Prevention In Women Research Articles

Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk of Cancer

Background: This study evaluates the effects of hydroxytyrosol (HT), a component of olive oil, on mammographic breast density reduction. We explored effects of HT on Wnt β‐catenin and other pathways involved in cancer stem cell renewal, DNA repair, cell proliferation, and differentiation.Methods: Twenty‐five milligrams per day oral dose of HT was given for 12 months in pre‐ and postmenopausal women at increased risk of breast cancer. Out of 51 patients enrolled, 41 completed the study. The annualized percent decrease in maximum mammographic volumetric breast density (max VBD%) between baseline (BL) and end of treatment (EOT) was analyzed. RNA sequencing (RNA‐Seq) and multiplex analysis was performed on the breast biopsies to compare the BL with EOT samples.Results: Max VBD% showed a nonsignificant change; however, in women 60 years or older, the max VBD% decrease was significant (3.7%, p = 0.0391), especially in those with high BL mammographic density. Using RNA‐Seq, 3330 unique transcripts were identified (p < 0.05). Mitotic telophase/cytokinesis and DNA damage were upregulated, whereas Wnt, Notch, and oxidative stress–induced senescence pathways were downregulated (p < 0.05). These pathways were confirmed by NanoString nCounter where significant decrease in proliferative genes (RELA and CDK4) and Wnt pathway (R‐HSA‐195721 and R‐HAS‐201681) was observed (p < 0.05).Conclusions: HT reduced breast density only in women over 60 years, especially in those with high BL breast density. HT also reduced proliferation and affected the Wnt signaling pathway. This study lays the foundation for future larger studies in exploring a natural compound with well tolerability and overall nontoxic profile for chemoprevention of breast cancer.Trial Registration: ClinicalTrials.gov identifier: NCT02068092

The Role of Healthcare Providers in Shared Decision Making for Cervical Cancer Prevention in Ghana: A Qualitative Study.

Cervical cancer is currently the second leading cause of cancer death among women in Ghana. Several studies have identified healthcare providers as key stakeholders in cervical cancer prevention. There is limited data on the role healthcare providers in Ghana play in shared decision making for cervical cancer prevention. The purpose of this study was to investigate healthcare providers' perceptions about women's cervical cancer prevention behaviors and their practices for recommending cervical cancer prevention services to their patients. In-depth interviews were conducted with healthcare providers (n=27) working at healthcare institutions in Ghana. Qualitative analysis was done using in-vivo coding and thematic content analysis. The PEN-3 model, and the SHARE approach were used as the theoretical framework for the study. Healthcare providers were the main source of cervical cancer information for their patients. However, several providers acknowledged that they have inadequate knowledge about cervical cancer. Several providers stated that they seek their patients' opinion about cervical cancer when recommending cervical cancer prevention services to them. Most of the providers recommend cervical cancer prevention services when patients have suggestive symptoms. They address their patients' concerns and fears about cervical cancer by educating and reassuring them. The cost of preventive services, lack of knowledge, cultural and religious beliefs, were identified as major factors that influence their patients' health seeking behavior for cervical cancer prevention services. In Ghana, healthcare providers play a significant role in cervical cancer prevention. Therefore, there is a need for training programs to empower providers in shared decision making, and in recommending cervical cancer prevention services to patients.

EE571 Economic Analysis of Liquid-Based Cytology for Cervical Cancer Prevention in Women in Austria

EE571 Economic Analysis of Liquid-Based Cytology for Cervical Cancer Prevention in Women in Austria

Navigating women's cancer prevention: Two cross-sectional studies to investigate psychosocial antecedents of cervical and breast cancer screening attendance.

Despite population-based cancer screening programmes effectively decreasing mortality, participation rates are unsatisfactory for both cervical and breast screening. This research tested an integrated theory of planned behaviour model applied to cervical cancer screening (CCS; Study 1) and breast cancer screening (BCS; Study 2) attendance. Women residing in Campania (Italy) and belonging to each screening target population joined two independent surveys (Study 1: n = 332, Mage = 41.03, SD = 11.45; Study 2: n = 298, Mage = 55.03; SD = 5.17). In both studies, screening behaviour was predicted by intention to undergo the screening, action and coping planning. Significant predictors of intention were subjective norms, perceived behavioural control and self-identity in Study 1, and subjective norms, anticipated regret and self-identity in Study 2. A mediation analysis confirmed the role of action and coping planning in the intention-behaviour relation. This model can guide forthcoming interventions and steer enhancements in healthcare access.

