Background: Psoriasis is a chronic autoimmune condition marked by elevated patches of unusual skin that are red, pink, or purple in color. These patches are dry, itchy, and covered in scales. The severity of psoriasis ranges from minor, limited areas to affecting the entire body. In recent years, the prevalence of psoriasis has increased. Factors like excessive cosmetic use, unhealthy dietary patterns, unprotected exposure to pesticides, nutritional deficiencies, psychological stress, and sedentary behavior are common lifestyle alterations that might contribute to this condition. Case: A 49-year-old male patient suffering from 5 years visited the hospital for treatment. From an Ayurvedic perspective, we can compare the disease with Kitibha kustha (a type of skin lesion) because most of its symptoms mimic the signs and symptoms of Plaque psoriasis. Conclusion: Even though plaque psoriasis is very difficult to treat, a thorough assessment of pathogenesis, proper Shodhana (purification), Shamana (pacifying therapy), and rasayana (rejuvenation therapy) have proven to be effective along with a swinging decrease of PASI, and DLQI from 36.8, 12 to 3.2 and 2.