This paper aims to establish the existence of traveling wave solutions connecting different equilibria for a spatial eco-epidemiological predator-prey system in advective environments. After applying the traveling wave coordinates, these solutions correspond to heteroclinic orbits in phase space. We investigate the existence of the traveling wave solution connecting from a boundary equilibrium to a co-existence equilibrium by using a shooting method. Different from the techniques introduced by Huang, we directly prove the convergence of the solution to a co-existence equilibrium by constructing a special bounded set. Furthermore, the Lyapunov-type function we constructed does not need the condition of bounded below. Our approach provides a different way to study the existence of traveling wave solutions about the co-existence equilibrium. The existence of traveling wave solutions between co-existence equilibria are proved by utilizing the qualitative theory and the geometric singular perturbation theory. Some other open questions of interest are also discussed in the paper.
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