Constructing, Deconstructing or Abolishing? Discourses on Masculinities in Violence Against Women Prevention by Stakeholders in Spain.

In the field of violence against women (VAW) prevention, one of the current questions at stake is how to address men's role and masculinities, but it is still an emerging field in Spain. The aim of this study was to analyze the up-to-date discourses on masculinity among stakeholders in the field of VAW prevention and gender equity in Spain. We used a qualitative methodology with semi-structured interviews, conducted between October 2019 and February 2020 in Madrid and Alicante (Spain), with 23 key stakeholders from different areas: in governmental (public health and VAW prevention/intervention, and institutional and policy positioning) and nongovernmental organizations (anti-violence masculinities workers, youth education workers, and feminist and LGBT associations). A discourse analysis was performed with the data collected. Our findings showed that discourses around masculinities among Spanish stakeholders in VAW prevention and gender equity were diverse and presented different layers of critique. Despite a general agreement on the importance of transforming sexist men's practices toward more gender equitable relations, three main interpretive repertoires were identified: "Constructing positive/new masculinities" discourse, focused on promoting men's engagement and egalitarian practices; "Deconstructing hegemonic masculinity" discourse, intended to critically identify and question harmful masculinities norms; and "Abolishing gender" discourse, which aims at dismantling masculinity, and gender in general, as a social structure that generates oppression in itself, advocating for its abolition. Those interpretive repertoires were not mutually exclusive and sometimes stakeholders incorporate in their work more than one approach. The study findings shed light on this current emerging and urgent debate and contributes more broadly to the critical assessment of the concepts used and their implications for VAW prevention.

Proposal to improve the patient journey for women's cardiovascular prevention

The relevance of gender medicine in cardiovascular prevention is still underestimated, and there is a lack of viable women-specific preventive, diagnostic, and therapeutic strategies. To ensure women have equal access to cardiovascular prevention, cardiovascular disease risk stratification needs to consider gender-specific factors related to women reproductive cycle phases together with the different impact that traditional risk factors have on men and women. The aim of this document is to improve the patient journey for cardiovascular risk prevention in women, enhancing the importance of a multidisciplinary approach and the role of the various professional figures involved, starting with the general practitioner, as the main actor of the first risk stratification. The goal of the proposed patient journey is to ensure effective risk assessment of cardiovascular disease in women, by raising attention on the risk factors related to different hormonal phases and to bridge the sex and gender gap in cardiovascular prevention. We hope that this journey can be implemented as uniformly as possible in clinical practice throughout Italy.

The Effect of Nutrition Education on Knowledge, Attitudes and Consumption Patterns of Young Women in Prevention of Chronic Energy Deficiency in Bengkulu City

Adolescents is one of age groups vulnerable to nutritional status. Adolescence requires higher nutrition in order to optimize physical, cognitive and psychosocial growth. Lifestyle and diet of adolescents will affect the fulfillment of nutritional needs. Nutrition education can be carried out properly and can be received directly depending on how the message is conveyed, how the message is received and where the message is delivered. Barriers to prevention of chronic energy deficiency in adolescents can be sourced from environmental influences. Several studies The existence of significant changes in behavior in eating patterns through interventions from nutrition education can prevent Chronic Energy Deficiency (CED) in adolescents. This research aims to evaluate the impact of nutrition education on knowledge, attitudes and consumption patterns in prevention of CED in Young Girls SMPN 19 Padang Serai and SMKS Kampung Bahari, Bengkulu City. This study used quasi experiment with a two-group pre-test and post-test design. The intervention was carried out in the form of nutrition counseling using booklets or modules with a frequency of 3 meetings in 3 weeks. Nutrition education is promoting nutrition messages through education with a learning process using booklets individually and in groups using the lecture method. This study resulted an increased in knowledge, attitudes and consumption patterns after being given nutrition education in prevention of chronic energy deficiency of young women in Bengkulu City (p=0.000). There is an increase and influence between knowledge, attitudes and consumption patterns after being given adolescent nutrition education.

