioning, physical role, bodily pain, general health perceptions, vitality, social function, emotional role, and the mental health index, were significantly improved at the sixth month after treatment in the PRF group compared with the sham group (P &lt; 0.01). The average dosage of pregabalin administered (mg/d) within the first month after treatment was also significantly reduced in the PRF group compared with the sham group (P &lt; 0.01). There were no bleeding, infection, or other severe side effects in both groups. Limitations: Single center study, relatively small number of patients. Conclusions: High-voltage, long-duration PRF on the Gasserian ganglion is an effective and safe therapeutic alternative for patients with acute/subacute zoster-related trigeminal neuralgia. Key words: Pulsed radiofrequency, zoster-related trigeminal neuralgia, visual analog scale, 36- Item Short Form Health Survey

A New Approach for Root Surface Biomodification Using Injectable Platelet-Rich Fibrin (I-PRF).

BackgroundThis study investigated the potential effects of Injectable Platelet-Rich Fibrin (I-PRF) on root coverage of free gingival graft surgery.Material/MethodA total of 40 patients with Miller class I or II gingival recession were included. The patients who participated in this study were randomly divided into 2 groups, including the control and experiment groups. The patients in the control group were treated only with free gingival graft (FGG). The patients in the experiment group were treated with free gingival graft and injected with I-PRF as a root surface biomodification agent (FGG+I-PRF). The patients were called back after 3 months, and the amount of exposed root surface was determined and compared to the preoperative findings.ResultsThe mean initial exposed root surface was 4.7±1.49 mm for the FGG+I-PRF group, 4.1±1.07 mm for the FGG group, and 4.4±1.31 mm for all subjects. Three months after the operation, the mean root surface coverage values of the 2 groups were 3.5±1.05 and 3.9±0.78 mm in the control and experiment groups, respectively.ConclusionsThe findings showed that the injection of Injectable Platelet-Rich Fibrin (I-PRF) had a positive effect on root coverage in free gingival graft surgery.

Comparative Evaluation of Coronally Advanced Flap Using Platelet-rich Fibrin Membrane and Fresh Amniotic Membrane in Gingival Recession

Background: the aim of this study was to evaluate and compare the effectiveness of root coverage with coronally advanced flap combined with Platelet Rich Fibrin or Fresh Amniotic Membrane. Materials and Methods: thirty patients had Miller class I or II in maxillary anterior teeth were involved in the present study. Each recession defect was randomly assigned to one of the treating groups: coronally advanced flap with Platelet rich fibrin (PRF group) and coronally advanced flap with fresh amniotic membrane (AM) (AM Group). Clinical measurements of recession depth (RD), root coverage percentage (RC%) pocket depth (PD), clinical attachment level (CAL) and width of keratinized tissue (WKT) were evaluated at the baseline, three months, six months and nine months postoperatively. Statistical analysis was performed for intergroup and intragroup comparisons respectively. Results: intragroup comparison displayed statistical significant difference with regard to RD and CAL at different time interval. No statistical significant difference between groups at different time interval with regard to RD, PD, CAL while WKT, AM group demonstrated statistical significant increase compared to PRF group. Conclusion: Both the membranes provided successful and predictable root coverage when combined with CAF. AM was more effective in terms of increase in WKT.