<h3>Background</h3> Catheter Associated Urinary Tract Infections (CAUTI) are the most frequent healthcare acquired infections. Key initiatives to reduce CAUTI have been supported by multiple healthcare organizations. A quality Improvement project was created to establish a robust, sustainable, enhanced multi-disciplinary CAUTI prevention program reducing catheter utilization and CAUTI rates. <h3>Methods</h3> Collaboration to reduce the incidence of CAUTI occurred through education, product evaluation, and practice changes via Centers Disease Control (CDC) evidence-based guidelines. These guidelines are organized into five evidence-based prevention initiatives: avoiding unnecessary catheters/limiting duration, aseptic technique and standardization for insertion, catheter maintenance, catheter necessity, and engaging healthcare workers (HCW) with culture change. Engaging HCW and culture change was incorporated into each of the other four initiatives. CAUTI were defined using National Healthcare Safety Network (NHSN) patient safety chapter, patient days from finance and device days from the electronic medical record; 10 months pre-implementation was compared with 10 months post-implementation. <h3>Results</h3> Implementing evidence based practices and engaging stakeholders, resulted in decreased catheter utilization and CAUTI rates, 24% and 42%, respectively. After the implementation of the evidence based strategies,10 fewer CAUTI were identified. The evidence-based improvements included: external female collection device, daily review of duration/necessity, limiting catheter insertion in the ED and OR, daily discussions with front line staff regarding necessity/removal, and senior leadership emphasis and support driving culture change. <h3>Conclusions</h3> The equal importance of each initiative was the key to program success, including skilled communication, true collaboration, and focused shared goals are key in developing partnerships to achieve cultural change and promote safe patient care. The most powerful strategy positively impacting these results was the executive leadership promoting initiative accountability. Leadership commitment powered decreased utilization, early catheter removal, and sustainment of evidence based initiatives. Continued decrease in the utilization will promote our low rates of CAUTI.