Knowledge and Attitudes Related to Behavior of Pregnant Women in Prevention of Covid-19

Background The Central Sulawesi Provincial Health Office noted that until April 7 2021 the number of Covid-19 patients was 11,424. Palu City occupies the maximum number of patients with 3,042 people. One of the groups at risk of exposure to Covid-19 is pregnant women. During the pandemic, pregnant women felt more comfortable doing examinations at the Independent Midwife Practice Place (TPMB) for fear of contracting Covid-19. Purpose This research is to find out the relationship between knowledge and attitudes in pregnant women's behavior toward the prevention of Covid-19 at the Mandiri Midwife Amanah Practice. Methods This quantitative research uses a cross-sectional design using 53 samples of pregnant women who visited TPMB Amanah from June to July 2021. Samples were taken accidentally using a questionnaire instrument. Univariate (frequency distribution) and bivariate data analysis using the kai square test reported in tabular and. Results The research found that most of the respondents had good knowledge, namely 22 respondents (41.5%), had a positive attitude 35 respondents (66%), and behaved not doing 3M totaling 30 respondents (56.6%) with a p-value ≤ 0, 05, which is 0.000. Conclusion There is a relationship between knowledge and attitudes regarding the behavior of pregnant women in preventing Covid-19. It is recommended to actively seek reliable information regarding the prevention of transmission of Covid-19 and get used to carrying out the stages of preventing

Abstract P2-07-01: Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk

Abstract Background Breast cancer is the most frequently diagnosed cancer in women in developed countries with increased incidence in women at high risk such as those with strong family history, BRCA mutations, atypical hyperplasia etc. Chemoprevention with drugs like tamoxifen and aromatase inhibitors come with challenges of intolerance and limited efficacy in estrogen receptor negative breast cancers. The purpose of our study was to evaluate the effects of hydroxytyrosol (HT), a component of olive oil on mammographic breast density reduction, which is a validated surrogate biomarker for breast cancer prevention as well as to explore on-target effects on Wingless-related integration site (Wnt) pathway, and alterations in key pathways of proliferation, DNA damage repair and stem cell function. Methods This study was conducted using 25mg/day oral dose of HT for 12 months in both pre- and post-menopausal women who are at increased risk of breast cancer with Gail 5-year risk score ≥ 1.67 and/or > 10% probability of BRCA mutation and had declined standard chemoprevention. These women underwent annual mammograms as well as had the option to have a biopsy of normal breast tissue before and after HT. Maximum volumetric breast density (Max VBD%) was assessed quantitatively using Volpara software (VIS 3.2) and the annualized percent decrease in max VBD% between baseline (BL) and end of treatment (EOT) with HT was analyzed in the study. RNA was extracted from the breast biopsies and RNA sequencing (RNA-Seq) and multiplex analysis of 28 proteins using NanoString nCounter analysis was performed to compare the BL with EOT samples. Results A total of 61 women were screened for the trial, 51 were enrolled and 41 patients completed the study. Median age for the study population was 54 years (range 35-76 years). There were 26 patients with paired BL and EOT mammograms. There were 14 patients with paired BL and EOT breast biopsies and seven patients with only BL and seven with only EOT biopsies. Mammographic density as measured by max VBD% showed a non-significant change of -0.038%, p = 0.49. However, on subgroup analysis in women 60-years or older, the mean decrease in max VBD% was - 3.7% (p = 0.0391), especially in those with high baseline mammographic density (> 10% baseline max VBD%). RNAseq data was generated from 15 BL and 17 EOT samples and pathways were confirmed by NanoString. Our bioinformatics pipeline identified 190 transcripts that were upregulated and 90 that were downregulated in EOT vs. BL by at least 1.5 fold. Reactome pathway R-HSA-195721 (Signaling by WNT) is identified as the top pathway enriched with EOT downregulated genes. On further review of the expression profiles, 82 of 261 member genes had p-value < 0.05 for EOT vs. BL, among which only 4 were upregulated and 78 were downregulated in EOT samples. These 82 genes were highly interactive with each other, with 379 high confidence protein-protein interactions (PPIs) (confidence score > 0.7 from STRING database) involving 81 out of 82 genes. In addition, mitotic telophase/cytokinesis (p = 0.004), ATM signaling (p = 0.007) were some pathways that were upregulated whereas, NOTCH signaling (p = 0.007), oxidative stress induced senescence (p = 0.0001) pathways were downregulated in EOT vs. BL. Conclusions Hydroxytyrosol, a component of olive oil did not show a decrease in breast density in the intention to treat population but showed some reduction in breast density in women 60-years of age and above, especially in those with high baseline breast density. HT showed on target effects by affecting Wnt signaling pathway, as well as decrease in proliferation. This study lays the foundation for future larger studies in exploring a natural compound such as HT for chemoprevention of breast cancer. Citation Format: Akshjot Puri, Zheng Yin, Sergio Granados-Principal, Joe Ensor, Liliana Guzman, Roberto Rosato, Hong Zhao, Stephen Wong, Tejal Patel, Jenny Chang. Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P2-07-01.

