ObjectivesLong-haul truck drivers experience multiple challenges, including increased health risks. A large percentage of professional truck drivers (PTDs) suffer from numerous chronic physical health conditions such as obesity, hypertension, diabetes, heart disease, sleep disorders, etc.) as well as poor mental health and social challenges. Furthermore, this population experiences numerous barriers related to accessing health care services including primary care and resources to improve their health. PTDs living in rural and remote areas are at higher risk. The objective of this study is to understand the views of PTDs and the trucking industry on health and personalized healthcare interventions and services.MethodsIn-depth semi-structured interviews were conducted with twenty-six individuals with contextual knowledge and experience in the trucking ecosystem, to better understand the needs, expectations, and preferences of PTDs based in New Brunswick (Canada), related to their health (physical, mental, and social). Analysis of the audiotape recording was conducted using thematic content analysis.ResultsThree major themes emerged from the qualitative analysis describing PTDs’ health needs, existing health and preventive services, as well as recommendations for personalized healthcare interventions and services to be implemented: (1) “My life as a trucker!” Understanding needs and challenges, (2) “Taking care of myself, do you think it is easy while you’re on the road?” Describing drivers and motivators for better health, and (3) “Can you hear what we need?” Translating needs into recommendations for tailored health services and preventative services.ConclusionA highly demanding work environment and lack of timely access to integrated primary care negatively affect PTDs’ health. Results of this study shed light on how to tailor primary care to improve its responsiveness and adequacy to PTDs’ needs and realities. PTDs-sensitive integrated services, including multicomponent interventions (health education, coaching for lifestyle changes, and social support), are still lacking within the New Brunswick health system.