Recommendations for Cardiovascular Disease Prevention in Women

Cardiovascular disease (CVD) is one of the leading causes of death in women. On an average, coronary artery disease develops 10 years later in women than men, but they represent the majority of patients when age above 75 years is considered. Men and women share most of the classic cardiovascular risk factors, but the relative importance of each risk factor may be gender specific. This review explores the recommendations for the management of cardiovascular risk and CVD prevention in women in the Indian clinical setting based on multiple advisory board meetings conducted with cardiology experts across India. The experts concurred that women have distinct patterns of ischemic heart disease (IHD) and that the presence of traditional risk factors, female-specific risk factors, and nontraditional risk variables may add to the increasing risk of IHD. Transition to postmenopausal status is associated with a worsening coronary heart disease risk profile in women. Evidence suggests that both traditional and novel cardiovascular risk factors are often under recognized and undertreated in women. Several female-specific risk factors such as preterm delivery, preeclampsia, gestational diabetes, and polycystic ovary syndrome are not included in primary prevention nor are they routinely considered in a cardiovascular assessment at the clinical level. Understanding and good diagnostic tools are necessary to evaluate the different pathophysiological aspects and early detection of CVD in women.

Female Health Across the Tree of Life: Insights at the Intersection of Women's Health, One Health and Planetary Health.

Across the tree of life, female animals share biological characteristics that place them at risk for similar diseases and disorders. Greater awareness of these shared vulnerabilities can accelerate insight and innovation in women's health. We present a broadly comparative approach to female health that can inform issues ranging from mammary, ovarian, and endometrial cancer to preeclampsia, osteoporosis, and infertility. Our focus on female health highlights the interdependence of human, animal, and environmental health. As the boundaries between human and animal environments become blurred, female animals across species are exposed to increasingly similar environmental hazards. As such, the health of female animals has unprecedented relevance to the field of woman's health. Expanding surveillance of animal populations beyond zoonoses to include noncommunicable diseases can strengthen women's health prevention efforts as environmental factors are increasingly implicated in human mortality. The physiology of nonhuman females can also spark innovation in women's health. There is growing interest in those species of which the females appear to have a level of resistance to pathologies that claim millions of human lives every year. These physiologic adaptations highlight the importance of biodiversity to human health. Insights at the intersection of women's health and planetary health can be a rich source of innovations benefitting the health of all animals across the tree of life.

Injury Prevention in Women's Gymnastics - A Need for New Routines.

Injury Prevention in Women's Gymnastics - A Need for New Routines.

Using the Stages of Change to Counsel Victims of Intimate Partner Violence

Medical, women's health, trauma, and violence prevention researchers have investigated the transtheoretical model and motivational interviewing as potential treatment models for victims of intimate partner violence. Despite these models’ prevalence in counseling, they have received minimal attention related to victims of intimate partner violence in counseling journals. The purpose of this paper is to conceptualize the use of the transtheoretical model and motivational interviewing to counsel victims of intimate partner violence. We provide overviews of both models and how they can be applied with intimate partner violence victims. Further, we explore how counselors can use the transtheoretical model and motivational interviewing to inform case conceptualization, treatment planning, and interventions for victims of intimate partner violence. Finally, we discuss the ethical implications of applying the transtheoretical model and motivational interviewing to intimate partner violence.

Dapivirine Vaginal Ring for HIV Prevention in Women in South Africa

Young women remain disproportionately affected by the HIV epidemic in South Africa. Clinical trials have shown that the dapivirine vaginal ring (DVR) is safe and effective at reducing HIV infection in women. In March 2022, the South African Health Products Regulatory Authority approved the use of the DVR in women aged 18 years and older who are unable or unwilling to use oral pre-exposure prophylaxis, as an additional choice for preventing HIV in women at substantial risk. Modelling studies have suggested that the DVR could have a substantial impact if prioritized for women at substantial risk of HIV or women aged 22–29 years. The licensing of the DVR in South Africa is a milestone event that brings the first long-acting and woman-controlled HIV prevention method another step closer to reaching the people who need it. As South Africa prepares its introduction, it is critical to examine the unmet need for HIV prevention and to review the clinical trial data that led to the DVR's approval.

Cervical Cancer Prevention Behaviors Among Criminal-Legal Involved Women from Three U.S. Cities.

Background: This study aims to understand how criminal-legal involved women from three U.S. cities navigate different health resource environments to obtain cervical cancer screening and follow-up care. Methods: We conducted a cross-sectional study of women with criminal-legal histories from Kansas City KS/MO; Oakland, CA; and Birmingham, AL. Participants completed a survey that explored influences on cervical cancer prevention. Responses from all women with/without up-to-date cervical cancer screening and women with abnormal Pap testing who did/did not obtain follow-up care were compared. Proportions and associations were tested with chi-square or analysis of variance tests. Multivariable regression was performed to identify variables independently associated with up-to-date cervical cancer screening and reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: There were n = 510 participants, including n = 164 Birmingham, n = 108 Kansas City, and n = 238 Oakland women. Criminal-legal involved women in Birmingham (71.3%) and Kansas City (68.9%) were less likely to have up-to-date cervical cancer screening than women in Oakland (84.5%, p = 0.01). More women in Birmingham (14.6%) and Kansas City (16.7%) needed follow-up for abnormal Pap than women in Oakland (6.7%, p = 0.003), but there were no differences in follow-up rates. Predictors for up-to-date cervical cancer screening included access to a primary care provider (OR: 3.3, 95% CI: 1.4-7.7), health literacy (OR: 0.3, 95% CI: 0.2-0.7), and health behaviors, including avoiding tobacco (OR: 0.4, 95% CI: 0.1-0.9) and HPV vaccination (OR: 3.4, 95% CI: 1.0-10.9). Conclusions: Cervical cancer screening and follow-up varied by study site. The results suggest that patient level factors coupled with the complexity of accessing care in different health resource environments impact criminal-legal involved women's cervical cancer prevention behaviors.

The Effect Of Koya Reboned Powder Consumption On Protein Levels Of Pregnant Women In Prevention Of Stunting In Babies

Linear growth retardation in childhood has decreased over the past few decades, but has not had a positive effect. In Indonesia, the change in the prevalence of stunting is around 37%. The nutritional status of pregnant women plays an important role in the incidence of stunting, which will be seen at the age of <5 years in 1000 days of their life. Pregnant women with poor nutrition and significant infection can give birth to a baby with stunting. For this reason, nutritional intake is needed, one of the animal foods that are high in protein is rebon shrimp about 62.4 g / 100 grams of dried shrimp. Protein has an important component so it is necessary for the physical development of children. The purpose of this study was to analyze serum protein levels before and after consuming rebon shrimp based PMT powder in the intervention group and control group and to analyze differences in serum protein levels for pregnant women before and after consuming PMT Koya powder made from rebon shrimp between the control and intervention groups. . This type of research is a quantitative study with a quasi-experimental method using the pre post test control group design approach. The number of respondents was 30 people who were divided into 2 groups, namely the intervention group and the control group. The intervention group was given koya powder as much as 100 grams / day for 7 days, assuming the fulfillment of 70 KKal. Data analysis using Data analysis using the Mann-Whitney test, if the data is not normally distributed. If the data are not normally distributed using the free sample t2 test. The conclusion of the analysis results to answer the research hypothesis. The results of the study were significant values P 0.000 <0.05. Conclusion There was a significant difference in serum protein levels of pregnant women before and after consuming PMT Koya powder made from boiled shrimp between the control and intervention groups.

Cervical cancer screening and follow-up among women in the criminal-legal system

<h3>Objectives:</h3> The one million U.S. women under supervision of the criminal-legal (CL) system are a populuation with 4-5 times the rate of cervical cancer than the general population–a disparity that has persisted for over 50 years. CL-involved women include those who have recently left jails/prisons, are on probation, or are in community corrections but still under legal supervision. Up to 60% of CL-involved women have a history of an abnormal Papanicolaou (Pap) test due to sexual health risks, trauma histories, and tenuous life circumstances that increase their risk of cervical dysplasia and serve as barriers to preventative care. The purpose of this study is to understand how women with CL involvement navigate individual, social, and community level systems to maintain their cervical health in varied funding and healthcare access environments. <h3>Methods:</h3> Retrospective cross-sectional study that analyzed baseline data from an ongoing longitudinal (2019-2024) study with CL-involved women, the Tri-City study. Data was collected from January-June 2020 and includes 508 CL-involved women from Kansas City, KS/MO (KC); Oakland, California (Oak); and Birmingham, AL (Birm). Participants completed a 288-item survey that explored influences on health services use as guided by the behavioral model for vulnerable populations (BMVP). Categorical variables were reported using frequencies and continuous data was reported as means with standard deviations. Proportions and associations were tested with chi-square or fisher's exact test. Multivariate regression was performed after controlling for study site and reported as odds ratios (OR) with 95% confidence intervals (CI) and corresponding p-values. <h3>Results:</h3> CL-involved women in KC (68.9%) and Birm (71.3%) were less likely to have up-to-date Pap testing than women in Oak (84.5%, p=0.01). Of the CL-involved women who needed follow-up for abnormal Pap results, only 58% of Birm and 66% of KC women completed follow-up whereas 88% of women in Oak completed follow-up and other 5% had an appointment scheduled (p=0.1). Using a BMVP framework, predictors for up-to-date Pap test included lower belief score for barriers to screening (OR 0.3, 95% CI 0.2-0.7, p=0.003), personal doctor (OR 3.3, 95% CI 1.4-7.7, p=0.005), not using tobacco (OR 0.4, 95% CI 0.1-0.9, p=0.05), and HPV vaccination (OR 3.4, 95% CI 1.0-10.9, p=0.04). When comparing CL-involved women who did or did not obtain follow-up for an abnormal Pap result, factors associated with follow-up in the bivariate analysis included lower susceptibility score (2.4 follow-up vs 3.1 no follow-up, p=0.007), lower severity of disease scores (3.3 follow-up vs 4.0 no follow-up, p=0.008), using hormonal birth control (22.5% follow-up vs 11.1% no follow-up, p=0.05), and not using condoms (42.5% follow-up vs 11.1% no follow-up, p=0.05). However, none of these variables were significant predictors of abnormal Pap follow-up in the multivariate model. <h3>Conclusions:</h3> Pap testing and follow-up varied by study site with the highest rates observed in Oakland, which was the only city that offered health services through Medicaid expansion. The results of our baseline data suggest that patient level factors coupled with the complexity of navigating community health delivery systems impacts CL-involved women's cervical cancer prevention behaviors.

PENDIDIKAN KESEHATAN MELALUI MEDIA ONLINE TERHADAP PENGETAHUAN DAN PERILAKU PENCEGAHAN KANKER SERVIKS PADA WUS DI SIKKA

Background: Reproductive health problems faced by women today are increasing infections in the reproductive organs, which in turn lead to cancer, one of that is cervical cancer. Lack of awareness to prevent cervical cancer is one of the problems that often occur in the health of Fertile Age Women. The effort that needs to be done to prevent cervical cancer is by providing health education through online media, to increase the knowledge and behavior of Fertile Age Women in preventing cervical cancer. The purpose of this research is to determine the effect of health education on early detection of cervical cancer through online media on the knowledge and behavior of Fertile Age Women in cervical cancer prevention in Nanga Public Health Center of Sikka Regency. Method of this research used a pre-experimental design with one group pre-test post-test design method, using a consecutive sampling technique, with as many as 199 respondents. The data collection tool used a questionnaire. Data were analyzed through the Wilcoxon Signed Rank Test with SPSS for windows version 20. Results of this research indicated that there was a very significant effect on the provision of health education through online media on early detection of cervical cancer on knowledge and behavior of cervical cancer prevention of Fertile Age Women in Nanga Public Health Center of Sikka Regency with a p-value of 0.000 (p &lt; 0.05). Providing health education on early detection of cervical cancer with online media can increase knowledge and behavior of cervical cancer prevention of Fertile Age Women. It is hoped that the public health center will provide health education with online media, to support the prevention of covid-19 transmission and to increase the knowledge and behavior of Fertile Age Women in cervical cancer prevention.

The Relationship of Diet and Physical Activity with Weight Gain and Weight Gain Prevention in Women of Reproductive Age.

Reproductive-age women often see increased weight gain, which carries an increased risk of long-term overweight and obesity and adverse maternal and child health outcomes. Supporting women to achieve optimal weight through lifestyle modification (diet and physical activity) is of critical importance to reduce weight gain across key reproductive life-stages (preconception, pregnancy and postpartum). This review comprehensively summarizes the current state of knowledge on the contribution of diet and physical activity to weight gain and weight gain prevention in reproductive-aged women. Suboptimal diets including a higher proportion of discretionary choices or energy intake from fats, added sugars, sweets or processed foods are associated with higher weight gain, whereas increased consumption of core foods including fruits, vegetables and whole grains and engaging in regular physical activity are associated with reduced weight gain in reproductive age women. Diet and physical activity contributing to excessive gestational weight gain are well documented. However, there is limited research assessing diet and physical activity components associated with weight gain during the preconception and postpartum period. This review highlights the need for further research to identify key dietary and physical activity components targeting the critical windows of reproductive life-stages in women to best guide interventions to prevent weight gain.

Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association.

This statement summarizes evidence that adverse pregnancy outcomes (APOs) such as hypertensive disorders of pregnancy, preterm delivery, gestational diabetes, small-for-gestational-age delivery, placental abruption, and pregnancy loss increase a woman's risk of developing cardiovascular disease (CVD) risk factors and of developing subsequent CVD (including fatal and nonfatal coronary heart disease, stroke, peripheral vascular disease, and heart failure). This statement highlights the importance of recognizing APOs when CVD risk is evaluated in women, although their value in reclassifying risk may not be established. A history of APOs is a prompt for more vigorous primordial prevention of CVD risk factors and primary prevention of CVD. Adopting a heart-healthy diet and increasing physical activity among women with APOs, starting in the postpartum setting and continuing across the life span, are important lifestyle interventions to decrease CVD risk. Lactation and breastfeeding may lower a woman's later cardiometabolic risk. Black and Asian women experience a higher proportion APOs, with more severe clinical presentation and worse outcomes, than White women. More studies on APOs and CVD in non-White women are needed to better understand and address these health disparities. Future studies of aspirin, statins, and metformin may better inform our recommendations for pharmacotherapy in primary CVD prevention among women who have had an APO. Several opportunities exist for health care systems to improve transitions of care for women with APOs and to implement strategies to reduce their long-term CVD risk. One proposed strategy includes incorporation of the concept of a fourth trimester into clinical recommendations and health care policy.